JACKSONVILLE, Fla. — A research team led by scientists at Mayo Clinic in Florida have decoded the entire pathway that regulates leakiness of blood vessels — a condition that promotes a wide number of disorders, such as heart disease, cancer growth and spread, inflammation and respiratory distress. They say their findings, published online Dec. 17 in the Journal of Cell Biology, suggest that several agents already being tested for other conditions might reverse vessel leakiness. "Now that we understand a lot more about the pathway that leads to leaky blood vessels, ...

BUFFALO, N.Y. — Coral colonies that suffered tissue damage in The Bahamas were still producing low numbers of eggs four years after the injuries occurred, according to new research by University at Buffalo scientists. Tiny sperm-producing factories called spermaries were also in short supply. The slow recovery was a surprise, said UB geology professor Howard Lasker, PhD, who led the study on the coral species Antillogorgia elisabethae. "The really interesting finding was that four years later, these colonies were still displaying an effect," Lasker said. "They don't ...

ROCHESTER, Minn. -- It appears that long, arduous hours in the hospital are causing more than stress and fatigue among doctors-in-training -- they're crashing, or nearly crashing, their cars after work, according to new Mayo Clinic research. Nearly half of the roughly 300 Mayo Clinic residents polled during the course of their residencies reported nearly getting into a motor vehicle crash during their training, and about 11 percent were actually involved in a traffic accident. The study, recently published in Mayo Clinic Proceedings, found that residents attributed the ...

Stratum ventilation systems have been touted as a much more energy efficient system for cooling buildings such as school rooms and offices in hotter climes based on the provisions of the recent ANSI/ASHRAE 55-2010. They may also reduce the risk of the spread of airborne diseases according to a study to be published early next year in the journal World Review of Science, Technology and Sustainable Development. This approach to cooling small and medium-sized rooms in a building has come to the fore as a low-cost alternative to high-energy air-conditioning systems particularly ...

This press release is available in German. In the period of atmospheric nuclear testing in the 1950s and 1960s significant amounts of uranium-236 were distributed world-wide. Despite this, uranium-236 has mostly eluded detection and clear attribution to this source. A team of three researchers based in Austria and Australia lead by Stephan Winkler have identified the bomb-pulse of this isotope in corals from the Caribbean Sea. Uranium is readily dissolved in seawater, and therefore is carried by ocean currents. This makes uranium-236 and ideal tool for investigating ...

This press release is available in German. The gonad is well known to be important for reproduction but also affects animal life span. Removal of germ cells – the sperm and egg producing cells – increases longevity of the roundworm Caenorhabditis elegans. However, the underlying molecular mechanisms were a mystery. Now scientists at the Cologne-based Max Planck Institute for Biology of Ageing, have discovered that germ cell removal flips a "molecular switch" that extends the life span by using components of a "developmental clock". The roundworm Caenorhabditis elegans ...

This press release is available in German. Multidrug-resistant bacteria remain a major concern for hospitals and nursing homes worldwide. Propagation of bacterial resistance is alarming and makes the search for new antimicrobials increasingly urgent. Scientists at the Max Planck Institute for Biophysical Chemistry in Göttingen have now identified a potential new target to fight bacteria: the factor EF-P. EF-P plays a crucial role in the production of proteins that are essential for the virulence of EHEC or salmonellae. The researchers' findings suggest that drugs blocking ...

This press release is available in French. Researchers at the Sainte-Justine University Hospital Center and the University of Montreal have found a possible heredity mechanism that predisposes children to acute lymphoblastic leukemia (ALL), the most common type of blood cancer in children. According to their findings published in Genome Research, the presence of a genetic defect in the egg or sperm from which children having ALL arise may be a prerequisite for the disease to develop. A significant number of children with ALL are thought to inherit a rare PRDM9 gene ...

