Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding, such as Alzheimer's, Parkinson's and Huntington's diseases, amyotrophic lateral sclerosis (ALS), cancer, cystic fibrosis and type 2 diabetes. To do its job properly within the cell, a protein first must fold itself into the proper shape. If it doesn't, trouble can result. More than 300 diseases have at their root proteins that misfold, aggregate and eventually cause cellular dysfunction and death. The new Northwestern ...

A new UCSF analysis of tobacco industry documents shows that Philip Morris USA manipulated data on the effects of additives in cigarettes, including menthol, obscuring actual toxicity levels and increasing the risk of heart, cancer and other diseases for smokers. Tobacco industry information can't be taken at face value, the researchers conclude. They say their work provides evidence that hundreds of additives, including menthol, should be eliminated from cigarettes on public health grounds. The article is published in PLoS Medicine http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001145 In ...

We generally think that views about how to integrate a diverse society depend on people's positions in that society—that is, whether they're in the racial, religious, or cultural majority or a member of a minority. In the U.S., "people tend to believe that blacks prefer pluralism and whites prefer assimilation," says University of Delaware psychologist Eric Hehman. Assimilation asks minorities—whether newly arrived or historically rooted—to drop their cultural identities and adopt the ways of the majority. Pluralism recognizes and even celebrates minority cultures, which ...

Older people tend to be happier. But why? Some psychologists believe that cognitive processes are responsible—in particular, focusing on and remembering positive events and leaving behind negative ones; those processes, they think, help older people regulate their emotions, letting them view life in a sunnier light. "There is a lot of good theory about this age difference in happiness," says psychologist Derek M. Isaacowitz of Northeastern University, "but much of the research does not provide direct evidence" of the links between such phenomena and actual happiness. In ...

GAINESVILLE, Fla. — A new University of Florida study shows genomes of a recently formed plant species to be highly unstable, a phenomenon that may have far-reaching evolutionary consequences. Published online this week in the Proceedings of the National Academy of Sciences, the study is the first to document chromosomal variation in natural populations of a recently formed plant species following whole genome doubling, or polyploidy. Because many agricultural crops are young polyploids, the data may be used to develop plants with higher fertility and yields. Polyploid ...

Reston, Va. (December 28, 2011) – In a new review of imaging studies spanning more than ten years, scientists find that a method of positron emission tomography (PET) safely and accurately detects dementia, including the most common and devastating form among the elderly, Alzheimer's disease. This research is featured in the January issue of the Journal of Nuclear Medicine. Researchers reviewed numerous PET studies to evaluate a molecular imaging technique that combines PET, which provides functional images of biological processes, with an injected biomarker called 18F-FDG ...

Insurance status doesn't affect the quantity (or value) of imaging services received by patients in a hospital, in-patient setting, according to a study in the January issue of the Journal of the American College of Radiology. Approximately 51 million Americans, or 16.7 percent of the population, were without health insurance for some or all of 2009. Lack of insurance is associated with less preventive care, delays in diagnosis and unnecessary deaths. "Americans without health insurance generally receive fewer health care services than those with insurance. Less ...

An article in the forthcoming issue of the Journal of Integrated Pest Management (JIPM) refutes claims by Greenpeace Germany that the western bean cutworm (WBC), Striacosta albicosta (Smith), is "a new plant pest" that was "caused by genetically engineered corn." The Greenpeace Germany report, which was written by author Christoph Then of Testbiotech, offers a "surprisingly simplistic conclusion" regarding the spread of western bean cutworm over the last decade, according to the JIPM authors. In "Genetically Engineered Bt Corn and Range Expansion of the Western Bean Cutworm ...

A biology lab at Washington University has just cracked the structure and function of a protein that plays a key role in the life of a parasite that killed 655,000 people in 2010. The protein is an enzyme that Plasmodium falciparum, the protozoan that causes the most lethal form of malaria, uses to make cell membrane. The protozoan cannot survive without this enzyme, but even though the enzyme has many lookalikes in other organisms, people do not make it. Together these characteristics make the enzyme an ideal target for new antimalarial drugs. The research was published ...

