ANN ARBOR—In 2006, the lab of Dr. David Ginsburg at the Life Sciences Institute put a call out for siblings attending the University of Michigan to donate blood for a study of blood-clotting disorders. The samples were collected over three years and have now enabled the researchers to identify the specific parts of the genome responsible for levels of a key substance for blood clotting. The findings were reported online Dec. 24 in the Proceedings of the National Academy of Sciences. Von Willebrand disease is the most common hereditary blood-clotting disorder—it's more ...

ANN ARBOR, Mich. — Postpartum depression not only affects mothers but it could mean higher health risks for the baby – especially in low-income countries like Ghana where the condition isn't well-recognized, University of Michigan Health System research shows. Efforts to reduce child mortality and improve infant growth, health, and nutritional status in less-developed countries must address the mental health of new moms, the study suggests. Two-thirds of participating mothers of sick, hospitalized babies in Ghana showed high risk for symptoms of clinical depression ...

WEST LAFAYETTE, Ind. - Researchers have demonstrated a new technology that combines a laser and electric fields to create tiny centrifuge-like whirlpools to separate particles and microbes by size, a potential lab-on-a-chip system for medicine and research. The theory behind the technology, called rapid electrokinetic patterning - or REP - has been described in technical papers published between 2008 and 2011. Now the researchers have used the method for the first time to collect microscopic bacteria and fungi, said Steven T. Wereley, a Purdue University professor of mechanical ...

The storage capacity of concentrating solar power (CSP) can add significant value to a utility company's optimal mix of energy sources, a new report by the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) suggests. The report found that CSP with a six-hour storage capacity can lower peak net loads when the sun isn't shining, enough to add $35.80 per megawatt hour to the capacity and operational value of the utility, compared to photovoltaic (PV) solar power alone, and even higher extra value when compared to CSP without storage. The net load is ...

TAMPA, Fla. (Jan. 8, 2013)—The current special issue of "Technology and Innovation-Proceedings of the National Academy of Inventors" is devoted to presentations from the Inaugural Conference of the National Academy of Inventors (NAI), which was hosted by the University of South Florida, Feb. 16-17, 2012. "This conference brought together inventors, researchers and leaders from universities, nonprofit research institutions, national laboratories and government institutions to discuss issues pertaining the technological development and commercialization," said Paul R. Sanberg, ...

AUSTIN, Texas - A new Department of Energy research facility could help bring the U.S. closer to generating power from the winds and waters along America's coasts and help alleviate a major hurdle for offshore wind and ocean power development. Will Shaw, an atmospheric scientist at DOE's Pacific Northwest National Laboratory, will describe plans for the facility at an 11:45 a.m. talk today at the 93rd American Meteorological Society Annual Meeting, which runs through Thursday in Austin, Texas. The Reference Facility for Offshore Renewable Energy will be used to test ...

Alexandria, VA – The size and type of earthquakes a given fault system may produce remain poorly understood for most major fault systems. Recent superquakes, such as the March 2011 magnitude-9 off Japan and the December 2004 magnitude-9-plus off Sumatra, have been far larger than what most scientists expected those faults to produce. The problem is that current models rely on short historical records, and even shorter instrumental records. Today, scientists are working to rewrite these models based on new paleoseismic and paleotsunami data to create a more comprehensive ...

Moms, especially those who are obese, are more likely to use TV to entertain and soothe infants who are more fussy and active, according to researchers at the University of North Carolina at Chapel Hill. The finding adds to the growing body of knowledge that may help explain the escalating rate of obesity and inactivity in U.S. children, and has led to behavioral and educational strategies that may help mothers combat these effects. The study, led by nutritionist Margaret E. Bentley, is the first to examine the interplay of maternal and infant risk factors that lead ...

URBANA – Speculation about how animals will respond to climate change due to global warming led University of Illinois researcher Patrick Weatherhead and his students to conduct a study of ratsnakes at three different latitudes—Ontario, Illinois, and Texas. His findings suggest that ratsnakes will be able to adapt to the higher temperatures by becoming more active at night. "Ratsnakes are a species with a broad geographic range so we could use latitude as a surrogate for climate change," Weatherhead said. "What are ratsnakes in Illinois going to be dealing with given ...

Stem cell manufacturing for drug screening and treatments for diseases such as Huntington's and Parkinson's could be boosted by a new method of generating stem cells, a study suggests. Scientists have developed a family of compounds that can support the growth of human embryonic stem cells on a large scale for use in drug testing or treatments. The new materials, which are water-based gels, act as a tiny scaffold to which cells can cling as they grow. Normally cells must be grown on expensive biological surfaces that can carry pathogens and contaminate cells. Once ...

New Rochelle, NY, January 8, 2013—The world's leading zebrafish researchers contribute to the community's active global efforts to promote science education. Scientific papers, many authored by students in grades K-12, as well as articles highlighting innovative curricula and educational tools, a collection of abstracts (including student, parent, and teacher authors), and an informative report from the recent Zebrafish in Education Workshops are featured in a special issue of Zebrafish, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The special issue ...

VIDEO: SMU study finds Jurassic ecosystems were similar to modern: animals flourish among lush plants. In modern ecosystems, it's widely known that animals flourish in regions where the climate and landscape produce... Click here for more information. In modern ecosystems, it's known that animals flourish in regions where the climate and landscape produce lush vegetation. A new study set out to discover whether that same relationship held true 150 million years ago ...

