Researchers from Queen Mary University of London analysed 2.6 million posts on popular social media network Nextdoor and accurately predicted individuals’ income by solely examining the posts they’ve published. Striking differences in the content shared by people who live in wealthier versus poorer neighbourhoods has led researchers to believe that our general online posting activity, beyond Nextdoor, can reveal our socioeconomic status, making user profiling possible. Knowing users’ income could allow social media platforms to recommend income-based content, and advertisers and online shops can target people based on their ...

ABSTRACTS: 3121, 4504, LBA4619 CHICAGO ― Three clinical trials led by researchers at The University of Texas MD Anderson Cancer Center demonstrated positive results from the targeted therapy erdafitinib for patients with multiple tumor types harboring FGFR alterations. The data are being presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting. Erdafitinib is an oral medication that blocks the activity of FGFR signaling proteins, which are important for a variety of normal cellular processes. However, FGFR genetic alterations can drive the development of many ...

Bipolar disorder (BD) is a major psychiatric condition that afflicts about 1% of people. Symptoms of BD include sudden onset of depressive mood with loss of interest which alternates with a manic state of hyperactivity. The suffering of the patients and societal cost of this disorder requires the use of continued therapeutic management. Current medications—although vital for patients with BD—are not perfect solutions, given their potential side-effects and treatment resistance. This necessitates ...

In the race to develop fusion energy, each unique approach requires its own specialized techniques to determine net energy gain, an equation balancing energy in and out that’s known by the letter Q. A new paper, published today in the journal Fusion Science and Technology, establishes the company’s method of measuring and calculating Q in Zap’s sheared-flow-stabilized Z-pinch fusion plasmas. The publication will be an important part of Zap demonstrating energy gain on the way to building a commercial fusion ...

Children who struggle with attention and behavior problems tend to end up earning less money, finish fewer years of school and have poorer mental and physical health as adults, compared with children who don’t show early attention and behavior problems, according to research published by the American Psychological Association. Children who struggle with attention are particularly likely to have lower levels of educational attainment as adults, while those who struggle with impulsivity are more likely to end up in trouble with the law, the research found. “Our study found broad support ...

Genes that make bacteria resistant to antibiotics are much more widespread in our environment than was previously realised. A new study, from Chalmers University of Technology and the University of Gothenburg in Sweden, shows that bacteria in almost all environments carry resistance genes, with a risk of them spreading and aggravating the problem of bacterial infections that are untreatable with antibiotics. “We have identified new resistance genes in places where they have remained undetected until now. These genes can constitute an overlooked threat to human health,” says Erik Kristiansson, a professor in the Department ...

The latest data from the nationwide INSPIRE study assessing the long-term symptoms and outcomes of the COVID-19 virus in nearly 6000 participants identifies four clinically distinct symptom presentations (phenotypes),adding to the growing body evidence that Long COVID is not singular condition but rather a range of conditions that may evolve, and typically improve, over time. Lead author Michael Gottlieb, MD, says this better understanding of the clinically distinct manner that patients experience post-COVID -19 complications ...

People with higher risks of cardiovascular disease are significantly more likely to develop carpal tunnel syndrome, tennis elbow, golfer’s elbow, and rotator cuff tendinitis, according to a new study involving researchers at the University of Utah and the Rocky Mountain Center for Occupational and Environmental Health. The findings of the study, published June 2 in the Journal of Occupational and Environmental Medicine, have implications for the prevention and treatment of these common musculoskeletal disorders, which affect ...

Artificial intelligence has entered our daily lives. First, it was ChatGPT. Now, it’s AI-generated pizza and beer commercials. While we can’t trust AI to be perfect, it turns out that sometimes we can’t trust ourselves with AI either. Cold Spring Harbor Laboratory (CSHL) Assistant Professor Peter Koo has found that scientists using popular computational tools to interpret AI predictions are picking up too much “noise,” or extra information, when analyzing DNA. And he’s found a way to fix this. Now, with just a couple new lines of code, scientists can get ...

In a new study of trastuzumab deruxtecan, a HER2-targeted antibody drug conjugate, researchers observed encouraging responses and long-lasting clinical benefit in several tumor types. These data from an interim analysis of the Phase II DESTINY-PanTumor02 study, led by The University of Texas MD Anderson Cancer Center, were presented today at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting.  The treatment achieved an objective response rate (ORR) of 61.3% with a median duration of response (DOR) of 22.1 months in patients with the highest levels of HER2 expression. Across ...

Research Highlights: A study of more than 100,000 women, ages 45 and older, taking oral estrogen hormone therapy for menopause, has found that estrogen ingested in pill form may be associated with an increased risk of high blood pressure compared to transdermal and vaginal estrogen. Oral estrogen was associated with a 14% higher risk of high blood pressure compared to transdermal estrogen creams and a 19% greater risk of high blood pressure compared to vaginal estrogen creams or suppositories. Non-oral estradiol (a specific form of estrogen) at the lowest dose and for the shortest period of time was associated with the lowest risk of developing high blood ...

Media Release   Embargoed by The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences until Monday, June 5 at 5 a.m. GMT (1 a.m. EDT)   Disadvantaged neighbourhoods and depression symptoms associated with premature aging   Hamilton, ON (June 5, 2023) - Feeling depressed and living in a deprived urban neighbourhood could be making you age faster, according to a new study led by researchers at McMaster University.   The findings, published June 5 in The Journals of Gerontology, Series ...

Marking a milestone in its role as a leading open access (OA) book publisher, Taylor & Francis has announced Technology and Sustainable Development: The Promise and Pitfalls of Techno-Solutionism as its 1,500th OA book. Reflecting the crucial role for open access in making relevant research available to readers outside of academia, Technology and Sustainable Development focuses on many of the practical challenges facing our governments and societies today. The potential of technology to both solve and exacerbate pressing global issues, including ...

