ABSTRACT: 4008 CHICAGO ― HER2-targeted bispecific antibody zanidatamab demonstrated durable responses in patients with treatment-refractory HER2-positive biliary tract cancer (BTC), researchers from The University of Texas MD Anderson Cancer Center reported at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting. The study results also were published today in The Lancet Oncology. In the first cohort of the global Phase II HERIZON-BTC-01 trial, which included 80 patients with HER2-positive tumors, the confirmed objective response rate (cORR) was 41% with a median duration of response (DOR) of 12.9 months at a median follow-up of 12.4 months. ...

Survival rate beyond 10 years in children with drug-resistant epilepsy (DRE) was highest after cranial epilepsy surgery and lowest when treated only with antiseizure medications, according to a study published in The Lancet Child and Adolescent Health. This large, retrospective study was the first to compare long-term survival in children with DRE among cohorts treated with medications only, vagus nerve stimulation plus medications, and cranial epilepsy surgery plus medications. Results show that risk of early death was reduced by over 80 percent after surgery and by 40 percent after ...

When one thinks of movie reviews, one might see them as harbingers of success or failure at the box office. Some researchers have previously found that both positive and negative reviews correlate to box office revenues, and the effect of negative reviews diminishes over time. However, researchers at the University of California, Davis, suggest that is not the case. Researchers analyzed pre-release commentary and opening weekend box office revenue, turning  the impact of movie reviews on its head and revealing an unexpected harbinger of failure phenomenon in the movie industry.  The study, ...

Bile duct cancers are uncommon and aggressive types of gastrointestinal cancer. They include cholangiocarcinomas, which can form inside or outside of the liver, as well as cancers of the gallbladder, and are highly likely to cause serious disease or prove fatal. Bile duct cancers affect the biliary tract, which consists of organs and ducts that make and store bile and release it into the small intestine. They are known as “silent” cancers, because there are usually no symptoms until they reach later stages. Surgery can be effective if bile duct cancer is caught early, ...

June 2, 2023   Contact: Emily Gowdey-Backus, 978-934-3369 or Emily_GowdeyBackus@uml.edu Nancy Cicco, 978-934-4944 or Nancy_Cicco@uml.edu   Startups to unveil cutting-edge point-of-care technologies at Boston medtech event   Medtech and life sciences entrepreneurs and investors forging the future of health care will come together Tuesday, June 6, to showcase pioneering technologies and grow the region’s medtech ecosystem.   The 2023 Point of Care Showcase and Pitch Event will be a free, in-person program beginning at 2 p.m. at Mintz, 1 Financial Center, 40th Floor, Boston, to introduce ...

A team of researchers from EPFL have found a way to use the phenomenon of strong gravitational lensing to determine with precision – about 3 times more precise than any other technique – the mass of a galaxy containing a quasar, as well as their evolution in cosmic time. Knowing the mass of quasar host galaxies provides insight into the evolution of galaxies in the early universe, for building scenarios of galaxy formation and black hole development. The results are published in Nature ...

BOSTON – Various medications can be prescribed to lower blood sugar levels in individuals at high risk for developing type 2 diabetes, but it’s often unclear which patients will benefit most from which drugs. In a study published in Diabetologia, investigators at Massachusetts General Hospital (MGH), founding member of Mass General Brigham (MGB), identified genetic variants associated with response to two such drugs: metformin and glipizide. The findings may help personalize ...

Twenty-five teachers from Redlands Unified School District in southern California recently completed training in integrating computer science into math education through a joint program offered by the University of California, Davis, and UC Riverside Extension. The Joint Computer Science Supplementary Teaching Credential Authorization Program has helped Redlands address gaps in student opportunity and achievement, and teachers’ skills. “Improving math instruction for student success is the most challenging task in education. Redlands partnered with UC Davis to make math instruction with ...

