Restoring our ubiquitination machinery to overcome resistance to cancer therapy

“[...] the identification of ubiquitin-conjugating enzymes like UBE2J1 and the innovative deployment of PROTAC-type androgen receptor degraders are crucial in combating prostate cancer and overcoming therapeutic resistance.”

BUFFALO, NY- June 7, 2024 – A new editorial paper was published in Oncoscience (Volume 11) on May 6, 2024, entitled, “Restoring our ubiquitination machinery to overcome resistance in cancer therapy.”

In this new editorial, researchers Xiaoling Li and Ping Mu from the University of Southwestern Medical Center discuss the ubiquitin-proteasome system (UPS), which is usually responsible for regulating protein degradation, important for cellular homeostasis, and crucial in cancer progression. Its ability to regulate the stability of proteins that drive cancer growth and survival indicates its potential as a therapeutic target. 

Among the UPS components, ubiquitin-conjugating enzymes, such as ubiquitin-conjugating enzyme E2 J1 (UBE2J1), have emerged as key players in cancer dynamics, especially in prostate cancer (PCa) where therapy resistance is a significant challenge.

“In our recent study, through a comprehensive in vivo library screening [2], we have identified the role of UBE2J1 in PCa, particularly its involvement in the degradation of the androgen receptor (AR) [3].” 
 

Continue reading: DOI: https://doi.org/10.18632/oncoscience.600 

Correspondence to: Ping Mu

Email: ping.mu@utsouthwestern.edu

Keywords: androgen receptor, prostate cancer, antiandrogen resistance, UBE2J1, ubiquitination, protein degradation, PROTAC
 

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