HOUSTON - Long overshadowed by p53, its famous tumor-suppressing sibling, the p63 gene does the tougher, important job of stifling the spread of cancer to other organs, researchers at The University of Texas MD Anderson Cancer Center report in the Oct. 21 issue of Nature. Not only does a specific form of p63 protein block metastasis, but it does so by activating the enzyme Dicer, which plays a pivotal role in the creation of micro RNAs, tiny bits of RNA that regulate a host of cellular processes. "p63 is a master regulator of metastasis, an important role in its own ...

Researchers from Mount Sinai School of Medicine, in collaboration with investigators of the National Institute of Health and Medical Research (INSERM) of France led by Nicolae Ghinea, PhD, have found a common link among several malignant tumor types in all grades of cancer. This breakthrough may ultimately provide a new diagnostic or therapeutic target to detect cancer early or stop tumor growth. The study is published in the October 21 issue of The New England Journal of Medicine. The team discovered that a hormone receptor typically found in human reproductive organs ...

COLUMBUS, Ohio – A new study led by Ohio State University cancer researchers describes a novel cancer-specific protein that is present in a broad range of cancer types and at all stages of tumor development, from premalignant cells to metastatic tumor cells. If verified, the antigen could serve as a marker for the early detection and treatment of primary and metastatic tumors, and provide a target for the development of anticancer therapies, the researchers say. In addition, a vaccine designed to target these cancer-cell proteins, called Piwil2-like (PL2L) proteins, ...

Groundbreaking research into fingerprint detection developed at the University of Leicester now has an industrial application, thanks to a new invention by the scientist who developed the technique. Dr John Bond's method of identifying fingerprints on brass bullet-casings, even after they have been wiped clean, was based on the minuscule amounts of corrosion which can be caused by sweat. First announced in 2008, this breakthrough was cited as one of the technologies 'most likely to change the world' by a panel of experts for BBC Focus magazine and was included in Time ...

A research team from Nanyang Technological University (NTU) has successfully designed the world's smallest on-chip low-pass filter which is 1,000 times smaller than existing off-chip filters. A low-pass filter is a circuit that allows low-frequency signals to pass through while reducing unwanted high-frequency signals from passing through. Compared to existing off-chip filters, which are discrete and bulky components, on-chip filters occupy a small area on integrated circuit chips, which can be found in portable devices such as mobile phones, laptops, vehicle-mounted ...

Sea levels around the Falkland Islands in the South Atlantic have risen since the mid nineteenth century and the rate of sea-level rise has accelerated over recent decades, according to newly published research. The findings are as expected under global warming and consistent with observations elsewhere around the globe. "We have been fortunate in being able to compare modern sea-level measurements obtained from tide gauges and from satellite radar altimeters with historical measurements made at Port Louis in the Falkland Islands in 1842," explained researcher Prof. Philip ...

BOSTON (October 20, 2010) - People who consume several servings of whole grains per day while limiting daily intake of refined grains appear to have less of a type of fat tissue thought to play a key role in triggering cardiovascular disease and type 2 diabetes, a new study suggests. Researchers at the Jean Mayer USDA Human Nutrition Researcher Center on Aging (USDA HNRCA) at Tufts University observed lower volumes of visceral adipose tissue (VAT) in people who chose to eat mostly whole grains instead of refined grains. "VAT volume was approximately 10 % lower in adults ...

The follicle stimulating hormone, FSH, targets the human reproductive organs: the ovaries and testicles. In women, it stimulates maturation of ovarian follicles and production of oestrogens (via its action on granulosa cells). In men, it stimulates production of spermatozoa (via its action on the Sertoli cells). FSH receptor, which was the subject of the work carried out by the Inserm researchers, is normally only found in cells stimulated by FSH (granulosa cells in women and Sertoli cells in men). However, it is also present in very small quantities in the blood vessels ...

