Milan, 16 March 2013 - At the 28th Annual EAU Congress currently ongoing in Milan until Tuesday, W. Tan and colleagues presented their study on neoadjuvant cisplatin-based chemotherapy which showed that epigenetic changes are potential key drivers in the development of chemo resistance in bladder cancer. Neoadjuvant cisplatin-based chemotherapy is recommended for patients with muscle invasive bladder cancer. Cisplatin-based regimes have similar efficacy with complete response in 30% a survival advantage if 16% (HR, 0.84;CI 0.72 to 0.99), wrote Tan of the UCL, Dept. ...

Milan, 16 March 2013 – Small kidney tumours have an agressive potential and should be treated, according to a the results of a large multicentre study presented at the 28th Annual EAU Congress in Milan. "Many clinicians regard small renal cell cancer as having a benign biologic behavior and non-operative surveillance protocols are often being used in patients with small renal tumours," write the authors in the findings. "The aim of this large retrospective multi-centre study was to evaluate the prevalence of locally advanced growth and distant metastases in patients with ...

Millions of birds die in the US each year as they collide with moving vehicles, but things have been looking up, at least in the case of cliff swallows. Today's swallows are hit less often, thanks to shorter wingspans that may help them take off more quickly and pivot away from passing cars. The findings, reported in the Cell Press journal Current Biology on March 18, show that urban environments can be evolutionary hotspots. "Evolution is an ongoing process, and all this—roads, SUVs, and all—is part of nature or 'the wild'; they exert selection pressures in a way we ...

Of course, roosters crow with the dawn. But are they simply reacting to the environment, or do they really know what time of day it is? Researchers reporting on March 18 in Current Biology, a Cell Press publication, have evidence that puts the clock in "cock-a-doodle-doo" (or "ko-ke-kok-koh," as they say in the research team's native Japan). "'Cock-a-doodle-doo' symbolizes the break of dawn in many countries," says Takashi Yoshimura of Nagoya University. "But it wasn't clear whether crowing is under the control of a biological clock or is simply a response to external ...

LA JOLLA, Calif., March 18, 2013 – Hormonal therapies can help control advanced prostate cancer for a time. However, for most men, at some point their prostate cancer eventually stops responding to further hormonal treatment. This stage of the disease is called androgen-insensitive or castration-resistant prostate cancer. In a study published March 18 in Cancer Cell, a team led by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) found a mechanism at play in androgen-insensitive cells that enables them to survive treatment. They discovered that ...

Oral estrogen therapy for menopausal women is associated with an increased risk of gallbladder surgery, according to a large-scale study of more than 70 000 women in France published in CMAJ (Canadian Medical Association Journal) Women who took estrogen therapy through skin patches or gels did not appear to be at increased risk. Gallstone disease is common in developed countries, and women over age 50 are most at risk. Other risk factors include obesity, diabetes, high cholesterol, poor diet and having given birth to two or more children. A large study of 70 928 ...

Higher levels of pregnancy-associated plasma protein A (PAPP-A) were associated with an increased risk of cardiovascular events in people with cardiac chest pain that developed as a result of heart disease/coronary artery disease, according to a study published in CMAJ. PAPP-A, used to screen for Down syndrome in pregnant women, has been suggested as a marker of unstable plaque in coronary arteries. The study was conducted in 2568 patients in Tübingen, Germany, to determine if the presence of PAPP-A could help predict cardiovascular events. The study included patients ...

Researchers with the Faculty of Medicine & Dentistry designed a one-day training program for the Edmonton Police Service that resulted in officers being more likely to quickly identify mental health issues during a call, and less likely to use physical force or a weapon in those situations. The training resulted in long-term behaviour change in the officers and saved the police force money because mental health-related calls were dealt with more efficiently. The pilot study published in the open access and peer-reviewed journal, Frontiers in Psychiatry, noted the following ...

