The longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation
2021-01-26
(Press-News.org) Authors from the German Center for Diabetes Research (DZD) presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation in the Journal of Clinical Investigation (JCI) insight. Reduced expression of mINDY, which is known to extend life span in lower organisms and to prevent from diet induced obesity, fatty liver and insulin resistance in mice, has now been shown to lower blood pressure and heart rate in rodents. The authors provided mechanistic insights for the underlying physiological mechanism based on in vivo data in a genetic knock out model as well as microarray and in vitro studies. Furthermore, the hypothesis is supported by confirming critical effects in vitro using a small molecule inhibitor of mINDY. The authors conclude that deletion of mIndy recapitulates beneficial cardiovascular and metabolic responses to caloric restriction, making it an attractive therapeutic target.
Andreas Birkenfeld and colleagues provide a comprehensive study showing that mIndy deletion attenuates sympathoadrenal support of blood pressure and reduced arterial blood pressure and heart rate in a muine knockout model. Blood pressure was assessed invasively using intra-arterial pressure probes over several days. Urinary analysis for catecholamines and metanephrines as well as unbiased transcriptomic analysis of adrenal glands identified the affected biosynthetic pathways. Indeed, catecholamine biosynthesis was attenuated in mINDY-KO adrenals, whereas plasma steroids and steroid hormone synthesis were unaffected.
In vitro studies on an adrenal cell line supported this hypothesis. mIndy codes for a is a carboxylic acid transporter protein expressed in plasma membrane. Citrate, the main substrate of the mINDY transporter, increased catecholamine content, while pharmacological inhibition of mINDY by a small molecule inhibitor blunted the effect.
The study provided further insights into the physiological mechanisms of the beneficial effects of reducing mINDY activity which is known to protect from diet and aging induced metabolic diseases by mechanisms akin to caloric restriction. Therefore, the data showed a novel mechanism contributing to a cardiometabolic cross talk and further supporting mINDY as a promising target for the whole spectrum of metabolic syndrome components, including increased blood pressure.
INFORMATION:
The study was published from the Institute of Diabetes Research and Metabolic Disorders (IDM) of the Helmholtz Center Munich at the University Tübingen and the Clinic of Diabetes, Endocrinology and Nephrology of the University Hospital Tübingen.
Publication:
Willmes DM, Daniels MA, Kurzbach A, Lieske S, Bechmann N, Schumann T, Henke C, El-Agroudy N, Da Costa Goncalves AC, Peitzsch M, Hofmann A, Kanczkowski W, Kräker K, Mu?ller DN, Morawietz H, Deussen A, Wagner M, El-Armouche A, Helfand SL, Bornstein SR, de Cabo R, Bernier M, Eisenhofer G, Tank J, Jordan J, Birkenfeld AL. The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms. JCI Insight. 2021, https://doi.org/10.1172/jci.insight.136083.
Contact:
Prof. Andreas L. Birkenfeld
German Center for Diabetes Research
Department of Internal Medicine IV
Tübingen University Hospital
Otfried-Müller-Str. 10, 72076 Tübingen, Germany
Phone: +49 (0)7071 29-82735
Email: andreas.birkenfeld@med.uni-tuebingen.de
The German Center for Diabetes Research (DZD) is one of six German Centers for Health Research. It brings together experts in the field of diabetes research and integrates basic research, epidemiology, and clinical applications. By adopting an innovative, integrative approach to research, the DZD aims to make a substantial contribution to the successful personalized prevention, diagnosis and treatment of diabetes mellitus. The members of the DZD are Helmholtz Zentrum München - German Research Center for Environmental Health, the German Diabetes Center (DDZ) in Düsseldorf, the German Institute of Human Nutrition (DIfE) in Potsdam-Rehbrücke, the Institute of Diabetes Research and Metabolic Diseases of Helmholtz Zentrum München at the University of Tübingen, the Paul Langerhans Institute Dresden of Helmholtz Zentrum München at the Carl Gustav Carus University Hospital of TU Dresden, associated partners at the universities in Heidelberg, Cologne, Leipzig, Lübeck and Munich, and other project partners. http://www.dzd-ev.de/en
ELSE PRESS RELEASES FROM THIS DATE:
2021-01-26
Children determine emotion by what they hear, rather than what they see, according to new research.
The first-of-its-kind study, by Durham University's Department of Psychology, looked at how children pick up on the emotions of a situation.
They found that whilst adults prioritised what they see, young children showed an auditory dominance and overwhelmingly prioritised what they could hear.
The researchers say their findings could benefit parents currently managing home learning and professional educators by increasing their understanding of how young children pick up on what is going on around them.
The research may also provide new avenues to understanding ...
2021-01-26
Theories were introduced as far back as the 1960s about the possible existence of superheavy elements. Their most long-lived atomic nuclei could give rise to a so-called "island of stability" far beyond the element uranium. However, a new study, led by nuclear physicists at Lund University, shows that a 50-year-old nuclear physics manifesto must now be revised.
