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Could drops replace eye injections for retina disease?

2023-07-12
NEW YORK, NY-- A new study suggests that eye drops developed by Columbia University researchers could be a more effective–and comfortable–therapy for a common eye disease currently treated with injections into the eye. Retinal vein occlusion (RVO), an eye disease that affects up to 2% of people over age 40, occurs when a vein in the eye’s retina becomes blocked, leading to swelling in the eye, inflammation, damage to the retina, and vision loss.  Standard therapy involves injecting into the eye a vascular endothelial growth factor inhibitor (anti-VEGF) that reduces swelling. ...

New radar technique lets scientists probe invisible ice sheet region on Earth and icy worlds

New radar technique lets scientists probe invisible ice sheet region on Earth and icy worlds
2023-07-12
Scientists at the University of Texas Institute for Geophysics (UTIG) have developed a radar technique that lets them image hidden features within the upper few feet of ice sheets. The researchers behind the technique said that it can be used to investigate melting glaciers on Earth as well as detect potentially habitable environments on Jupiter’s moon Europa. The near-surface layers of ice sheets are difficult to study with airborne or satellite ice-penetrating radar because much of what’s scientifically important happens too close to the surface to be accurately imaged. ...

How the immune system can alter our behavior

2023-07-12
New Haven, Conn. — Simply the smell of seafood can make those with an allergy to it violently ill — and therefore more likely to avoid it. The same avoidance behavior is exhibited by people who develop food poisoning after eating a certain meal. Scientists have long known that the immune system played a key role in our reactions to allergens and pathogens in the environment, but it was unclear whether it played any role in prompting these types of behaviors towards allergic triggers. According to Yale-led research published July ...

Warmer ocean temperatures increase risk of salmon bycatch in Pacific hake fishery

2023-07-12
NEWPORT, Ore. – Rates of Chinook salmon bycatch in the Pacific hake fishery rise during years when ocean temperatures are warmer, a signal that climate change and increased frequency of marine heatwaves could lead to higher bycatch rates, new research indicates. During years when sea surface temperatures were higher, including during a marine heatwave, Chinook salmon were more likely to overlap with the Pacific hake and raise the risk of bycatch as they sought refuge from higher temperatures. The findings, based on ...

Bacterium associated with disease found in NC chiggers

Bacterium associated with disease found in NC chiggers
2023-07-12
July 12, 2023              Bacterium Associated With Disease Found in N.C. Chiggers EMBARGOED FOR RELEASE UNTIL NOON EDT ON WEDNESDAY, JULY 12 A bacterium that causes a disease called scrub typhus – a disease not previously reported in the United States – has been detected in North Carolina, according to a new study by researchers at North Carolina State University and UNC-Greensboro.  The researchers stress that scrub typhus, which can cause fever, headache and body aches – and can be fatal if left untreated by antibiotics – has not yet been ...

Mass General Brigham researchers make key improvements to Parkinson’s disease cell therapies

2023-07-12
  Researchers at McLean and Mass General Hospital demonstrated that a transplant surgical procedure (called “needle trauma”) triggers a profound immune response and causes the death of most grafted dopamine neurons They also found that co-transplantation of neuronal cell therapy with host regulatory T cells resulted in effective suppression of needle trauma and significant improvement in the survival and recovery of grafts Findings suggest a path for the ‘realistic’ use of cell therapy to treat neurodegenerative disorders Cell therapy holds promise as a new treatment for Parkinson’s disease but, in many trials to date, most transplanted dopamine ...

County-level income inequality, social mobility, and deaths of despair in the US

2023-07-12
About The Study: This study found that the joint exposure of unequal income distribution and lack of social mobility was associated with additional risks for deaths of despair (deaths from suicide, drug overdose, and alcohol-related liver disease), suggesting that addressing the underlying social and economic conditions is crucial in responding to the epidemic of deaths of despair.  Authors: Chun-Tung Kuo, Ph.D., of National Taiwan University in Taipei, is the corresponding author.  To access the embargoed study: Visit our ...

Trends in acute care use for mental health conditions among youth during pandemic

2023-07-12
About The Study: Into the second year of the pandemic, mental health emergency department visits increased notably among adolescent females, and there was an increase in prolonged boarding (waiting in an emergency department or medical inpatient unit) of youth awaiting inpatient psychiatric care. Interventions are needed to increase inpatient child psychiatry capacity and reduce strain on the acute mental health care system. Authors: Haiden A. Huskamp, Ph.D., of Harvard Medical School in Boston, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (10.1001/jamapsychiatry.2023.2195) Editor’s ...

Study: The ocean’s color is changing as a consequence of climate change

Study: The ocean’s color is changing as a consequence of climate change
2023-07-12
CAMBRIDGE, MA -- The ocean’s color has changed significantly over the last 20 years, and the global trend is likely a consequence of human-induced climate change, report scientists at MIT, the National Oceanography Center in the U.K., and elsewhere.  In a study appearing today in Nature, the team writes that they have detected changes in ocean color over the past two decades that cannot be explained by natural, year-to-year variability alone. These color shifts, though subtle to the human eye, have occurred over 56 percent of the world’s oceans — an expanse that is larger than ...

