Spacious new homes on large, hillside homesites in Fair Oaks Ranch are coming to Santa Clarita at Crest View, where Los Angeles homebuilder Pardee Homes has set Saturday, March 3 for grand opening festivities. The Crest View sales center will open at 10 a.m. and home shoppers are invited to enjoy self-guided tours of 4 fully decorated model homes. Grand opening visitors can also take in a lively session with Sandy Krogh of Culinary Consultants. Demonstrating Crest View's upscale G.E. appliance line in a model home kitchen, Sandy will present delicious and easy springtime ...

Age-related macular degeneration (AMD) is one of the leading causes of blindness worldwide, especially in developed countries, and there is currently no known treatment or cure or for the vast majority of AMD patients. New research published in BioMed Central's open access journal Genome Medicine has identified genes whose expression levels can identify people with AMD, as well as tell apart AMD subtypes. It is estimated that 6.5% of people over age 40 in the US currently have AMD. There is an inheritable genetic risk factor but risk is also increased for smokers and ...

In recent years, a number of controversial claims have been made about the female mammal's egg supply – that it is renewed over her adult lifetime (as opposed to the conventional understanding that she is born with all of her eggs), and that the source of these eggs is stem cells that originate in the bone marrow. Now, Weizmann Institute scientists have disproved one of those claims and pointed in new directions toward resolving the other. Their findings, based on an original method for reconstructing lineage trees for cells, were published online today in PLoS Genetics. The ...

Scientists have discovered a new target in their fight against the devastating global disease 'malaria' thanks to the discovery of a new protein involved in the parasite's life cycle. The research has uncovered a vital player in the sexual phase of the malaria parasite's reproduction which could prove an effective target for new treatments to stop the disease in its tracks. The scientists from The University of Nottingham's School of Biology, with collaborators from the Universities of Leicester, Oxford, Imperial College London and Leiden in the Netherlands, have just ...

CHICAGO --- Millions of "good" bacteria exist harmoniously on the skin and in the intestines of healthy people. When harmful bacteria attack, the immune system fights back by sending out white blood cells to destroy the disease-causing interlopers. But how do white blood cells know which bacteria are good and which are harmful? Northwestern University Feinberg School of Medicine researchers studied one type of white blood cell known as a macrophage, which is among the immune system's first to detect and eliminate harmful bacteria. The research team, led by Christian ...

Numerous mouse strains show great biological variation in features such as behavior, coat color and susceptibility to cancer and other diseases. This study examines one possible genetic cause for differential gene expression and biological variation. COLUMBUS, Ohio – The many short pieces of mobile DNA that exist in the genome can contribute to significant biological differences between lineages of mice, according to a new study led by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research ...

How we move is an excellent indicator of overall health. When we feel good, we move around continually. When we're in pain, we reduce our physical activity. This observation might seem trivial, but it has led to an original approach for evaluating chronic pain. A team from EPFL's Laboratory of Movement Analysis and Measurement (LMAM) has developed a clever, easy-to-use visual tool to help doctors assess their patients' pain levels. The research appears online February 23 in the journal PLoS One. "Movement is an objective indicator of pain. You move differently if you're ...

The tiny, little-noticed jewel wasp may provide some answers as to how different species differ in size and shape. And that could lead to a better understanding of cell growth regulation, as well as the underlying causes of some diseases. Using the wings of these insects as a tool to study how growth is regulated, biologists at the University of Rochester have discovered that changes in expression of a well-known cell regulator gene called "unpaired" (upd) accounts for wing growth differences between males of closely related species. Unpaired is distantly related to ...

Researchers at National Jewish Health have discovered specific molecular and signaling events by which vitamin D inhibits inflammation. In their experiments, they showed that low levels of Vitamin D, comparable to levels found in millions of people, failed to inhibit the inflammatory cascade, while levels considered adequate did inhibit inflammatory signaling. They reported their results in the March 1, 2011, issue of The Journal of Immunology. "This study goes beyond previous associations of vitamin D with various health outcomes. It outlines a clear chain of cellular ...

A major register study from the Swedish medical university Karolinska Institutet shows that children born to certain groups of immigrants in Sweden had an increased risk of developing autism with intellectual disability. The study includes all children in Stockholm County from 2001 to 2007, and brings the question of the heredity of autism to the fore. "This is an intriguing discovery, in which we can see strong links between a certain kind of autism and the time of the mother's immigration to Sweden," says principal investigator Cecilia Magnusson, Associate Professor ...

Prof. Dr. Albert Newen and Dr. Leon de Bruin from the Institute of Philosophy II at the Ruhr-Universität explain their theory in the journal Cognition. In the first year of life, children already have a basic "theory of mind", that is, they are capable of distinguishing their own beliefs from those of others. At the age of four, this capacity is fully developed. According to the Bochum model, this development is guided by two interacting systems. Contradictory results: "false belief" test with and without language The test: Sally puts her ball into a basket and goes ...

Some Parkinson's Disease patients can suddenly become creative when they take dopamine therapy, producing pictures, sculptures, novels and poetry. But their new-found interests can become so overwhelming that they ignore other aspects of their everyday life, such as daily chores and social activities, according to research published in the March issue of the European Journal of Neurology. Italian researchers studied 36 patients with Parkinson's Disease - 18 with increased artistic production and 18 without - and compared them with 36 healthy controls without Parkinson's. ...

To connect a laptop to an additional monitor, projector or even to a monitor wall, a special cable was required, until now. Researchers of the Saarland University's Intel Visual Computing Institute overcome this obstacle by linking computer and monitor via an 'Internet Service'. By this means, a screen's contents can be shifted freely to any terminal's display and even shown on large-scale monitor walls. The Saarland University's scientists present their results for the first time at stand F34, in hall 9 at the computer fair Cebit. The trade show takes place in Hannover ...

