Nanotechnology offers powerful new possibilities for targeted cancer therapies, but the design challenges are many. Northwestern University scientists now are the first to develop a simple but specialized nanoparticle that can deliver a drug directly to a cancer cell's nucleus -- an important feature for effective treatment. They also are the first to directly image at nanoscale dimensions how nanoparticles interact with a cancer cell's nucleus. "Our drug-loaded gold nanostars are tiny hitchhikers," said Teri W. Odom, who led the study of human cervical and ovarian ...

Miami… A six-year collaboration between two faculty members of Bascom Palmer Eye Institute of the University of Miami Miller School of Medicine has yielded new insight regarding the regulation of intraocular pressure (IOP) in glaucoma - an irreversible blinding disease that causes progressive visual impairment due to optic nerve damage and is the leading cause of blindness worldwide. The key finding by associate professors of ophthalmology Richard K. Lee, M.D., Ph.D. and Sanjoy Bhattacharya, M. Tech., Ph, D. validates their hypothesis that the response of aqueous humor ...

One of the defining moments for teenagers in the U.S. is earning a driver's license, which equates to gaining some independence from parental supervision. This defining moment can quickly turn devastating, however, due to various factors like disobeying traffic laws and distracted driving. There has been an alarming spike recently in the number of teenagers who die in car accidents each year across the nation. Particularly in North Carolina, the rate of teenage driver deaths is on the rise, so safety groups in the state are ready for action. Spike in Deaths According ...

With a 95 percent genomic similarity to humans, mice have long been used to learn about the genetic causes of human disease. Once researchers can shine a light on the genetic factors that cause disease in mice, they can start to develop prevention and treatment options to protect the human population. But this process, called genetic mapping, is a long and difficult road, made more challenging by the 5% difference between the humans and lab mice. Now Prof. Fuad Iraqi of Tel Aviv University's Sackler Faculty of Medicine is closing the gap with an international project ...

Despite the fact that nifedipine increases the risk of heart attacks and death, doctors still prescribe this immediate-release blood pressure drug to elderly patients. The Cologne-based research group led by Ingrid Schubert has now published the results of their investigation in the current issue of Deutsches Ärzteblatt International (Dtsch Arztebl Int 2012; 109[12]: 215-9). Immediate-release nifedipine is classified as a potentially dangerous drug in the PRISCUS list published in 2010. Earlier studies demonstrated that, in comparison to other antihypertensive drugs, ...

If you have been arrested or convicted of a crime in New Jersey, you may simply want to move on with life without a criminal record haunting you in the future. It is true in many respects that decisions made earlier in life are not reliable indicators of future behavior. Unfortunately, many people still see trouble in a criminal record. Certain employers may choose to pass you by, rental agencies may disqualify you and military recruiters can be particularly sensitive about criminal records. In an effort to promote ex-offender re-entry back into the community, the law allows ...

In the largest multicenter clinical trial of children undergoing early-stage surgery for single-ventricle heart defects, differences in intraoperative management did not significantly affect neurodevelopmental outcomes at 14 months of age. Instead, the strongest influences were innate patient characteristics and general medical morbidity during the child's first year of life. Children born with hypoplastic left-heart syndrome (HLHS) and related single-ventricle defects have long been known to be vulnerable to developmental impairments, and researchers suspected that ...

New Rochelle, NY, April 5, 2012—In most people, high blood levels of the fat known as triglycerides are an early warning sign of type 2 diabetes and metabolic syndrome, but in people of African descent these dangerous health conditions may go undiagnosed because triglyceride levels are not at the level used to diagnose metabolic syndrome (>150 mg/dL). This is known as the "TG (or lipid) paradox." Understanding how African Americans are at increased risk for cardiovascular disease (CVD) despite a normal TG level is unclear and is the focus of a review article in Metabolic ...

