University of Pittsburgh researchers have developed a universal receptor system that allows T cells to recognize any cell surface target, enabling highly customizable CAR T cell and other immunotherapies for treating cancer and other diseases. The discovery could extend into solid tumors and give more patients access to the game-changing results CAR T cell therapy has produced in certain blood cancers. Described in a Nature Communications study published today, the new approach involves engineering T cells with receptors bearing a universal ...

COVID vaccines offered varying degrees of protection in the six months after patients receive them, with levels climbing and plunging in two cases and climbing and climbing in another. Age, sex, body mass index (BMI) and smoking status also play roles, according to new UC San Francisco research.    In the BOOST study (Building Optimal antibOdies STudy), researchers tracked the response to the Pfizer, Moderna and Johnson & Johnson vaccines in blood samples of 498 healthy volunteers, ages 18 to ...

A world-leading oral health expert from the University of Birmingham, whose pioneering research concentrates on the link between oral health and non-communicable diseases such as diabetes, is to investigate the impact of a technology described as one of the biggest innovations in preventative dentistry since fluoride. Professor Iain Chapple and his research group at the University’s School of Dentistry, will work with Sigrid Therapeutics to identify and develop further applications for a technology ...

Maynooth University’s Kathleen Londsdale Institute for Human Health Research has just published ground-breaking research into the benefits of the popular obesity treatment drug, GLP-1. Previous research has found that people with obesity are at a greater risk of developing cancer, in part due to their anticancer immune cell -- better known as the ‘Natural Killer (NK)’ cell -- being rendered useless due to their disease. New Health Research Board (HRB) funded research carried out by Dr Andrew Hogan ...

The touch of another person may increase levels of the “feelgood” hormone oxytocin. But the context really matters. The situation impacts oxytocin levels not only in the moment, but also later, as is shown by researchers at Linköping University and the University of Skövde in Sweden. Their study has been published in the scientific journal eLife. An embrace from a parent, a warm hand on your shoulder or a caress from a romantic partner are examples of how touch can strengthen social bonds between people and influence emotions. ...

Carbapenem-resistant Acinetobacter baumannii (CRAB) was brought into the ICU, in Hangzhou, on multiple occasions as patients were admitted, creating a large ‘reservoir’ of the bacteria which contaminated beds and equipment. Of 35 CRAB-positive patients in the study, 14 acquired CRAB during their ICU stay. Samples of the drug-resistant bacteria were found more frequently in bed unit environments (54·6%) than patients (24·1%), with ventilators (27·9%) and dispensing trolleys (25·6%) most likely to yield samples of CRAB. Publishing their findings today (Date ...

The emergence and global spread of antimicrobial resistant bacteria among companion animals (e.g., dogs and cats) pose a risk of the animals being reservoirs for cross-species transmission because of their close contact with humans. In Japan, for the first time, a research team led by Associate Professor Mayo Yasugi from the Osaka Metropolitan University Graduate School of Veterinary Science discovered Escherichia coli resistant to both colistin and third-generation cephalosporin antibiotics in a companion dog. Outside Japan, both colistin ...

CHICAGO (May 9, 2023) — Four in 10 posts about liver disease on TikTok contain misinformation, with most pushing inaccurate claims about fad diets, “detox” drinks and herbal remedies, according to a study being presented today at Digestive Disease Week® (DDW) 2023. Results suggest that liver disease patients who seek medical information on TikTok may need help separating good information from the bad. “People should always consult their doctor first for guidance on their specific medical condition, but we also know that getting health information and tips from social media is extremely common these days,” ...

Metabolic syndrome with heavy alcohol use may have contributed to recent surge in alcoholic liver disease-related mortality Abstract: https://www.acpjournals.org/doi/10.7326/M23-0518 URL goes live when the embargo lifts A brief research report evaluating the relationship between metabolic syndrome (MetS) and a recent increase in alcohol-associated liver disease (ALD) deaths has found that heavy alcohol use and the presence of MetS was associated with a higher risk for advanced liver disease. This association may provide some explanation ...

BATON ROUGE – Does altitude play a role in weight loss? Why is it easier to lose weight in Colorado versus Louisiana? Researchers at the Pennington Biomedical Research Center are seeking answers to these questions through one of the latest research trials, the “Low Oxygen and Weight Status,” or LOWS study. The LOWS study will determine whether exposure to low oxygen levels in the air, similar to those at higher altitudes, can help individuals with obesity lose weight and improve health. The LOWS study is now open for participant enrollment. Participants will be randomized to ...

Eight low-cost and easily implementable proven interventions for pregnant women in 81 low- and middle-income countries (LMICs) could prevent an estimated 566,000 stillbirths and 5.2 million babies a year from being born preterm or small for gestational age—some with low birth weight—the impacts of which would also affect long-term health and economic output, says a new four-paper Series published in The Lancet.   Additionally, the eight interventions, multiple micronutrient supplements balanced protein energy supplements aspirin treatment of syphilis education for smoking cessation prevention of malaria in pregnancy treatment ...

Sophia Antipolis, 9 May 2023:  Adults in their 20s and 30s with mental disorders have an up to three-fold elevated likelihood of a heart attack or stroke, according to a study in more than 6.5 million individuals published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).1 Lifestyle behaviours did not explain the excess risk. One in every eight of the 20-to-39-year-old participants had some kind of mental illness including depression, anxiety and insomnia. “Psychological problems were common in young adults and had strong ...

Grown in labs, human brain organoids are cultivated from stem cells, feed on nutrient broth and serve as a model of human brain development in miniature. Their growth and structure mimic portions of real brains, allowing scientists to better investigate the origins and potential treatments of neural diseases. How similar are they to actual human brains, though? Are they close enough to be considered people in their own right? The question is complicated in myriad ethical and moral ways, but researchers based in Japan and Taiwan propose that the legal lens may prove critical when understanding the potential personhood of human ...

