Imagine being able to control genetic expression by flipping a light switch. Researchers at North Carolina State University are using light-activated molecules to turn gene expression on and off. Their method enables greater precision when studying gene function, and could lead to targeted therapies for diseases like cancer. Triplex-forming oligonucleotides (TFOs) are commonly used molecules that can prevent gene transcription by binding to double-stranded DNA. NC State chemist Dr. Alex Deiters wanted to find a way to more precisely control TFOs, and by extension, the ...

A health nutrition education program to fight childhood obesity in America is a possible outcome of a study by a University of Oklahoma researcher and a colleague. The study looked at factors affecting a child's decision when choosing healthy or unhealthy snacks. Paul Branscum, assistant professor, OU Department of Health and Exercise Science, College of Arts and Sciences, surveyed 167 fourth- and fifth-grade students in the Midwest to find out what snacks the students were eating between meals. Branscum asked the students to record their choices over a 24-hour-period. Survey ...

The link between psoriasis and cardiovascular events has been observed for years, however the mechanics were unknown. For the first time, Case Western Reserve University School of Medicine researchers have discovered preclinical evidence demonstrating that the inflammatory skin disease leads to cardiovascular disease. Further, the research demonstrated that aggressive reversal of psoriasis reduces the cardiovascular risk as well. Psoriasis is a chronic disease of the immune system that appears as raised, inflamed, scaly red patches of skin and is often associated with intense ...

Actor George Clooney is planning a fundraising dinner to raise $10 million for President Barack Obama. Comedian Chelsea Handler and actor Tom Hanks are also Obama supporters. Comedian Jeff Foxworthy, rocker Ted Nugent and country singer Trace Adkins have said they back the likely Republican nominee, Mitt Romney. Star-studded endorsements may be attention grabbing, but does it influence voters? Yes, it does, according to research recently published by a political scientist at the University of Tennessee, Knoxville. Professor Anthony Nownes has found that celebrities ...

Alexandria, VA — A study in the May 2012 issue of Otolaryngology–Head and Neck Surgery suggests a threshold for when to choose surgery over medical therapy for recurrent acute rhinosinusitis (RARS) based on the patients' lost productivity in response to RARS and each treatment strategy. The authors compare the burden of surgery and the burden of disease. On one hand, "Surgery and postoperative convalescence for comprehensive endoscopic sinus surgery can take 5 to 7 days or 3 to 5 workdays…," they write. However, the impact of each bout of infection also diminishes quality ...

OAK BROOK, Ill. – May 10, 2012 – Researchers report that unsedated transnasal endoscopy is a feasible, safe, and well-tolerated method to screen for esophageal disease in a primary care population. This study is the largest reported experience with transnasal endoscopy in the United States. The study appears in the May issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE). Esophageal cancer is the most rapidly increasing type of neoplasia in terms of incidence in the United ...

New Rochelle, NY, May 10, 2012—A citywide ban on public smoking in Colorado led to significant decreases in maternal smoking and preterm births, providing the first evidence in the U.S. that such interventions can impact maternal and fetal health, according to an article in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Women's Health website at http://www.liebertpub.com/jwh. Prenatal exposure to tobacco smoke–whether the mother is a smoker or exposure is from environmental ...

The human body does a great job of generating new cells to replace dead ones but it is not perfect. Cells need to communicate with or signal to each other to decide when to generate new cells. Communication or signaling errors in cells lead to uncontrolled cell growth and are the basis of many cancers. At The University of Texas Health Science Center at Houston (UTHealth) Medical School, scientists have made a key discovery in cell signaling that is relevant to the fight against melanoma skin cancer and certain other fast-spreading tumors. The scientists report that ...

WASHINGTON – A study of 7,424 privately insured colon cancer patients found that managed care presence in the market and hospital competition increased the likelihood laparoscopic surgery to treat colon cancer lowered costs, a national team of researchers led by a professor at the George Washington University School of Public Health and Health Services reported in the journal Cancer, May 8, 2012. Colon cancer is the second leading cause of cancer death in the U.S., and surgical resection is the standard of care. In 2004, there were approximately 134,000 colectomies performed ...