Hydroelectric power is the oldest and the "greenest" source of renewable energy. In Germany, the potential would appear to be completely exploited, while large-scale projects in developing countries are eliciting strong criticism due to their major impact on the environment. Researchers at Technische Universitaet Muenchen (TUM) have developed a small-scale hydroelectric power plant that solves a number of problems at the same time: The construction is so simple, and thereby cost-efficient, that the power generation system is capable of operating profitably in connection ...

ANN ARBOR, Mich.---A groundbreaking new equation developed in part by researchers at the University of Michigan could do for organic semiconductors what the Shockley ideal diode equation did for inorganic semiconductors: help to enable their wider adoption. Without the Shockley equation, the computers of today would not be possible. Developed in 1949 by William Shockley, the inventor of the transistor, the Shockley equation describes the relationship between electric current and voltage in inorganic semiconductors such as silicon. The new equation describes the ...

Recent work by Dr. David Lohman, assistant professor of biology at The City College of New York, suggests the Philippines, considered by biologists to be a "biodiversity hotspot," could have more unique species of birds than previously thought. If that proves to be the case, it could have important ramifications for conservation practices there. Many of the animal species found in the Philippines are endemic to this nation, which is made up of more than 7,100 islands. For example, 64 percent of its land mammal species and 77 percent of its amphibians are not found anywhere ...

In the brain, dopamine is involved in a number of processes that control the way we behave. If an action results in the substance being released, we are more likely to repeat the action. This applies to actions such as eating, sexual intercourse or winning a competition. However, the same also holds true when individuals take harmful narcotics. Scientists believe that mental illnesses such as schizophrenia can be linked to dopamine imbalances. Learning signal If an action leads to a better response than expected, the brain will temporarily release more dopamine. If ...

Over the last few decades, the dramatic rise in pediatric obesity rates has emerged as a public health threat requiring urgent attention. The responsibility of identifying and treating eating and weight-related problems early in children and adolescents falls to health care providers and other professionals who work with the child, according to Professor Denise Wilfley and colleagues from the Department of Psychiatry at Washington University School of Medicine in the US. Furthermore, the key to successful treatment is a team effort involving providers and parents. Wilfley's ...

BUFFALO, N.Y. -- Results of a new Women's Health Initiative (WHI) report show that hormone therapy is associated with an increased the risk of death from breast cancer, as well as an increased risk of developing invasive breast cancer in postmenopausal women. Jean Wactawski-Wende, PhD, professor of social and preventive medicine at the University at Buffalo and one of the primary authors on the paper, published today in JAMA, says the breast cancers found in these women also tended to have more lymph node involvement, indicating a poorer prognosis. "This report, which ...

WASHINGTON — Motherhood may actually cause the brain to grow, not turn it into mush, as some have claimed. Exploratory research published by the American Psychological Association found that the brains of new mothers bulked up in areas linked to motivation and behavior, and that mothers who gushed the most about their babies showed the greatest growth in key parts of the mid-brain. Led by neuroscientist Pilyoung Kim, PhD, now with the National Institute of Mental Health, the authors speculated that hormonal changes right after birth, including increases in estrogen, ...

Montreal, October 20, 2010 – Daily sleeping and eating patterns are critical to human well-being and health. Now, a new study from Concordia University has demonstrated how the brain chemical dopamine regulates these cycles by altering the activity of the "clock-protein" PER2. Published in the Journal of Neuroscience, these findings may have implications for individuals with Parkinson's Disease with disrupted 24-hour rhythms of activity and sleep. "PER2 is a protein well-known for its role in the regulation of daily or circadian rhythms, this is why it is referred to ...

The UK's National Physical Laboratory (NPL) is working to provide more reliable measurement of the electrical properties of materials used in nanotechnology – which could lead to much more accurate devices in the future. Scanning probe microscopy (SPM) won the Nobel Prize in 1986. It uses a nano-sized probe to feel the surface of a material – akin to a finger reading Braille on an extremely small scale. The technique can also measure the electrical properties of materials used in nanotechnology – and "feel" how the materials react when electricity is passed through it. ...