Climate change is having a more profound effect on alpine vegetation than at first anticipated, according to a study carried out by an international group of researchers and published in Nature Climate Change. The first ever pan-European study of changing mountain vegetation has found that some alpine meadows could disappear within the next few decades. Led by researchers from the Austrian Academy of Sciences and the University of Vienna, biologists from 13 different countries in Europe analysed 867 vegetation samples from 60 different summits sited in all major European ...

We've all seen the story in the news before. Whether it's the death of a physically fit high school athlete at football training camp in August, or of an elderly woman gardening in the middle of the day in July, heat stroke is a serious, life-threatening condition for which there is no treatment beyond submersion in ice water or the application of ice packs to cool the body to a normal temperature. But, in a new study published today in the journal Nature Medicine, scientists discovered what they believe is one of the first drugs to combat heat stroke. AICAR – an experimental ...

Summertime hail could all but disappear from the eastern flank of Colorado's Rocky Mountains by 2070, according to a new modeling study by scientists from NOAA and several other institutions. Less hail damage could be good news for gardeners and farmers, said Kelly Mahoney, Ph.D., lead author of the study and a postdoctoral scientist at NOAA's Earth System Research Laboratory in Boulder, Colo. But a shift from hail to rain can also mean more runoff, which could raise the risk of flash floods, she said. "In this region of elevated terrain, hail may lessen the risk of ...

A team of scientists, led by researchers at the University of California, San Diego School of Medicine and Zacharon Pharmaceuticals, have developed a simple, reliable test for identifying biomarkers for mucopolysaccharidoses (MPS), a group of inherited metabolic disorders that are currently diagnosed in patients only after symptoms have become serious and the damage possibly irreversible. The findings will be published online January 8 in the journal Nature Chemical Biology. MPS is caused by the absence or malfunctioning of a lysosomal enzyme required to break down ...

Much of what living cells do is carried out by "molecular machines" – physical complexes of specialized proteins working together to carry out some biological function. How the minute steps of evolution produced these constructions has long puzzled scientists, and provided a favorite target for creationists. In a study published early online on Sunday, January 8, in Nature, a team of scientists from the University of Chicago and the University of Oregon demonstrate how just a few small, high-probability mutations increased the complexity of a molecular machine more than ...

CHAMPAIGN, Ill. — Those making land use decisions to reduce the harmful effects of climate change have focused almost exclusively on greenhouse gases – analyzing, for example, how much carbon dioxide is released when a forest is cleared to grow crops. A new study in Nature Climate Change aims to present a more complete picture – to incorporate other characteristics of ecosystems that also influence climate. "We know that forests store a lot of carbon and clearing a forest releases carbon dioxide into the atmosphere and contributes to climate change," said University of ...

In a report published in Nature Physics, they used graphene, the world's thinnest and strongest material, and made it magnetic. Graphene is a sheet of carbon atoms arranged in a chicken wire structure. In its pristine state, it exhibits no signs of the conventional magnetism usually associated with such materials as iron or nickel. Demonstrating its remarkable properties won Manchester researchers the Nobel Prize in Physics in 2010. This latest research led by Dr Irina Grigorieva and Professor Sir Andre Geim (one of the Nobel prize recipients) could prove crucial ...

The decade from 2000 to 2009 was the warmest since global climate has been measured, and while localized studies have shown evidence of changes in mountain plant communities that reflect this warming trend, no study has yet taken a continental-scale view of the situation – until now. With the publication of "Continent-wide response of mountain vegetation to climate change," scheduled for Advance Online Publication (AOP) in Nature Climate Change on 8 January, researchers from 13 countries report clear and statistically significant evidence of a continent-wide warming effect ...

