EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, JULY 12, 2023 MINNEAPOLIS – Older people who have little social contact with others may be more likely to have loss of overall brain volume, and in areas of the brain affected by dementia, than people with more frequent social contact, according to a study published in the July 12, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study does not prove that social isolation causes brain shrinkage; it only shows an association. “Social isolation is a growing problem for older ...

“Our data demonstrate that cetuximab plus radiotherapy represents an active treatment option for laCSCC, with manageable toxicity.” BUFFALO, NY- July 12, 2023 – A new research paper was published in Oncotarget's Volume 14 on July 7, 2023, entitled, “Effectiveness and toxicity of cetuximab with concurrent RT in locally advanced cutaneous squamous cell skin cancer: a case series.” Treatment for locally advanced cutaneous squamous cell cancers (laCSCC) remains poorly defined. Most laCSCC tumors express high levels of epidermal growth factor receptors (EGFR). Cetuximab has activity in other EGFR expressing cancers and enhances the effectiveness ...

The University of Texas at Arlington received an Award of Excellence for Innovation from the International Parking & Mobility Institute (IPMI). The award was for the RAPID (Rideshare, Automation and Payment Integration Demonstration) program, a self-driving shuttle system for students and the general public that started in 2021. It was originally funded through the city of Arlington and a Federal Transit Administration grant, with additional support from the North Central Texas Council of Governments. Via Transportation Inc. and May Mobility also are partners in the program. RAPID, the first program in the United States to integrate on-demand, ...

The incidence of primary involuntary childlessness, the rate of women seeking treatment for infertility, as well as the success rate of assisted reproductive technology all increased in birth cohorts studied from 1916 to 1975, according to a new study published this week in the open-access journal PLOS ONE by Finn Egil Skjeldestad of the Arctic University of Norway. There have been tremendous advances in assisted reproductive technologies (ARTs) over the past 50 years. In the new study, Dr. Skjeldestad analyzed data on 11,064 women born between 1916 and 1975 ...

Ice Age saber-tooth cats and dire wolves experienced a high incidence of bone disease in their joints, according to a study published July 12, 2023 in the open-access journal PLOS ONE by Hugo Schmökel of Evidensia Academy, Sweden and colleagues. Osteochondrosis is a developmental bone disease known to affect the joints of vertebrates, including humans and various domesticated species. However, the disease is not documented thoroughly in wild species, and published cases are quite rare. In this study, Schmökel and colleagues identify signs of this disease in fossil limb bones of Ice Age saber-tooth cats (Smilodon fatalis) ...

A new mathematical model of UK cat populations suggests that neutering of cats that belong to people not only affects the population dynamics of owned cats, but also affects feral, stray, and shelter subpopulations. Jenni McDonald of Cats Protection and co-authors present these findings in the open-access journal PLOS ONE on July 12. More than ten million cats live as owned pets in UK homes, and hundreds of thousands of additional cats live in shelters or as free-roaming feral or stray cats. Cats may transition from any of these subpopulations to another. However, while many prior studies have investigated cat population ...

Slow population declines might be going undetected, while later rates of extinction could increase exponentially ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0285945 Article Title: The rate of species extinction in declining or fragmented ecological communities Author Countries: Greece, USA Funding: The authors received no specific funding for this work. END ...

Simulation study of how body shapes and sizes affected energetic efficiency helps explain relative success of early Polynesian voyaging ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287290 Article Title: Estimated energetic demands of thermoregulation during ancient canoe passages from Tahiti to Hawaii and New Zealand, a simulation analysis Author Countries: USA, Australia, New Zealand Funding: AM received financial support from the Maritime Encounters (M21-0018) project funded by Sweden's Riksbankens Jubileumsfond. ...

Prosthetic limbs are the most common solution to replace a lost extremity. However, they are hard to control and often unreliable with only a couple of movements available. Remnant muscles in the residual limb are the preferred source of control for bionic hands. This is because patients can contract muscles at will, and the electrical activity generated by the contractions can be used to tell the prosthetic hand what to do, for instance, open or close. A major problem at higher amputation levels, such as above the elbow, is that not many muscles remain to command the many robotic joints needed to truly restore the function of an arm and hand. A multidisciplinary team of surgeons and engineers ...

On the Moon, there are raw materials that humanity could one day mine and use. Various space agencies, such as the European Space Agency (ESA), are already planning missions to better explore Earth’s satellite and find minerals. This calls for appropriate exploration vehicles. Swiss researchers led by ETH Zurich are now pursuing the idea of sending not just one solitary rover on an exploration tour, but rather an entire team of vehicles and flying devices that complement each other. The researchers equipped three ANYmal – a type of legged robot developed ...

COLUMBUS, Ohio – For the first time, researchers have developed a model to estimate how much energy the original colonizers of New Zealand expended to maintain their body temperatures on the cold, harrowing ocean journey from Southeast Asia.   Results showed that people making the first voyages from Tahiti to New Zealand in sailing canoes would expend 3.3 to 4.8 times more energy on thermoregulation – the technical term for maintaining body temperature - than those making a trip of similar length to Hawaii.   The ocean route to New Zealand required much more energy for thermoregulation ...

AUKLAND, NZ and DURHAM, N.C. – Companion robots enhanced with artificial intelligence may one day help alleviate the loneliness epidemic, suggests a new report from researchers at Auckland, Duke, and Cornell Universities. Their report, appearing in the July 12 issue of Science Robotics, maps some of the ethical considerations for governments, policy makers, technologists, and clinicians, and urges stakeholders to come together to rapidly develop guidelines for trust, agency, engagement, and real-world efficacy. It also proposes a new way to measure whether a companion robot is helping someone. “Right now, all the evidence ...

Cognitive abilities not only vary among different species but also among individuals within the same species. It is expected that smarter individuals live longer, as they are likely to make better decisions, regarding habitat and food selection, predator avoidance, and infant care. To investigate the factors influencing life expectancy of wild gray mouse lemurs, researchers from the German Primate Center conducted a long-term study in Madagascar. They administered four different cognitive tests and two personality tests to 198 animals, while also measuring their weight and tracking their survival over several years. ...

Within the scope of a vast research program undertaken in coordination with the Egyptian Ministry of Antiquities and the University of Liège, an international team—including scientists from the CNRS, Sorbonne University, and Université Grenoble Alpes—has revealed the artistic license exercised in two ancient Egyptian funerary paintings (dating to ~1,400 and ~1,200 BCE, respectively), as evident in newly discovered details invisible to the naked eye. Their findings are published in PLOS ONE (12 July). The language of ancient ...

By combining multiple advanced technologies into a single system, EPFL researchers have made a significant step forward in diagnosing neurodegenerative diseases (NDDs) such as Parkinson's disease (PD) and Alzheimer's disease (AD). This novel device is known as the ImmunoSEIRA sensor, a biosensing technology that enables the detection and identification of misfolded protein biomarkers associated with NDDs. The research, published today in Science Advances, also harnesses the power of artificial intelligence (AI) by employing neural networks to quantify disease ...

Schistosomiasis, a parasitic disease that causes organ damage and death, affected more than 250 million people worldwide in 2021, according to the World Health Organization. One of the world’s most burdensome neglected tropical diseases, schistosomiasis occurs when worms are transmitted from freshwater snails to humans. The snails thrive in water with plants and algae that proliferate in areas of agricultural runoff containing fertilizer. People become infected during routine activities in infested water. Researchers from the University of Notre Dame, in a study recently published in Nature, found that removing invasive vegetation at water access points in and around several ...