Scientists at the University of Arizona Cancer Center and the Moffitt Cancer Center, led by Dr. Robert Gillies, have demonstrated that an advanced magnetic resonance imaging (MRI) method can non-invasively evaluate the cellular proliferation of tumor models of breast cancer. This quantitative imaging method evaluates the diffusion of water in tumor tissue, which correlates with the growth rates of the tumor models. The results, which appear in the November 2012 issue of Experimental Biology and Medicine, can contribute to the development of new tumor models for cancer ...

From extreme drought to super storms, many wonder what the future holds for the climate of the eastern United States. A study conducted by researchers at the University of Tennessee, Knoxville, does away with the guessing. Results show the region will be hotter and wetter. Joshua Fu, a civil and environmental engineering professor, and Yang Gao, a graduate research assistant, developed precise scales of cities which act as a climate crystal ball seeing high resolution climate changes almost 50 years into the future. The study found that heat waves will become more ...

New York, NY (December 17, 2012) — Are you stressed? Results of a new meta-analysis of six studies involving nearly 120,000 people indicate that the answer to that question may help predict one's risk of incident coronary heart disease (CHD) or death from CHD. The study, led by Columbia University Medical Center researchers, was published in a recent issue of the American Journal of Cardiology. The six studies included in the analysis were large prospective observational cohort studies in which participants were asked about their perceived stress (e.g., "How stressed ...

WASHINGTON, December 17, 2012 — With the holiday season a high-risk period for packing on unwanted pounds, the American Chemical Society (ACS) today posted a new video that may lend perspective on this year's battle of the bulge. Produced by the world's largest scientific society, it explains the science behind the calorie counts and other information on those Nutrition Facts Labels on food packages. Available at www.BytesizeScience.com, the video tells the story of how scientists first determined the calorie content of food in the 1800s, and how scientists determine fat, ...

ROCHESTER, Minn. -- A new series of studies in mouse models by Mayo Clinic researchers uncovered that the aging process is characterized by high rates of whole-chromosome losses and gains in various organs, including heart, muscle, kidney and eye, and demonstrate that reducing these rates slows age-related tissue deterioration and promotes a healthier life span. The findings appear in today's online issue of Nature Cell Biology. "We've known for some time that reduced levels of BubR1 are a hallmark of aging and correspond to age-related conditions, including muscle weakness, ...

Scientists from the Structural Computational Biology Group at the Spanish National Cancer Research Centre (CNIO), led by Alfonso Valencia, together with French and American researchers, have published recently two articles in the journal Nucleic Acid Research (NAR) that introduce two new databases for studying the human genome. Living eukaryote beings are capable of generating several proteins from the information contained in a single gene. This special characteristic exists partly thanks to the alternative splicing process that selectively joins some exons (the regions ...

A leading international expert on autism at the University of Leicester has been involved in contributing to a major new study of global health. Professor Terry Brugha, of the Department of Health Sciences, is co-author of two papers in The Lancet's special issue on the Global Burden of Disease. Because of his work on Autism Epidemiology, which was used to develop one new element of these global data syntheses, Professor Brugha was a co-author at the University of Leicester on two of the reports. He said: "The most pressing issue to come out of the Global Burden of ...

More than one in every ten schoolchildren suffers from a transient tic disorder, and 1% have a particular type of tic disorder known as Tourette syndrome. In this issue of Deutsches Ärzteblatt International, Andrea G. Ludolph of the Universitätsklinikum Ulm and her coauthors report on the available modes of diagnosis and treatment for these disorders (Dtsch Arztebl Int 2012; 109(48): 821). Tic disorders usually take a benign course; in about 90% of patients, the tics regress spontaneously in adolescence. Specific treatment is indicated only if the tics are severe or cause ...

HOUSTON – (Dec. 17, 2012) – Rice University scientists have discovered a new way to look inside living cells and see the insoluble fibrillar deposits associated with Parkinson's disease. The combined talents of two Rice laboratories – one that studies the misfolded proteins that cause neurodegenerative diseases and another that specializes in photoluminescent probes – led to the spectroscopic technique that could become a valuable tool for scientists and pharmaceutical companies. The research by the Rice labs of Angel Martí and LauraSegatori appeared online this month ...