More than three in five children (63 percent) enrolled in Medicaid do not receive mental health services within six months after a firearm injury, according to a new study published in the journal Pediatrics. In the United States, 11,258 youth experienced nonfatal firearm injuries in 2020. Children who survive firearm injuries are at increased risk for adverse mental health outcomes, such as newly diagnosed trauma-related disorders, substance use and disruptive disorders. In addition to these disorders, the study found that ...

Night-time pollinators such as moths need protecting as effectively as bees, as new research found they could be less resilient to the pressures of urbanisation Moths account for a third of the pollinator visits to crops, flowers and trees in urban areas More moths were found to be carrying pollen than previously thought, and visiting more types of plant and fruit crops than previously identified Moth abundance has declined by 33 per cent in the last 50 years and this represents a threat to the plants and crops that rely on insects for pollination Night-time pollinators such as moths may visit just as many ...

Serious heart attacks are more likely to happen at the start of the working week than at any other time, according to new research presented today at the British Cardiovascular Society (BCS) conference in Manchester.   Doctors at the Belfast Health and Social Care Trust and the Royal College of Surgeons in Ireland analysed data of 10,528 patients across the island of Ireland (7,112 in the Republic of Ireland, 3,416 in Northern Ireland) admitted to hospital between 2013 and 2018 with the most serious type of heart attack. This is known as an ST-segment elevation myocardial infarction (STEMI) and occurs when a major coronary artery is completely blocked.   The researchers ...

Testing older potential organ donors for dangerous ‘zombie’ cells could help to increase the number of hearts available for transplant, according to research part-funded by the British Heart Foundation (BHF) and presented at the British Cardiovascular Society conference in Manchester.  Currently, hearts from donors aged over 65 are not accepted for donation due to the likelihood of a poor clinical outcome. However, our hearts age at different rates and age isn’t necessarily the best indicator of heart health.   Researchers ...

Do whales increase the removal of carbon from the atmosphere?  Despite some hope that this would be the case, a new study led by Griffith University and a team of global researchers has found the amount of potential carbon capture by whales is too little to meaningfully alter the course of climate change.  Marine scientist Dr Olaf Meynecke and the team from the Griffith-led Whales and Climate Research Program including Professor Brendan Mackey and Dr Jasper De Bie, reviewed the primary ways in which baleen whales (such as humpback whales) removed atmospheric carbon ...

Key takeaways A targeted therapy drug called vorasidenib had positive results in delaying progression of a specific form glioma, a slow-growing but deadly brain cancer. In a study of 331 people with the disease, the drug was effective in lengthening the period of time before the patients’ cancer worsened, and with no observed adverse effects. New treatment approaches for glioma are needed because current treatments, including chemotherapy and radiation, can cause neurological deficits. In ...

An unprecedented investment by the University of Sydney, Australia will support up to 40 new continuing positions, empowering the world’s most talented emerging researchers to undertake innovative research to address some of the biggest challenges of our time. A $100 million investment and a cornerstone of the University’s 2032 Strategy, the Sydney Horizon Fellowship scheme is the first of its kind in Australia and among the most generous university fellowships in the world. “The Sydney ...

CHICAGO – Over the past decade, the approval of immune checkpoint inhibitors has revolutionized treatment for patients with advanced lung cancer, helping many live longer lives and improving overall survival for the disease. However, an important question has remained unanswered: How long should a patient with advanced non-small cell lung cancer (NSCLC), who receives immunotherapy as part of their initial treatment, continue with treatment? A new retrospective cohort study, published today in JAMA Oncology and presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting (Abstract ...

About The Study: The findings of this study provide reassurance that for patients with advanced non–small cell lung cancer whose disease is still responding to immune checkpoint inhibitor therapy at two years, stopping therapy and monitoring rather than continuing immunotherapy indefinitely is a reasonable strategy with sustained clinical benefit.  Authors: Lova Sun, M.D., M.S.C.E., of the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamaoncol.2023.1891) Editor’s ...

Presented today by VHIO’s Ana Oaknin at the 2023 ASCO Annual Meeting, 2-6 June (Chicago, IL),  updated dose expansion data of the STRO-002-GM1 global phase I study* show promise of FolRα-targeting antibody drug conjugate (ADC) luveltamab tazevibulin in patients with recurrent FolRα-expressing epithelial ovarian cancer.   80% of patients included in this study presented with FolRα expression levels higher than 25%. The overall response rate among these patients was 43.8% in the dose expansion cohort, with a median duration of response ...

Carbon-based stimuli-responsive nanomaterials are gaining much attention due to their versatility, including disease diagnosis and treatment. They work under endogenous (pH, temperature, enzyme, and redox) or exogenous (temperature, light, magnetic field, ultrasound) stimuli. Carbon-based stimuli-responsive nanomaterials can be used as smart materials with dynamically tunable physicochemical properties in response to changes in internal or external environmental stimuli. Their diverse combinations of nanostructures and molecular designs, as well as functional ...

ABSTRACT: 4008 CHICAGO ― HER2-targeted bispecific antibody zanidatamab demonstrated durable responses in patients with treatment-refractory HER2-positive biliary tract cancer (BTC), researchers from The University of Texas MD Anderson Cancer Center reported at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting. The study results also were published today in The Lancet Oncology. In the first cohort of the global Phase II HERIZON-BTC-01 trial, which included 80 patients with HER2-positive tumors, the confirmed objective response rate (cORR) was 41% with a median duration of response (DOR) of 12.9 months at a median follow-up of 12.4 months. ...