The skin is the largest organ in the human body and plays an important role in maintaining homeostasis as well as protecting the body from the outside environment. Skin diseases can be life-threatening or heavily impair patients’ quality of life. Urticaria (also called “hives”) is common, affecting at least one in five people in their lifetime, and can persist for years or even decades. Many skin diseases are unique to humans, and their pathogenesis often remains unclear due to the lack of an appropriate experimental animal model and limited clinical data. One such human-specific disease is chronic spontaneous urticaria (CSU), which is characterized by the ...

A radical theory that consistently unifies gravity and quantum mechanics while preserving Einstein’s classical concept of spacetime is announced today in two papers published simultaneously by UCL (University College London) physicists. Modern physics is founded upon two pillars: quantum theory on the one hand, which governs the smallest particles in the universe, and Einstein’s theory of general relativity on the other, which explains gravity through the bending of spacetime. But these two theories are in contradiction with each other and a reconciliation ...

Nearly 1,000 birds were killed Oct. 4-5 when they collided with an illuminated glass building in Chicago. Though mass fatalities of this magnitude are rare, light pollution poses a serious – and growing – threat to migrating birds.   In the largest study of its kind, published in Nature Communications, scientists used weather radar data to map bird stopover density in the United States and found that artificial light is a top indicator of where birds will land. City lights lure birds into what can be an ecological trap, said lead author Kyle Horton, an assistant professor ...

Decades after blood pressure-related pregnancy complications, Hispanic/Latina women can have changes in heart structure and function Findings highlight importance of early monitoring and management of hypertension during and after pregnancy Hispanic/Latina women with a history of hypertensive disorders of pregnancy (HDP) – conditions marked by high blood pressure during pregnancy – are more likely to have abnormalities in their heart structure and function decades later when compared with women without a history of HDP, according to a National Institutes ...

Lesbian, gay, and bisexual (LGB) adolescents and young adult cancer survivors in the United States are more likely to report experiencing chronic health conditions than their heterosexual peers with a history of cancer as well as their LGB peers without a past cancer diagnosis. The findings come from a survey-based study published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. Previous studies have indicated that minority sexual orientation and gender identity populations have higher prevalence rates of many chronic conditions—including heart disease, ...

BETHESDA, Maryland (December 4, 2023) — Societal issues — including the growth in ultra-high-cost treatments, the epidemic of mental health and substance use disorders, climate change, and the rise of artificial intelligence (AI)— could alter how health systems serve their communities within five years, according to the latest annual ASHP/ASHP Foundation Pharmacy Forecast Report. The 2024 Pharmacy Forecast, released today at the ASHP Midyear Clinical Meeting & Exhibition, drew ...

Polar bears are icons of the Arctic, elusive and vulnerable. Detailed monitoring of their populations is crucial for their conservation — but because polar bears are so difficult to find, we are missing critical data about population size and how well connected those populations are. Scientists have now developed a new tool to help: DNA analysis using skin cells shed in the bears’ footprints in the snow. “It is particularly challenging, expensive, and time-consuming to find polar bears in the Arctic, let alone count them and understand how they are coping with climate change,” said Dr Melanie Lancaster of the World Wide Fund for Nature Global ...

Often referred to as the ‘dream batteries’, all-solid-state batteries are the next generation of batteries that many battery manufacturers are competing to bring to market. Unlike lithium-ion batteries, which use a liquid electrolyte, all components, including the electrolyte, anode, and cathode, are solid, reducing the risk of explosion, and are in high demand in markets ranging from automobiles to energy storage systems (ESS). However, devices that maintain the high pressure (tens of MPa) required for stable operation of all-solid-state batteries have problems that reduce the battery performance, such as energy density and capacity, ...

