Two major barriers to the advancement of DNA nanotechnology beyond the research lab have been knocked down. This emerging technology employs DNA as a programmable building material for self-assembled, nanometer-scale structures. Many practical applications have been envisioned, and researchers recently demonstrated a synthetic membrane channel made from DNA. Until now, however, design processes were hobbled by a lack of structural feedback. Assembly was slow and often of poor quality. Now researchers led by Prof. Hendrik Dietz of the Technische Universitaet Muenchen (TUM) ...

Treating infection-prone patients over a 12-month period with high doses of vitamin D reduces their risk of developing respiratory tract infection – and consequently their antibiotic requirement. This according to a new study by researchers at Karolinska Institutet and Karolinska University Hospital published in the online scientific journal BMJ Open. "Our research can have important implications for patients with recurrent infections or a compromised immune defence, such as a lack of antibodies, and can also help to prevent the emerging resistance to antibiotics that ...

In a study published today in the Open Access journal PLOS Pathogens, researchers at Emory University have discovered a potentially important mechanism by which the Ebola virus alters and evades the immune response of its infected host. Ebola virus is the causative agent of Ebola Hemorrhagic Fever (EHF), a disease with up to 90 percent mortality. While human outbreaks of Ebola hemorrhagic fever have been confined to Africa, Ebola virus infections in bats, the presumed natural reservoir of the virus, have also been detected in Europe and Asia. The high lethality of ...

ANN ARBOR — A new genetic analysis has revealed that many Amazon tree species are likely to survive human-caused climate warming in the coming century, contrary to previous findings that temperature increases would cause them to die out. However, the authors of the new study warn that extreme drought and forest fires will impact Amazonia as temperatures rise, and the over-exploitation of the region's resources continues to be a major threat to its future. Conservation policy for the Amazon should remain focused on reducing global greenhouse-gas emissions and preventing ...

In a study published today in the Open Access journal PLOS Pathogens, scientists at McMaster University in Hamilton, Ontario have determined that a specialized class of immune cells, known as T cells, retains its functionality with age and can respond to virus infections with the same vigor as T cells from a young person. This is a valuable finding as it is generally believed that elderly individuals are at increased risk of infection because immunity deteriorates with age. T cells play an important role in defending the body from virus infections. For a long time, ...

New genetic analysis has revealed that many Amazon tree species are likely to survive man-made climate warming in the coming century, contrary to previous findings that temperature increases would cause them to die out. A study, published in the latest edition of Ecology and Evolution, reveals the surprising age of some Amazonian tree species – more than 8 million years – and therefore shows that they have survived previous periods as warm as many of the global warming scenarios forecast for the year 2100. The authors write that, having survived warm periods in the ...

Multiple myeloma is a type of leukaemia which affects B lymphocytes. There have been some indications that exposure to pesticides or chlorinated solvents increases the risk of developing this cancer. New research published in Biomed Central's open access journal Journal of Occupational Medicine and Toxicology provides a large (from 22 centres across Europe), matched control study into lifetime risk of multiple myeloma. They find that risk of Multiple myeloma is related to farm work, printing and cleaning. But although exposure to pesticides seemed to be a risk, exposure ...

Wearable technology is not only for sports and fashion enthusiasts it can also be used to monitor and aid clinical rehabilitation according to new research published in BioMed Central's open access journal BioMedical Engineering OnLine. Neurorehabilitation researchers from Italy have developed a low cost, wearable system, consisting of strain sensors made of conductive elastomers printed onto fabric. A low voltage battery powers the sensors, which are then able to send data to a computer via Bluetooth. In this case study a wireless inertial sensor (MEMS) containing ...

The origins of congenital heart defects could be traced right back to the first stages of embryonic development - according to University of East Anglia (UEA) research. Findings published today in the journal PLOS ONE show that the beginnings of important parts of the heart can be traced to very early stages of embryo development. The research has been funded by the British Heart Foundation. Biologists investigated chicken eggs at the gastrulation stage - between 12 and 14 hours after fertilisation. They found that some cells would go on to create the anterior ...

Survival of the fittest: longevity of Olympic medallists in the modern era Mortality in former Olympic athletes: retrospective cohort analysis Editorial: Everyone could enjoy the "survival advantage" of elite athletes Olympic medallists live longer than the general population, regardless of country of origin, medal won, or type of sport played, finds a study in the Christmas issue published on bmj.com today. A second study comparing athletes who trained at different physical intensities, found that those from high or moderate intensity sports have no added survival ...

A detection dog to identify Clostridium difficile in stool samples and infected patients: proof of principle study Dogs can sniff out Clostridium difficile (the infective agent that is responsible for many of the dreaded "hospital acquired infections") in stool samples and even in the air surrounding patients in hospital with a very high degree of accuracy, finds a study in the Christmas issue published on bmj.com today. The findings support previous studies of dogs detecting various types of cancer and could have great potential for screening hospital wards to help ...

Researchers in Belgium also show how dogs can help patients with severe sleep problems. They describe a 35 year old patient with severe excessive daytime sleepiness. She suffered sleep attacks up to six times a day and sometimes slept up to 16 hours a day. Until recently, this severe sleepiness considerably hampered her social life and limited her use of public transport, as she usually fell asleep within a few minutes of sitting down. She'd then wake up at the end of the line and have to fight sleepiness on the way back. Sometimes she'd forget where she started ...

The tooth fairy and malpractice Opinions of the tooth fairy as kind and giving may need to be revised following "mounting reports of less child-friendly activity", says a paper published in the BMJ Christmas edition and appearing online today. Researchers from across London became concerned following misdemeanours of the mythical character and a worrying trend in malpractice. One boy in particular became extremely distressed because the tooth fairy "had put a tooth in his left ear" after he left it under his pillow. Further investigation turned out he was right. Further ...

