DNA methylation, a process by which methyl groups are added to DNA molecules, is essential for the maintenance of DNA and the overall health of an organism. Disruptions in the standard DNA methylation patterns can lead to immunodeficiency and diseases such as cancer. Helicase lymphoid-specific (HELLS) is an enzyme that facilitates DNA methylation by remodeling the nucleosome - the tightly packed structure of DNA wound around histone proteins. The absence of HELLS or its activator, cell division cycle associated 7 (CDCA7) is known to be a factor that leads to the disruption of DNA methylation. Mutations in the genes that code for HELLS and CDCA7 cause rare disorder immunodeficiency, ...

RESTON, Va. — Two recent amphibian-focused studies shed light on the ecological importance of red-backed salamanders, while confirming that proactive measures would prevent costly impacts from a wildlife disease spreading across Europe that has not yet reached North America.   Scientists knew that red-backed salamanders were abundant in eastern North America, but a recent study found their densities and biomass across the region were much higher than expected. The study authors estimated an average of ...

The fight against cancer is an arms race, and one of the most effective weapons in clinicians’ arsenals is immunotherapy. Immune checkpoint therapy has become the standard for treating several types of cancer. However, the Nobel Prize-winning strategy is ineffective for most pancreatic ductal adenocarcinoma (PDAC) patients. “Immune checkpoint therapy is only an option in rare cases of PDAC,” Cold Spring Harbor Laboratory (CSHL) Professor Douglas Fearon says. “It’s only effective for patients with a specific subtype of PDAC—that’s less than 5% of all cases.” Until recently, it was thought that PDAC didn’t ...

A new study uses co-creation with reference communities to develop an app for sign language machine translation (SLMT). The research team designed a theatrical performance in sign language, seen through the eyes of artificial intelligence (AI), as one of the methodologies. “Historically, deaf people have been excluded from the development of automatic translation technologies,” says Shaun O’Boyle, Research Fellow in the School of Inclusive and Special Education (Dublin City University DCU). “This has often caused backlash and resistance from deaf communities, as the projects were designed and ...

SAN FRANCISCO — The University of South Carolina and the Public Library of Science (PLOS) today announced a three-year Open Access agreement that allows researchers to publish in PLOS journals[1] without incurring article processing charges (APC). This partnership brings together two organizations that believe researchers should be able to access content freely and make their work available publicly, regardless of their access to funds. “The evidence is undeniable — open research enables the convergence of ...

COLUMBUS, Ohio – Scientists have learned that children find it hard to focus on a task, and often take in information that won’t help them complete their assignment. But the question is, why?   In a new study, researchers found that this “distributed attention” wasn’t because children’s brains weren’t mature enough to understand the task or pay attention, and it wasn’t because they were easily distracted and lacked the control to focus.   It now appears that kids distribute their attention broadly either out of simple curiosity or because their working memory isn’t developed enough to complete a task without “over ...

Cognitive functions, also known as intellectual functions, encompass thinking, understanding, memory, language, computation, and judgment, and are performed in the cerebrum. The prefrontal cortex (PFC), located in the frontal lobe of the cerebral cortex, handles these functions. Studies have shown that exercise improves cognitive function through mechanisms such as enhanced cerebral blood flow, structural changes in the brain, and promotion of neurogenesis. However, 81% of children globally do not engage in enough physical activity, leading to high levels of sedentary behavior and insufficient exercise. This lack of physical ...

Austocystin D, a natural compound produced by fungi, has been recognized for its cytotoxic effects and anticancer activity in various cell types. It exhibits potent activity even in cells that express proteins associated with multidrug resistance, attracting significant global research interest. Austocystin D promotes cell death by damaging their DNA, a process which might be dependent on cytochrome P450 (CYP) oxygenase enzymes. Notably, austocystin D has shown significant activity against cancer cells with increased CYP expression. However, the specific role and function of the CYP2J2 enzyme in the cytotoxicity of austocystin D remain ...