Some Texas DWI defense attorneys estimate the financial costs of a drunk driving conviction anywhere between $10,000 and $20,000 for even a first time offender. For those who made one mistake or for those who were wrongly accused of driving while impaired, the cost of just three drinks can quickly become very expensive. A driver can be arrested for a Texas DWI if his or her blood alcohol content is at or above .08. Consuming three beers is enough for some people to reach the level of legal intoxication; others may consume more and others may consume less and still reach ...

The risks of distracted driving to South Carolina motorists, passengers, pedestrians and bicyclists are well understood. When drivers focus their attention on something other than the road ahead, the chances of a truck, motorcycle or car accident increase substantially. According to the U.S. Department of Transportation, more than 3,000 people died in 2010 in motor vehicle crashes caused by distracted driving. Studies funded by the National Highway Traffic Safety Administration (NHTSA) have shown that drivers are 30 percent more likely to be involved in a car wreck if ...

URBANA - When University of Illinois researchers surveyed over 3,500 college applicants, more than a third couldn't report their weight accurately, and overweight and obese men were more likely to underestimate their weight than women. "This misperception is important because the first step in dealing with a weight problem is knowing that you have one," said Margarita Teran-Garcia, a U of I professor of food science and human nutrition. The study is part of the Up Amigos project, a collaboration between scientists at the U of I and the Universidad Autónoma de San Luis ...

New England is expected to experience a "moderate" regional "red tide" this spring and summer, report NOAA-funded scientists working in the Gulf of Maine to study the toxic algae that causes the bloom. The algae in the water pose no direct threat to human beings, however the toxins they produce can accumulate in filter-feeding organisms such as mussels and clams— which can cause paralytic shellfish poisoning (PSP) in humans who consume them. Under a newly developed rating system, a moderate bloom could cause the closure of shellfish beds along an estimated 126 – 250 miles ...

The Hampton Inn & Suites Atlanta Airport Hotel (North I-85) offers nearby accommodations to guests attend the upcoming Atlanta Braves Major League Baseball (MLB) games. The home baseball games are held at Turner Field, near downtown Atlanta. The Braves 2012 home opener will take place on Friday, April 13 at 7:35pm at Turner Field. The Braves will play the Brewers. Other upcoming home games at Turner Field include: - Braves verses Brewers, April 14 - 15 - Braves verses Mets, April 16 - 18 - Braves verses Pirates, April 27 - 30 Since opening in 1997, Turner ...

Washington, D.C. (April 5, 2012) The International Communication Association's flagship journal, Journal of Communication, released a special issue on social media and democracy. As revolutions erupted in real time in Tunisia and Egypt in late 2010 and early 2011, it was obvious that social media were important and not well understood. This special issue has a selection of articles that tell a fascinating but complicated story of media and political change in the Middle East and other countries. "With pundits of all persuasions rushing to judgment, I believed it was ...

In early March, Google's head of search spam, Matt Cutts, announced a release of an algorithm update to target sites with excessive SEO. Since that time, there has been some ambiguity as to when this algorithm will be released and how it will affect rankings. Since the announcement, there have been some random online complaints that site owners have experienced sudden, unexplained ranking drops. Some of these reports claim considerable drops in ranking, although Mr. Cutts has claimed in his blog that this update is not very large. At this point, the update does not ...

Designers at Hotter Comfort Concept Shoes have launched 8 new women's sandals so the nation can enjoy every step this season in the ultimate comfort and style. Designed to make every day an occasion, Hotter's women's sandals have been designed to be stylish with on trend detailing. Followers of fashion will enjoy popular colourful shades such as pastels, nudes, metallic as well as bright summer colours. What's more every pair is crammed with ultra-comfy features such as super soft leathers, lightweight flexible soles whilst clever adjustability features help to create ...

