(Press-News.org) Contact information: Cara Lasala
cara.lasala@cshs.org
310-423-7798
Cedars-Sinai Medical Center
Novel study charts aggressive prostate cancer
Study in the Journal Cell Cycle reveals new developments in prognosis
LOS ANGELES (Nov. 18, 2013) – Many patients diagnosed with prostate cancer have indolent, slow-growing forms of the disease that are not life-threatening. However, more than 30,000 American men will die from aggressive prostate cancer this year alone. This sharp contrast between low-risk and aggressive disease presents a challenge for many researchers and physicians as they diagnose patients and also determine the prognosis of the men with the most aggressive forms of prostate cancer.
Investigators in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute have made extensive progress in understanding the molecular mechanisms of disease progression. These results may help scientists better understand the prognosis of patients diagnosed with advanced prostate cancer. The study, published in the journal Cell Cycle and led by Dolores Di Vizio, MD, PhD, may ultimately lead to the development of new biomarkers for not only prognosis, but also a patient's potential response to therapy.
"One of the long-standing difficulties in treating men with advanced prostate cancer has been predicting the response to given therapies or treatments," said Di Vizio, associate professor in the Department of Surgery, Department of Pathology and Laboratory Medicine and Department of Biomedical Sciences. "These latest research findings provide tangible insight into the molecular and structural phenomena that result in prostate cancer metastases. They have the potential to create a new source of biomarkers and an innovative standard of care. These findings may also help distinguish individualized treatment plans best suited for each patient."
The new source of biomarkers is large oncosomes, which are vesicles released from aggressive prostate cancer cells with highly migratory features. These large oncosomes carry tumor molecules and have been shown in previous studies to contribute to tumor progression. This study demonstrates, for the first time in human samples, that identification of circulating large oncosomes can be an indicator of patients with more aggressive, treatment-resistant disease. Also notable, researchers found that large oncosomes contain microRNA, a molecule that regulates several biological processes now proven to influence tumor progression.
At the Cedars-Sinai Urologic Oncology Program, researchers and physicians work in close collaboration to discover personalized options for patients with indolent prostate disease to those with aggressive cancer. This latest study will amplify the genetic and molecular understanding of aggressive prostate cancer.
"Many of the latest research developments and treatments for urologic cancers have been initiated from Cedars-Sinai investigators and physicians," said Robert Figlin, MD, FACP, associate director of the Samuel Oschin Comprehensive Cancer Institute, professor of Medicine and Biomedical Sciences and the Steven Spielberg Family Chair in Hematology Oncology. "These latest research observations may identify novel ways to measure a patient's prognosis and are just a stepping stone for the many discoveries moving down the pipeline in our cancer institute."
###
Cedars-Sinai collaborators include Michael Freeman, PhD, director of Cancer Biology and Therapeutics and vice chair of Research and Surgery in the department of Biomedical Sciences; Leland Chung, PhD, director of the Urologic Oncology Research Program and professor in the Department of Medicine; Edwin Posadas, MD, FACP, co-medical director in the Urologic Oncology Program and assistant professor in the Department of Medicine; Hyung Lae Kim, MD, director of Academic Programs in the Division of Urology and co-medical director of the Urologic Oncology Program; Neil Bhowmick, PhD, research scientist and associate professor in the Department of Medicine; and fellows Matteo Morello, PhD, Valentina Minciacchi, and Julie Yang.
Francesca Demichelis, PhD, from Centro for Integrative Biology at the University of Trento, as well as researchers from Istituto Nazionale di Genetica Molecolare and Istituto Nazionale Tumori in Milan and NanoSight Inc. contributed to the study.
The research was supported by the National Cancer Institute (CA131472 [R00] to DDV, R01CA143777 to MRF) and the Steven Spielberg Discovery Fund in Prostate Cancer Research.
Citation: Cell Cycle. 2013 Nov 15
Novel study charts aggressive prostate cancer
Study in the Journal Cell Cycle reveals new developments in prognosis
2013-11-18
ELSE PRESS RELEASES FROM THIS DATE:
New research finds link between red cell distribution width levels and depression in heart patients
2013-11-18
New research finds link between red cell distribution width levels and depression in heart patients
DALLAS – Researchers at the Intermountain Medical Center Heart Institute have discovered a link between elevated red cell distribution width levels and ...