DNA element with a murky past is borrowing cell’s repair machinery

DNA element with a murky past is borrowing cell’s repair machinery
2023-07-12
Like its viral cousins, a somewhat parasitic DNA sequence called a retrotransposon has been found borrowing the cell’s own machinery to achieve its goals. In a new work appearing online Wednesday in the journal Nature, a Duke University team has determined that retrotransposons hijack a little-known piece of the cell’s DNA repair function to close themselves into a ring-like shape and then create a matching double strand. The finding upends 40 years of conventional wisdom saying these rings were just a useless by-product of bad gene copying. It may also offer new insights into cancer, viral infections and immune responses. Retrotransposons are segments ...

Plastic pollution on coral reefs increases with depth and mostly comes from fishing activities, Nature study finds

Plastic pollution on coral reefs increases with depth and mostly comes from fishing activities, Nature study finds
2023-07-12
SAN FRANCISCO, CA (July 12, 2023) — In a paper published today in Nature, researchers from the California Academy of Sciences, University of São Paulo, University of Oxford, University of Exeter, and other collaborators reveal the extent of plastic pollution on coral reefs, finding that debris increases with depth, largely stems from fishing activities, and is correlated with proximity to marine protected areas.  Through underwater visual surveys spanning more than two dozen locations across the Indian, Pacific, and Atlantic ...

Mast cells as a sensor: Enigmatic immune cells help to avoid harmful allergens

2023-07-12
The function of mast cells, which are part of the immune system, is still a mystery. Scientists at the German Cancer Research Center (DKFZ) have now shown in mice: mast cells function as a sensor that signals the animals to avoid antigens, including harmful allergens, and thereby protect themselves from health-threatening inflammatory reactions. The findings were published in the journal Nature. Mast cells are found primarily in tissues that separate the outside and inside worlds of the body, such ...

Detailed map of the heart provides new insights into cardiac health and disease

2023-07-12
In a new study, published today (12 July) in Nature, researchers have produced the most detailed and comprehensive human Heart Cell Atlas to date, including the specialised tissue of the cardiac conduction system - where the heartbeat originates. The multi-centre team is led by the Wellcome Sanger Institute and the National Heart and Lung Institute at Imperial College London, and has also presented a new drug-repurposing computational tool called Drug2cell, which can provide insights into the effects of drugs on heart rate. This study is part of the international Human Cell Atlas* ...

Second year of COVID pandemic brought spike in child mental health visits to ED

2023-07-12
The number of young people in the United States visiting hospital emergency departments for mental health crises increased sharply during the second year of the COVID-19 pandemic, according to a study led by researchers from the Department of Health Care Policy in the Blavatnik Institute at Harvard Medical School. The findings are published Jul 12 in JAMA Psychiatry. These results come amidst growing national concern about a crisis in youth mental health and provide important new details about how young people with mental health problems such as self-harm ...

Global study details microplastics contamination in lakes and reservoirs

Global study details microplastics contamination in lakes and reservoirs
2023-07-12
LAWRENCE, Kan. — Around 14 million tons of plastic end up in the ocean every year. But that is not the only water source where plastic represents a significant intrusion. “We found microplastics in every lake we sampled,” said Ted Harris, associate research professor for the Kansas Biological Survey & Center for Ecological Research at the University of Kansas. “Some of these lakes you think of as clear, beautiful vacation spots. But we discovered such places to be perfect examples of the link between plastics and humans.” Harris ...

A foundation that fits just right gives superconducting nickelates a boost

A foundation that fits just right gives superconducting nickelates a boost
2023-07-12
Researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University say they’ve found a way to make thin films of an exciting new nickel oxide superconductor that are free of extended defects. Not only does this improve the material’s ability to conduct electricity with no loss, they said, but it also allows them to discover its true nature and properties, both in and out of the superconducting state, for the first time. Their first look at a superconducting nickel oxide, or nickelate, that does ...

New study using human fibroid cells supports use of green tea compound as treatment for uterine fibroids

2023-07-12
In a pre-clinical, proof-of-concept study from Johns Hopkins Medicine, researchers found that epigallocatechin gallate (EGCG), a green tea compound with powerful antioxidant properties, could be promising for both treating and preventing uterine fibroids. Results of the study, first posted online May 25 in Scientific Reports, add to growing evidence that EGCG may reduce fibroid cell growth. The study was specifically designed to identify the biochemical mechanisms responsible for EGCG action in fibroid cells. The investigators emphasize that their study involves human fibroid cells grown in the laboratory and treated with EGCG extract to explore the possibility of oral EGCG supplementation ...