The heaviest element found in nature is uranium, with a nucleus containing 92 protons and 146 neutrons. The nuclei of heavier elements become more and more unstable due to the increased number of positively charged protons. They therefore decay faster and faster, usu-ally within a fraction of a second. ...
2021-01-26
As the world prepares to commemorate International Holocaust Remembrance Day on January 27th, communities and memorials around the world are addressing how to meaningfully commemorate the day while protecting public health and safety. The day marking the anniversary of the liberation of Auschwitz is ordinarily commemorated with hundreds of individual memorial events across the globe. This year, most of those events will be impossible for any sizable gathering of people due to COVID-19.
With the goal of proposing relevant solutions to this challenge, Dr. Tobias Ebbrecht-Hartmann and research student Tom Divon of the Hebrew ...
2021-01-26
ATLANTA - JANUARY 26, 2021 - A new study shows 4 in 10 cancer deaths are attributable to cigarette smoking in parts of the South region and Appalachia. For this study, appearing in Cancer Causes & Control, Farhad Islami, MD, PhD, and colleagues at the American Cancer Society examined the proportion of cancer deaths from 2013 to 2017 attributed to cigarette smoking in 152 metropolitan and micropolitan statistical areas (MMSAs).
Data show the proportion of cancer deaths attributable to cigarette smoking was greater in men than in women in all evaluated MMSAs. In both sexes combined, the proportion of smoking-related cancer deaths ranged from 8.8% in Logan ...
2021-01-26
The battle to stop false news and online misinformation is not going to end any time soon, but a new finding from MIT scholars may help ease the problem.
In an experiment, the researchers discovered that fact-checking labels, when attached to online news headlines, actually work better after people read false headlines, compared to when they precede the headline or accompany it.
"We found that whether a false claim was corrected before people read it, while they read it, or after they read it influenced the effectiveness of the correction," says David Rand, an MIT professor and co-author of a new paper detailing the study's results.
Specifically, the researchers found, when "true" and "false" labels were shown immediately after participants in the experiment read headlines, ...
2021-01-26
A new neural network developed by researchers at the University of Eastern Finland and Kuopio University Hospital enables an easy and accurate assessment of sleep apnoea severity in patients with cerebrovascular disease. The assessment is automated and based on a simple nocturnal pulse oximetry, making it possible to easily screen for sleep apnoea in stroke units.
Up to 90% of patients experiencing a stroke have sleep apnoea, according to earlier studies conducted at Kuopio University Hospital. If left untreated, sleep apnoea can reduce the quality of life and rehabilitation of patients with stroke and increase ...
2021-01-26
An estimated 48 million cases of foodborne illness are contracted in the United States every year, causing about 128,000 hospitalizations and 3,000 deaths, according to the Centers for Disease Control (CDC). In some instances, the source is well known, such as a batch of tainted ground beef that infected 209 people with E. Coli in 2019. But 80 percent of food poisoning cases are of unknown origin, making it impossible to inform consumers of hazardous food items.
David Goldberg, assistant professor of management information systems at San Diego State University, wants to improve the traceability and ...
2021-01-26
Overview:
Phycocyanobilin (PCB) is a natural blue chromophore found in cyanobacteria. PCB is expected to be applied as food colorants and pharmaceuticals with anti-inflammatory and antioxidant properties. PCB also functions as the chromophore of photoswitches that control biological functions in synthetic biology. PCB is covalently bound to phycocyanin, a component of photosynthetic antenna protein, and its extraction requires specialized expertise, time-consuming procedures, and/or expensive reagents. A research group led by Assistant Professor Yuu Hirose at Toyohashi University of Technology succeeded in developing a highly efficient and rapid extraction method for PCB by treating cyanobacterial cells with alcohol ...
2021-01-26
The use of online messaging and social media apps among Singapore residents has spiked during the COVID-19 pandemic, a Nanyang Technological University, Singapore (NTU Singapore) study has found.
Three in four respondents (75%) said that their use of WhatsApp during the pandemic increased. This was followed by Telegram (60.3%), Facebook (60.2%) and Instagram (59.7%).
Accompanying this spike is videoconferencing fatigue, found the NTU Singapore study, which surveyed 1,606 Singapore residents from 17 to 31 December last year. Nearly one in two Singapore residents (44%) said they felt drained from videoconferencing activities, which ...
2021-01-26
Utilizing a newly developed state-of-the-art synchrotron technique, a group of scientists led by Dr. Ho-kwang Mao, Director of HPSTAR, conducted the first-ever high-pressure study of the electronic band and gap information of solid hydrogen up to 90 GPa. Their innovative high pressure inelastic X-ray scattering result serves as a test for direct measurement of the process of hydrogen metallization and opens a possibility to resolve the electronic dispersions of dense hydrogen. This work is published in the recent issue of Physical Review Letters.
The pressure-induced evolution of hydrogen's electronic band from a wide gap insulator to a closed gap metal, or metallic ...
LAST 30 PRESS RELEASES:
[Press-News.org] The longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation
