Restoring our ubiquitination machinery to overcome resistance to cancer therapy
2024-06-07
(Press-News.org)
“[...] the identification of ubiquitin-conjugating enzymes like UBE2J1 and the innovative deployment of PROTAC-type androgen receptor degraders are crucial in combating prostate cancer and overcoming therapeutic resistance.”
BUFFALO, NY- June 7, 2024 – A new editorial paper was published in Oncoscience (Volume 11) on May 6, 2024, entitled, “Restoring our ubiquitination machinery to overcome resistance in cancer therapy.”
In this new editorial, researchers Xiaoling Li and Ping Mu from the University of Southwestern Medical Center discuss the ubiquitin-proteasome system (UPS), which is usually responsible for regulating protein degradation, important for cellular homeostasis, and crucial in cancer progression. Its ability to regulate the stability of proteins that drive cancer growth and survival indicates its potential as a therapeutic target.
Among the UPS components, ubiquitin-conjugating enzymes, such as ubiquitin-conjugating enzyme E2 J1 (UBE2J1), have emerged as key players in cancer dynamics, especially in prostate cancer (PCa) where therapy resistance is a significant challenge.
“In our recent study, through a comprehensive in vivo library screening [2], we have identified the role of UBE2J1 in PCa, particularly its involvement in the degradation of the androgen receptor (AR) [3].”
Continue reading: DOI: https://doi.org/10.18632/oncoscience.600
Correspondence to: Ping Mu
Email: ping.mu@utsouthwestern.edu
Keywords: androgen receptor, prostate cancer, antiandrogen resistance, UBE2J1, ubiquitination, protein degradation, PROTAC
About Oncoscience:
Oncoscience is a peer-reviewed, open-access, traditional journal covering the rapidly growing field of cancer research, especially emergent topics not currently covered by other journals. This journal has a special mission: Freeing oncology from publication cost. It is free for the readers and the authors.
To learn more about Oncoscience, visit Oncoscience.us and connect with us on social media:
X, formerly Twitter
Instagram
Facebook
YouTube
LinkedIn
For media inquiries, please contact media@impactjournals.com.
Oncoscience Journal Office
6666 East Quaker Str., Suite 1D
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 4
###
END
ELSE PRESS RELEASES FROM THIS DATE:
2024-06-07
The United States has enough biomass potential to produce 35 billion gallons per year of aviation biofuel by 2050, a new report confirms.
Oak Ridge National Laboratory’s John Field provided biomass feedstock production expertise to the report focused on the role of the bioeconomy in U.S. decarbonization strategies, which was produced by the Department of Energy’s DECARB program.
The report examined the role of biomass in reducing greenhouse gas emissions across the economy, including opportunities to reach negative emissions. It includes data ...
2024-06-07
About The Study: The results of this randomized clinical trial showed that a 15-day course of nirmatrelvir-ritonavir in a population of patients with postacute sequelae of SARS-CoV-2 infection (PASC) was generally safe but did not demonstrate a significant benefit for improving select PASC symptoms in a mostly vaccinated cohort with protracted symptom duration. Further studies are needed to determine the role of antivirals in the treatment of PASC.
Corresponding Author: To contact the corresponding authors, email Linda N. Geng, M.D., Ph.D. (geng@stanford.edu) and Upinder Singh, M.D. (usingh@stanford.edu).
To ...
2024-06-07
In a clinical trial conducted by Stanford Medicine investigators and their colleagues, a 15-day course of Paxlovid — an antiviral drug combination targeting SARS-CoV-2, the virus that causes COVID-19 — proved safe as an extended-duration treatment but didn’t lessen select symptoms of the syndrome known as long COVID: the persistence, or reappearance, of COVID-related symptoms three months or more after an initial COVID-19 infection.
The findings are described in a paper to be published ...
2024-06-07
Northwestern University researchers have developed a new antioxidant biomaterial that someday could provide much-needed relief to people living with chronic pancreatitis.
The study will be published on June 7 in the journal Science Advances.
Before surgeons remove the pancreas from patients with severe, painful chronic pancreatitis, they first harvest insulin-producing tissue clusters, called islets, and transplant them into the vasculature of the liver. The goal of the transplant is to preserve a patient’s ability to control their own blood-glucose levels without insulin injections.
Unfortunately, the ...
2024-06-07
Ancient apes in Germany co-existed by partitioning resources in their environment, according to a study published June 7, 2024 in the open-access journal PLOS ONE by Madelaine Böhme of Eberhard Karls University of Tübingen, Germany and David R. Begun, of University of Toronto, Canada and colleagues.
The Hammerschmiede fossil site in Bavaria, Germany is best known for exceptional remains of the ancient great ape Danuvius dating to the late Miocene Epoch, 11.6 million years ago. Other experts contest the strength of the evidence to support whether Danuvius is a hominid or whether ...
2024-06-07
Off the coasts of southern British Columbia, Washington, Oregon and northern California lies a 600 mile-long strip where the Pacific Ocean floor is slowly diving eastward under North America. This area, called the Cascadia Subduction Zone, hosts a megathrust fault, a place where tectonic plates move against each other in a highly dangerous way. The plates can periodically lock up and build stress over wide areas―eventually to be released when they finally lurch against each other. The result: the world’s greatest earthquakes, shaking both seabed and land, and generating tsunamis 100 feet high or more. Such a fault ...
2024-06-07
Scientists at the University of Dundee have uncovered the inner relay of a molecular switch that protects the brain against the development of Parkinson’s disease.
The research provides new potential strategies to develop drugs that may benefit patients with Parkinson’s.
Parkinson’s is the fastest growing brain disorder in the world, however, there are currently no treatments that can slow or arrest the condition.
Previous research conducted at the University had found a gene called PINK1 is central to protecting brain cells against stress. In patients ...
2024-06-07
While smell plays a considerable role in the social interactions of humans—for instance, signaling fear or generating closeness—for ants, it is vitally important. Researchers from New York University and the University of Florida found that a key protein named Orco, essential for the function of olfactory cells, is also critical for the cells’ survival in ants.
Their study showed that mutating the orco gene in Harpegnathos saltator jumping ants dramatically decreased the number of olfactory neurons, suggesting that Orco is necessary for the development and life of these cells. The findings, published in Science Advances, offer insights into the cellular ...
2024-06-07
ITHACA, N.Y. – Cornell University researchers have provided a simple and comprehensive – if less dramatic – explanation for bright radar reflections initially interpreted as liquid water beneath the ice cap on Mars’ south pole.
Their simulations show that small variations in layers of water ice – too subtle for ground-penetrating radar instruments to resolve – can cause constructive interference between radar waves. Such interference can produce reflections whose intensity and variability match observations to date – not only in the area proposed to be liquid water, but across the so-called south ...
2024-06-07
Toronto, ON, Canada - A new study conducted by researchers at the University of Toronto has unveiled a significant association between the use of photo filters on social media and increased symptoms of muscle dysmorphia among adolescents and young adults in Canada. This study, which analyzed data from 912 participants from the Canadian Study of Adolescent Health Behaviors, emphasizes the growing concern over the impact of digital image manipulation on body image and mental health.
The research reveals that the use of photo filters, commonly found on apps like Snapchat, Instagram, and TikTok, is linked to greater muscle dysmorphia symptomatology, a condition marked ...
LAST 30 PRESS RELEASES:
[Press-News.org] Restoring our ubiquitination machinery to overcome resistance to cancer therapy
