WASHINGTON, Aug. 15, 2012 — The latest episode in the American Chemical Society's (ACS') award-winning Global Challenges/Chemistry Solutions podcast series describes a potential new approach for treating urinary tract infections (UTIs) — which affect millions of people annually — without traditional antibiotics. Because it involves non-antibiotic compounds, the approach would not contribute to the growing problem of antibiotic-resistant bacteria, or "superbugs." Based on a report by Beat Ernst, Ph.D., and colleagues in ACS' Journal of Medicinal Chemistry, the new podcast ...

WASHINGTON, Aug. 15, 2012 — Progress toward developing an alternative to organ transplantations in which doctors could actually grow a new heart or liver for a patient is among the topics in the 2012 premier of a popular video series from the American Chemical Society (ACS), the world's largest scientific society. The videos are available at www.acs.org/PrizedScience and on DVD. Titled Prized Science: How the Science Behind American Chemical Society Awards Impacts Your Life, the first episode of the 2012 series features the research of Dr. Robert Langer, winner of the ...

VIDEO: This computer animation, created using new software called Arepo, simulates nine billion years of cosmic history. Arepo can accurately follow the birth and evolution of thousands of galaxies over billions... Click here for more information. Scientists at the Harvard-Smithsonian Center for Astrophysics (CfA) and their colleagues at the Heidelberg Institute for Theoretical Studies (HITS) have invented a new computational approach that can accurately follow the birth and ...

EAST LANSING, Mich. — A professor at Michigan State University is part of a team developing a new method of removing phosphorous from our wastewater – a problem seriously affecting lakes and streams across the country. In addition, Steven Safferman, an associate professor of biosystems and agricultural engineering, and colleagues at Columbus, Ohio, based-MetaMateria Technologies, are devising a cost-effective way of recovering the phosphorous, which then can be reused for fertilizer products. Although its use is regulated in many states, including Michigan, in items ...

In public comments submitted yesterday, People for the Ethical Treatment of Animals (PETA) applauds the United States Department of Agriculture (USDA) Center for Veterinary Biologics (CVB) for announcing its plans to allow firms to secure exemptions from the target animal batch safety tests (TABST) that have until now been required for each batch of veterinary biologics products, including live and inactivated vaccines. In draft memorandum 453, USDA states that CVB intends to consider TABST exemptions in line with recommendations in the TABST waiver guideline drafted by ...

Amid policy debate over potential liquefied natural gas (LNG) exports from the United States, a new paper from Rice University's Baker Institute for Public Policy predicts the long-term volume of exports from the U.S. will not likely be very large. The paper also argues that the impact on U.S. domestic natural gas prices will not be large if exports are allowed by the U.S government. Significant changes in the global gas market in the past decade, particularly the emergence of shale in North America, have dramatically altered the global outlook for LNG markets and ...

Amsterdam, NL, August 15, 2012 – In a study published in the current issue of Restorative Neurology and Neuroscience scientists report that a therapy combining exercise with the neurovascular protective agent S-nitrosoglutathione (GSNO) improved recovery from stroke in a rat model. GSNO is a compound found naturally in the body and it has no known side effects or toxicity. "In our study, GSNO or motor exercise provided neuroprotection, reduced neuronal cell death, maintained tissue structure, and aided functional recovery by stimulating the expression of neuronal repair ...

The World Health Organization estimates that in 2011 there were 216 million cases of malaria and 34.2 million people living with HIV. These diseases particularly afflict sub-Saharan Africa, where large incidence of co-infection result in high mortality rates. Yet, in spite of this global pandemic, interactions between the parasite that causes malaria, Plasmodium falciparum, and HIV-1 are poorly understood. However, a new video article in JoVE, the Journal of Visualized Experiments, that describes a novel technique to study the interactions between HIV-1 and P. falciparum ...

BOSTON--The genomic tumult within tumor cells has provided scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard with clues to an entirely new class of genes that may serve as an Achilles' heel for many forms of cancer. As reported in the Aug. 17 issue of the journal Cell, the researchers identified 56 such genes, only a few of which had previously been identified as potential targets for cancer therapy. Unlike most such targets, these genes don't cause normal cells to turn cancerous. Instead, they are essential to all cells but have been ...

PHILADELPHIA — Treatment with denosumab resulted in a greater reduction in skeletal-related events in patients with breast cancer that spread to the bones compared with zoledronic acid, while also maintaining health-related quality of life, according to the results of a phase III study published in Clinical Cancer Research, a journal of the American Association for Cancer Research. "Our data indicate that denosumab should be the treatment of choice for the prevention of skeletal-related events and hypercalcemia in patients with breast cancer that has metastasized to the ...

How the intricate network of blood vessels forms within the brain has long fascinated biologists. Though the human brain comprises only 2 percent of body weight it receives up to 15 percent of the cardiac output through this network, or vessel vasculature. The vasculature in the human brain consists of a complex branching network of blood vessels, in total some several hundred miles in length. The network is formed so as to distribute blood efficiently to all brain regions, and abnormalities can lead to various neurological disorders, including strokes, learning difficulties ...

Among pregnant women who did not develop gestational diabetes, overweight women were 65 percent more likely, and obese women 163 percent more likely, to have overly large babies than their healthy weight counterparts. In this study, an overly large infant was identified based on having a birth weight over the 90th percentile for their gestational age at delivery and gender. Gaining excess weight during pregnancy also contributed to having a large for gestational age baby, regardless of maternal weight or whether she developed gestational diabetes. This Kaiser Permanente ...