Researchers from North Carolina State University have come up with a low-cost way to enhance a polymer called MEH-PPV's ability to confine light, advancing efforts to use the material to convert electricity into laser light for use in photonic devices. "Think of a garden hose. If it has holes in it, water springs out through a million tiny leaks. But if you can eliminate those leaks, you confine the water in the hose and improve the water pressure. We've plugged the holes that were allowing light to leak out of the MEH-PPV," says Dr. Lewis Reynolds, a teaching associate ...

BOSTON (March 18, 2013) — New research published in The Journal of Neuroscience suggests that modifying signals sent by astrocytes, our star-shaped brain cells, may help to limit the spread of damage after an ischemic brain stroke. The study in mice, by neuroscientists at Tufts University School of Medicine, determined that astrocytes play a critical role in the spread of damage following stroke. The National Heart Foundation reports that ischemic strokes account for 87% of strokes in the United States. Ischemic strokes are caused by a blood clot that forms and travels ...

A new study from the University of Maryland School of Medicine suggests that depression results from a disturbance in the ability of brain cells to communicate with each other. The study indicates a major shift in our understanding of how depression is caused and how it should be treated. Instead of focusing on the levels of hormone-like chemicals in the brain, such as serotonin, the scientists found that the transmission of excitatory signals between cells becomes abnormal in depression. The research, by senior author Scott M. Thompson, Ph.D., Professor and Interim Chair ...

Bochum, 18.3.2013 In the fruit fly Drosophila, the functions of the three enzymes Tan, Ebony and Black are closely intertwined - among other things they are involved in neurotransmitter recycling for the visual process. RUB researchers from the Department of Biochemistry showed for the first time that flies cannot see without this recycling. Their analysis of the enzyme Black also raises new questions as to its function. Anna Ziegler, Florian Brüsselbach and Bernhard Hovemann report in the „Journal of Comparative Neurology", which chose this topic as cover story. Tan, ...

A new online database combining symptoms, family history and genetic sequencing information is speeding the search for diseases caused by a single rogue gene. As described in an article in the May issue of Human Mutation, the database, known as PhenoDB, enables any clinician to document cases of unusual genetic diseases for analysis by researchers at the Johns Hopkins University School of Medicine or the Baylor College of Medicine in Houston. If a review committee agrees that the patient may indeed have a previously unknown genetic disease, the patient and some of his or ...

Daejeon, Republic of Korea, March 18, 2013 -- Nonvolatile memory that can store data even when not powered is currently used for portable electronics such as smart phones, tablets, and laptop computers. Flash memory is a dominant technology in this field, but its slow writing and erasing speed has led to extensive research into a next-generation nonvolatile memory called Phase-Change Random Access Memory (PRAM), as PRAM's operating speed is 1,000 times faster than that of flash memory. PRAM uses reversible phase changes between the crystalline (low resistance) and amorphous ...

Milan, 18 March 2013 – Markers such as CA9, CD31, CD34 and VEGFR1/2 in the primary tumours might serve as predictors of a good response to a sunitinib treatment in patients with metastatic clear cell renal cell carcinoma (ccRCC), according to a new study to be presented at the 28th Annual EAU Congress currently on-going in Milan. "The inactivation of the von Hippel-Lindau gene (VHL) is a common event in ccRCC and finally leads to the induction of HIF1α target genes such as CA9 and VEGF," write the authors. "Besides VEGF, the VEGF and PDGF receptors also play an important ...

Drs Lewis and Carré in the University's Department of Mechanical Engineering have been measuring the dynamic friction between the material of the ball and the skin on the fingertips and palm, and the mitts that some players choose to wear under different weather conditions. They're looking to answer one question: what's the best way to ensure that players don't fumble the ball? "Catching and handling a ball with great skill and confidence is practically second nature to players at this level," says Dr Lewis. "But handling errors are still seen in professional rugby games ...

