Small peptide ameliorates autoimmune skin blistering disease in mice Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive bonds that hold skin cells together and keep the skin intact. Currently, pemphigus vulgaris is treated by long-term immune suppression; however, this can leave the patient susceptible to infection. In this issue of the Journal of Clinical Investigation, researchers led by Jens Waschke ...

Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive bonds that hold skin cells together and keep the skin intact. Currently, pemphigus vulgaris is treated by long-term immune suppression; however, this can leave the patient susceptible to infection. In this issue of the Journal of Clinical Investigation, researchers led by Jens Waschke at the Institute of Anatomy and Cell Biology in Munich, Germany, ...

WASHINGTON — Scientists have long wondered how nerve cell activity in the brain's hippocampus, the epicenter for learning and memory, is controlled — too much synaptic communication between neurons can trigger a seizure, and too little impairs information processing, promoting neurodegeneration. Researchers at Georgetown University Medical Center say they now have an answer. In the January 10 issue of Neuron, they report that synapses that link two different groups of nerve cells in the hippocampus serve as a kind of "volume control," keeping neuronal activity throughout ...

Chronic kidney disease (CKD) patients frequently suffer from mineral bone disorder, which causes vascular calcification and, eventually, chronic heart failure. Similar to patients with CKD, mice with low levels of the protein klotho (klotho hypomorphic mice) also develop vascular calcification and have shorter life spans compared to normal mice. In this issue of the Journal of Clinical Investigation, Florian Lang and colleagues at the University of Tübingen in Germany, found that treatment with the mineralocorticoid receptor antagonist spironolactone reduced vascular calcification ...

Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice. In this issue of the Journal of Clinical Investigation, researchers led by Matti Annala at Tampere University of Technology in Finland identified a fusion between the FGFR3 and TACC3 genes in human glioblastoma samples. The protein produced by this fusion gene promoted tumor growth and progression in a mouse model of glioblastoma, while increased expression of either of the normal genes did not alter tumor progression. Ivan Babic ...

Extremely loud noise can cause irreversible hearing loss by damaging sound sensing cells in the inner ear that are not replaced. But researchers reporting in the January 9 issue of the Cell Press journal Neuron have successfully regenerated these cells in mice with noise-induced deafness, partially reversing their hearing loss. The investigators hope the technique may lead to development of treatments to help individuals who suffer from acute hearing loss. While birds and fish are capable of regenerating sound sensing hair cells in the inner ear, mammals are not. Scientists ...

San Diego, California – January 9, 2013 – How does mathematics improve our understanding of weather and climate? Can mathematicians determine whether an extreme meteorological event is an anomaly or part of a general trend? Presentations touching on these questions will be given at the annual national mathematics conference in San Diego, California. New results will also be presented on the MJO (pronounced "mojo"), a tropical atmospheric wave which governs monsoons and also impacts rainfall in North America, and yet does not fit into any current computer models of the ...

NEW YORK (January 9, 2013) – Exposure to a chemical once used widely in plastic bottles and still found in aluminum cans appears to be associated with a biomarker for higher risk of heart and kidney disease in children and adolescents, according to an analysis of national survey data by NYU School of Medicine researchers published in the January 9, 2013, online issue of Kidney International, a Nature publication. Laboratory studies suggest that even low levels of bisphenol A (BPA) like the ones identified in this national survey of children and adolescents increase oxidative ...

WASHINGTON—Video games have been blamed for contributing to the epidemic of childhood obesity in the United States. But a new study by researchers at the George Washington University School of Public Health and Health Services (SPHHS) suggests that certain blood-pumping video games can actually boost energy expenditures among inner city children, a group that is at high risk for unhealthy weight gain. The study, "Can E-gaming be Useful for Achieving Recommended Levels of Moderate to Vigorous-Intensity Physical Activity in Inner-City Children," will appear January 9 in ...

PASADENA, Calif., January 9, 2013 – The presence of microscopic hematuria – blood found in urine that can't be seen by the naked eye – does not necessarily indicate the presence of cancer, according to a Kaiser Permanente Southern California study published in the journal Mayo Clinic Proceedings. The study suggests that tests routinely done on patients with this condition could be avoided and has led to the creation of a screening tool to better diagnose certain types of cancers. The observational study examined the electronic health records of more than 4,000 patients ...

DURHAM, N.C. -- Two years of painstaking observation on the social interactions of a troop of free-ranging monkeys and an analysis of their family trees has found signs of natural selection affecting the behavior of the descendants. Rhesus macaques who had large, strong networks tended to be descendants of similarly social macaques, according to a Duke University team of researchers. And their ability to recognize relationships and play nice with others also won them more reproductive success. "If you are a more social monkey, then you're going to have greater reproductive ...

Boston (Jan. 9, 2013) — Hearing loss is a significant public health problem affecting close to 50 million people in the United States alone. Sensorineural hearing loss is the most common form and is caused by the loss of sensory hair cells in the cochlea. Hair cell loss results from a variety of factors including noise exposure, aging, toxins, infections, and certain antibiotics and anti-cancer drugs. Although hearing aids and cochlear implants can ameliorate the symptoms somewhat, there are no known treatments to restore hearing, because auditory hair cells in mammals, ...

Scientists at the University of Granada and Alcalá de Henares University have found out that not all isolated stem cells are equally valid in regenerative medicine and tissue engineering. In a paper recently published in the prestigious journal Tissue Engineering the researchers report that, contrary to what was thought, only a specific group of cord blood stem cells (CB-SC) maintained in culture are useful for therapeutic purposes. At present, CB-SCs are key to regenerative medicine and tissue engineering. From all types of CB-SC those called "Wharton's jelly stem cells ...