Since the International Organisation of Vine and Wine (OIV) approved the use of ultrasound to promote the extraction of grape compounds back in 2019, its application for obtaining superior red wines has been studied extensively. Now researchers are turning their attention to rosé – an expanding market which has seen strong growth over the past 15 years. A team from the University of Castilla-La Mancha and the University of Murcia in Spain used high-power ultrasound technology to treat Monastrell crushed grapes – a process known as sonication ...

On July 12, 2023, a new research paper was published in Aging, titled, “Chemically induced reprogramming to reverse cellular aging.” BUFFALO, NY- July 12, 2023 – In a groundbreaking study, researchers have unlocked a new frontier in the fight against aging and age-related diseases. The study, conducted by a team of scientists at Harvard Medical School, has published the first chemical approach to reprogram cells to a younger state. Previously, this was only achievable using a powerful gene ...

The Naval Innovation Center (NIC) at the Naval Postgraduate School (NPS) in Monterey, Calif., is part of the Secretary of the Navy’s initiative to leverage the power of American innovation for national security. Integral to the function of the NIC is the Naval Innovation Exchange (NIX), a new program that organizes and empowers multidisciplinary teams of NPS students and faculty focused on developing prototype research solutions.  While in its early stages, the NIC at NPS will leverage and empower ...

At a glance: Working with mice and zebrafish, researchers identify a gene, expressed in neurons, that produces a signal needed for development and maintenance of the blood-brain barrier. When mutated, the gene makes certain regions of the blood-brain barrier more permeable. The findings could help scientists control the blood-brain barrier — important for delivering drugs into the central nervous system or countering damage from neurodegenerative disease What makes the vital layer of protective cells around the brain and spinal cord — ...

Psychedelic-based therapies are poised to change the treatments that psychiatrists can offer patients. “I often talk about psychedelic treatments as catalysts for change, for both the individual and the field of psychiatry,” said Medical University of South Carolina psychiatrist Jennifer Jones, M.D., who conducts research on these treatments. The highly anticipated approval of MDMA, or “ecstasy,” to treat post-traumatic stress disorder would be the first for a psychedelic drug, ushering in changes for patients, mental health providers and society. The Food and Drug Administration is expected to issue a decision on MDMA-assisted ...

Cancer therapies that target specific genetic abnormalities in tumors have revolutionized treatment possibilities over the past two decades. While quality of life and survival are improved with targeted therapies, relapse is common due to the evolution of new tumor cells that are resistant to the targeted therapy. A new study by investigators from the Mass General Cancer Center, a member of the Mass General Brigham healthcare system, reveals how lung tumors may develop drug resistance over time, pointing to a protein, called APOBEC3A, that could be a promising target. Results, published in Nature, may help researchers develop new ...

NEW YORK, NY-- A new study suggests that eye drops developed by Columbia University researchers could be a more effective–and comfortable–therapy for a common eye disease currently treated with injections into the eye. Retinal vein occlusion (RVO), an eye disease that affects up to 2% of people over age 40, occurs when a vein in the eye’s retina becomes blocked, leading to swelling in the eye, inflammation, damage to the retina, and vision loss.  Standard therapy involves injecting into the eye a vascular endothelial growth factor inhibitor (anti-VEGF) that reduces swelling. ...

Scientists at the University of Texas Institute for Geophysics (UTIG) have developed a radar technique that lets them image hidden features within the upper few feet of ice sheets. The researchers behind the technique said that it can be used to investigate melting glaciers on Earth as well as detect potentially habitable environments on Jupiter’s moon Europa. The near-surface layers of ice sheets are difficult to study with airborne or satellite ice-penetrating radar because much of what’s scientifically important happens too close to the surface to be accurately imaged. ...

New Haven, Conn. — Simply the smell of seafood can make those with an allergy to it violently ill — and therefore more likely to avoid it. The same avoidance behavior is exhibited by people who develop food poisoning after eating a certain meal. Scientists have long known that the immune system played a key role in our reactions to allergens and pathogens in the environment, but it was unclear whether it played any role in prompting these types of behaviors towards allergic triggers. According to Yale-led research published July ...