A newly found understanding of receptor signaling may have revealed a better way to design drugs. A study from Nationwide Children's Hospital suggests that a newly identified group of proteins, alpha arrestins, may play a role in cell signaling that is crucial to new drug development. The study appears in PLOS ONE. More than one-third of drugs on the market work by targeting G protein-coupled receptors that control how cells communicate and function. With many hundreds of members, G protein-coupled receptors are the largest family of signaling receptors throughout the ...

Infants with severe lower respiratory tract infection caused by respiratory syncytial virus (RSV) may have a dysfunctional innate immune response that relates to the severity of their disease. These are the findings from a Nationwide Children's Hospital study appearing in a recent issue of the Journal of Infectious Diseases. RSV is the leading cause of lower respiratory tract infection in young children worldwide. The majority of children hospitalized with this condition are previously healthy with no known risk factors for serious disease. Of these infants, up to 20 ...

ATLANTA – December 10, 2012—A new American Cancer Society study finds a strong inverse association between caffeinated coffee intake and oral/pharyngeal cancer mortality. The authors say people who drank more than four cups of caffeinated coffee per day were at about half the risk of death of these often fatal cancers compared to those who only occasionally or who never drank coffee. The study is published online in the American Journal of Epidemiology. The authors say more research is needed to elucidate the biologic mechanisms that could be at work. Previous epidemiologic ...

HERSHEY, Pa. -- Overweight women are not receiving proper advice on healthy weight gains or appropriate exercise levels during their pregnancies, according to Penn State College of Medicine researchers. "Excessive weight gain during pregnancy is associated with weight retention after delivery and is a positive predictor of obesity after pregnancy," Dr. Cynthia Chuang, associate professor of medicine and public health sciences said. "Excessive gestational weight is particularly concerning for overweight and obese women given their already increased risk for pregnancy ...

An analysis of sulfide ore deposits from one of the world's richest base-metal mines confirms that oxygen levels were extremely low on Earth 2.7 billion years ago, but also shows that microbes were actively feeding on sulfate in the ocean and influencing seawater chemistry during that geological time period. The research, reported by a team of Canadian and U.S. scientists in Nature Geoscience, provides new insight into how ancient metal-ore deposits can be used to better understand the chemistry of the ancient oceans – and the early evolution of life. Sulfate is the ...

Ground-breaking research by a UCLA team of physicians and engineers demonstrates that prostate cancer can be diagnosed using image-guided targeted biopsy. Traditionally found only by blind biopsy, a procedure that dates from the 1980s, prostate cancer now appears detectable by direct sampling of tumor spots found using Magnetic Resonance Imaging (MRI) in combination with real-time ultrasound, according to the UCLA study released Dec. 10, 2012 early online for the January 2013 issue of The Journal of Urology®. The study indicates that the MRI and ultrasound fusion biopsy, ...

New York, NY, December 10, 2012 – Diagnosis of prostate cancer remains imperfect. Current methods of prostate biopsy are limited by over detection of slow-growing tumors and under detection of clinically relevant cancers. Investigators at the University of California-Los Angeles Department of Urology have found that a new technique of targeted biopsy in a clinic setting, using local anesthesia, may improve diagnosis and aid in selecting which patients are suitable for active surveillance and which need focal therapy (noninvasive techniques for destroying small tumors within ...

Renewable energy could fully power a large electric grid 99.9 percent of the time by 2030 at costs comparable to today's electricity expenses, according to new research by the University of Delaware and Delaware Technical Community College. A well-designed combination of wind power, solar power and storage in batteries and fuel cells would nearly always exceed electricity demands while keeping costs low, the scientists found. "These results break the conventional wisdom that renewable energy is too unreliable and expensive," said co-author Willett Kempton, professor ...