CLEVELAND -- Researchers at Case Western Reserve University School of Medicine have identified a molecule linked to more aggressive forms of breast cancer – a discovery that could point the way to potential cures. Until this study, the ribonucleic acid (RNA) molecule called miR-181a had never before been tied to breast cancer metastasis. But when scientists found elevated levels of the molecule in late-stage breast cancer tissues, they in turn tested an inhibitor in mouse models. The approach not only prevented metastasis, but also extended the animals' lives. "Overall, ...

(Edmonton) Make no mistake, Alex Clark and Lionel Messi were not separated at birth. Both might be stars in their own right, but Clark, associate dean of research in the Faculty of Nursing at the University of Alberta, realizes he's not about to woo stadiums of crazed soccer fans like FC Barcelona's all-time top scorer. "It would probably take you about five seconds of watching Lionel Messi move the ball to work out who is the more talented soccer player; however, a lot of health research would see us as very similar," says Clark, noting they're both male, under 5-foot-11, ...

Daejeon, Republic of Korea, December 17th, 2012—Cell phones are getting ever smarter today, savvy enough to tell you where to go and what to buy in shopping centers or department stores. Although still in nascent stages, indoor positioning and navigation using mobile phones will be arriving anytime soon. People widely rely on the Global Positioning System (GPS) for location information, but unlike outdoor environments, GPS does not work well in indoor spaces or urban canyons with streets cutting through dense blocks of high-rise buildings and structures. GPS requires ...

There is no difference between proton radiotherapy (PRT) and intensity-modulated radiotherapy (IMRT) when comparing the toxicity among Medicare beneficiary patients with prostate cancer at 12 months post-treatment according to a study published December 14 in the Journal of the National Cancer Institute. IMRT is the standard form of radiotherapy for the treatment of prostate cancer, accounting for more than 80% of all treatments. Alternative treatments for radiotherapy have emerged, with the most notable being PRT. PRT treatment has surfaced partly due Medicare reimbursement, ...

A father's death can have long-term effects on a child's later success in life and can be particularly harmful if the father passes away during a child's late childhood or early adolescence, according to new research by a University of Missouri anthropologist. Recognizing the impact that a father's death can have on adolescents could lead to improved counseling and assistance programs, especially for needy families in the developing world. "Certain negative effects of a father's death can't be compensated for by the mother or other relatives," said Mary Shenk, assistant ...

New Rochelle, NY, December 17, 2012—The health care system in the U.S. is a $2.5 trillion industry and depends heavily on communication and the transfer of information via the Internet. This puts it at ever-increasing risk of a cyberterrorism attack, which could jeopardize lives and threaten patient care and privacy. Cyber threats are on the rise, and U.S. health care organizations must be better prepared to deal with them, according to an article published in Telemedicine and e-Health, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers (http://www.liebertpub.com). ...

Want your children to be healthier snackers? A new Cornell study finds that serving children combined snacks of vegetables and cheese led them to eat 72 percent fewer calories — and be just as satisfied as those who were served only potato chips. "Snack combos are fun to eat, and they take longer to eat than potato chips. This is why kids find them satisfying and why they eat so much less," said Brian Wansink, professor of marketing at the Charles H. Dyson School of Applied Economics and Management at Cornell University. In the forthcoming Pediatrics study, 201 elementary ...

Current special education laws are geared towards integrating special-needs children into the general classroom environment from a young age, starting as early as preschool. Prof. Tova Most of Tel Aviv University's Jaime and Joan Constantiner School of Education and the Department of Communications Disorders at the Stanley Steyer School of Health Professions says that these laws present a unique set of challenges for children with hearing loss, and that a sense of isolation may inhibit a successful education. While studies show that many children with hearing loss are ...