Research Highlights: People diagnosed with unruptured cerebral aneurysms (weakened areas in brain blood vessels) who are being monitored without treatment have a higher risk of developing mental illness compared to those who have not been diagnosed with a cerebral aneurysm. The largest impact was among adults younger than age 40. The study conducted in South Korea found that the psychological burden caused by the diagnosis of an unruptured aneurysm may contribute to the development of mental health conditions, such as anxiety, stress, depression, eating ...

A new Nature Human Behaviour study, jointly led by Dr Margherita Malanchini at Queen Mary University of London and Dr Andrea Allegrini at University College London, has revealed that non-cognitive skills, such as motivation and self-regulation, are as important as intelligence in determining academic success. These skills become increasingly influential throughout a child's education, with genetic factors playing a significant role. The research, conducted in collaboration with an international team of experts, suggests that fostering non-cognitive skills alongside cognitive abilities could significantly improve educational ...

We use the word ‘love’ in a bewildering range of contexts — from sexual adoration to parental love or the love of nature. Now, more comprehensive imaging of the brain may shed light on why we use the same word for such a diverse collection of human experiences. ‘You see your newborn child for the first time. The baby is soft, healthy and hearty — your life’s greatest wonder. You feel love for the little one.’ The above statement was one of many simple scenarios presented to fifty-five parents, self-described as being in a loving relationship. Researchers from Aalto University utilised ...

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have developed a sustainable, biodegradable, biorecyclable material: high-entropy non-covalent cyclic peptide (HECP) glass. This innovative glass features enhanced crystallization-resistance, improved mechanical properties, and increased enzyme tolerance, laying the foundation for its application in pharmaceutical formulations and smart functional materials. This study was published in Nature Nanotechnology on ...

Malaria is caused by a eukaryotic microbe of the Plasmodium genus, and is responsible for more deaths than all other parasitic diseases combined. In order to transmit from the human host to the mosquito vector, the parasite has to differentiate to its sexual stage, referred to as the gametocyte stage. Unlike primary sex determination in mammals, which occurs at the chromosome level, it is not known what causes this unicellular parasite to form males and females. New research at Stockholm University has implemented high-resolution genomic tools to map the global repertoire of genes ...

Climate scientists have long agreed that humans are largely responsible for climate change. However, people often do not realize how many scientists share this view. A new 27-country study published in the journal Nature Human Behaviour finds that communicating the consensus among scientists can clear up misperceptions and strengthen beliefs about climate change. The study is co-led by Bojana Većkalov at the University of Amsterdam and Sandra Geiger of the University of Vienna. Kai Ruggeri, professor of health policy and management at Columbia University Mailman School of Public Health, is the corresponding author. Scientific consensus identifying humans as primarily ...

Artificial intelligence (AI) has practically limitless applications in healthcare, ranging from auto-drafting patient messages in MyChart to optimizing organ transplantation and improving tumor removal accuracy. Despite their potential benefit to doctors and patients alike, these tools have been met with skepticism because of patient privacy concerns, the possibility of bias, and device accuracy. In response to the rapidly evolving use and approval of AI medical devices in healthcare, a multi-institutional team of researchers at the UNC School of Medicine, Duke University, Ally Bank, Oxford University, Colombia University, and University of Miami have been on a mission to build ...

High levels of traffic-related air pollutants have been linked with elevated risks of developing cancer and other diseases. New research indicates that multiple aspects of structural racism—the ways in which societal laws, policies, and practices systematically disadvantage certain racial or ethnic groups—may contribute to increased exposure to carcinogenic traffic-related air pollution. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. Most studies suggesting that structural racism, which encompasses factors such as residential segregation and differences in economic status and homeownership, may influence ...