The Response Evaluation Criteria In Solid Tumors (RECIST), used in many clinical trials to evaluate changes in tumor burden over time, classify objective tumor response into one of four categories (complete or partial response, or stable or progressive disease) based on the percent of change in the sum of the longest diameters of a set of target lesions.  An analysis of data from the SWOG S1609 trial conducted by the NCI-funded National Clinical Trials Network (NCTN) finds that in patients treated with immune checkpoint inhibitors, survival times correlate linearly with that change, rather than exhibiting threshold effects ...

A new study from researchers in the Khurana lab at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, in close collaboration with researchers from the Ritz lab at UCLA and the Rubin lab at Harvard University, identified pesticides that could be relevant to the development of Parkinson’s disease. The study was led by Richard Krolewski, MD, PhD, a neurologist in the Brigham’s Division of Movement Disorders and Ann Romney Center for Neurologic Diseases, and Kimberly ...

Among patients with extensive stage small-cell lung cancer (SCLC) that is positive for expression of the Schlafen-11 gene (SLFN11), those who received maintenance atezolizumab immunotherapy plus the PARP inhibitor talazoparib had significantly longer progression-free survival (PFS) times than those who received atezolizumab alone (median PFS 4.2 months versus 2.8 months). These results from the phase II S1929 trial conducted by the SWOG Cancer Research Network, a clinical trials group funded by the National Cancer Institute (NCI), will be reported ...

Oncology specialists from around the globe will gather for the American Society of Clinical Oncology (ASCO) Annual Meeting to discuss the latest cancer therapies, technologies, research and education.      The theme this year is Partnering With Patients: The Cornerstone of Cancer Care and Research. More than 30,000 people are expected to attend the meeting taking place in Chicago and online June 2-6, 2023.     “As the world’s leading clinical cancer meeting, ASCO is an important event for oncology professionals to share information on the latest ...

Multiple sclerosis has traditionally been considered a condition that predominantly affects white people of European ancestry. However, a new analysis conducted by a North American team led by University of Maryland School of Medicine (UMSOM) researchers suggests that the debilitating neurological condition is more prevalent in Black Americans than once thought. It is also far more prevalent in Northern regions of the country including New England, the Dakotas, and the Pacific Northwest. Findings from the new study were recently published in the journal JAMA Neurology. “We found a much higher prevalence of multiple sclerosis in Black Americans than previously ...

New results from a study led by USC researchers at Children’s Hospital Los Angeles show that a sensory adapted dental clinic environment creates less distressing oral care experiences for autistic children. The open-access article is available today in JAMA Network Open. “We’ve shown that the combination of curated visual, auditory and tactile adaptations — all of which are easily implemented, relatively inexpensive and don’t require training to safely use — led to statistically significant decreases in autistic children’s behavioral ...

Key takeaways: A UCLA study shows that a the outset of the COVID-19 pandemic, social interactions, both virtual and in person, declined significantly for married couples. The decline was found to be greater and more long-lasting for Black and Latino couples and lower-income couples than for white couples and wealthier couples. The researchers suggest exploring new ways of protecting public health during crises that also help more vulnerable populations sustain meaningful relationships. Following the lockdowns and restrictions on public gatherings in the early days of COVID-19, the social networks of white, ...

Predicting a protein’s location within a cell can help researchers unlock a plethora of biological information that’s critical for developing future scientific discoveries related to drug development and treating diseases like epilepsy. That’s because proteins are the body’s “workhorses,” largely responsible for most cellular functions. Recently, Dong Xu, Curators Distinguished Professor in the Department of Electrical Engineering and Computer Science at the University of Missouri, and colleagues updated their protein localization prediction model, MULocDeep, ...

Beneath and beyond the reddish, flaky lesions that form in the skin of those with psoriasis, mild and severe forms of the disease can be told apart by the activity of key cells and signaling pathways, a new study shows. Led by researchers at NYU Grossman School of Medicine, the study mapped hidden features of inflammation and how they compared in cases of increasing severity of psoriatic disease. The team’s findings may help explain how small areas of skin inflammation can have wide-ranging effects in other parts of the body. Up to one-fifth of those with the skin disease, the researchers note, ...