Founder of EditCopyProof, Charlon Bobo, today announced the official launch of a new website featuring products and services specifically developed for evolutionary entrepreneurs. As one of only a few businesses worldwide addressing the specific needs of this market, Bobo is the only copywriter. Affectionately known as the "conscious copywriter," Bobo enjoys the success of a worldwide clientele and a loyal following of evolutionary entrepreneurs; a quickly-emerging market. The term is a relatively new one, coming onto the business scene within the past year. Evolutionary ...

HOUSTON -- (Jan. 8, 2012) – The anxiety and behavioral issues associated with excess MeCP2 protein result from overexpression of two genes (Crh [corticotropin-releasing hormone] and Oprm 1 [mu-opioid receptor MOR 1]), which may point the way to treating these problems in patients with too much of the protein, said Baylor College of Medicine scientists in a report that appears online in the journal Nature Genetics. Much of the work was done at the Jan and Dan L. Duncan Neurological Research Institute at Texas Children's Hospital. MeCP2 is a "Goldilocks" in the protein ...

GAINESVILLE, Fla. --- Unprecedented levels of greenhouse gases in the Earth's atmosphere are disrupting normal patterns of glaciation, according to a study co-authored by a University of Florida researcher and published online Jan. 8 in Nature Geoscience. The Earth's current warm period that began about 11,000 years ago should give way to another ice age within about 1,500 years, according to accepted astronomical models. However, current levels of carbon dioxide are trapping too much heat in the atmosphere to allow the Earth to cool as it has in its prehistoric past ...

First Evangelical Methodist Church of Glendora is pleased to announce the official hiring of Mark Quiroz as their new Senior Pastor. He will be replacing the churches long time dedicated pastor Wenzel Sperl who passed away on September 26, 2011. Pastor Quiroz brings to Glendora EMC, five years of church leadership as Youth Pastor of multiple churches. He graduated in 2011 with a Bachelors of Science Degree in Christian Ministry from Crown College in Minnesota. He is currently enrolled in the Master of Ministry program at Point Loma University in San Diego. For more ...

A new study by NYU Langone Medical Center researchers identified a new culprit that leads to atherosclerosis, the accumulation of fat and cholesterol that hardens into plaque and narrows arteries. The research, published online by Nature Immunology on January 8, 2012, explains why cholesterol-laden, coronary artery disease-causing cells called macrophages, accumulate in artery plaques. "We have discovered that macrophages that accumulate in plaques secrete a molecule called netrin-1," said Kathryn J. Moore, PhD, senior author of the study and associate professor in the ...

St. Louis Society for the Blind and Visually Impaired is very pleased to announce it has been selected to participate in the "Year of Making a Difference" program presented by Gallop, a major law firm headquartered in St. Louis. (www.GallopLaw.com). "Year of Making a Difference" is a unique charitable awareness and fundraising initiative managed by Gallop that will benefit not only Society for the Blind and Visually Impaired but additional non-profit organizations in St. Louis that assist people right here in our community. David Ekin, President ...

A new form of graphene created by researchers at The University of Texas at Austin could prevent laptops and other electronics from overheating, ultimately, overcoming one of the largest hurdles to building smaller and more powerful electronic devices. The research team, which includes colleagues at The University of Texas at Dallas, the University of California-Riverside and Xiamen University in China, published its findings online today in the Advance Online Publication of Nature Materials. The study will also appear in the print journal of Nature Materials. Led ...

In the chemistry of the living world, a pair of nucleic acids—DNA and RNA—reign supreme. As carrier molecules of the genetic code, they provide all organisms with a mechanism for faithfully reproducing themselves as well as generating the myriad proteins vital to living systems. Yet according to John Chaput, a researcher at the Center for Evolutionary Medicine and Informatics, at Arizona State University's Biodesign Institute®, it may not always have been so. Chaput and other researchers studying the first tentative flickering of life on earth have investigated various ...