Passive smoking, also known as 'second-hand' smoke or environmental tobacco smoke (ETS), is known to cause serious cardiovascular and respiratory diseases, including coronary heart disease and lung cancer. However, until now it has been uncertain whether ETS increases the risk of dementia, mainly due to lack of research. Previous studies have shown an association between ETS and cognitive impairment, but this is the first to find a significant link with dementia syndromes. The study, published in Occupational and Environmental Medicine, is a collaboration between scientists ...

After uncovering a mechanism that promotes chronic intestinal inflammation and the development of colorectal cancer, scientists from Virginia Commonwealth University Massey Cancer Center have found that fingolimod, a drug currently approved for the treatment of multiple sclerosis, could potentially eliminate or reduce the progression of colitis-associated cancer (CAC). The study, published online in the journal Cancer Cell, was led by Sarah Spiegel, Ph.D., Mann T. and Sara D. Lowry Chair in Oncology, co-leader of the Cancer Cell Signaling program at VCU Massey Cancer ...

WASHINGTON – When it comes to losing weight, a popular New Year's resolution for many, people often focus on eating less and exercising more. But results of a new survey of psychologists suggest dieters should pay attention to the role emotions play in weight gain and loss if they hope to succeed. The survey, conducted by the Consumer Reports National Research Center, asked more than 1,300 licensed psychologists how they dealt with clients' weight and weight loss challenges. When asked which strategies were essential to losing weight and keeping it off, psychologists ...

SANTA CRUZ, CA--The remarkable diversity of California's plant life is largely the result of low extinction rates over the past 45 million years, according to a new study published in the journal Evolution. Although many new species have evolved in California, the rate at which plant lineages gave rise to new species has not been notably higher in California than elsewhere, researchers found. Botanists have long recognized California as a biodiversity hotspot. With more than 5,500 native plant species, 40 percent of which are "endemic" (occurring nowhere else), California ...

Singapore, 9 January 2013 Attitudes of Singaporeans and permanent residents toward gays and lesbians although sharply polarised and predominantly negative, have shifted slightly over a five-year span to become a little more favourable. This was found by a research team from the Wee Kim Wee School of Communication and Information at Nanyang Technological University (NTU). A nationally representative survey found that people with higher levels of education and freethinkers tend to have more positive attitudes. Those who had higher interpersonal contact with gay men ...

The channel protein Pannexin1 keeps nerve cells flexible and thus the brain receptive for new knowledge. Together with colleagues from Canada and the U.S., researchers at the Ruhr-Universität Bochum led by the junior professor Dr. Nora Prochnow from the Department of Molecular Brain Research describe these results in PLoS ONE. In the study, mice comprising no Pannexin1 in memory-related brain structures displayed symptoms similar to autism. Their nerve cells lacked synaptic plasticity, i.e. the ability to form new synaptic contacts or give up old contacts based on the level ...

The results of a pioneering UK-wide clinical trial that compared treatments for patients with a common type of kidney disease has found one to be significantly more effective. The results of the study, published online in The Lancet today [9 Jan], will be recommended to clinicians worldwide as the most effective approach to treating the condition. The Medical Research Council-funded study, led by researchers from the University of Bristol's Academic Renal Unit based in Southmead Hospital, compared three treatment approaches in a type of kidney disorder known as 'membranous ...

The new study analyses data from school aged children in Tanzania infected with the most common forms of worms. It was found that infection by one parasitic species actually changes the risk of catching another, over and above other risk factors. The study is the first to look at the significance of infection with one disease as a risk for further infections (i.e. co-infection). The findings could help us better understand the importance of co-infection as a risk, and could help inform disease control strategies. Traditionally, co-infection, where the person or ...

In collaboration with the National University of Mexico, a team of Spanish researchers has analysed for the first time remains of cosmetics in the graves of prehispanic civilisations on the American continent. In the case of the Teotihuacans, these cosmetics were used as part of the after-death ritual to honour their city's most important people. A research team from the Polytechnic University of Valencia and the University of Valencia has studied various funerary samples found in urns in the Teotihuacan archaeological site (Mexico) that date from between 200 and 500 ...

AUDIO: Melanie Hingle, Ph.D., MPH, RD, University of Arizona, discusses the effectiveness of using text messaging to engage adolescents in ‘‘conversations’’ about health using a familiar communication method -- that is... Click here for more information. Philadelphia, PA, January 9, 2013 – According to the Nielsen consumer research group, teens receive an average of 3,417 text messages per month (that's 114 texts per day!). Couple this with CDC's report that high school students' ...

The key to giving whole wheat bread a more appetizing aroma and taste may lie in controlling the amounts of a single chemical compound that appears in the bread, which nutritionists regard as more healthful than its refined white counterpart. That's the finding of a new study in ACS' Journal of Agricultural and Food Chemistry, which opens the door to making whole wheat bakery products more appealing to millions of people. Devin G. Peterson and colleagues explain that whole wheat flour includes all three layers of the grain — bran, germ and endosperm — while refined flour ...

Scientists are reporting development of chemical modules that can reproduce, on an "unprecedented" molecular level, changes and interactions that occur in natural populations of plants and animals, including those of hunting and being hunted for food, conducting mutually beneficial relationships and competing for resources. The report on these new "predator-prey biochemical oscillators," which could become building blocks for molecular machines and computers, appears in ACS Nano. Yannick Rondelez and Teruo Fujii explain that just as plants and animals interact in complex ...