A panel of experts has released a new 33-item protocol checklist focusing on clarifying the content of clinical trials. While the protocol of a clinical trial serves as the foundation for study planning, conduct, reporting, and appraisal, trial protocols and existing protocol guidelines vary greatly in content and quality. Adherence to SPIRIT would enhance the transparency and completeness of trial protocols and could help ensure that protocols contain the requisite information for critical appraisal and interpretation. High-quality protocols can provide important ...

MINNEAPOLIS – Parkinson's disease itself does not increase the risk of impulse control problems such as compulsive gambling and shopping that have been seen in people taking certain drugs for Parkinson's disease, according to new research published in the January 8, 2013, print issue of Neurology®, the medical journal of the American Academy of Neurology. "We've known for some time that these behaviors are more common in people taking certain Parkinson's medications, but we haven't known if the disease itself leads to an increased risk of these behaviors," said study ...

Despite wide investments nationally in electronic medical records and related tools, the cost-saving promise of health information technology has not been reached because the systems deployed are neither interconnected nor easy to use, according to a new RAND Corporation analysis. The potential of health information technology to both improve patient care and reduce spending are unlikely to be realized until health care providers reengineer their processes to focus on the benefits that can be achieved, according to the paper published in the January edition of Health ...

PHILADELPHIA – In the first study of its kind, a team of researchers led by faculty at the Perelman School of Medicine at the University of Pennsylvania and the Baylor College of Medicine, has analyzed data on the impact of prolonged operational confinement on sleep, performance, and mood in astronauts from a groundbreaking international effort to simulate a 520-day space mission to Mars. The findings, published online-first in the Proceedings of the National Academy of Sciences, revealed alterations of life-sustaining sleep patterns and neurobehavioral consequences for ...

SAN DIEGO – People taking the blood pressure drugs called beta blockers may be less likely to have changes in the brain that can be signs of Alzheimer's disease and other types of dementia, according to a study released today that will be presented at the American Academy of Neurology's 65th Annual Meeting in San Diego, March 16 to 23, 2013. The study involved 774 elderly Japanese-American men who took part in the Honolulu-Asia Aging Study. Autopsies were performed on the men after their death. Of the 774 men, 610 had high blood pressure or were being treated with medication ...

More than a third of U.S. physicians responding to a national survey indicated they often or sometimes prescribed brand-name drugs when appropriate generic substitutes were available simply because patients requested the brand-name drug. Survey respondents who had marketing relationships with industry were more likely to fulfill such patient requests than were those without those relationships. The report from investigators at the Mongan Institute for Health Policy (MIHP) at Massachusetts General Hospital (MGH) will appear in JAMA Internal Medicine (formerly Archives ...

Despite the decline in cancer death rates in the U.S., there is an increase in incidence rates for cancers associated with human papillomavirus (HPV) infection and more efforts are needed to increase HPV vaccination coverage levels to prevent the occurrence of these cancers in the future according to a study published January 7 in the Journal of the National Cancer Institute. The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) ...

A metanalysis published in BioMed Central's open access journal BMC Medicine has confirmed that polymorphisms (SNP) in the gene coding for interleukin-28 (IL28B) influence natural hepatitis C viral (HCV) clearance and response to pegylated interferon-α plus ribavirin (PEG-IFN/RBV). Information about IL28B genotype could be used to provide personalized medicine and target treatment options effectively. Over 200 million people worldwide are chronically infected with hepatitis C virus (HCV) and about a quarter of these will go on to develop cirrhosis of the liver. Treatment ...

The question 'How do songbirds sing?' is addressed in a study published in BioMed Central's open access journal BMC Biology. High-field magnetic resonance imaging and micro-computed tomography have been used to construct stunning high resolution, 3D, images, as well as a data set "morphome" of the zebra finch (Taeniopygia guttata) vocal organ, the syrinx. Like humans, songbirds learn their vocalizations by imitation. Since their songs are used for finding a mate and retaining territories, birdsong is very important for reproductive success. The syrinx, located at the ...

January 8, 2013 – A multinational team of researchers made a significant step forward in trying to understand how birds produce their beautiful songs. "We used cutting-edge 3D imaging techniques to understand the complicated structure of the vocal organ of songbirds, the syrinx", says Dr. Coen Elemans, from the University of Southern Denmark, the senior author on the study. Elemans and his colleagues are publishing their findings January 8, 2013 in BioMed Central's open access journal BMC Biology. Communicating with sounds is central to the life of most animals and they ...

Even though Medicare spends over $1 billion per year on breast cancer screenings such as a mammography, there is no evidence that higher spending benefits older women, researchers at Yale School of Medicine found in a study published Online First by JAMA Internal Medicine, a JAMA Network publication. Led by Cary Gross, M.D., associate professor of internal medicine at Yale School of Medicine and director of the Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale, the study sought to provide a comprehensive understanding of breast cancer ...

An international team of scientists has described a fossil marine predator measuring 8.6 meters in length (about 28 feet) recovered from the Nevada desert in 2010 as representing the first top predator in marine food chains feeding on prey similar to its own size. A paper with their description will appear the week of January 7, 2013 in the EE (early electronic) issue of Proceedings of the National Academy of Sciences. Scientists who studied the fossil include lead author Dr. Nadia Fröbisch and Prof. Jörg Fröbisch (both at Museum für Naturkunde Leibniz-Institut für Evolutions- ...

The average physician can expect to spend nearly 11 per cent of his or her career with a malpractice claim waiting to be resolved. Some specialists will spend nearly a third of their careers with open claims. The length of time it takes to resolve a malpractice claim is a stress on patients, physicians and the legal system. The time spent with open claims may be even more distressing for physicians than the financial costs of malpractice claims. "We believe that the time required to resolve malpractice claims may be a significant reason that physicians are so vocal ...