PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Study shows economic impact of post-op delirium

Results suggest that delirium has substantial public health implications

2021-02-24
(Press-News.org) BOSTON (February 24, 2021) - Results of a study published today in JAMA Surgery reveal the impact post-operative delirium has on health care costs in the U.S. Data from the study shows that if delirium were prevented or made less severe for patients, it could reduce health care costs by $33 billion per year, that is, $44,300 per patient per year. Severe delirium resulted in an additional $56,500 per patient per year, as compared to routine health care costs for older post-operative patients.

Tammy Hshieh, M.D., M.P.H., Adjunct Scientist, and Ray Yun Gou, M.A., Data Scientist II, both with the Aging Brain Center in the Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniorLife, are co-first authors. Sharon K. Inouye, M.D., M.P.H., Director of the Aging Brain Center in the Marcus Institute, is principal investigator and senior author on the study. Douglas L. Leslie, Ph.D., a Health Economist at Penn State University, is co-senior author on the paper.

Delirium is a common, serious clinical problem for older adults, often complicating major surgery. It has been associated with poor hospital outcomes, including prolonged hospital stay, functional and cognitive decline, institutionalization, and death. Prior to this study, existing data did not accurately indicate current costs of delirium to the health care system. This information is essential to helping guide policymakers and health care leaders in decision-making and prioritization surrounding delirium care. According to the study's authors, the aim of the study was to update cost estimates to help funders and health systems develop incentives and strategies that improve processes and quality of care for older adults, and to track improvements over time.

The study included 497 patients from the Successful Aging after Elective Surgery (SAGES) study, an ongoing cohort study of older adults undergoing major elective surgery. Eligible patients were age 70 or older and scheduled to undergo major surgery at one of two Harvard-affiliated hospitals with an anticipated length of stay of at least three days. Eligible surgical procedures included total hip or knee replacement; lumbar, cervical, or sacral laminectomy; lower extremity arterial bypass surgery; open abdominal; aortic aneurysm repair; and open or laparoscopic colectomy. Cumulative and period-specific costs were examined using Medicare claims and extensive clinical data for one year following surgery. Data showed that adjusted cumulative health care costs per patient were significantly higher for those who developed delirium compared with those who did not.

"The economic impacts of delirium and severe delirium after elective surgery are substantial," said Dr. Hshieh.

"Our study highlights the need for policy imperatives to address delirium as a large-scale public health issue that warrants renewed efforts to bolster prevention, early detection, and management," said Dr. Inouye.

INFORMATION:

Collaborating institutions on the study included Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Brown University, and Penn State University.

This study was supported in part by grants from the National Institute on Aging; grants no. P01AG031720 (SKI), R24AG054259 13 (SKI), R01AG044518 (SKI/RNJ).

About the Hinda and Arthur Marcus Institute for Aging Research Scientists at the Marcus Institute seek to transform the human experience of aging by conducting research that will ensure a life of health, dignity, and productivity into advanced age. The Marcus Institute carries out rigorous studies that discover the mechanisms of age-related disease and disability; lead to the prevention, treatment, and cure of disease; advance the standard of care for older people; and inform public decision-making.

About Hebrew SeniorLife Hebrew SeniorLife, an affiliate of Harvard Medical School, is a national senior services leader uniquely dedicated to rethinking, researching, and redefining the possibilities of aging. Based in Boston, the nonprofit organization has provided communities and health care for seniors, research into aging, and education for geriatric care providers since 1903. For more information about Hebrew SeniorLife, visit https://hebrewseniorlife.org and our blog, or follow us on Facebook, Instagram, Twitter, and LinkedIn.



ELSE PRESS RELEASES FROM THIS DATE:

Daily emails about chemicals in tobacco lead some smokers to consider quitting

Daily emails about chemicals in tobacco lead some smokers to consider quitting
2021-02-24
CHAPEL HILL, N.C.--For the last decade, the U.S. Food and Drug Administration has required tobacco manufacturers and importers to report the levels of harmful and potentially harmful chemicals found in their tobacco products and tobacco smoke. The idea was to educate the public and ultimately to decrease tobacco use, but little research has demonstrated if such information can impact on people's decisions to quit smoking. A new study from the University of North Carolina at Chapel Hill has found that smokers who saw messages about tobacco chemicals with associated ...

