COLUMBUS, Ohio – A new study suggests that blocking cancer cells' access to cholesterol may offer a new strategy for treating glioblastoma, the most common and deadly form of brain cancer, and perhaps other malignancies. The potential treatment could be appropriate for tumors with a hyperactive PI3K signaling pathway, which accounts for up to 90 percent of glioblastomas cases. Researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) and at UCLA's Jonsson Comprehensive ...

Blocking the uptake of large amounts of cholesterol into brain cancer cells could provide a new strategy to battle glioblastoma, one of the most deadly malignancies, researchers at UCLA's Jonsson Comprehensive Cancer Center have found. The study, done in cells lines, mouse models and analysis of tissue from brain cancer patients, uncovered a novel mechanism by which the most commonly activated oncogene, the mutated epidermal growth factor receptor (EGFR), overcomes normal cell regulatory mechanisms to feed large amounts of cholesterol to the brain cancer cells, said ...

X Bingo has become renowned for its unique gaming experience and magical themed interface. Mad About Bingo has been keeping an eye on the site since its launch and especially in the last few months as the Out of this World promotions take shape. The Out of this World promotions have been running for months now and every month they seem to grow in popularity. The prizes available through the promotion are unlike any other which is available in the world of online bingo. In previous months, holidays to Dubai, tickets to Rihanna and Android Tablets have been given away ...

The first "big picture" study of the effects of rapidly rising temperatures in the northeast Atlantic Ocean shows that a major shift in fish stocks is already well underway. But it isn't all bad news. The research, published today (15th Sept.) in Current Biology, shows that some fishes' losses are other fishes' gain. The study led by Dr Steve Simpson of the University of Bristol in collaboration with researchers from eight other institutions, is the first to combine a suite of European datasets, which included more than 100 million fish, to explore how warming is affecting ...

Although cold and gaseous rather than a desert world, the newfound planet Kepler-16b is still the closest astronomers have come to discovering Luke Skywalker's home world of Tatooine. Like Tatooine, Kepler-16b enjoys a double sunset as it circles a pair of stars approximately 200 light-years from Earth. It's not thought to harbor life, but its discovery demonstrates the diversity of planets in our galaxy. "Kepler-16b is the first confirmed, unambiguous example of a circumbinary planet - a planet orbiting not one, but two stars," said Josh Carter of the Harvard-Smithsonian ...

Raised yellow patches of skin (xanthelasmata) around the upper or lower eyelids are markers of an individual's increased risk of having a heart attack or suffering from heart disease, finds research published on bmj.com today. The study, led by Professor Anne Tybjærg-Hansen at the University of Copenhagen, also concludes that white or grey rings around the cornea (arcus corneae) are not linked to an increased risk. Previous research has established that both xanthelasmata and arcus corneae are deposits of cholesterol. However, around half of the individuals who have ...

Archaeologists have long known that Yavneh-Yam, an archaeological site between the Israeli cities of Tel Aviv and Ashdod on the Mediterranean coast, was a functioning harbor from the second millennium B.C. until the Middle Ages. Now Tel Aviv University researchers have uncovered evidence to suggest that the site was one of the final strongholds of Early Islamic power in the region. According to Prof. Moshe Fischer of TAU's Department of Archaeology and Near Eastern Cultures and head of the Yavneh-Yam dig, the recent discovery of a bath house from the Early Islamic period ...

In order to better prevent blood clots, the drugs clopidogrel or prasugrel can be prescribed to patients with acute ischaemia of the heart muscle, in addition to acetylsalicylic acid (ASA). The German Institute for Quality and Efficiency in Health Care (IQWiG) has now investigated whether, in patients whose vessels were dilated by a percutaneous coronary intervention (PCI), the combination of prasugrel plus ASA has a higher patient-relevant benefit than ASA alone, or than combination therapy with clopidogrel plus ASA. The findings of the assessment provide indications that ...