WORCESTER, Mass. — The movement of genetic materials, such as RNA and ribosomes, from the nucleus to the cytoplasm is a critical component in a cell's ability to make the proteins necessary for essential biological functions. Until now, it was believed the nuclear pore complex was the sole pathway between the cell nucleus and cytoplasm for these materials. New evidence published in Cell by Vivian Budnik, PhD, Melissa J. Moore, PhD, and colleagues at the University of Massachusetts Medical School, reveals a novel budding mechanism, similar to the process used by some viruses, ...

SAN ANTONIO (May 10, 2012) — The typical naked mole rat lives 25 to 30 years, during which it shows little decline in activity, bone health, reproductive capacity and cognitive ability. What is the secret to this East African rodent's long, healthy life? Scientists from the United States and Israel found a clue. From infancy to old age, naked mole rats are blessed with large amounts of a protein essential for normal brain function. "Naked mole rats have the highest level of a growth factor called NRG-1 in the cerebellum. Its levels are sustained throughout their life, ...

HOUSTON – (May 9, 2012) – With the aid of multiple force sensors and a digital dinosaur, a team of Rice University seniors known as Helping Hands hopes to restore strength and flexibility to the hands and wrists of children with cerebral palsy. "These kids have a real problem with their hands," said Jenna Desmarais, a senior at Rice majoring in mechanical engineering. "The fingers and wrists are locked into a sort of claw-like position. Even after surgery to correct it, they need physical therapy to get stronger." The team's rehabilitation device, the Dino-Might, was ...

ANN ARBOR, Mich.—A hidden facet of a math problem that goes back to Sanskrit scrolls has just been exposed by nanotechnology researchers at the University of Michigan and the University of Connecticut. It turns out we've been missing a version of the famous "packing problem," and its new guise could have implications for cancer treatment, secure wireless networks, microelectronics and demolitions, the researchers say. Called the "filling problem," it seeks the best way to cover the inside of an object with a particular shape, such as filling a triangle with discs ...

SAN ANTONIO (May 10, 2012) — A review of 30 years of life-threatening asthma cases in a San Antonio intensive care unit found that annual ICU admissions for the condition have dropped 74 percent. The study, by UT Medicine San Antonio physicians who reviewed cases at University Hospital between 1980 and 2010, also showed intubation in the emergency department to help patients breathe did not result in longer hospital stays. UT Medicine is the clinical practice of the School of Medicine at The University of Texas Health Science Center San Antonio. Faculty studied inpatient ...

GAINESVILLE, Fla. — Harvesting tropical forests for timber may not be the arch-enemy of conservation that it was once assumed to be, according to a new study led by a University of Florida researcher. Selective logging may be one of the few feasible options left for conserving tropical forests given the huge financial incentives pushing tropical landholders to convert primary forests into cash-generating agricultural plantations. The report analyzed data from more than 100 studies of tropical forests on three continents that had been harvested for timber. Results ...

Researchers from the Spanish National Cancer Research Centre (CNIO), led by Jorge L. Martínez-Torrecuadrada from the Proteomics Unit, have demonstrated that the antibody-based blocking of ephrinB2, a protein involved in angiogenesis and lymphoangiogenesis, may represent an effective strategy for the development of antiangiogenic and antitumoural therapies. The results of this study appeared in this month's issue of Blood, the journal of the American Society of Hematology. CNIO researchers generated highly-specific human antibodies against ephrin-B2 using a phage display ...

A carbon nanotube sponge that can soak up oil in water with unparalleled efficiency has been developed with help from computational simulations performed at the Department of Energy's (DOE's) Oak Ridge National Laboratory. Carbon nanotubes, which consist of atom-thick sheets of carbon rolled into cylinders, have captured scientific attention in recent decades because of their high strength, potential high conductivity and light weight. But producing nanotubes in bulk for specialized applications was often limited by difficulties in controlling the growth process as well ...

