R. Graham Cooks, the Henry B. Hass Distinguished Professor of Chemistry, and his postdoctoral researcher Lingqi Qiu have experimental evidence that the key step in protein formation can occur in droplets of pure water, and have recently published these findings in the Proceedings of the National Academy of Sciences (PNAS). In this key step, amino acids are dehydrated (they lose water) even though they are in a water solution, a paradox that is resolved by the fact that these droplet surfaces are unusually dry and highly ...

Like humans, mice live in complex social groups, fight over territory and mates, and learn when it is safer to avoid certain opponents. After losing even a brief fight, the defeated animals will flee from the mice that hurt them for weeks afterward, a new study shows. Led by researchers at NYU Grossman School of Medicine, the study reveals that such “retreating behavior” is influenced by a distinct area on the underside of the hypothalamus, a part of the brain that controls hunger, sleep, and levels of many hormones. The team had previously found that this special region, called the anterior ventrolateral part of the ventromedial hypothalamus (aVMHvl), ...

Bacterial infections cause millions of deaths each year, with the global threat made worse by the increasing resistance of the microbes to antibiotic treatments. This is due in part to the ability of bacteria to switch genes on and off as they sense environmental changes, including the presence of drugs. Such switching is accomplished through transcription, which converts the DNA in genes into its chemical cousin in mRNA, which guides the building of proteins that make up the microbe’s structure. For this ...

Cryptocurrency is usually “mined” through the blockchain by asking a computer to perform a complicated mathematical problem in exchange for tokens of cryptocurrency. But in research appearing in the journal Chem on January 24, a team of chemists have repurposed this process, asking computers to instead generate the largest network ever created of chemical reactions which may have given rise to prebiotic molecules on early Earth. This work indicates that at least some primitive forms of metabolism might have emerged without the involvement of ...

About The Study: This survey study found a reduced rate of overall fractures but an excess of vertebral fractures among living kidney donors compared with controls after a mean follow-up of 25 years. Treatment of excess vertebral fractures with dietary supplements such as vitamin D3 may reduce the numbers of vertebral fractures and patient morbidity. Authors: Rajiv Kumar, M.B.B.S., of the Mayo Clinic in Rochester, Minnesota, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2023.53005) Editor’s ...

About The Study: In this study of 4,360 patients with traumatic brain injury (TBI), functional limitations six months after injury were common after sports-related TBI, even mild sports-related TBI. Persisting impairment was evident in the sports-related TBI group despite better recovery compared with non–sports-related TBI on measures of mental health and post-concussion symptoms. These findings caution against taking an overoptimistic view of outcomes after sports-related TBI, even if the initial injury appears mild. Authors: Lindsay Wilson, ...

Researchers at the Universities of Basel and Zurich have discovered the genetic material of the pathogen Treponema pallidum in the bones of people who died in Brazil 2,000 years ago. This is the oldest verified discovery of this pathogen thus far, and it proves that humans were suffering from diseases akin to syphilis – known as treponematoses – long before Columbus’s discovery of America. The new findings, published in the scientific journal Nature, call into question previous theories concerning the spread of syphilis ...

(Santa Barbara, Calif.) — Groundwater is rapidly declining across the globe, often at accelerating rates. Writing in the journal Nature, UC Santa Barbara researchers present the largest assessment of groundwater levels around the world, spanning nearly 1,700 aquifers. In addition to raising the alarm over declining water resources, the work offers instructive examples of where things are going well, and how groundwater depletion can be solved. The study is a boon for scientists, policy makers and resource managers working to understand global groundwater dynamics. “This study was driven by curiosity. We wanted to better understand the state of global ...

DALLAS, Jan. 24, 2024 — In an effort to identify effective food is medicine approaches for incorporating healthy food into health care delivery, the American Heart Association, the world’s leading voluntary organization focused on heart and brain health research, now celebrating 100 years of lifesaving work, today announced grants totaling $7.8 million to 19 research projects nationwide as part of its Health Care by Food™ initiative. The research projects focus on areas including food resource coaching for patients of a safety-net clinic, delivering food is medicine interventions ...

The Krantz Family Center for Cancer Research at the Mass General Cancer Center today announced the selection of 17 scientists who have been awarded a combined $6 million in funding. These competitive awards, which will be granted annually, were established to recognize the trailblazing efforts of Krantz Center scientists and accelerate ideas, projects and initiatives with the potential to fundamentally change how cancer is diagnosed and treated.     Philanthropists Jason and Keely Krantz, who ...

Despite strict EU regulations on plastic recycling, there is little oversight on plastic waste shipped from the EU to Vietnam. A large percentage of the exported European plastic cannot be recycled and gets dumped in nature. That is what new research led by Utrecht University’s Kaustubh Thapa has found. Following the recycling path About half of Europe’s plastic waste is exported to a number of countries in the Global South, including Vietnam. A Dutch and Vietnamese research team ventured to Minh Khai Craft Village, the largest recycling hub ...

Cincinnati Children’s continues to be a cradle for great discoveries. Our latest Research Annual Report, online now, recounts a remarkable year of scientific advancement supported by a record-high level of research funding from federal, state, industry and philanthropic sources. Among the many accomplishments from more than 1,000 faculty working in 50 research areas: Promising results from the world’s first clinical trial of FLASH proton therapy for cancer treatment Developing the first intestine organoids with functional immune cells, a major step closer to testing potential treatments using these amazing lab-grown tissues Completing ...

The American Meteorological Society continuously publishes research on climate, weather, and water in its 12 journals. Many of these articles are available for early online access–they are peer-reviewed, but not yet in their final published form. Below is a selection of articles published early online recently. To view full article text, members of the media can contact kpflaumer@ametsoc.org for press login credentials. Searching for the Most Extreme Temperature Events in Recent History Bulletin ...