The small fragments of tropical forests left behind after deforestation are suffering extensive species extinction, according to new research led by the University of East Anglia (UEA). Publishing today in the journal PLoS ONE, the researchers carried out a comprehensive assessment to estimate the long-term impact of forest fragmentation and hunting on tropical biodiversity in Brazil. They studied the Atlantic Forest of eastern Brazil, including the region's largest and least disturbed old-growth forest remnants, and found that remaining habitat fragments had been virtually ...

CHICAGO – Among couples in which one partner was diagnosed as having posttraumatic stress disorder (PTSD), participation in disorder-specific couple therapy resulted in decreased PTSD symptom severity and increased patient relationship satisfaction, compared with couples who were placed on a wait list for the therapy, according to a study in the August 15 issue of JAMA, a theme issue on violence and human rights. "There are well-documented associations between PTSD and intimate relationship problems, including relationship distress and aggression, and studies demonstrate ...

CHICAGO – The results of two studies in the August 15 issue of JAMA report on the psychological status of workers at the Fukushima nuclear power plants in Japan several months after the earthquake and tsunami in March 2011, and the amount of internal radiation exposure among residents of a city north of the power plant that experienced a meltdown. As reported in a Research Letter, Jun Shigemura, M.D., Ph.D., of the National Defense Medical College, Saitama, Japan, and colleagues examined the psychological status of Fukushima workers 2 to 3 months after the disaster for ...

CHICAGO – In a study that included more than 2,700 women receiving care in primary care clinics, those who were screened for partner violence and received a partner violence resource list did not experience significant differences for several outcomes, including overall quality of life, general health, and recurrence of partner violence, compared to women who just received a partner violence resource list, according to a study in the August 15 issue of JAMA, a theme issue on violence and human rights. "Recognition of partner violence as a health and public health problem ...

People with blood type A, B, or AB had a higher risk for coronary heart disease when compared to those with blood type O, according to new research published in Arteriosclerosis, Thrombosis and Vascular Biology, an American Heart Association journal. People in this study with the rarest blood type — AB, found in about 7 percent of the U.S. population — had the highest increased heart disease risk at 23 percent. Those with type B had an 11 percent increased risk, and those with type A had a 5 percent increased risk. About 43 percent of Americans have type O blood. "While ...

Computer and web-based weight management programmes may provide a cost effective way of addressing the growing problem of obesity, according to a team of seven researchers who undertook a Cochrane systematic review. The researchers, from Maryland, Massachusetts, New York, Pennsylvania and Rhode Island, USA, found that delivering weight loss or weight maintenance programmes online or by computer helped overweight and obese patients lose and/or maintain weight. Being overweight or obese can increase a person's risk of diabetes, heart disease, high blood pressure, stroke ...

Compounds in cocoa may help to reduce blood pressure, according to a new systematic review in The Cochrane Library. The researchers reviewed evidence from short-term trials in which participants were given dark chocolate or cocoa powder daily and found that their blood pressure dropped slightly compared to a control group. Cocoa contains compounds called flavanols, thought to be responsible for the formation of nitric oxide in the body. Nitric oxide causes blood vessel walls to relax and open wider, thereby reducing blood pressure. The link between cocoa and blood pressure ...

Exercise may improve quality of life for people with cancer, according to Cochrane researchers. In two separate Cochrane systematic reviews, the authors gathered together evidence showing that activities such as walking and cycling can benefit those who are undergoing or have completed treatment for cancer. People with cancer suffer from many different physical, psychological and social effects related to cancer, as well as treatment-related symptoms. There has been much interest in the effects of exercise on physical and psychological well-being in people with cancer. ...

Cold Spring Harbor, NY – A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases – those with pathology caused by errors in the splicing of RNA messages copied from genes. To date, about 6,000 such RNA "editing" errors have been found in various human illnesses, ranging from neurodegenerative disorders to cancer. The new modeling approach can provide unique insights into how certain diseases progress and is likely to boost efforts to develop novel treatments. It was ...

Nurse-centred care of HIV patients can be just as safe and effective as care delivered by doctors and has a number of specific health benefits, according to a new study led by the University of East Anglia (UEA) and the University of Cape Town (UCT). Published today in The Lancet, the research shows that neither survival rates nor virus suppression reduced when nurses administered antiretroviral drugs to patients in South Africa. Health benefits included: significantly improved detection of tuberculosis; increased white blood cell count; increased weight; and improved ...

Financial incentives (pay for performance) schemes for health professionals "can undermine motivation and worsen performance" warn US experts in an editorial published on bmj.com today. They also say that gaming of the system is rife. Their views are published alongside an analysis of the positive and negative effects of financial incentives led by Professor Paul Glasziou of Bond University in Australia. Glasziou and colleagues describe the current evidence on the effectiveness of financial incentives as "modest and inconsistent" and say that, although reward schemes ...

Certain medical students may be more likely to stay in their own countries or work in rural areas of their own countries when they qualify as doctors, suggests a study published on bmj.com today. Given that many low income countries have insufficient doctors to meet their needs, particularly in rural areas, the authors suggest that policy makers could use this evidence to adjust entrance criteria for medical schools that favour subsequent practice in less well served areas of their country. Previous studies have shown that, in high income countries, doctors with rural ...

A paper published on bmj.com today suggests that over 1000 people have committed suicide due to the 2008-2010 economic recession in the UK (846 men and 155 women). Suicides began to rise in the UK in 2008 following 20 years of decline - suicides rose 8% among men and 9% among women in 2008, compared to 2007. And even though suicides did begin to fall in 2010 figures were still above the 2007 averages. Previous studies have concluded that unemployment does increase the risk of suicide and non-fatal self-harm but while suicides tend to increase during economic downturns, ...