The good advice that could lift people out of poverty

2023-07-12
Providing access to housing, debt, and benefit advice within food banks could help lift people out of poverty - according to a University of East Anglia study. Researchers worked with Norwich Foodbank centres, part of the Trussell Trust, on a pilot project that saw representatives from Citizens Advice and Shelter posted within the service. The ‘Making a Difference’ initiative meant that people forced to use a food bank were also able to access advice on a range of issues - from housing and debt to benefits. It is now hoped that this scheme will be rolled out to foodbanks nationally. Lead researcher Dr Sarah Hanson, from UEA’s School of ...

Amplified Sciences receives $400,000 NCI grant to improve early detection of pancreatic cancer

Amplified Sciences receives $400,000 NCI grant to improve early detection of pancreatic cancer
2023-07-12
WEST LAFAYETTE, Ind. – Health care providers and their patients could know with greater confidence whether pancreatic cysts are benign or potentially malignant, and if surgery is required to remove them, by using a new diagnostic test currently in development. Amplified Sciences, a clinical-stage life sciences diagnostic company that licenses Purdue University innovations, has received a Phase I Small Business Innovation Research, or SBIR, grant of approximately $400,000 from the National Cancer Institute (NCI) to develop the test. The company focuses on accurately detecting and categorically assessing the risks of debilitating ...

Birmingham start-up awarded funding for technology that generates water out of air

2023-07-12
NovNat Tech Ltd, a visionary new company based in the Unit 9 incubator at the Birmingham Research Park, has secured funding from Innovate UK to develop a novel technology that can generate water out of air.  NovNat Tech is offering solutions to one of the most critical problems of today and the future, the global water scarcity crisis, and is developing a first of its kind ‘atmospheric water harvester’ to help address the global water shortage.  The harvest uses a proprietary material that has already been ...

Webb celebrates first year of science with close-up on birth of sun-like stars

Webb celebrates first year of science with close-up on birth of sun-like stars
2023-07-12
From our cosmic backyard in the solar system to distant galaxies near the dawn of time, NASA’s James Webb Space Telescope has delivered on its promise of revealing the universe like never before in its first year of science operations. To celebrate the completion of a successful first year, NASA has released Webb’s image of a small star-forming region in the Rho Ophiuchi cloud complex. “In just one year, the James Webb Space Telescope has transformed humanity’s view of the cosmos, peering ...

Lupus Research Alliance announces recipients of 2023 Diversity in Lupus Research Awards

2023-07-12
NEW YORK, NY, July 12. The Lupus Research Alliance is pleased to announce the 2023 recipients of the Career Development and Postdoctoral Awards to Promote Diversity in Lupus Research. The Diversity in Lupus Research Awards aim to foster the development of outstanding, underrepresented minority scientists and establish a diverse community of researchers and clinicians in the field of lupus. Lupus is a debilitating autoimmune disorder, and the prevalence, severity of symptoms, and mortality are higher among people of color. Yet a recent report by the National Science Foundation showed that while “Blacks or African Americans, Hispanics or Latinos, ...

A glimpse into the hexasome: 40 years on

A glimpse into the hexasome: 40 years on
2023-07-12
In 1983, scientists discovered hexasomes – a unique molecular structure that helps cells package their DNA. Now, a study conducted by the Eustermann group at EMBL Heidelberg has shed light on how DNA packaging into hexasomes can affect the function of enzymes involved in gene regulation. DNA: a lot to unpack DNA is a very long, thin thread containing our genetic instructions. Being much longer than the tiny space inside our cells, it needs a clever packaging system. That’s where nucleosomes come into play – tiny spool-like structures that help compact our genetic information. Multiple nucleosomes are then linked ...

Award for dementia researcher from New York City

2023-07-12
This year’s “Hartwig Piepenbrock-DZNE Prize”, endowed with 60,000 euros, goes to the British neuroscientist Alison Goate, DPhil. The award recognizes her outstanding contributions to research into Alzheimer’s disease and frontotemporal dementia. Professor Goate researches and teaches at the Icahn School of Medicine at Mount Sinai, an international leader in biomedical education, research, and patient care located in New York City. The prize is presented jointly by the Piepenbrock Group and the German Center for Neurodegenerative Diseases (DZNE). The award ...

Towards crack-resistant nanoparticle-based latex films

Towards crack-resistant nanoparticle-based latex films
2023-07-12
Synthetic polymer materials, such as plastics and rubbers, have become ubiquitous in our daily lives. It is, therefore, essential to ensure that they are safe, durable, and sustainable. This is especially true for synthetic latex films, which are widely used in packaging, biomedicine, and electronics. But what exactly are synthetic latex films? Simply put, they are a type of nanoparticle-based films that are produced by drying out a mixture of polymer nanoparticles and water. As the solvent evaporates, the nanoparticles become more packed until finally the interactions between polymer chains at the boundaries of nanoparticles create a coherent film. Unfortunately, the latex films ...
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