Dynamic DNA structures and the formation of memory
An international collaborative research team, including scientists from UQ’s Queensland Brain Institute (QBI), has discovered a novel mechanism underlying memory involving rapid changes in a specific DNA structure.
The team found that G-quadraplex DNA (G4-DNA) accumulates in neurons and dynamically controls the activation and repression of genes underlying long-term memory formation.
In addition, using advanced CRISPR-based gene editing technology, the team revealed the causal mechanism underlying the regulation ...













