The proteins that have now been identified shouldn't actually exist. Nevertheless, they build the core of cellular aggregates whose identity has been enigmatic until now. These aggregates are typically associated with hereditary neurodegenerative diseases including variants of frontotemporal dementia (FTD), also known as frontotemporal lobar degeneration (FTLD), and amyotrophic lateral sclerosis (ALS). They are likely to be damaging and might be a target for therapy. FTD and ALS are part of a group of neurodegenerative diseases that show a broad and overlapping variety ...

Work-related stress is not linked to the development of colorectal, lung, breast or prostate cancers, a study published today on bmj.com suggests. Around 90% of cancers are linked to environmental exposures and whilst some exposures are well recognised (such as UV radiation and tobacco smoke), others are not (psychological factors such as stress). Stress can cause chronic inflammation which has been shown to have various roles in the development of cancer, plus stressed individuals are more likely to smoke, consume excessive amounts of alcohol and be obese – all ...

Research: Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analysis The number of deaths and liver transplants due to paracetamol overdoses has significantly reduced thanks to UK legislation to make pack sizes smaller, a paper published today on bmj.com suggests. Paracetamol overdoses are a common method of suicide and frequent cause of liver damage. In September 1998, a new legislation was introduced by the UK Government which restricted pack sizes to a maximum of ...

GAINESVILLE, Fla. --- An international team of scientists including University of Florida researchers has generated the most comprehensive tree of life to date on placental mammals, which are those bearing live young, including bats, rodents, whales and humans. Appearing Thursday in the journal Science, the study details how researchers used both genetic and physical traits to reconstruct the common ancestor of placental mammals, the creature that gave rise to many mammals alive today. The data show that contrary to a commonly held theory, the group diversified after ...

WASHINGON, D.C.—February 7, 2013—Today, The Lancet Infectious Diseases published a new report that examines the global economic burden of Chagas disease. In the first study of its kind, researchers measured the health and economic impact of Chagas disease and found that the total economic burden of Chagas disease matches or exceeds that of many more well-known diseases such as rotavirus, Lyme disease and cervical cancer. Chagas disease infects an estimated 10 million people worldwide, with most cases occurring in Latin America. It is a parasitic infection transmitted ...

New Haven, Conn.— A team of scientists anchored at Yale University has demonstrated a new, highly versatile approach for quickly assembling drug-like compounds, establishing a broad new route to drug discovery and medical treatment. They report their results in the journal Science on Feb 8. Drug molecules interact with their targets, such as proteins or enzymes, by attaching to them in a way that neutralizes the target's undesirable effects in the body. This is sometimes called the "lock-and-key" method. The new approach offers scientists far greater control over the ...

The cause of the fireworks seen in this Hubble image and video is hidden behind a dense disc and envelope of dust. However, astronomers think that the strobe effect is due to periodic interactions between two newly-formed stars that are gravitationally bound to each other. These two stars drag material inwards from a surrounding disc of gas and dust. Astronomers propose that the light flashes seen in this video are due to this material suddenly being dumped onto the growing stars as they near one another in their orbits, unleashing a blast of radiation. "The protostar ...

The scientific and ethical debate over the use of animals in medical research has raged for years, but perspectives are shifting, viewpoints are becoming more nuanced, and new initiatives are seeking alternatives to animal testing, according to a special report by The Hastings Center, "Animal Research Ethics: Evolving Views and Practices." The report is available on a new Web site, animalresearch.thehastingscenter.org, a hub of educational information that defines and interprets this changing landscape. These resources are the outcome of a project on the ethics of medical ...

Researchers at the University of California, San Diego School of Medicine say overexpression of a protein called alpha-synuclein appears to disrupt vital recycling processes in neurons, starting with the terminal extensions of neurons and working its way back to the cells' center, with the potential consequence of progressive degeneration and eventual cell death. The findings, published in the February 6, 2013 issue of the Journal of Neuroscience, have major implications for more fully understanding the causes and mechanisms of Parkinson's disease (PD), a neurodegenerative ...

VIDEO: This video, created from a sequence of images from the Hubble Space Telescope, shows a pulse of light emanating from the protostellar object LRLL 54361. Most if not all of... Click here for more information. Two of NASA's great observatories, the Spitzer and Hubble space telescopes, have teamed up to uncover a mysterious infant star that behaves like a strobe light. Every 25.34 days, the object, designated LRLL 54361, unleashes a burst of light. Although a similar ...

A recent study of the amphibians and reptiles of Sierra Madre Mountain Range, northeastern Luzon, reveals a preliminary enumeration of more than 100 species that contribute to the unique biodiversity of the region. At present, the Luzon region's herpetological range stands at more than 150 species. Out of these, a total of 49 amphibian species have been documented, 44 of which are native and a remarkable 32 endemic. In the world of reptiles, Luzon can boast with 106 native species, 76 of which are unique to this region. The catalogue published in the open access journal ...

Tumourigenesis is driven by genetic alterations and by changes in the epigenome, for instance by the addition of methyl groups to cytosine bases in the DNA. A deeper understanding of the interaction between the genetic and epigenetic mechanisms is critical for the selection of tumour biomarkers and for the future development of therapies. Human tumour specimens and cell lines however contain a plethora of genetic and epigenetic changes, which complicate data analysis. In contrast, certain mouse tumour models contain only a single genetic mutation and allow the analysis ...

Researchers have identified a microRNA liver gene, miR-27b, which regulates lipid (cholesterol or fat) levels in the blood. This regulator gene controls multiple genes involved in dyslipidemia—abnormal blood cholesterol levels that can contribute to heart disease. Study details published in the February issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD), describe a new in silico approach to identify the significance of microRNAs in regulating disease-related gene pathways. The Human Genome Project (HGP) was completed in ...