Recent PET-measurements in Turku, Finland, show that the GSM mobile phone electromagnetic field suppresses glucose metabolism in temporoparietal and anterior temporal areas of the hemisphere next to the antenna. Thirteen young healthy males were exposed to the GSM signal for 33 minutes. The study, initiated by Centre for Cognitive Neuroscience (CCN) at University of Turku, was methodologically unique combining the expertice in brain imaging (National PET-Center and CCN), measurements and modeling of radiation (Radiation and Nuclear Safety Authority in Finland, STUK) ...

People are adept at recognizing sensations such as sounds or smells, even when many stimuli appear simultaneously. But how the association works between the current event and memory is still poorly understood. Scientists at the Bernstein Center and the Ludwig-Maximilians Universität (LMU) München have developed a mathematical model that accurately mimics this process with little computational effort and may explain experimental findings that have so far remained unclear. (PLoS ONE, September 14, 2011) The so-called 'cocktail party-problem' has already kept scientists ...

PITTSBURGH—The signature spiral arms of the Milky Way galaxy were likely formed by an epic collision between the Milky Way and the Sagittarius Dwarf galaxy, according to a University of Pittsburgh researcher and his collaborators, published today in the prestigious British journal Nature. Supercomputer simulations by Christopher W. Purcell, postdoctoral research associate in the Department of Physics and Astronomy in Pitt's School of Arts and Sciences, and colleagues report their findings in a paper titled "The Sagittarius Impact as an Architect of Spirality and Outer ...

Dr. Shervin Louie, best Los Angeles dentist, has earned the status of Invisalign premier provider. This certificate is only awarded to those dental professionals who have achieved an exceptional level of Invisalign case experience. Invisalign Preferred Providers have achieved a level of clinical training and experience in treating patients with the Invisalign system. Dentists must maintain regular treatment submission and complete ongoing training classes in order to earn the designation as a Preferred Provider of Invisalign. "I am honored to be name an Invisalign ...

NAIROBI, KENYA (12 SEPTEMBER 2011) – Restoring and preserving dryland forests and planting more trees to provide food, fodder and fertilizer on small farms are critical steps toward preventing the recurrence of the famine now threatening millions of people in the Horn of Africa, according to forestry experts from the CGIAR Consortium. Across the Horn, drought-induced famine has claimed tens of thousands of lives and swelled refugee camps in Kenya, Ethiopia and elsewhere, with millions of starving people – many of them children. Bearing the brunt of the crisis is Somalia, ...

This press release is available in German. The stars are boiling! The reason is the energy generated in the center of the star that wants to escape. If this does not happen quickly enough, the star starts to 'boil' in the outer layers causing vibrations that result in light variations, like in the Sun. Such oscillations have now been discovered by Victoria Antoci and collaborators using the NASA spacecraft Kepler, but in a much hotter star. The scientists publish this in the most recent issue of Nature. Besides the discovery of earth-like planets, astronomy is concerned ...

Fluctuations of serotonin levels in the brain, which often occur when someone hasn't eaten or is stressed, affects brain regions that enable people to regulate anger, new research from the University of Cambridge has shown. Although reduced serotonin levels have previously been implicated in aggression, this is the first study which has shown how this chemical helps regulate behaviour in the brain as well as why some individuals may be more prone to aggression. The research findings were published today, 15 September, in the journal Biological Psychiatry. For the study, ...

LOS ANGELES (Sept. 15, 2011) – Treatment with a telaprevir-based combination regimen for hepatitis C – heretofore a chronic, destructive and difficult to manage disease – effectively can be shortened to six months in about two-thirds of patients, finds a new study published Thursday in the New England Journal of Medicine. Telaprevir, a drug approved for use against hepatitis C in May, inhibits replication of virus. This anti-viral drug and a similar medication called boceprevir have nearly doubled the number of patients with sustained response. Among patients treated ...

