Arnhem, 11 March 2013 - A new study by British scientists reveals that motile Escherichia coli isolates demonstrated significant activation of NF-κB signaling suggesting that flagellin plays a key role in up-regulating the host innate defences against urinary tract infections (UTIs). UTIs are commonly caused by Escherichia coli. The host innate defences function to protect the uro-epithelium from microbial assault via a variety of mechanisms. These include NF-κB signalling pathways activated via cell-surface Toll-like-receptors responding to bacterial pathogen ...

Arnhem, 11 March 2013- Multi-peptide vaccination therapy combined with the low-dose steroid drug dexamethasone shows promise in treating chemotherapy-naive castration resistant prostate cancer (CRPC) patients. The study, which won the third prize for best abstract in oncology at the 28th European Association of Urology Congress held in Milan, Italy from 15 to 19 March, showed the promising benefit of this combination therapy in patients who are chemotherapy-naive or those not yet exposed to specific antigens. "Results of our randomized prospective study suggest that ...

Arnhem, 14 March 2013 - As part of an EU-supported IMI-PREDECT consortium (http://www.predect.eu), a Dutch study showed that anti-androgenic properties of the drug abiraterone may provide an additional mechanism of action in blocking tumour growth of castration resistant prostate cancer (CRPC). The study, which won the first prize for best abstract in oncology at the 28th European Association of Urology (EAU) Congress to be held in Milan from March 15 to 19, demonstrated that although the use of abiraterone can potentially lead to an accumulation of precursor hormones, ...

Many Americans have more credit card debt than savings, survey says Article provided by Jeffrey P. White and Associates, P.C. Visit us at http://www.whitelawoffices.com Financial experts often recommend that you keep almost three month's pay on hand in case it is needed in an emergency. This is sound advice, but nonetheless advice that many Americans are not heeding, according to a recent survey by Bankrate.com. For the survey, Bankrate.com asked participants what they have more of: credit card debt or emergency savings. The results were quite frightening. Only ...

SSA expands Compassionate Allowances list Article provided by Alan J. Nuta, Attorney at Law Visit us at http://www.ssbenefitslawyer.com If you have ever filed for disability benefits, you know that the process is often long and arduous. In order to qualify for benefits in most cases, the Social Security Administration (SSA) requires you to prove that you have a disabling condition that prevents you from working for at least a year (or result in your death). As this can be difficult to prove, many initial applications are denied, requiring the applicant to file and ...

Agency says new commercial bus seat belt requirement is coming soon Article provided by Greenstein & Milbauer, LLP Visit us at http://www.nyclawfirm.com/ After years of debate, regulations that will require all new commercial buses to have safety belts installed are likely to come "very soon," said David Strickland, National Highway Traffic Safety Administrator, at the North American International Auto Show. The use of seat belts on buses is a key factor in reducing the risk of serious injury in an accident, and some bus companies are already buying ...

Grandparent visitation rights in Pennsylvania Article provided by Prince Law Offices, P.C. Visit us at http://www.princelaw.com During a separation and subsequent divorce, grandparents may find that they do not get to see their grandkids as often. In a tragic event when an adult child dies, grandparents might also have fewer opportunities to see their grandchildren. Pennsylvania law has strict criteria for grandparents seeking more time with their grandchildren. Because of the requirements, it is a good idea to consult a grandparents' rights attorney when relationships ...

What happens when parents cannot come to a child custody agreement? Article provided by Law Offices of Jonathan W. Fein Visit us at http://www.feinlaw.com When a couple decides that they can no longer make their marriage or relationship work, they begin taking the necessary steps toward ending their relationship. This can be an extremely emotional time, leaving both parties to wonder what went wrong. When a couple has children, they will need to determine a child custody arrangement that will meet the needs of both parents, as well as the child. This can become ...