Hairtrade, the UK's leading retailer of hair extensions, hair care and beauty products has added a new range of crystal beaded jewellery to its fashion accessories line. The crystal beaded bracelets and necklaces have been added to further increase the accessories range which is becoming more popular with customers. The bracelets have already been a huge hit with online customers as the Spring/Summer season begins. The recent trend in friendship bracelets is set to continue through the summer, especially for the upcoming festival season. Keven Kou, managing director ...

findmypast.co.uk, a leading UK family history website, has announced that it has been awarded a contract by Canterbury Cathedral Archives to publish historic records from the archive online. The first phase of the Canterbury Collection project will see an online version of the parish registers of the historic Archdeaconry of Canterbury, to be published in the coming weeks at findmypast.co.uk. An estimated 270,000 images containing over a million entries will be published on the website, covering parish churches from a wide expanse of East Kent, including: - the city ...

American Health Care Lending, dedicated to providing superior health care financing, announces Payment Stream, one of their four comprehensive payment solutions offered on a single platform. Exclusive to American Health Care Lending, this product is unlike any other dental financing option available and can provide funding for every patient. Payment Stream instantly approves all patients to a certain risk tier based on their credit profile. Then providers have the power to accept or reject the approval. If accepted, the documents can be signed and treatment can begin ...

Corcentric, a leading provider of SaaS-hosted financial process automation solutions for the retail industry, today announced they will host Pod #4 at the National Retail Federation's 2012 Global Supply Chain Summit. This conference will take place May 6-8, 2012 at the Hyatt Regency in Atlanta, Georgia. Corcentric specializes in providing comprehensive Accounts Payable automation and invoice approval workflow solutions to the retail industry. Corcentric solutions for the retail industry enable retail finance professionals to manage unique challenges such as managing ...

When Rusty Moore, a popular fitness author and full-time fitness blogger, hired Kevin McMillian to design the graphics for his new course, Visual Impact Cardio, he also provided Kevin with a copy of the program. After reading through it and putting the new information and workout routines together, Kevin had some amazing results to show for it. In a live case study and review of Visual Impact Cardio, Kevin McMillian documented his weight loss as well as his fat loss in real time. He continually updated the review site as he went. After the 8 weeks were up he compiled ...

Want to update a tired living room this Bank Holiday weekend? With vintage inspired furniture to luxurious upholstery and stylish accessories, Next has everything you need to help create your dream living room. Stunning chairs, bookcases, sideboards and coffee tables compliment our brilliant range of sofas. Whether your style is retro, tribal, oriental or serene choose from beautiful accessories to make the finishing touches to your perfect haven. Cream Tea Cream tea is a charming vintage take on English style, punctuated with strawberry motifs, teatime inspired accessories, ...

Patricia Gracia, founder of Power Media Group, participated in a crucial roundtable discussion at the White House Urban Economic Forum on Thursday March 22. The forum, sponsored by the White House Business Council and the U.S. Small Business Administration, was co-hosted by Los Angeles City Mayor Antonio Villaraigosa. The White House Business Council Forum is a multi-city series held in over 500 cities to create a discussion focused on improving economic conditions and job creation. The forum will feature high level discussions between senior White House and Administration ...

Multifamily Ancillary Group, LLC (MAG), the leading ancillary service provider for the multifamily industry, proudly announced the launch of its redesigned and improved www.multifamilyancillarygroup.com. The website is informational, clean and features an easy-to-navigate design. The new layout provides streamlined content for each service, contact information, and relevant material regarding the company's profile. MAG increased its functionality based on a 2011 statistic; citing that users will spend an average of 10-20 seconds on a web page. "Our new website ...

To what extremes can greed, passion, and jealousy push human beings? The Rendezvous provides at least one chilling answer. The slick and sexy 12-minute thriller will be shown at a private screening on Friday, April 20th at the AFI Theater in Silver Spring, MD, before it makes its way onto the film festival circuit. Shot at a stunning mansion in Potomac, MD, an upscale suburb of Washington, DC, the film centers on a beautiful woman with a love of racy lingerie and the finer things in life who convinces her greed-driven lover to engage in a risky plan. The plan consists ...