Stroke the soft body of a newborn fruit fly larva ever-so-gently with a freshly plucked eyelash, and it will respond to the tickle by altering its movement—an observation that has helped scientists at the University of California, San Francisco (UCSF) uncover the molecular basis of gentle touch, one of the most fundamental but least well understood of our senses. Our ability to sense gentle touch is known to develop early and to remain ever-present in our lives, from the first loving caresses our mothers lavish on us as newborns to the fading tingle we feel as our lives ...

(Philadelphia, PA) – Despite treatment with imatinib, a successful drug that targets chronic myeloid leukemia (CML), a deadly type of cancer, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant to treatment and may even accumulate additional genetic aberrations, eventually leading to disease progression and relapse. These leukemia stem cells are full of genetic errors, loaded with potentially lethal breaks in DNA, and are in a state of constant self-repair. Now, scientists at Temple University School of Medicine may have ...

Researchers show that the global epidemic of Clostridium difficile 027/NAP1/BI in the early to mid-2000s was caused by the spread of two different but highly related strains of the bacterium rather than one as was previously thought. The spread and persistence of both epidemics were driven by the acquisition of resistance to a frontline antibiotic. Unlike many other healthcare-associated bacteria, C. difficile produces highly resistant and infectious spores. These spores can promote the transmission of C. difficile and potentially facilitates its spread over greater geographical ...

Queen sweat bees 'choose' the role of their daughters, according to a new study published in BioMed Central's open access journal Frontiers in Zoology. The amount of food provided for the developing larvae determines whether the daughter becomes a worker or a new queen. The sweat bee Halictus scabiosae are a primitive eusocial insect. Eusocial insects have a hierarchical society with a division of labor between reproductive queens and males, and workers. However for H. scabiosae all the adults have retained the ability to reproduce, although their role in the nest may ...

Wellcome Trust researchers have discovered how the brain assesses confidence in its decisions. The findings explain why some people have better insight into their choices than others. Throughout life, we're constantly evaluating our options and making decisions based on the information we have available. How confident we are in those decisions has clear consequences. For example, investment bankers have to be confident that they're making the right choice when deciding where to put their clients' money. Researchers at the Wellcome Trust Centre for Neuroimaging at UCL ...

By reprogramming a 7-year-old girl's own immune cells to attack an aggressive form of childhood leukemia, a pediatric oncologist has achieved a complete response in his patient, who faced grim prospects when she relapsed after conventional treatment. The innovative experimental therapy used bioengineered T cells, custom-designed to multiply rapidly in the patient, and then destroy leukemia cells. After the treatment, the child's doctors found that she had no evidence of cancer. Pediatric oncologist Stephan A. Grupp, M.D., Ph.D., of The Children's Hospital of Philadelphia, ...

ATLANTA -- Nine of twelve leukemia patients who received infusions of their own T cells after the cells had been genetically engineered to attack the patients' tumors responded to the therapy, which was pioneered by scientists in the Perelman School of Medicine at the University of Pennsylvania. Penn Medicine researchers will present the latest results of the trial today at the American Society of Hematology's Annual Meeting and Exposition. The clinical trial participants, all of whom had advanced cancers, included 10 adult patients with chronic lymphocytic leukemia treated ...

COLUMBUS, Ohio – A new study led by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) shows that preparing older acute myeloid leukemia (AML) patients for bone marrow transplants with a reduced intensity conditioning regimen appears to be associated with higher rates of disease-free survival relative to the more typical treatments usually given to such patients. The study was presented at the 2012 American Society of Hematology (ASH) Annual Meeting in Atlanta, ...

Researchers at Emory University School of Medicine have obtained a detailed molecular picture that shows how glucocorticoid hormones shut off key immune system genes. The finding could help guide drug discovery efforts aimed at finding new anti-inflammatory drugs with fewer side effects. The results are scheduled for publication Sunday, Dec. 9 by the journal Nature Structural & Molecular Biology. Synthetic glucocorticoid hormones – for example, prednisone and dexamethasone -- are widely used to treat conditions such as allergies, asthma, autoimmune diseases and cancer. ...