Long-term oral contraceptive users are twice as likely to have serious eye disease
2013-11-18
Long-term oral contraceptive users are twice as likely to have serious eye disease
Research shows birth control use over three years could be a risk factor for glaucoma
NEW ORLEANS – Nov. 18, 2013 – Research presented today, at the 117th Annual Meeting of the American ...
Faster surgery may be better for hip fractures: McMaster study
2013-11-18
Faster surgery may be better for hip fractures: McMaster study
In many countries waits for hip surgery can be 24 hours or longer
Hamilton, Nov. 18, 2013 – The speed of surgery after a hip fracture may have a significant impact on outcomes for older patients, ...
Program helps at-risk family members of patients with heart disease improve their own heart health
2013-11-18
Program helps at-risk family members of patients with heart disease improve their own heart health
Randomized clinical trial
Family members of patients with heart disease adopted healthier lifestyles and decreased their risk of a cardiovascular ...
Early surgery for hip fractures in older adults may improve outcomes
2013-11-18
Early surgery for hip fractures in older adults may improve outcomes
Randomized controlled trial
Early surgery for hip fractures in older people may substantially improve outcomes for patients, according to the results from a randomized controlled ...
Blood growth factor boosts effect of exercise in peripheral artery disease
2013-11-18
Blood growth factor boosts effect of exercise in peripheral artery disease
A blood cell growth factor can boost the effects of exercise in improving mobility for patients with peripheral artery disease, a clinical study has shown.
The results are scheduled for ...
Greater density of coronary artery calcium associated with lower risk of CHD, CVD
2013-11-18
Greater density of coronary artery calcium associated with lower risk of CHD, CVD
Chicago – Michael H. Criqui, M.D., M.P.H., of the University of California, San Diego, and colleagues determined the independent associations of coronary artery calcium (CAC) volume and ...
Type of cell therapy does not improve walking ability for patients with peripheral artery disease
2013-11-18
Type of cell therapy does not improve walking ability for patients with peripheral artery disease
Chicago – Joseph Poole, M.D., Ph.D., of the Emory University School of Medicine, Atlanta, and colleagues studied whether therapy with granulocyte-macrophage ...
Therapy using stem cells, bone marrow cells, appears safe for patients with ischemic cardiomyopathy
2013-11-18
Therapy using stem cells, bone marrow cells, appears safe for patients with ischemic cardiomyopathy
Chicago – Alan W. Heldman, M.D., of the University of Miami Miller School of Medicine, and colleagues conducted a study to examine the safety of transendocardial ...
Addition of certain drugs to diuretic therapy does not improve kidney function
2013-11-18
Addition of certain drugs to diuretic therapy does not improve kidney function
Chicago – Horng H. Chen, M.B.B.Ch., of the Mayo Clinic, Rochester, Minn., and colleagues conducted a randomized trial to determine whether, as compared with placebo, the addition of ...
LAST 30 PRESS RELEASES:
Cercus electric stimulation enables cockroach with trajectory control and spatial cognition training
Day-long conference addresses difficult to diagnose lung disease
First-ever cardiogenic shock academy features simulation lab
Thirty-year mystery of dissonance in the “ringing” of black holes explained
Less intensive works best for agricultural soil
Arctic rivers project receives “national champion” designation from frontiers foundation
Computational biology paves the way for new ALS tests
Study offers new hope for babies born with opioid withdrawal syndrome
UT, Volkswagen Group of America celebrate research partnership
New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll
Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes
University of Cincinnati Cancer Center presents research at AACR 2025
Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025
AACR: Researchers share promising results from MD Anderson clinical trials
New research explains why our waistlines expand in middle age
Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker
Chips off the old block
Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia
Cutting the complexity from digital carpentry
Lung immune cell type “quietly” controls inflammation in COVID-19
Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity
State and sociodemographic trends in US cigarette smoking with future projections
Young adults drive historic decline in smoking
NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research
Chimpanzee stem cells offer new insights into early embryonic development
This injected protein-like polymer helps tissues heal after a heart attack
FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology
In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity
Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects
A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions
[Press-News.org] Novel study charts aggressive prostate cancerStudy in the Journal Cell Cycle reveals new developments in prognosis