A study in Spain shows that insecurity at work is directly and negatively linked to satisfaction in work and life, as well as affecting performance and commitment. Furthermore, the research reveals that the consequences of this insecurity are different according to the occupational group they work in. A study led by Spanish psychologists has concluded that the feeling that one is going to lose their job worsens satisfaction levels in other areas of life, such as family, health, financial circumstances and the work-free time balance. As the fear of unemployment increases ...

Bisphenol A (BPA) is a controversial chemical widely used in the plastics industry. A new study followed people over a 10-year time period and shows that healthy people with higher urine concentrations of BPA were more likely to later develop heart disease. The study was carried out by researchers at the Peninsula College of Medicine and Dentistry, the University of Exeter and the European Centre for the Environment and Human Health, in association with the University of Cambridge. The analysis was funded by the British Heart Foundation. The paper is published online ...

In an exclusive interview with Physics World, astronaut Drew Feustel gives a vivid account of his two missions into space and recalls his determination to make his childhood ambition – space flight – come true. In the video, Feustel discusses his two missions – his maiden flight in 2009, as part of a team sent to repair the Hubble Space telescope, and his return to space in 2011 as the lead spacewalker on Endeavour's final mission to the International Space Station. Recalling the first moments of launch, when you're sitting on the launch pad and the countdown hits ...

Researchers at the universities of Granada and Jaén, Spain, have discovered why recalling some items from memory reduces our ability to recall other related items. In the field of Psychology, this phenomenon is known as "Retrieval-Induced Forgetting" (RIF), and researchers have determined the cognitive process that causes this phenomenon and its duration. To carry out this study, the researchers designed a set of memory tasks where the participants had to learn a material and then recall it partially. Memory tasks had different levels of difficulty and included different ...

A 28-year comparative study of wild emmer wheat and wild barley populations has revealed that these progenitors of cultivated wheat and barley, which are the best hope for crop improvement, have undergone changes over this period of global warming. The changes present a real concern for their being a continued source of crop improvement. Wheats and barleys are the staple food for humans and animal feed around the world, and their wild progenitors have undergone genetic changes over the last 28 years that imply a risk for crop improvement and food production, reveals a ...

Is there such a thing as a typical criminal career? This was the question addressed by criminologist Volker Grundies from the Max Planck Institute for Foreign and International Criminal Law in Freiburg. This study examined the data of approximately 21,000 men from Baden-Württemberg, who had come into conflict with the law on one or more occasions. The results of his study challenge widely held criminological theories surrounding the development of delinquent behaviour in the life of an individual. In this project, Grundies and his colleagues at the Freiburg-based Institute ...

A new report by the National Institute of Standards and Technology (NIST) and the Department of Justice's National Institute of Justice (NIJ) has documented 149 potential sources of human error in the analysis of crime scene fingerprints. The study by a working group of 34 experts recommends a series of improvements to significantly reduce or eliminate the errors, based on the findings from its three-year scientific assessment of the effects of human factors on forensic latent print analysis. The working group consisted of experts from various forensic disciplines, statisticians, ...

Cogent Road, a provider of innovative cloud-based mortgage technologies, has introduced GravityTM, the first mortgage-specific CRM/Lead Management System that helps loan officers obtain a loan commitment in a single call. Gravity is the only cloud-based CRM/lead management system fully integrated with credit, 1003, FHA Scorecard, a pricing engine (Price My Loan), loan comparison tools and anti-steering disclosure, allowing loan originators to take a complete application, select and price a loan, accurately discuss financial benefits and qualify borrowers in one call. ...

WASHINGTON, Feb. 23, 2012 – National results indicate that tree cover in urban areas of the United States is declining at a rate of about 4 million trees per year, according to a U.S. Forest Service study published recently in Urban Forestry & Urban Greening. Tree cover in 17 of the 20 cities analyzed in the study declined while 16 cities saw increases in impervious cover, which includes pavement and rooftops. Land that lost trees was for the most part converted to either grass or ground cover, impervious cover or bare soil. Of the 20 cities analyzed, the greatest percentage ...

A case-control study from Newfoundland/Labrador has reported that greater alcohol intake may increase the risk of colorectal cancer (CRC) among obese subjects, but not among non-obese subjects. This is not a particularly large study, and only 45-60% of subjects who were recruited by telephone ended up providing data. Further, it is a case-control comparison, rather than a cohort analysis, making bias in the results more likely. In this study, there was no relation of alcohol with the risk of CRC when considering the entire population. However, when subjects were ...

CAMBRIDGE, Mass. — The condensation of water is crucial to the operation of most of the powerplants that provide our electricity — whether they are fueled by coal, natural gas or nuclear fuel. It is also the key to producing potable water from salty or brackish water. But there are still large gaps in the scientific understanding of exactly how water condenses on the surfaces used to turn steam back into water in a powerplant, or to condense water in an evaporation-based desalination plant. New research by a team at MIT offers important new insights into how these droplets ...

WASHINGTON, Feb. 23— In order to build the next generation of very large supercomputers, it's essential that scientists and engineers find a way to seamlessly scale computation performance without exceeding extraordinary power consumption. It is widely agreed that the major challenge to scaling future systems will no longer be the CMOS (Complementary Metal–Oxide–Semiconductor) integrated circuit technology but rather the data movement among processors and memory. The rapidly evolving technology of photonic interconnects promises to deliver this increase in computing capabilities ...