New research has discovered that some patients with motor neuron disease (MND) and frontotemporal dementia (FTD) carry the same rare genetic defects that cause other neurodegenerative diseases. Researchers from the Macquarie University MND Research Centre and The Walter and Eliza Hall Institute of Medical Research have identified the defects in the genomes of some people with non-inherited, or sporadic, MND and FTD. MND results in the death of the neurons, or motor nerves, connecting the brain and spinal cord to the muscles. These are the cells that control our ability to move, breathe and swallow. The disease ...

Water oxidation reaction involves a four-electron and four-proton transfer process, which requires an uphill energy transformation and limits the efficiency of the overall photocatalytic water splitting reaction. Although loading appropriate water oxidation cocatalysts can enhance the performance of water oxidation reactions, the interfacial barrier between the semiconductor and the water oxidation cocatalyst can impede the transfer and utilization of photogenerated charges. Recently, a research team led by Profs. LI Can and LI Rengui from the Dalian Institute of Chemical Physics (DICP) ...

The Southwest Rural Health Research Center at the Texas A&M University School of Public Health has published a peer-reviewed paper detailing Healthy People 2030 priorities that will be most critical for rural America in the upcoming decade. These priorities were identified by rural health stakeholders across the United States. This publication comes ahead of the center’s release of Rural Healthy People 2030 — a continuation of a long-standing tradition of the Southwest Rural Health Research Center in which multidisciplinary authors ...

Do you hate the camera bumps on the back of your smartphone? A new optical component called metalens – which was named one of the top 10 future technologies by the World Economic Forum in 2019 – may be the answer. Composed of a nanostructured array, this incredibly thin and lightweight optical device is currently the focus of much attention in the scientific community, even featured in a special issue of Nature Photonics. However, the production of metalenses requires highly precise techniques and can be expensive, posing a challenge for their scalable manufacturing.   In ...

Video anomaly detection is a research hotspot in the field of computer vision, attracting many researchers.Video anomaly detection differs from traditional video analysis. Usually, abnormal events occur only in a small percentage of the video pixels and therefore, it is unnecessary to focus on all the video pixels as most of them are harmless—called “the background”. Therefore, in the video feature extraction process, attention should be focused on a few detectable partial objects. Object detection is very complicated and consumes a significant amount of time during video processing. Therefore, ...

As the executor of life activities, proteins exert their specific biological functions through interactions such as forming protein complexes. The localization effects, crowding effects, and organelle microenvironments within cells are crucial for maintaining the structure and function of protein complexes. Recently, a research team led by Prof. ZHANG Lihua from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) has developed a glycosidic-bond-based mass-spectrometry-cleavable cross-linker, which improves the data ...

The COVID-19 pandemic has boosted the unnecessary use of antimicrobial chemicals linked to health problems, antimicrobial resistance, and environmental harm, warn more than two dozen scientists in the peer-reviewed journal Environmental Science & Technology. Their critical review details how quaternary ammonium compounds (QACs) are increasingly marketed and used in home, healthcare, education, and workplace settings despite the availability of safer alternatives and in some cases limited evidence of reduced disease transmission. “Disinfectant wipes containing ...

The race is on to provide high speed satellite internet to the Earth’s most remote areas. New tech companies such as Starlink, One Web, and Amazon’s Kuiper are competing with traditional, established “satcomm” companies such as Thuraya and Inmarsat to provide global high speed, low latency satellite internet across the globe. These new mega-constellations rely on tens of thousands of small low earth orbit satellites flying at a few hundred miles altitude. Network interconnectivity is a basic building block for providing the fastest, more reliable coverage to end users. While all these mega-constellations are driven to provide high ...

Considering the millions of research papers and reports from open domains such as biomedicine, agriculture, and manufacturing, it is humanly impossible to keep up with all the findings. Constantly emerging world events present a similar challenge because they are difficult to track and even harder to analyze without looking into thousands of articles.  To address the problem of relying on human effort in situations such as these, Lifu Huang, an assistant professor in the Department of Computer Science and core faculty at the Sanghani Center for Artificial Intelligence ...

“Importantly, the expression of several LY6 genes is elevated in UCEC [uterine corpus endometrial carcinoma] when compared to the expression in normal uterine tissue.” BUFFALO, NY- May 8, 2023 – A new research paper was published in Oncotarget's Volume 14 on May 4, 2023, entitled, “Human LY6 gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma.” The human Lymphocyte antigen-6 (LY6) gene family has recently gained interest for its possible role in tumor progression. In this new study, researchers Luke A. Rathbun, Anthony M. Magliocco ...

Woods Hole, Mass. (Monday, May 8, 2023) -- New research provides clear evidence of a human “fingerprint” on climate change and shows that specific signals from human activities have altered the temperature structure of Earth’s atmosphere. Differences between tropospheric and lower stratospheric temperature trends have long been recognized as a fingerprint of human effects on climate. This fingerprint, however, neglected information from the mid to upper stratosphere, 25 to 50 kilometers above the Earth’s surface. “Including this information improves the detectability of a human fingerprint by a factor of five. Enhanced detectability occurs because the mid ...

Irvine, Calif., May 8, 2023 – While conducting a study of Petermann Glacier in northwest Greenland, researchers at the University of California, Irvine and NASA’s Jet Propulsion Laboratory uncovered a previously unseen way in which the ice and ocean interact. The glaciologists said their findings could mean that the climate community has been vastly underestimating the magnitude of future sea level rise caused by polar ice deterioration. Using satellite radar data from three European missions, the UCI/NASA team learned that Petermann Glacier’s grounding line – where ice detaches from the land bed and begins floating in the ocean – shifts substantially ...