-With pictures- In a new study, bioscientists argue that strengthening the protection given to areas already protected under law or by local communities is as critical for safeguarding biodiversity as creating new protected areas. The research team, which included scientists from Durham University, National University of Singapore (NUS) and Princeton University, found that about 70 per cent of the roughly 5000 species analysed either have no apparent representation in protected areas, occur in protected areas that have been downgraded, downsized or degazetted, ...

Researchers have for the first time characterised a unique molecular mechanism of the early stages of programmed cell death or apoptosis, a process which plays a crucial role in prevention of cancer.   The study, which is published today (Friday 2nd June 2023) in Science Advances, was led by Dr Luke Clifton at the STFC ISIS Neutron and Muon Source (ISIS) in Oxfordshire, alongside co-lead Professor Gerhard Gröbner at the University of Umeå and partners at the European Spallation Source in Sweden.  It is ...

1. The National Institute for Materials Science (NIMS) has developed an AI-based mass spectrometric technique capable of determining the monomeric sequence of a polymer. This technique may be useful in gaining a deeper understanding of basic polymeric structures, facilitating the development of new materials and helping solve plastic recycling problems.   2. A polymer is a very large molecule composed of a chain of many (ranging from hundreds to hundreds of thousands) small molecules called monomers that are bonded together. Many common polymers (e.g., plastics and resins) are copolymers, consisting of several different types of monomers. During the copolymerization process, the monomers ...

BATON ROUGE – A collaboration among Dr. Frank Greenway of Pennington Biomedical Research Center, Dr. Beverly Ogden of Woman’s Hospital in partnership with LSU, and the University of Louisiana at Lafayette, was named as one of three award recipients at the Baton Rouge Health-Tech Catalyst Pitch Night. The team will investigate non-invasive treatment of uterine fibroids, or benign growths, such as leiomyomas or myomas, that development from the muscle tissue of the uterus. “Fibroids are non-cancerous tumors in the wall of the uterus that are common, and can cause bleeding, pain, and infertility,” ...

East Hanover, NJ – June 2, 2023 – In a sharp reversal, employment indicators rebounded for people with disabilities in May, according to today’s National Trends in Disability Employment – semi-monthly update (nTIDE), issued by Kessler Foundation and the University of New Hampshire’s Institute on Disability (UNH-IOD). Employment appears to be remaining strong despite the threats to the labor market posed by the debt ceiling crisis and ongoing efforts to control inflation. Month-to-Month nTIDE Numbers (comparing April 2023 to May 2023) Based ...

DETROIT – The American Tinnitus Association (ATA) has elected Jinsheng Zhang, Ph.D., professor and chair of the Department of Communication Sciences and Disorders in Wayne State University’s College of Liberal Arts and Sciences, as the new chair of its board of directors. With decades of experience in tinnitus research and work with the ATA, Zhang aims to assist with proactive recruitment of scientists to the field of tinnitus and engage more researchers in ATA grant opportunities that will spur progress toward more effective treatments and cures. Tinnitus ...

The American College of Cardiology will host the annual Care of the Athletic Heart course on June 8-10, 2023, in Washington, including poster abstracts and educational sessions. The course is designed for all clinicians who provide cardiovascular care for the professional, occupational, tactical or recreational athlete. As the athletic population expands to all demographic groups, it is critical that there is a larger contingent of clinicians who understand the latest care and practice management for athletes at every level. Dermot Phelan, BAO, MBBCh, PhD, FACC, and Megan Wasfy, ...

In a phase 2 clinical trial of the immune checkpoint inhibitor pembrolizumab, investigators found that 42 percent of patients with metastatic brain cancer benefited from the therapy, with seven patients in the trial surviving longer than two years. The authors caution that these benefits must be weighed against risk of toxicity, but, overall, the study shows promising results that warrant larger studies and efforts to identify patients most likely to benefit from this treatment. Their findings are published in Nature Medicine and presented simultaneously at the 2023 ASCO Annual Meeting on June 2. “There ...