The report "Sequestration: Health Research at the Breaking Point," released today by Research!America, demonstrates the damaging consequences of potential automatic spending cuts, or sequestration, to the nation's medical research enterprise and public health, and offers examples on how these cuts would delay scientific discoveries that could lead to new treatments and cures for deadly diseases. This report provides: The estimated budget cuts to the National Institutes of Health, the Centers for Disease Control and Prevention, the Agency for Healthcare Research and ...

TEMPE, Ariz. – New findings from NASA's Dawn spacecraft lay the groundwork for the first geological overview of asteroid (4)Vesta and confirm the existence of not one but two giant impact basins in its southern hemisphere. The findings, published today in a set of Science papers, will help scientists better understand the early solar system and processes that occurred as it formed and evolved. The Dawn spacecraft, orbiting asteroid Vesta since July 2011, has already acquired several thousand images of the asteroid's surface, revealing a complex landscape. The images ...

MAYWOOD, Ill. – Patients see potential benefits from direct-to-consumer genetic testing, but are also concerned about how test results will be used, and generally are unwilling to pay more than $10 or $20 for them, according to focus groups conducted by researchers at Loyola University Chicago Stritch School of Medicine. Findings by first author Katherine Wasson, PhD, MPH, and colleagues are published in the American Journal of Bioethics Primary Research. Wasson, an assistant professor in Loyola's Neiswanger Institute for Bioethics and Health Policy, is an expert on the ...

Seaweeds are important foundational species that are vital both as food and habitat to many aquatic and terrestrial shore organisms. Yet seaweeds that cling to rocky shores are continually at risk of being broken or dislodged from their holds by crashing waves with large hydrodynamic forces. So how do such seaweeds survive in intertidal zones? Do they have special properties that make them extremely flexible or particularly strong? Patrick Martone (University of British Columbia) has spent a considerable amount of time standing on the shore watching big waves crash ...

When UCLA's Christopher T. Russell looks at the images of the protoplanet Vesta produced by NASA's Dawn mission, he talks about beauty as much as he talks about science. "Vesta looks like a little planet. It has a beautiful surface, much more varied and diverse than we expected," said Russell, a professor in UCLA's Department of Earth and Space Sciences and the Dawn mission's principal investigator. "We knew Vesta's surface had some variation in color, but we did not expect the diversity that we see or the clarity of the colors and textures, or their distinct boundaries. ...

PHILADELPHIA — When the Deepwater Horizon drilling rig exploded April 20, 2010, residents feared that their Gulf of Mexico shores would be inundated with oil. And while many wetland habitats and wildlife were oiled during the three-month leak, the environmental damage to coastal Louisiana was less than many expected, in part because much of the crude never made it to the coast. Research by a trio of geoscientists, including the University of Pennsylvania's Douglas Jerolmack, now offers an explanation for why some of the oil stayed out at sea. Using publicly available ...

For the last few decades, space scientists have generally accepted that the bubble of gas and magnetic fields generated by the sun – known as the heliosphere – moves through space, creating three distinct boundary layers that culminate in an outermost bow shock. This shock is similar to the sonic boom created ahead of a supersonic jet. Earth itself certainly has one of these bow shocks on the sunward side of its magnetic environment, as do most other planets and many stars. A collection of new data from NASA's Interstellar Boundary Explorer (IBEX), however, now indicate ...

Forests in the Amazon Basin are expected to be less vulnerable to wildfires this year, according to the first forecast from a new fire severity model developed by university and NASA researchers. Fire season across most of the Amazon rain forest typically begins in May, peaks in September and ends in January. The new model, which forecasts the fire season's severity from three to nine months in advance, calls for an average or below-average fire season this year within 10 regions spanning three countries: Bolivia, Brazil and Peru. "Tests of the model suggested that ...