How is child custody handled in Colorado? Article provided by Frost & Beck, LLP Visit us at http://www.frostbecklaw.com When a married couple with children decides to divorce, typically the most pressing and difficult questions involve how decision-making responsibilities and the children's time will be divided. In Colorado, the courts consider a number of factors before making these decisions. Physical custody is referred to as "parenting time" in Colorado. Parents are also responsible for making decisions on behalf of their children regarding ...

NHTSA to ask automakers to crank up the volume on hybrids Article provided by Law Offices of Aleixo and Murray, P.C. Visit us at http://www.aleixoandmurray.com Whether it is because of the rising cost of gas or the desire to leave a smaller carbon footprint, hybrid vehicles have exploded in popularity in recent years. Although the vehicles deliver on their promise to be "greener" than gas or diesel engines, they come with a dark side: they operate at such a low volume at slow speeds that bicyclists and pedestrians often cannot hear them, putting them at ...

Beware of asset concealment when divorcing a small-business owner Article provided by The Law Firm of Hauer & Snover Visit us at http://www.hauersnover.com/ In Michigan, the law provides that divorcing couples must divide their property according to the principle of equitable distribution. This means that their property must be divided equitably, or fairly, but not necessarily equally. The rule of equitable distribution applies to a couple's marital property, which typically includes all assets acquired by either spouse during the marriage, such as bank accounts, ...

Widespread consequences likely in Massachusetts drug lab scandal Article provided by Carleen & Caramanica, P.C. Visit us at http://www.massfelonydefense.com A chemist formerly employed by a Massachusetts drug lab was accused in September 2012 of tampering with tens of thousands of drug samples over a period of nine years, allegedly falsifying the results used in a multitude of criminal cases. 34,000 criminal cases may have been affected Massachusetts Gov. Deval Patrick has ordered a "file-by-file" review of every case handled by the chemist over ...

Massachusetts court: Nervousness does not justify police vehicle search Article provided by Carleen & Caramanica, P.C. Visit us at http://www.massfelonydefense.com Many drivers become understandably nervous when stopped by the police, even if they know they have done nothing wrong. Unfortunately for these individuals, the telltale signs of ordinary nervousness -- stammering, shakiness, sweating -- can easily be misinterpreted by police as an indication that a driver has something to hide. In a recent decision that may help put anxious drivers at ease, the Massachusetts ...

What you need to know about family-based immigrant visas Article provided by Law Offices of Garcia, Ramirez, and Pina Visit us at http://www.southtexasimmigration.com Foreign nationals can obtain a visa in the United States on the basis of a family relationship with a U.S. citizen. Specifically, foreign nationals can take advantage of Immediate Relative Immigrant Visas or Family Preference Immigrant Visas, depending upon the specifics of the relationship. Immediate Relative Immigrant Visas In order to obtain an Immediate Relative Immigrant Visa, also known ...

Court backlogs threaten efficiency of the immigration system Article provided by Law Offices of Garcia, Ramirez, and Pina Visit us at http://www.southtexasimmigration.com Recent news about the U.S. immigration courts may be cause for concern, both from a taxpayer standpoint and from the perspective of foreign nationals awaiting their day in court. According to a report issued by the Justice Department's inspector general, cases handled by U.S. immigration courts relating to deportation of undocumented immigrants are deeply flawed. Judges are finding it difficult ...

Why an attorney should be at the side of any disability applicant Article provided by Reyes & Reyes Law Firm, PLLC Visit us at http://www.reyesandreyesaustin.com No matter if you are seeking benefits through a state agency or from the federal Social Security Disability Insurance (SSDI) or Supplemental Security Income (SSI) programs, the application process can be tedious, time-consuming and confusing. There are miles of proverbial red tape to wade through, myriad medical records that need to be compiled, exacting diagnosis criteria that must be proven and numerous ...