Researchers have developed a way to use ultrasound to predict whether a pregnant person is at risk of delivering a baby prematurely, which occurs in upward of 10% of pregnancies in the U.S. The new method — the result of more than 20 years of collaboration between researchers in nursing and engineering at University of Illinois Chicago and University of Illinois Urbana-Champaign — measures microstructural changes in a woman’s cervix using quantitative ultrasound. The ultrasound method works as early as 23 weeks into a pregnancy, according to the research, which is published in ...

(SACRAMENTO, Calif.) — In the largest study of its kind, researchers at UC Davis Health found that exposure to organophosphate ester flame retardants during pregnancy was associated with preterm birth, especially among females. The chemicals were also linked to higher birth weight, a concern for increased obesity risk. The major new research study was published in Environmental Health Perspectives. “The importance of this study lies in unraveling the potential impact of exposure to environmental chemicals during pregnancy on fetal development. Our findings guide our understanding of how these chemicals may be silently seeding lasting challenges ...

The human immune system is constantly fending off a wide range of invaders – a feat that requires a diverse array of cellular troops and molecular weaponry. Although a great deal is already known about immune defense cells and the strategies they employ, many molecular details have remained elusive. Now a research team led by Professor Oliver Daumke, a lab head at the Max Delbrück Center, has managed to unravel the main activation mechanism of GBP1, a protein that plays a pivotal role in combating certain bacteria. They report in “The EMBO ...

A groundbreaking technology with immense potential in treating ischemic retinopathy in premature infants and diabetic patients has been developed by Professor Byoung Heon Kang and his research team in the Department of Biological Sciences at UNIST, in collaboration with Professor Dong Ho Park’s team at Kyungpook National University Hospital. Ischemic retinopathy, characterized by the breakdown of the blood-retinal barrier and abnormal blood vessel growth, often leads to vision impairment and loss. The researchers have identified the critical role of a mitochondrial ...

The death rate for patients with functional, nonepileptic seizures is higher than expected, with a rate comparable to epilepsy and severe mental illness, a Michigan Medicine-led study finds.  A team of researchers reviewed data from 700 patients who were diagnosed with functional seizures, also called psychogenic or nonepileptic seizures, between 2014 and mid-2023 and followed for a median of 15 months.  It is the largest study of its kind in the United States, matching international studies in Australia, Denmark, Sweden and the United Kingdom, all of which have nationalized health care systems.  Of the 700 patients with functional ...

The Kavli Foundation and the U.S. National Science Foundation (NSF) Directorate for Biological Sciences' Division for Integrative Organismal Systems have joined forces to launch a grant program in neurobiology and changing ecosystems. Research in this emerging field has great potential to reveal novel scientific insights that will accelerate understanding of basic biology in neural adaptation and resilience at the molecular, biophysical, cellular, and circuit levels.  “NSF’s partnership with The Kavli Foundation will enable the U.S. to advance research in this emerging and understudied field,” remarked Denise Dearing, Division ...

A new mobile phone-based facial recognition application for dogs has the potential to significantly improve rabies vaccination efforts in endemic areas like Africa and Asia, according to a study on the research published in the journal Scientific Reports. Led by researchers at Washington State University, a team used the app to test its effectiveness at a rabies vaccination clinic in rural Tanzania where they microchipped, vaccinated and registered dogs. The technology proved remarkably accurate during a subsequent visit to surrounding villages once poor images and improperly recorded ...

Reactive oxygen species (ROS) are highly reactive molecules containing oxygen. These compounds, which are normal byproducts of biological processes in all living organisms such as aerobic respiration as well as photosynthesis, are highly toxic. In most cases, ROS damage cellular machinery and can trigger a harmful stress response if their levels are not kept in tight check; this is why antioxidants are an important part of our diet.   However, over the past few decades, scientists have discovered that ROS are often intentionally ...

HOUSTON – (Jan. 24, 2023) – Rice University researchers in the lab of chemist Han Xiao have identified a promising new immunological pathway to treat stubborn bone tumors, one of most prevalent forms of metastases in breast cancer patients. “More than 70% of people with metastatic breast cancer will see the cancer cells move to bone, which can lead to skeletal-related events like bone pain, fractures, and hypercalcemia,” said Yixian Wang, a Rice graduate student in the Han lab who is a lead author on a study published in Proceedings of the National Academy of Sciences. ...

The fountain of youth has eluded explorers for ages. It turns out the magic anti-aging elixir might have been inside us all along. Cold Spring Harbor Laboratory (CSHL) Assistant Professor Corina Amor Vegas and colleagues have discovered that T cells can be reprogrammed to fight aging, so to speak. Given the right set of genetic modifications, these white blood cells can attack another group of cells known as senescent cells. These cells are thought to be responsible for many of the diseases we grapple with later in life. Senescent cells are those that stop replicating. As we age, they build up in our bodies, ...

New UCLA-led research finds that infants born full term to mothers who were infected with COVID-19 during pregnancy had three times the risk of having respiratory distress compared with unexposed infants, even though they themselves were not infected with the virus. The risk was significantly lower when the mothers infected during pregnancy were previously vaccinated. The researchers found that in-utero exposure to SARS-CoV-2 sparked an “inflammatory cascade” in the infants, increasing the risk of a breathing disorder that most often ...

Highlights: More than half (51%) of respondents in a 2023 Harris Poll survey conducted on behalf of the American Heart Association did not identify heart disease as the leading cause of death in the U.S. According to the 2024 Heart Disease and Stroke Statistics: A Report of U.S. and Global Data From the American Heart Association, heart disease has been the leading cause of death in the U.S. for 100 years. Heart disease along with stroke, which is the fifth leading cause of death, claimed more lives ...