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Social Science

Bats worth billions to agriculture

AUDIO: Insect-eating bats provide pest-control services that save the U.S. agriculture industry over $3 billion per year, according to a study released today in the journal Science. However, scientists with the... Click here for more information. Pest-control services provided by insect-eating bats in the United States likely save the U.S. agricultural industry at least $3 billion a year, and yet insectivorous bats are among the most overlooked economically important, non-domesticated ...

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Social Science

A national survey: The value of otolaryngologists' services in America

Alexandria, VA — In recent years reimbursement for surgical services has declined, failing to keep up with inflation and economic growth. Financial incentives aimed at re-distributing reimbursement from procedural specialties to primary care specialties have been ineffective thus far, and the financial returns of being a physician continue to decrease, according to new research published in the April 2011 issue of Otolaryngology – Head and Neck Surgery. According to a national survey of 409 members of the general population, survey participants said that a reasonable ...

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Science

Internet program reduces infant and toddler sleep problems, helps moms sleep better too

DARIEN, Ill. – A study in the April 1 issue of the journal SLEEP demonstrates that an Internet-based intervention was effective at reducing infant and toddler sleep disturbances, as well as providing positive, indirect benefits for maternal sleep, mood and confidence. The study suggests that the Internet can give parents widespread access to individualized, behaviorally based advice for sleep problems in young children. Results show that there were significant improvements in the sleep of infants and toddlers in the Internet-based intervention groups. The number and duration ...

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Medicine

New opportunities for covalent drugs published by Avila scientists

WALTHAM, MA – April 1, 2011 – Avila Therapeutics™, Inc., a biotechnology company developing novel targeted covalent drugs, today announced the publication of a scientific review article in Nature Reviews Drug Discovery titled "The Resurgence of Covalent Drugs" (www.nature.com/reviews/drugdisc, Vol. 10, April 2011, Singh, J.). This article discusses the broad opportunities for covalent drugs and how structural bioinformatics coupled with structure-based drug design can enable the design of highly selective covalent drugs with unique therapeutic properties for treating ...

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Science

Risk of death is high in older adults with sleep apnea and daytime sleepiness

DARIEN, IL – A study in the April 1 issue of the journal SLEEP suggests that the risk of death is more than two times higher in older adults who have sleep apnea and report struggling with excessive daytime sleepiness. Results of adjusted proportional hazards modeling show that older adults with moderate to severe sleep apnea who reported struggling with excessive daytime sleepiness at baseline were more than twice as likely to die (hazard ratio = 2.28) as subjects who had neither problem. The risk of death was insignificant in older adults with only excessive daytime ...

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Medicine

New tool allows for an alternate method of prostate cancer diagnosis

PHILADELPHIA — Researchers have found that it may not be necessary to look for tumors directly in patients with prostate cancer — analyzing non-tumor tissue may be an effective option, according to study results published in Cancer Research, a journal of the American Association for Cancer Research. "A biopsy needle does not need to hit a tumor to detect the presence of tumor," said lead researcher Dan Mercola, M.D., Ph.D., professor of pathology and laboratory medicine at the University of California at Irvine. "It is reminiscent of the game Battleship; we can detect ...

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Medicine

Breast health global initiative offers unprecedented tools for developing nations

SEATTLE – A landmark breast health care publication reveals a multitude of barriers that keep women of developing nations from being screened and treated for breast cancer – but offers tools to help countries improve their breast care programs. "Global Breast Health Care: Optimizing Delivery in Low- and Middle-Resource Countries," published as a supplement to the April 1 edition of The Breast, compiles three consensus statements and 11 research papers that were based on projects and proposals presented last June at the Breast Health Global Initiative Global Summit on ...

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Science

Many US women have children by more than one man

ANN ARBOR, Mich.---The first national study of the prevalence of multiple partner fertility shows that 28 percent of all U.S. women with two or more children have children by more than one man. The study will be presented April 1 in Washington, D.C., at the annual meeting of the Population Association of America. "I was surprised at the prevalence," said demographer Cassandra Dorius, a postdoctoral fellow at the University of Michigan Institute for Social Research. "Multiple partner fertility is an important part of contemporary American family life, and a key component ...

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Science

The Population Bomb: How we survived it

ANN ARBOR, Mich.---World population will reach 7 billion this year, prompting new concerns about whether the world will soon face a major population crisis. "In spite of 50 years of the fastest population growth on record, the world did remarkably well in producing enough food and reducing poverty," said University of Michigan economist David Lam, in his presidential address at the annual meeting of the Population Association of America. Lam is a professor of economics and a research professor at the U-M Institute for Social Research. The talk is titled "How the World ...