Reactivating aging stem cells in the brain

Reactivating aging stem cells in the brain
2021-02-24
The stem cells in our brain generate new neurons throughout life, for example in the hippocampus. This region of the brain plays a key role for a range of memory processes. With increasing age, and in patients suffering from Alzheimer's disease, the hippocampus' ability to create new neurons declines steadily - and with it, its memory functions. Distribution of age-dependent cell damage A study conducted by the research group of Sebastian Jessberger, a professor at the Brain Research Institute of the University of Zurich, shows how the formation of new neurons is impaired with advancing age. Protein structures in the nuclei of neural stem cells make sure that harmful proteins accumulating ...

Accelerator physics: Experiment reveals new options for synchrotron light sources

Accelerator physics: Experiment reveals new options for synchrotron light sources
2021-02-24
The most modern light sources for research are based on particle accelerators. These are large facilities in which electrons are accelerated to almost the speed of light, and then emit light pulses of a special character. In storage-ring-based synchrotron radiation sources, the electron bunches travel in the ring for billions of revolutions, then generate a rapid succession of very bright light pulses in the deflecting magnets. In contrast, the electron bunches in free-electron lasers (FELs) are accelerated linearly and then emit a single super-bright flash of ...

Scientists map the brain of a nematode worm

Scientists map the brain of a nematode worm
2021-02-24
Researchers have mapped the physical organization of the brain of a microscopic soil-living nematode worm called Caenorhabditis elegans, creating a new model for the architecture of the animal's brain and how it processes information. In a surprise twist, they found a large degree of variation in the structure of some neural circuits or pathways in individual worms which complemented a core set of neural circuits common to different animals. The scientists say the worms' brains might have a lot more in common with larger animals than previously thought. Created by neuroscientists at the University of Leeds in collaboration with researchers in New York's Albert Einstein College of Medicine, the brain map reveals that ...

Researchers identify mechanism by which exercise strengthens bones and immunity

Researchers identify mechanism by which exercise strengthens bones and immunity
2021-02-24
Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have identified the specialized environment, known as a niche, in the bone marrow where new bone and immune cells are produced. The study, published in Nature, also shows that movement-induced stimulation is required for the maintenance of this niche, as well as the bone and immune-forming cells that it contains. Together, these findings identify a new way that exercise strengthens bones and immune function. Researchers from the Morrison laboratory discovered that forces created from walking or running are transmitted from bone surfaces along arteriolar blood vessels into the marrow inside bones. Bone-forming ...

New experiences enhance learning by resetting key brain circuit

2021-02-24
A study of spatial learning in mice shows that exposure to new experiences dampens established representations in the brain's hippocampus and prefrontal cortex, allowing the mice to learn new navigation strategies. The study, published in Nature, was supported by the National Institutes of Health. "The ability to flexibly learn in new situations makes it possible to adapt to an ever-changing world," noted Joshua A. Gordon, M.D., Ph.D., a senior author on the study and director of the National Institute of Mental Health, part of NIH. "Understanding the neural basis of this flexible learning in animals gives us insight into ...

Nature's funhouse mirror: understanding asymmetry in the proton

Natures funhouse mirror: understanding asymmetry in the proton
2021-02-24
Asymmetry in the proton confounds physicists, but a new discovery may bring back old theories to explain it. Symmetry -- displayed in areas ranging from mathematics and art, to living organisms and galaxies -- is an important underlying structure in nature. It characterizes our universe and enables it to be studied and understood. Because symmetry is such a pervasive theme in nature, physicists are especially intrigued when an object seems like it should be symmetric, but it isn't. When scientists are confronted with these broken symmetries, it's as if they've found an object with a strange reflection in the mirror. "Nature is leading the way for concepts in older models of the proton to get a second look." -- ...