ANN ARBOR, Mich. –  Among things many families don’t wish to pass down to their children and grandchildren: medical issues. One in five parents say their child has been diagnosed with a hereditary condition, while nearly half expressed concerns about their child potentially developing such a condition, a new national poll suggests. And two thirds of parents want their healthcare provider to suggest ways to prevent their child from developing a health problem that runs in the family, according to the University of Michigan Health C.S. Mott Children’s Hospital National ...

by Amy Norton PISCATAWAY, NJ – After years of being seen as dangerous “party drugs,” psychedelic substances are receiving renewed attention as therapies for addiction -- but far more research is needed, according to a new special series of articles in the Journal of Studies on Alcohol and Drugs, published at Rutgers University. Psychedelics are substances that essentially alter users’ perceptions and thoughts about their surroundings and themselves. For millennia, indigenous cultures have used plants with psychedelic properties in traditional medicine and spiritual rituals. And for a time in the mid-20th ...

Amid the rising human population and pressure on food supplies, the world can’t be everyone’s oyster. But perhaps there might be more oysters to eat if an Osaka Metropolitan University-led research team’s findings mean sturdy plastic rafts will be used in their farming. Conventional oyster farming uses bamboo rafts with additional flotation devices such as Styrofoam. Though relatively affordable, these rafts can be damaged in typhoons. The OMU-led researchers propose a polyethylene raft that keeps costs manageable but is about five times more durable than a bamboo raft. OMU Graduate School of Engineering Associate ...

Despite increased funding for cataract surgeries to private, for-profit clinics, access to surgery fell 9% for lower-income people, according to new research published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.240414. “Unexpectedly, despite new public funding for operations provided in private for-profit surgical centres, which was intended to fully cover all overhead costs and remove the need to charge patients, this disparity did not decrease, but instead grew ...

With tick-borne viruses such as Powassan virus increasing in Canada, clinicians should consider these infections in patients with encephalitis, as a case study shows in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.240227. Although rare, Powassan virus is serious, with a death rate of 10%–15% in people with encephalitis, and it can cause lingering health effects after infection. The virus can transmit within 15 minutes of tick attachment, and symptoms can develop 1–5 weeks later. In this case study, a 9-year-old child with up-to-date vaccinations ...

EMBARGOED UNTIL 12:01 A.M. AUGUST 26, 2024  NOTE TO EDITOR: (To download broadcast-quality video and other multimedia elements: https://bit.ly/3M2ljhX (password: naloxone) COLUMBUS, Ohio – International Overdose Awareness Day is a worldwide campaign held each Aug. 31 that acknowledges the grief of family and friends left behind from those who have died from a drug overdose. This year’s campaign theme “Together we can” highlights the power of the community standing together to help end overdose. However, a new survey of 1,000 Americans from The Ohio State University Wexner Medical ...

Many of us feel that we, or our children, spend too much time staring at a screen. From gaming to social media use or ‘doomscrolling,’ it can sometimes feel that we are mindlessly spending hours going down a rabbit hole of technology. However, according to Catherine Knibbs, a psychotherapist who specializes in cybertrauma and online harms, there are tangible steps we can all take to wrestle back control from the hands of the technology corporations. In her new book, Managing Your Gaming and Social ...

DALLAS (SMU) – An international team of researchers led by SMU paleontologist Louis L. Jacobs has found matching sets of Early Cretaceous dinosaur footprints on what are now two different continents.  More than 260 footprints were discovered in Brazil and in Cameroon, showing where land-dwelling dinosaurs were last able to freely cross between South America and Africa millions of years ago before the two continents split apart. “We determined that in terms of age, these footprints were similar,” Jacobs said. “In their geological and plate ...

In a world overrun by petroleum-based plastics, scientists are searching for alternatives that are more sustainable, more biodegradable and far less toxic to the environment. Two new studies by biologists at Washington University in St. Louis highlight one potential source of game-changing materials: purple bacteria that, with a little encouragement, can act like microscopic factories for bioplastics. A study led by graduate student Eric Conners found that two relatively obscure species of purple bacteria have the ability to produce polyhydroxyalkanoates (PHAs), natural ...