In a world where plant-based lifestyles are on the rise, the power of foods such as broccoli, celery, and tofu, which are rich in flavonoids, is becoming clearer. Flavonoids are phenolic compounds produced by plants that are essential for plant development and defense and have long been said to have therapeutic and preventive effects against cancer and heart disease. However, the exact process of how our bodies metabolize flavonoids remains unclear. An international team of researchers led by visiting researcher Tsutomu Shimada and Professor Shigeo ...

How do emergency department staff determine whether older adults who have fallen need imaging? A new decision rule will help emergency department physicians determine which older adults need imaging for head injuries, describes new research in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.230634. With aging populations, emergency departments are managing an increasing number of older adults who fall; falling on level ground, like in one's house, is a common cause of a brain bleed. Computed tomography (CT) of the head is commonly used to assess patients who have fallen, but sending every patient who has fallen ...

To improve primary care, Canada can learn from Organisation for Economic Co-operation and Development (OECD) countries with high rates of patients attached to primary care clinicians, write authors in an analysis in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.221824. It is well known in Canada that there is a crisis in primary care, with about 17% of people reporting that they were without a regular primary care clinician before the COVID-19 pandemic. ...

EMBARGOED UNTIL MONDAY, DECEMBER 4, 2023 AT 12:01 a.m. EST The holiday season is a time for joy and celebration but many Americans admit the endless flurry of activities make it difficult to eat healthy, exercise and get adequate rest, according to a new survey from The Ohio State University Wexner Medical Center. Two-thirds of those surveyed said they overindulge in food, nearly 45% said they take a break from exercise and more than half report feeling tired and have less time for themselves. Plus, a third admit they drink more alcohol during the holidays. “Holiday travel, activities with friends and ...

SYDNEY, Dec. 4, 2023 – An estimated quarter of adults and two-thirds of children have strong fears around needles, according to the U.S. Centers for Disease Control and Prevention. Yet, public health depends on people being willing to receive vaccines, which are often administered by a jab. Darcy Dunn-Lawless, a doctoral student at the University of Oxford’s Institute of Biomedical Engineering, is investigating the potential of a painless, needle-free vaccine delivery by ultrasound. He will share the recent advancements in this promising technique as part of Acoustics 2023 Sydney, running ...

University of Queensland-led research shows being overweight can impair the body’s antibody response to SARS-CoV-2 infection but not to the protection offered by vaccination. Research lead, School of Chemistry and Molecular Biosciences PhD candidate Marcus Tong, said the finding built on the team’s existing research on how COVID-19 affects people who are overweight. “We’ve previously shown that being overweight – not just being obese – increases the severity of SARS-CoV-2,” Mr Tong said. “But this ...

The recent publication in Science by Mogila, Tamulaitiene et al. represents a continuation of the successful scientific research conducted by Gintautas Tamulaitis’ group. In this study, the Vilnius University researchers using bioinformatic analysis, biochemical, and structural studies characterized a novel family of effector proteins, named Cami1. They showed that when a virus attacks a bacterium, CRISPR-Cas10 signaling molecules activate Cami1 - a ribosome-dependent ribonuclease. “Activated Cami1 cleaves mRNAs that are involved in protein synthesis, thereby inhibiting cell growth. This allows the bacterium to save resources and prevents production ...

A major clinical trial led by Queen Mary University of London and the Harvard T.H. Chan School of Public Health has found that vitamin D supplements do not increase bone strength or prevent bone fractures in children with vitamin D deficiency. The findings challenge widely held perceptions relating to the effects of vitamin D on bone health. Around one-third of children have at least one fracture before the age of 18. This is a major global health issue, as childhood fractures can lead to life years of disability and/or poor quality of life. The potential for vitamin D supplements to improve bone strength has attracted growing interest in recent years, based ...

Societies and political structures, like the humans they serve, appear to become more fragile as they age, according to an analysis of hundreds of pre-modern societies. A new study, which holds implications for the modern world, provides the first quantitative support for the theory that the resilience of political states decreases over time.  Triggers of societal collapse have been well studied and vary from conquest and coups to earthquakes and droughts. This new study shows that pre-modern states faced a steeply increasing risk of collapse within the first two centuries after they ...