CAMBRIDGE, Mass., Oct. 20, 2010 -- Microbes living at the bottom of the Gulf of Mexico may consume far more of the gaseous waste from the Deepwater Horizon oil spill than previously thought, according to research carried out within 100 miles of the spill site. A paper on that research, conducted before the Deepwater Horizon rig exploded six months ago today, will appear in a forthcoming issue of the journal Deep-Sea Research II. It describes the anaerobic oxidation of methane, a key component of the Gulf oil spill, by microbes living in seafloor brine pools. "Because ...

CHAMPAIGN, lll. — After the campus shootings at Virginia Tech in 2007 and Northern Illinois University in 2008, hundreds of affected students turned to social media websites to share their grief and search for solace. A new study of these students found that their online activities neither helped nor harmed their long-term psychological health. The study, which appears in Personality and Social Psychology Bulletin, gives a first-of-its-kind portrait of student reactions to shootings on their campuses. It also documents the (online and off-line) activities they engaged ...

For the first time, researchers have discovered a disease mechanism that links hereditary amyotrophic lateral sclerosis to the more common "sporadic" form of ALS -- and points to a possible therapeutic target. The findings are reported online in advance of publication in the journal Nature Neuroscience. ALS is an adult-onset disease that causes progressive degeneration of motor neurons and death within three to five years of diagnosis. Scott Brady, professor and head of anatomy and cell biology at the University of Illinois at Chicago College of Medicine, studies ...

BOSTON––Raising the survival rate of children with sarcoma in low-income countries will require steps to diagnose the disease sooner, train cancer pathologists, expand radiation therapy services, create multi-specialty teams to review each case, and other actions, according to an international study led by Dana-Farber/Children's Hospital Cancer Center researchers. The findings will be presented at the 42nd Congress of the International Society of Paediatric Oncology (SIOP) in Boston on Friday, Oct. 22. The study explored why, despite advances in the treatment of pediatric ...

So disease-causing bacteria in the body finally have multiplied to the point where their numbers are large enough to cause illness. What's next? They get out their "smart phones" and whisper "Let's roll!" That's how an article in ACS' monthly Chemical Reviews describes the substances — "smart phones of the microbial world" — that bacteria use to transmit chemical signals that launch infections and monitor their environment. The authors describe progress toward understanding and blocking this biochemical chitchat, a development that could lead to new treatments for the growing ...

BOSTON – Researchers from Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) have found that as many as 50 percent of young girls treated for germ-cell ovarian tumors might safely be spared chemotherapy using a "watch and wait" strategy to determine if the follow-up treatment is needed. In contrast to the current practice of administering chemotherapy to all patients following removal of these rare tumors, researchers said the study demonstrated that treatment could safely be delayed and given only if the cancer recurred. Data from the trial involving 25 young ...

Amid ongoing concern about plastic waste accumulating in municipal landfills, and reliance on imported oil to make plastics, scientists are reporting development of a new ultra-light biodegradable foam plastic material made from two unlikely ingredients: The protein in milk and ordinary clay. The new substance could be used in furniture cushions, insulation, packaging, and other products, they report in the ACS' Biomacromolecules, a monthly journal. David Schiraldi and colleagues explain that 80 percent of the protein in cow milk is a substance called casein, which already ...

Scientists are reporting evidence that black rice — a little-known variety of the grain that is the staple food for one-third of the world population — may help soothe the inflammation involved in allergies, asthma, and other diseases. Their study appears in ACS' bi-weekly Journal of Agricultural and Food Chemistry. Mendel Friedman and colleagues point out that their previous research showed several potential health benefits of eating black rice bran. Bran is the outer husk of the grain, which is removed during the processing of brown rice to produce the familiar white ...