Sabal Financial Group, L.P., formerly Milestone Asset Resolution Company, LLC, a diversified financial services management firm, announces the recent acquisition of a $158 million portfolio of performing and non-performing commercial real estate loans and commercial acquisition, development and construction loans and credit facilities. The acquisition represents the first sale transaction under the FDIC's pilot Small Investor Program ("SIP") and represents the commercial loan component of a larger $297 million loan sale mandated by the FDIC for the assets of failed ...

Small group homes for people with dementia provide good quality care and a domestic environment where people can live as individuals and families can get involved. But tension can arise when it comes to deciding who takes responsibilities for certain practical and caring tasks. Those are the key findings of a study of two group living care homes in the Netherlands, published in the September issue of the Journal of Clinical Nursing. "It's estimated that 80 million people worldwide will suffer from dementia by 2040" says Ezra van Zadelhoff from Maastricht University. ...

At least one of the "Big Three" credit ratings agencies exaggerated credit scores of private debt compared to public bonds during the last 30 years, according to a new study by researchers from Rice University, American University and Indiana University. The recent downgrade of U.S. debt by Standard & Poor's makes the study timely, and the research adds to the current debate surrounding regulatory reliance on credit ratings and the current Securities and Exchange Commission proposal to standardize credit ratings across asset classes. For the study, "Credit Ratings ...

It has long been known that roots alter the soil in their immediate vicinity, where other microorganisms live and the chemical composition is altered compared to that further away from the roots. An international research team has now demonstrated in experiments at the Paul Scherrer Institute that the soil in the vicinity of roots also contains more water – contrary to the earlier belief that there must be less water in this region, as the plant takes up water from the soil. Apparently, however, plants create a small water reserve that helps to tide them over through short ...

Tuesday, September 13, 2011, Cleveland: Researchers at Cleveland Clinic have discovered that cardiac patients receiving medicated stents – a procedure that occurs often when blood vessels are blocked – have a lower likelihood of suffering heart attacks or developing new blockages in the vessel downstream from the stent. Stents have been used to prevent re-narrowing of coronary arteries after balloon angioplasty and newer designs have included coatings with medications to prevent re-narrowing from occurring within the stent after implantation. The recent study – led by ...

September 2011, Paris, France The 24th ECNP Congress, which was held from 3 to 7 September 2011 in Paris, France, was once again a great success, bringing together more than 6,700 psychiatrists, neurologists, psychologists and neuroscience researchers from all over the world. ECNP is especially pleased to see an increasing number of delegates coming from outside Europe. The annual ECNP Congress is the largest scientific meeting on mental and neurological health in Europe, promoting fruitful dialogue between neuroscientists and medical professionals. With more than ...

Scientists reveal in more detail than ever before how white blood cells kill diseased tissue using deadly granules, in research published today in PLoS Biology. The researchers, from Imperial College London and the University of Oxford, used 'optical' laser tweezers and a super-resolution microscope to see the inner workings of white blood cells at the highest resolution ever. The researchers describe how a white blood cell rearranges its scaffolding of actin proteins on the inside of its membrane, to create a hole through which it delivers deadly enzyme-filled granules ...

Are children as young as five years old so driven by consumerism and fashion that they are in danger of 'losing' their childhood? Not necessarily, according to Dr Jane Pilcher, a sociologist at the University of Leicester, whose research findings on children and fashion were recently reported in the international journal, Childhood. Nonetheless, her findings showed that brands and logos are highly important to some children, influenced by family attitudes, peer pressure and celebrity culture. The desire for certain brands and logos, especially in boys' sportswear, ...

Martha Stokes C.M.T. will be speaking at the AAII Puget Sound Chapter in Mercer Island, WA! Saturday, September 24, 2011 from 9:00 AM - 12:00 PM. Registration/Social at 8:30 AM. The topic will be New Technology Cycle Investing Opportunities. Attend this meeting and learn: - Which sectors and industries could experience exponential growth - Methods for separating the most competitive companies from those that are losing momentum - The reasons why certain new industries are growing exponentially For more information please visit: http://sites.google.com/site/pugetsoundchapter/home http://technitrader.com/get-connected/ Contact ...