CORAL GABLES, FL (March 18, 2012) -- University of Miami (UM) doctoral student in Environmental Science and Policy, David Shiffman was invited to tweet updates in real-time, at the International Congress of Conservation Biology, New Zealand, 2011. As a result, more than 100,000 twitter users worldwide saw at least one tweet from the conference, and nearly 200 people from more than 40 countries, on six continents shared at least one tweet from the conference -- greatly exceeding the number of conference attendees. "While live-tweeting is not a new phenomenon, ...

Marine biologists have, for the first time, found a whale skeleton on the ocean floor near Antarctica, giving new insights into life in the sea depths. The discovery was made almost a mile below the surface in an undersea crater and includes the find of at least nine new species of deep-sea organisms thriving on the bones. The research, involving the University of Southampton, Natural History Museum, British Antarctic Survey, National Oceanography Centre (NOC) and Oxford University, is published today in Deep-Sea Research II: Topical Studies in Oceanography. "The planet's ...

The scientists looked at glaciers which behave independently from the ice sheet, despite having some physical connection to it, and those which are not connected at all. The discovery, just published in Geophysical Research Letters, is important as it will help scientists improve the predictions of the future contribution of Greenland's ice to sea-level rise. Using lasers which measure the height of the ice from space, and a recently completed inventory of Greenland's glaciers and ice caps, scientists from the European-funded ice2sea programme, were able to determine ...

Washington, D.C.— It has long been believed that male lions are dependent on females when it comes to hunting. But new evidence suggests that male lions are, in fact, very successful hunters in their own right. A new report from a team including Carnegie's Scott Loarie and Greg Asner shows that male lions use dense savanna vegetation for ambush-style hunting in Africa. Their work is published in Animal Behavior. Female lions have long been observed to rely on cooperative strategies to hunt their prey. While some studies demonstrated that male lions are as capable at hunting ...

ANN ARBOR, Mich. — The long-term consequences of pneumonia can be more detrimental to a person's health than having a heart attack, according to joint research from the University of Michigan Health System and University of Washington School of Medicine. Older adults who are hospitalized for pneumonia have a significantly higher risk of new problems that affect their ability to care for themselves, and the effects are comparable to those who survive a heart attack or stroke, according to the new findings in the American Journal of Medicine. "Pneumonia is clearly not ...

VIDEO: This NASA research model, prepared on Mar. 15, 2013, from a space weather model known as ENLIL named after the Sumerian storm god, shows the way the CME was expected... Click here for more information. On March 17, 2013, at 1:28 a.m. EDT, the coronal mass ejection (CME) from March 15 passed by NASA's Advanced Composition Explorer (ACE) as it approached Earth. Upon interacting with the giant magnetic bubble surrounding Earth, the magnetosphere, the CME caused a kind of ...

New research from an international team of scientists suggests evolution, or basic survival techniques adapted by early humans, influences the decisions gamblers make when placing bets. The findings may help to explain why some treatment options for problem gamblers often don't work, the researchers say. For the study, recently published in Frontiers in Psychology, scientists from McMaster University, the University of Lethbridge and Liverpool John Moores University examined how gamblers made decision after they won or lost. They found that, like our ancestors, ...

Researchers in Manchester have found a link between several lifestyle factors and pre-existing conditions, including smoking cigarettes and diabetes, and an increased risk of developing rheumatoid arthritis. Rheumatoid Arthritis (RA) is a chronic disease which affects around 0.8% of the population; and its causes are of great interest to the medical world. Research led by Professor Ian Bruce, NIHR Senior Investigator and Professor of Rheumatology at The University of Manchester and consultant at Central Manchester University Hospitals NHS Foundation Trust, looked into ...

Electrically charged lunar dust near shadowed craters can get lofted above the surface and jump over the shadowed region, bouncing back and forth between sunlit areas on opposite sides, according to new calculations by NASA scientists. The research is being led by Michael Collier at NASA's Goddard Space Flight Center, Greenbelt, Md., as part of the Dynamic Response of the Environment At the Moon (DREAM) team in partnership with the NASA Lunar Science Institute (NLSI), managed at NASA's Ames Research Center, Moffett Field, Calif. "The motion of an individual dust particle ...