PASADENA, Calif., December 10, 2012 – Children who had in-utero exposure to ischemic-hypoxic conditions, situations during which the brain is deprived of oxygen, were significantly more likely to develop attention deficit hyperactivity disorder later in life as compared to unexposed children, according to a Kaiser Permanente study published in the journal Pediatrics. The findings suggest that events in pregnancy may contribute to the occurrence of ADHD over and above well-known familial and genetic influences of the disorder. The population-based study examines the association ...

WINSTON-SALEM, N.C. – Dec. 10, 2012 – When you're postmenopausal and overweight, losing weight is a good thing, but gaining back just a few pounds may actually be detrimental to your cardiovascular health. New research from Wake Forest Baptist Medical Center found that gaining weight back after intentional weight loss is associated with negative long-term effects on some cardiometabolic (CM) risk factors in postmenopausal women. In this paper, published online by the Journal of Gerontology: Medical Sciences, lead authors Daniel Beavers, Ph.D., and Kristen Beavers, Ph.D., ...

For three years, University of Utah researchers have been deploying a computer-based design program called SketchUp in workshops to teach and develop life skills for youth on the autism spectrum. An earlier study showed that using the program helps kids develop their spatial and visual acuity, as well as to leverage those strengths to build positive social interactions. In the latest analysis of experiences from the educational workshops, researchers have found that using the technology also helps open new communication doors with grandparents of the students. The shared ...

Sara Stablein, named 2011 Southwestern Pro of the Year by the U.S. Professional Tennis Association (USPTA), has joined The Bridges at Rancho Santa Fe as its new Tennis Director. Stablein will oversee instruction and programming at The Bridges' $5 million Tennis & Recreation Centre, a five-acre facility serving club members and their children and grandchildren. "Sara is not only an accomplished competitor but she has proven herself as an effective and innovative club director," said The Bridges General Manager Sean McCune, who noted that Stablein spent ...

Forget about Chicago, the biggest toddlin' town around is Montessori International School's Toddler House, 2447 Fairbrook Road and the Toddler Community at 2401 E. Brown Road, both in Mesa. Tots from 12 months to three years of age play with puzzles, don plastic coats and paint, sit in a circle and sing, learn Spanish, and interact happily with one another. A visit to either school denotes a surprisingly calm environment. While the occasional unhappy camper may surface, for the most part the school is free of the sound of whining and the smell of disinfectant that permeates ...

The first bit of advice that a parent will receive from the school system if a child is struggling with reading is that the child needs a tutor. Parents have been listening to this advice for so long that they actually believe it. Stop listening to those that say you can't be helpful and take on the 31 day reading challenge for yourself. All you need to do is read every day for 31 days with your child. If you are looking for tips each day, then there is a new book that was just released called 31 Days to Become a Better Reader: Increasing your Struggling Reader's Reading ...

Today, Pure Hedonist Omnimedia President and Editorial Director Letitia Elizabeth announced the launch of Lillie, a bi-monthly hybrid fashion + food magazine for a new class of woman who cares deeply about the impact her personal style choices have on the environment. Lillie fills a void in the marketplace with substance, wit and unwavering respect for sustainable design and craftsmanship. Created for the nostalgic, modern and highly discerning woman, the magazine play's on women's desire to showcase their personal tastes without sacrificing lifestyle standards. This is ...

The city of Cambridge, Minnesota, its Economic Development Division, and Golden Shovel Agency have teamed up together to launch an online web solution, Economic Gateway. The purpose of the website is to raise awareness of the area of Cambridge, MN and all that it has to offer to its residents, current and future business enterprises, and site selectors. The new site can be viewed at http://ci.cambridge.mn.us/. John Marshall, Vice President of Business Development at Golden Shovel explains that "Cambridge has taken a very progressive step in partnering with Golden ...