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Science

Manage biological invasions like natural disasters, biologists say

Biological invasions get less prime-time coverage than natural disasters, but may be more economically damaging and warrant corresponding investments in preparedness and response planning, according to three biologists writing in the April issue of BioScience. Anthony Ricciardi of McGill University and his coauthors point out that species invasions are becoming more frequent worldwide, largely because of international trade. Although many alien species establish themselves in a new location without causing harm, the worst biological invasions may cause multiple extinctions ...

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Science

Cat's out of the bag: PUMA contributes to ulcerative colitis

Ulcerative colitis (UC) is an inflammatory bowel disease thought to be related to aberrant activation of the immune system in the intestine. Recent research has also suggested that regulated cell death (apoptosis) of the intestinal epithelial cells is a contributing factor to the pathogenesis. However, the molecular mechanisms that control the cellular response to inflammation are incompletely understood. In this paper, Lin Zhang, at the University of Pittsburgh, in Pennsylvania, found that in mice, a protein called PUMA (p53 upregulated modulator of apoptosis) was responsible ...

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Medicine

Gag order: how DNA silencing can promote cancer

Cells control which genes they express by multiple mechanisms, one of which is the direct modification of DNA with small molecules. Methylation of genes effectively silences them, and excess DNA methylation, particularly of genes that control the cell cycle, is known to promote cancer formation. However, it is unclear whether the enzymes that modify DNA in this way target specific genes or whether random modifications select cells for enhanced tumorigenic capactiy. In new research, Rudolf Jaenisch and colleagues, at the Whitehead Institute in Cambridge, Massachusetts, ...

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Science

JCI online early table of contents: April 1, 2011

EDITOR'S PICK Cat's out of the bag: PUMA contributes to ulcerative colitis Ulcerative colitis (UC) is an inflammatory bowel disease thought to be related to aberrant activation of the immune system in the intestine. Recent research has also suggested that regulated cell death (apoptosis) of the intestinal epithelial cells is a contributing factor to the pathogenesis. However, the molecular mechanisms that control the cellular response to inflammation are incompletely understood. In this paper, Lin Zhang, at the University of Pittsburgh, in Pennsylvania, found that in ...

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Environment

Sugar-grain sized meteorites rocked the climates of early Earth and Mars, according to new study

Bombardments of 'micro-meteorites' on Earth and Mars four billion years ago may have caused the planets' climates to cool dramatically, hampering their ability to support life, according to research published today in the journal Geochimica et Cosmochimica Acta. Scientists from Imperial College London studied the effects of the Late Heavy Bombardment (LHB), a period of time in the early Solar System when meteorite showers lasting around 100 million years barraged Earth and Mars. This bombardment discharged sulphur dioxide into the upper atmospheres of both planets and ...

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Medicine

Smyrna, GA Dentist Reaches Out to Patients Through New Website

Leading dentists in Smyrna, Dr. James C. Pitts and Dr. Joseph M. Pitts, are pleased to introduce patients to a new avenue for communication and education through the launch of the practice's innovative website. The new informative website was created in order to enhance patient awareness of dental health care. The new website for this dentist in Smyrna offers a wide array of valuable tools and information that patients can use to better inform themselves of various dental health care topics. Patients can visit this Smyrna dentist's website via the Internet at any moment ...

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Science

From science fiction to research breakthrough

Focusing on interdisciplinary research is now leading to breakthroughs in bio nanotechnology research. A new method for drug development has become a reality. Four years ago, the biologist Karen Martinez almost didn't believe in the research project herself when she started with her team working on it, but now it has been proven. Together with colleagues at the Nano-Science Center, her team has been able to combine nanoscale materials and technologies that are traditionally used for electronic devices with individual living cells. The researchers have shown that cells ...

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Medicine

Progress toward the clinical application of autologous induced pluripotent stem cells and gene repair therapy for treatment of familial hypercholesterolemia

Study shows, for the first time, the successful reprogramming of diseased human hepatocytes into induced pluripotent stem cells (iPSC).1 Results also found differentiation into mature hepatocytes was more efficient than that with fibroblast-derived iPSCs. The generation of diseased hepatocyte-derived human iPSC lines provides a good basis for the study of liver disease pathogenesis. Such technology could give a potentially unlimited reservoir of cells for the treatment of human liver diseases: generating genetically corrected liver cells via auto-transplantation of ...