Mind wandering and driving: responsibility case-control study People whose minds wander whilst driving, especially when intense, are significantly more likely to be responsible for a crash and are threatening safety on the roads, warns a study in the Christmas issue published on bmj.com today. The term "mind wandering" has been coined to describe thinking unrelated to the task at hand. It happens most often at rest or during repetitive tasks. All drivers experience occasional drifting of their minds towards internal thoughts, a temporary "zoning out" that might dangerously ...

Can I take a space flight? Considerations for doctors With the prospect of space travel for tourists looming, clinicians could soon be asked to advise on medical clearance for their patients, says a paper published in the BMJ Christmas edition and appearing online today. Space travel opportunities are becoming increasingly available to the general public with bookings already in place. A team of experts from North America therefore looked to provide advice to clinicians who require direction when advising patients on space travel. The Aerospace Medical Association ...

Hamilton, Ont. (Dec. 13, 2012) — Our immune system does not shut down with age, says a new study led by McMaster University researchers. A study published in PLOS Pathogens today shows a specialized class of immune cells, known as T cells, can respond to virus infections in an older person with the same vigour as T cells from a young person. "For a long time, it was thought the elderly were at a higher risk of infections because they lacked these immune cells, but that simply isn't the case," said Jonathan Bramson, the study's principal investigator. "The elderly are ...

(TORONTO, Canada – Dec. 13, 2012 ) – Cancer scientists led by Dr. John Dick at the Princess Margaret Cancer Centre have found a way to follow single tumour cells and observe their growth over time. By using special immune-deficient mice to propagate human colorectal cancer, they found that genetic mutations, regarded by many as the chief suspect driving cancer growth, are only one piece of the puzzle. The team discovered that biological factors and cell behaviour – not only genes – drive tumour growth, contributing to therapy failure and relapse. The findings, published ...

Wrinkles, dryness, and a translucent and fragile appearance are hallmarks of old skin, caused by the natural aging of skin cells. But while most of us can recognize the signs of lost youth when we peer into the mirror each morning, scientists do not have a standardized way to measure the extent of age damage in skin. Now a group of Taiwanese researchers has used a specialized microscope to peer harmlessly beneath the skin surface to measure natural age-related changes in the sizes of skin cells. The results, which are published in the Optical Society's (OSA) open-access ...

The insurance industry, the world's largest business with $4.6 trillion in revenues, is making larger efforts to manage climate change-related risks, according to a new study published today in the journal Science. "Weather- and climate-related insurance losses today average $50 billion a year. These losses have more than doubled each decade since the 1980s, adjusted for inflation," says the study's author Evan Mills, a scientist in Lawrence Berkeley National Laboratory (Berkeley Lab)'s Environmental Energy Technologies Division. "Insurers have become quite adept at quantifying ...

BOSTON—Scientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur the cancer's growth. They say the finding could lead to a new treatment for prostate cancers that are no longer controlled by hormone-blocking drugs. The researchers report in the Dec. 14 issue of Science that the molecular switch occurs in a protein, EZH2, which is increased in these tumors, termed castration-resistant prostate cancers (CRPC). EZH2 is part of a ...

Montreal, December 13, 2012 – From Gran Turismo to WWE Smackdown, sports-based video games represent a wide variety of pursuits. When it comes to the people who actually play those games, however, little is known. How do sports video game players fit their games into a larger sports-related context? How does their video game play inform their media usage and general sports fandom? That's what Concordia University communications professor Mia Consalvo sought to discover when she embarked on a large-scale study of video game players, the results of which were recently published ...

CHICAGO -- Northwestern Medicine researchers have discovered a "two-faced" group of cells at work in human colon cancer, with opposing functions that can suppress or promote tumor growth. These cells are a subset of T-regulatory (Treg) cells, known to suppress immune responses in healthy individuals In this previously unknown Treg subset, the presence of the protein RORγt has been shown to differentiate between cancer-protecting and cancer-promoting properties. The Northwestern team, led by Khashayarsha Khazaie, research associate professor at the Robert H. ...

ARGONNE, Ill. – For the first time, scientists witnessed the details of the full, ultrafast process of liquid droplets evolving into a bubble when they strike a surface. Their research determined that surface wetness affects the bubble's fate. This research could one day help eliminate bubbles formed during spray coating, metal casting and ink-jet printing. It also could impact studies on fuel efficiency and engine life by understanding the splashing caused by fuel hitting engine walls. "How liquid coalesces into a drop or breaks up into a splash when hitting something ...

Prostate cancer patients receiving the costly treatment known as proton radiotherapy experienced minimal relief from side effects such as incontinence and erectile dysfunction, compared to patients undergoing a standard radiation treatment called intensity modulated radiotherapy (IMRT), Yale School of Medicine researchers report in the Journal of the National Cancer Institute. Standard treatments for men with prostate cancer, such as radical prostatectomy and IMRT, are known for causing adverse side effects such as incontinence and erectile dysfunction. Proponents of ...

New research by a University of Alberta archeologist may lead to a rethinking of how, when and from where our ancestors left Africa. U of A researcher and anthropology chair Pamela Willoughby's explorations in the Iringa region of southern Tanzania yielded fossils and other evidence that records the beginnings of our own species, Homo sapiens. Her research, recently published in the journal Quaternary International, may be key to answering questions about early human occupation and the migration out of Africa about 60,000 to 50,000 years ago, which led to modern humans ...