BLOOMINGTON, Ind. — Similar to a burglar breaking a window to get into a house, Indiana University researchers have discovered a previously unknown process by which pathogens enter a cell with physical force, breaching the body's immune defenses that prevent infection. The work, published in the journal Proceedings of the National Academy of Sciences, introduces a potential game-changer in the fight against intracellular pathogens responsible for causing devastating infectious diseases, such as tuberculosis, malaria and chlamydia. These diseases are notoriously ...

Texas has the second-most bridges in the United States after California, 30% of which do not have sufficient height, width or capacity to handle the increasing volume and type of traffic using them. Nur Yazdani, a civil engineering professor at The University of Texas at Arlington, has received a three-year, $997,275 grant from the Texas Department of Transportation (TxDOT) to evaluate the performance of selected deteriorating and aging highway bridges. His approach includes non-destructive evaluation (NDE), on-site load testing and computer simulation to help engineers determine the current condition of bridges ...

It first appeared as a glowing blob from ground-based telescopes and then vanished completely in images from the Hubble Space Telescope. Now, the ghostly object has reappeared as a faint, yet distinct galaxy in an image from the James Webb Space Telescope (JWST). Astronomers with the COSMOS-Web collaboration have identified the object AzTECC71 as a dusty star-forming galaxy. Or, in other words, a galaxy that’s busy forming many new stars but is shrouded in a dusty veil that’s hard to see through — from nearly 1 billion years after the Big Bang. ...

A University of Texas at Arlington civil engineer is leading a statewide initiative to use more accurate forecasting to guide reservoir storage and release to improve water supply reliability and reduce flood damages. Yu Zhang, a UT Arlington associate professor in the Department of Civil Engineering, is heading a new project—“Advancing Forecast-Informed Drought Planning for the West Gulf Region Through Integration of Climate Forecasts and Predictions of Reservoir Water Balance Predictions”—funded by the National ...

Botanist Denis Conover does not have to go far to study the growing problem of invasive plants. During an autumn stroll outside his office at the University of Cincinnati, the biology professor pointed out numerous examples of nonnative, invasive species in campus landscaping. “This is winged euonymus, otherwise known as burning bush. And here is Chinese silver grass. It’s a popular ornamental, but the seeds are dispersed by the wind,” he said. And there were many others: English ivy, wintercreeper, Callery pear. For his latest study published in the journal Ecological Restoration, he and his students examined the impact ...

Texas Children’s Hospital, an internationally-recognized, top-ranked children’s hospital and pediatric research center affiliated with Baylor College of Medicine, is the first to deliver a novel gene therapy to treat Rett syndrome in pediatric patients. Two female patients with Rett syndrome were the first children worldwide to receive this promising treatment. This exciting milestone is part of an ongoing first-in-human Phase I/II trial of a new investigational gene therapy, NGN-401, conducted by Neurogene Inc., a clinical-stage company founded to bring life-changing genetic medicines to patients ...

Robotics researchers have already made great strides in developing sensors that can perceive changes in position, pressure, and temperature – all of which are important for technologies like wearable devices and human-robot interfaces. But a hallmark of human perception is the ability to sense multiple stimuli at once, and this is something that robotics has struggled to achieve. Now, Jamie Paik and colleagues in the Reconfigurable Robotics Lab (RRL) in EPFL’s School of Engineering have developed a sensor that can perceive combinations of bending, stretching, compression, and temperature changes, all using a robust system that boils down ...

new study from Simon Fraser University researchers examines the Canadian military’s efforts to reduce the impacts of underwater noise pollution on species during training exercises in the Pacific Ocean but caveat that more can still be done. The paper, published today in Marine Policy, takes aim at a report commissioned by the Canadian Department of National Defence (DND) to reduce the effects of noise pollution from military small-arms munitions training within “Whiskey Hotel”, a 330-square-kilometre ...