Local disability services offices keep benefits applications moving forward Article provided by Reyes & Reyes Law Firm, PLLC Visit us at http://www.reyesandreyesaustin.com There is a little-known yet very valuable resource in Texas for people seeking federal Social Security Disability Insurance (SSDI) or Supplemental Security Income (SSI) benefits: the Texas Department of Assistive and Rehabilitative Services' Division for Disability Determinations Services (DDS). What is the DDS? The DDS is a state-level office that is funded by the federal Social Security ...

Money laundering can put well-meaning Georgians in hot water Article provided by Nick Lotito & Seth Kirschenbaum Visit us at http://www.atlanta-criminal-law.com Co-founders of a charitable organization based in Georgia faced accusations of money laundering last month. A well-meaning family started a non-profit organization that provided low-cost food to needy individuals through a number of churches and civic organizations throughout the nation. Based on federal charges, two of the founders may be sentenced in May to serve up to seven years each in prison. What ...

Title insurance is an important investment Article provided by Lonergan Law Firm, PLLC Visit us at http://www.lonerganlaw.com Texas residents who purchase a piece of property are usually given title to the property. However, many property owners have questions about what exactly "title" is or why title insurance is necessary. Definition of a title and its purposes When a piece of property is purchased, the new owner is given "title" to the property. Having title gives an individual the right to possess and use a particular property. Property ...

Traffic fatalities in motor vehicle accidents increase in 2012 Article provided by Dano ? Gilbert PS Visit us at http://www.danogilbertlaw.com Most of us spend a significant amount of time driving. Whether we are commuting to work or just running errands, we rely upon our vehicles to help make our lives easier. We know that there is a risk of being in an accident whenever we are out on area roadways, but believe that if we remain alert, we can avoid being injured in a crash. However, no matter how safe we think we might be behind-the-wheel, we do not know if ...

A myriad of child pornography offenses carry stiff penalties in Maryland Article provided by The Law Office of Flynn M. Owens Visit us at http://www.flynnowens.com A 28-year-old man was recently sentenced in a federal court in Baltimore to 10 years in prison for producing and possessing child pornography. He was accused of using his cellphone to create videos of boys using urinals in highway reststops and transferring the images to his computers at his home. He did not face accusations of distributing child pornography. Last year, a high school track coach in ...

Child custody decisions in Alaska Article provided by Law Offices of Dan Allan & Associates Visit us at http://www.danallanlaw.com When a marriage or other long-term relationship is coming to an end, it can be a very difficult and emotional time. Finding the right time to end a relationship is never easy, and couples that have spent a lot of time together may have difficulty drifting apart. If the couple has had children together, both parents will likely want to remain involved in the lives of their children. These child custody disputes are often the most ...

NTSB Proposes Mandatory Ignition Interlock Law Article provided by Edward T. McCormack Visit us at http://www.upstateny-dwitrafficlaw.com The United States National Transportation Safety Board (NTSB) met recently to discuss recommending that all states enact legislation requiring the installation of ignition interlock devices in the vehicles of all those convicted of his or her first driving under the influence (DUI) or driving while impaired (DWI) offense. Federal accident researchers are evaluating whether these sorts of measures would help prevent car accidents ...

Spotlight on distracted driving continues in NC and across the US Article provided by Maynard & Harris Attorneys at Law, PLLC Visit us at http://www.maynardharris.com As the federal government continues its focus on eliminating distracted driving, North Carolina highway patrol officers are stepping up their efforts to prevent such risky behavior on the road over the holiday season. Last summer, Transportation Secretary Ray LaHood and the Transportation Department encouraged states to enact laws to limit cellphone use on the road. Most states currently have ...

Medicaid for the elderly takes a hit in Texas, TMA fights back Article provided by Wright Abshire, Attorneys, A Professional Corporation Visit us at http://www.wrightabshire.com/ In June of 2011, the Texas Legislature adopted a budget plan that reduced the amount of funding provided to the state's Medicaid program. The plan required the Texas Health and Human Services Commission to limit certain types of Medicaid payments over a span of two years. One area that took a hit under the plan: dual eligibles. Dual eligible is a term used to refer to patients that can ...