Materials scientists show way to make durable artificial tendons from improved hydrogels

2021-02-24
UCLA materials scientists and their colleagues have developed a new method to make synthetic biomaterials that mimic the internal structure, stretchiness, strength and durability of tendons and other biological tissues. The researchers developed a two-pronged process to enhance the strength of existing hydrogels that could be used to create artificial tendons, ligaments, cartilage that are 10 times tougher than the natural tissues. Although the hydrogels contain mostly water with little solid content (about 10% polymer), they are more durable than Kevlar and rubber, which are both 100% polymer. This kind of breakthrough has never been achieved in water-laden polymers until this study, which was recently published in Nature. ...

Cancer research to gain from identification of 300 proteins that regulate cell division

Cancer research to gain from identification of 300 proteins that regulate cell division
2021-02-24
With the hope of contributing to the fight against cancer, researchers in Sweden have published a new molecular mapping of proteins that regulate the cell division process - identifying 300 such proteins. The release of the data, which was published today in the scientific journal, Nature, is significant because it helps bring medical research closer to the point of being able to target specific proteins to treat cancer. Identifying and understanding what characterizes these proteins is important, says co-author Emma Lundberg, a professor at KTH Royal Institute of Technology whose research group at Science ...

Characteristics, outcomes of US children, adolescents with multisystem inflammatory syndrome in children compared with severe COVID-19

2021-02-24
What The Study Did: National COVID-19 registry data are used in this study to describe the epidemiology, clinical characteristics, complications, and hospital and postdischarge outcomes of pediatric patients with multisystem inflammatory syndrome in children (MIS-C) and to compare each in patients with severe COVID-19. Authors: Adrienne G. Randolph, M.D., of Boston Children's Hospital, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2021.2091) Editor's Note: The article includes conflict of ...

LAST 30 PRESS RELEASES:

Normalizing blood sugar can halve heart attack risk

Lowering blood sugar cuts heart attack risk in people with prediabetes

Study links genetic variants to risk of blinding eye disease in premature infants

Non-opioid ‘pain sponge’ therapy halts cartilage degeneration and relieves chronic pain

AI can pick up cultural values by mimicking how kids learn

China’s ecological redlines offer fast track to 30 x 30 global conservation goal

Invisible indoor threats: emerging household contaminants and their growing risks to human health

Adding antibody treatment to chemo boosts outcomes for children with rare cancer

Germline pathogenic variants among women without a history of breast cancer

Tanning beds triple melanoma risk, potentially causing broad DNA damage

Unique bond identified as key to viral infection speed

Indoor tanning makes youthful skin much older on a genetic level

Mouse model sheds new light on the causes and potential solutions to human GI problems linked to muscular dystrophy

The Journal of Nuclear Medicine ahead-of-print tip sheet: December 12, 2025

Smarter tools for peering into the microscopic world

Applications open for funding to conduct research in the Kinsey Institute archives

Global measure underestimates the severity of food insecurity

Child survivors of critical illness are missing out on timely follow up care

Risk-based vs annual breast cancer screening / the WISDOM randomized clinical trial

University of Toronto launches Electric Vehicle Innovation Ontario to accelerate advanced EV technologies and build Canada’s innovation advantage

Early relapse predicts poor outcomes in aggressive blood cancer

American College of Lifestyle Medicine applauds two CMS models aligned with lifestyle medicine practice and reimbursement

Clinical trial finds cannabis use not a barrier to quitting nicotine vaping

Supplemental nutrition assistance program policies and food insecurity

Switching immune cells to “night mode” could limit damage after a heart attack, study suggests

URI-based Global RIghts Project report spotlights continued troubling trends in worldwide inhumane treatment

Neutrophils are less aggressive at night, explaining why nighttime heart attacks cause less damage than daytime events

Menopausal hormone therapy may not pose breast cancer risk for women with BRCA mutations

Mobile health tool may improve quality of life for adolescent and young adult breast cancer survivors

Acupuncture may help improve perceived breast cancer-related cognitive difficulties over usual care

[Press-News.org] Study shows economic impact of post-op delirium
Results suggest that delirium has substantial public health implications