CHESTNUT HILL, MA (February 7, 2013) – Using the geometric and material properties of a unique nanostructure, Boston College researchers have uncovered a novel photonic effect where surface plasmons interact with light to form "plasmonic halos" of selectable output color. The findings appear in the journal Nano Letters. The novel nanostructure proved capable of manipulating electron waves known as surface plasmon polaritons, or SPPs, which were discovered in the 1950s but of late have garnered the attention of scientists for their potential applications in fields that ...

Chicago (February 7, 2013): Colorectal surgical patients are often discharged from the hospital with vague guidance on how to recognize complications, but researchers at the Michael DeBakey Veterans Administration (VA) Medical Center and Baylor College of Medicine, Houston, aim to change that scenario. A health services research team convened a panel of surgical experts to develop a list of postoperative complication signs that should prompt colorectal surgical patients to call their surgeons or go to an emergency room. The study on the development of this early patient-centered ...

The hippocampus – a structure of the brain whose shape resembles that of a seahorse – is also called the "gateway" to memory. This is where information is stored and retrieved. Its performance relies on new neurons being continually formed in the hippocampus over the entire lifetime. "However, in old age, production of new neurons dramatically decreases. This is considered to be among the causes of declining memory and learning ability", Prof. Dr. Ana Martin-Villalba, a neuroscientist, explains. Martin-Villalba, who heads a research department at the German Cancer Research ...

(SACRAMENTO, Calif.) — Scientists have long puzzled over why "bad" bacteria such as E. coli can thrive in the guts of those with inflammatory bowel disease (IBD), causing serious diarrhea. Now UC Davis researchers have discovered the answer—one that may be the first step toward finding new and better treatments for IBD. The researchers discovered a biological mechanism by which harmful bacteria grow, edge out beneficial bacteria and damage the gut in IBD. This new understanding, published in the Feb. 8 issue of Science, may help researchers develop new treatments for ...

Jacob Rutt is a bright 11-year-old who likes to draw detailed maps in his spare time. But the budding geographer has a hard time with physical skills most children take for granted -- running and climbing trees are beyond him, and even walking can be difficult. He was diagnosed with a form of muscular dystrophy known as Duchenne when he was two years old. The disease affects about 1 in 3,500 newborns -- mostly boys -- worldwide. It usually becomes apparent in early childhood, as weakened skeletal muscles cause delays in milestones such as sitting and walking. Children ...

A single embryonic stem cell can develop into more than 200 specialized cell types that make up our body. This maturation process is called differentiation and is tightly regulated. If the regulation is lost, specialized cells cannot develop correctly during development. In adulthood, the specialized cells may forget their identity and develop into cancer cells. Research from BRIC, University of Copenhagen, has identified a crucial role of the molecule Fbxl10 in differentiation of embryonic stem cells and suggests the molecule as a new potential target for cancer therapy. "Our ...

Highlights of this news release: Six-month study finds that progestin-releasing contraceptives show a slight negative impact on metabolic markers, raising the risk for type 2 diabetes. Contraceptive implants under the skin increase the risk more than uterine implants. Longer and larger studies are needed to see if metabolic changes are temporary or long-term. LOS ANGELES – A first-of-its-kind study by researchers at the Keck School of Medicine of the University of Southern California (USC) indicates that healthy, obese, reproductive-age women who use long-acting ...

Fishing communities living on the islands of Indonesia's Karimunjawa National Park have found an important balance, improving their social well-being while reducing their reliance on marine biodiversity, according to the Wildlife Conservation Society and the University of Western Australia. Over the past 5 years, the Government of Indonesia has turned Karimunjawa National Park—a marine paradise of turquoise seas and mangrove-ringed islands in the Java Sea just south of Borneo—into a model of co-management for the country, largely by increasing community participation ...

ARGONNE, Ill. – Although scientists have been aware that magnetism and electricity are two sides of the same proverbial coin for almost 150 years, researchers are still trying to find new ways to use a material's electric behavior to influence its magnetic behavior, or vice versa. Thanks to new research by an international team of researchers led by the U.S. Department of Energy's Argonne National Laboratory, physicists have developed new methods for controlling magnetic order in a particular class of materials known as "magnetoelectrics." Magnetoelectrics get their ...

Triple-negative breast cancer is an aggressive form of breast cancer that has few treatment options; This large-scale study shows that abnormal levels of small molecules called microRNA can be used to classify this malignancy into four subtypes; The findings could lead to new ways to identify the best therapy for individual patients and to more effective therapies in the future. COLUMBUS, Ohio – A new, large-scale study of triple-negative breast cancer shows that small molecules called microRNA can be used to define four subtypes of this aggressive malignancy. The ...

In the world of microscopy, this advance is almost comparable to the leap from photography to live television. Two young EPFL researchers, Yann Cotte and Fatih Toy, have designed a device that combines holographic microscopy and computational image processing to observe living biological tissues at the nanoscale. Their research is being done under the supervision of Christian Depeursinge, head of the Microvision and Microdiagnostics Group in EPFL's School of Engineering. Using their setup, three-dimensional images of living cells can be obtained in just a few minutes ...

WASHINGTON –Requiring individuals to pay a premium for public health insurance coverage can counteract the coverage effects of expanding eligibility for public health insurance programs to higher income families. That is the finding of a study by a team of researchers from Georgetown University School of Nursing & Health Studies (NHS), University of California at Los Angeles (UCLA), and Columbia University published today in the journal Health Services Research. "Our findings speak to the importance of not just the availability of insurance coverage, but also the ...