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Medicine

Dentist in West Orange, NJ Offers Patients Opportunity to Learn About Other Patients' Experiences

Skilled West Orange dentist, Dr. Paul Feldman, allows patients to submit reviews of himself, his practice and his staff. The reviews are easily accessible via the practice's website and allow patients to view how other patients' experiences were. Patients can visit the website for this West Orange, NJ dentist to read reviews from previous patients who have received treatment from Dr. Feldman. "It is important that I know what my patients concerns are and what I am doing correctly. I value their opinion and the patient review section allows me to find out what they think, ...

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Medicine

In vivo RNAi screening identifies new regulators of liver regeneration

This study establishes a unique system to perform in vivo RNAi screens for genetically dissecting the cellular signalling networks that regulate hepatocyte proliferation during chronic liver damage.1 Functional in vivo validation studies show that stable knockdown of the candidate gene by different shRNAs can significantly increase the repopulation efficiency of mouse hepatocytes and also increase the regenerative capacity of chronically damaged mouse livers. Such detailed understanding of the signalling pathways involved in hepatocyte proliferation control holds the ...

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Medicine

New studies provide beneficial insights expanding the pool of liver grafts and transplants

Berlin, Germany, 01 April 2011: Findings from two new studies presented today at the International Liver CongressTM confirm that there are options for clinicians to expand the pool of liver grafts for use in patients with liver disease. A UK retrospective study analysed liver transplant donation after cardiac death (DCD) between May 2001 and October 2010.1 186 DCD allografts were used for transplantation and included 19 paediatric recipients. Overall the study found positive outcomes of transplant, with an overall patient survival of 89.9%, 85.6% and 83.6% at one, three ...

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Science

Smile Gallery for Warrenton Dentist Effectively Displays Smile Transformations

Drs. Yung and Jelinek, experienced Warrenton dentists, are pleased to announce the addition of a smile gallery to their innovative website. Patients can now access pictures of previous patient's before and after treatment photos for a look at Drs. Yung and Jelinek's expertise and skillful cosmetic work. When accesses the online smile gallery, patients have the option to view before-and-after photos of procedures such as: anterior crowns, bleaching, crowns, crown replacement, implants and bridges, implants and crowns, orthodontics, and porcelain veneers. "We want our ...

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Medicine

First vaccine for viral hepatitis C could become a reality

Berlin, Germany, Friday 01 April 2011: Early data from phase I trials of an HCV vaccine presented today at the International Liver CongressTM show encouraging results, with high immunogenicity and good safety profile.1,2 In the first study1, a therapeutic T-cell vaccine, based on novel adenoviral vectors was used on a small population of treatment naive patients with chronic genotype 1 HCV infection. Intra-muscular vaccination was administered 2 or 14 weeks into a 48-week course of treatment with Peg-IFNa2a/ribavirin. 50% of vaccinated patients had CD4+ and CD8+ HCV specific ...

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Medicine

The future looks bright for HCV patients who have failed to respond to current treatments

Berlin, Germany, Friday 1st April 2011: Highly anticipated data from a number of clinical trials presented for the first time at the International Liver CongressTM confirmed that a range of new proteases inhibitors will help treat patients who have previously failed therapy for the treatment of chronic hepatitis C.1,2,3,4,5 The treatments have been tested for efficacy and safety in combination with PegIFN-alpha and ribavirin in patients that have previously failed treatment (either non-responder or relapse). Following different treatment and dosing, all of the trials ...

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Medicine

Fratricide of HBV-specific CD8 T cells by NK cells mediated through the TRAIL pathway

A new study presented today at the International Liver CongressTM shows a novel pathway where activated natural killer (NK) cells expressing death ligands may excessively down-modulate the antiviral immune response in chronic HBV patients.1 Blocking the TNF-related apoptosis-inducing ligand (TRAIL) pathway partially reconstitutes HBV-specific T cells, suggesting that these cells are vulnerable to NK cell-mediated apoptosis through this death ligand pathway. NK cells are one of the main effectors of the innate immune response that plays a key role in containing intracellular ...

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777 Dragon Casino Pays Out 100.16% On Poker Games
Science

777 Dragon Casino Pays Out 100.16% On Poker Games

777 Dragon Casino, who assert that they are the best Asian online casino, have definitely stepped up to the plate with their latest Casino Payout Reports. With the latest payout report that has been released by the independent auditing body who regularly audits the casino, during the month of February, 2011, Poker Games have proven to be a prominent part of the casino's payouts as they paid out 100.16%! Jessica Drake, spokesperson and manager at the casino, explained, "Receiving our payout report on a monthly basis keeps us in the know about how well our players are ...

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