May 8, 2024—(BRONX, NY)—Researchers at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors—an advance that could transform cancer treatment. The promising findings, reported today in Science Advances, involve CAR-T cell therapy, which supercharges the immune system to identify and attack cancer cells. “CAR-T cell therapy has revolutionized ...

The American College of Cardiology (ACC) and the American Heart Association (AHA) today released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM). The guideline reiterates the importance of collaborative decision-making with patients who have HCM and provides updated recommendations for the most effective treatment pathways for adult and pediatric patients. HCM is an inherited cardiac condition most often caused by a gene mutation that makes the heart muscle too thick (hypertrophy), which impairs its ability to adequately pump blood throughout ...

When scientists look for an earthquake’s cause, their search often starts underground. As centuries of seismic studies have made clear, it’s the collision of tectonic plates and the movement of subsurface faults and fissures that primarily trigger a temblor.  But MIT scientists have now found that certain weather events may also play a role in setting off some quakes.  In a study appearing today in Science Advances, the researchers report that episodes of heavy snowfall and rain likely contributed to ...

New USC research shows that iron serves as a gas pedal driving certain immune cells that cause inflammation in the lungs during an allergic asthma attack – and blocking or limiting iron may reduce the severity of symptoms. During an attack, immune cells known as group 2 innate lymphoid cells (ILC2s) can become overactive, causing excessive inflammation and a tightening of the airways, making it difficult to breath. However, the underlying biology is poorly understood. Now, researchers from the Keck School ...

Type 1 diabetes is an autoimmune disease that leads to disrupted glucose metabolism. It requires lifelong insulin therapy. The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) collaborates within a European network to develop new methods to prevent this condition which is, to date incurable. AVAnT1A is GPPAD's third intervention study. It will investigate whether vaccination against SARS-CoV-2 in the first year of life can protect children who have an increased genetic risk for type 1 diabetes from developing the condition. The study is supported by funding from The Leona M. and Harry B. Helmsley ...

Another ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) treatment trial is open as part of the ComboMATCH precision medicine study platform. ComboMATCH-E5 is evaluating treatment for patients with KRAS G12C-mutated advanced solid tumors with two different targeted drugs given together. The two drugs include the KRAS G12C inhibitor sotorasib and panitumumab, a human monoclonal antibody antagonist specific to the epidermal growth factor receptor (EGFR). Each drug is approved by the US Food and Drug Administration (FDA) as single-agent therapy for particular cancer types.    "Given the preclinical data demonstrating EGFR over-dependency ...

Poultry production and processing is a $10 billion industry in Tennessee, with more investment expected. To support the future of the industry, the University of Tennessee Institute of Agriculture is investing in the construction of a state-of-the-art, next generation poultry research and education facility at its Middle Tennessee AgResearch and Education Center in Spring Hill. On Thursday, May 2, nearly 100 state and local officials and members of the poultry production and processing industry joined university officials to celebrate the official groundbreaking for the new project. Four commercial-size (54’ ...

Lugano, Switzerland, 8 May 2024 – ESMO Breast Cancer 2024 will be held in Berlin, Germany, between 15-17 May where the latest research in breast cancer will be presented. Participants from all over the world are expected to come to Berlin to listen to renowned experts presenting key innovative areas – including new agents, molecular and functional diagnostics, biomarkers and cutting-edge research applications – and providing perspectives on how transformative new data can find a clear path to the clinic.   The congress can be attended in person and online.  The scientific programme is ...

Each year, the American Association for the Advancement of Science elects distinguished scientists, engineers and innovators to become AAAS Fellows. Seven faculty members from the University of Tennessee, Knoxville, were awarded this lifetime honor as members of the recently announced 2023 class of AAAS Fellows. Elected faculty are Rigoberto Advincula, Takeshi Egami, Heidi Goodrich-Blair, Sergei Kalinin, Keith Kline, Anthony Mezzacappa and Michela Taufer. They represent a wide range of disciplines across the College of Arts and Sciences, the UT Institute of Agriculture and the Tickle College of Engineering. They join a distinguished group of UT faculty who have been elected AAAS ...

New research shows human activity is significantly altering the ways in which marine organisms are preserved, with lasting effects that can both improve and impair the fossil record.   “We are not only changing the environment; we’re also changing the nature of the record that archives this information,” said Michal Kowalewski, the Thompson chair of invertebrate paleontology at the Florida Museum of Natural History. “These changes can be both good and bad. On one hand, human activities ...

WASHINGTON, D.C. - Today, the U.S. Department of Energy (DOE) announced $160 million to advance President Biden’s vision to secure the future of American leadership in semiconductor innovation by implementing a key provision in the historic CHIPS and Science Act of 2022 (42 U.S.C. §19331), Microelectronics Research for Energy Innovation. This funding will support the formation of Microelectronics Science Research Centers (MSRCs) focused on energy efficiency and extreme environments. For ...

  INRS professor recognized for international research and mentoring efforts in nanotechnology.     Federico Rosei, a professor at the Institut national de la recherche scientifique (INRS) in materials science and nanotechnology, has been appointed Materials Research Society (MRS) Fellow 2024 for “his leadership in the nanomaterials synthesis and characterization and his sustained international efforts in service, mentoring and outreach in the field.” He thus becomes the first researcher in Quebec and the third ...

Boronic acid has been used in organic chemistry for decades, even though it is not present in any organism. ‘It gives rise to different chemical reactions than those we find in nature,’ explains Gerard Roelfes, Professor of Biomolecular Chemistry & Catalysis at the University of Groningen. His group created an enzyme with boronic acid at its reactive centre and then used directed evolution to make it more selective and to improve its catalytic power. Furthermore, enzymatic reactions are more sustainable than classical chemical reactions, as they take place at low temperatures and without toxic solvents. The study was presented online in the journal ...

Local decision-makers looking for ways to reduce the impact of heat waves on their communities have a valuable new capability at their disposal: a new study on vegetation resilience. Scientists at the Department of Energy’s Oak Ridge National Laboratory completed a study of how well vegetation survived extreme heat events in both urban and rural communities across the country in recent years. The analysis informs pathways for climate mitigation, including ways to reduce the effect of urban heat islands. Vegetation such as trees provide a valuable cooling effect, shading surfaces and deflecting solar radiation while releasing ...

CHICAGO – The American College of Surgeons (ACS) Clinical Congress 2024 will take place Saturday, October 19, through Tuesday, October 22, in San Francisco and will feature opportunities for members of the media to learn about the latest evidence-based practices and research in surgery and healthcare.   This year’s Clinical Congress will once again be a hybrid event, allowing reporters to cover the conference onsite or virtually.  Clinical Congress is one of the world’s largest educational meetings for surgeons, ...

Janelia Senior Group Leader Gerry Rubin and Cori Bargmann of The Rockefeller University have been jointly awarded the 2024 Gruber Neuroscience Prize for their pioneering work in elucidating the organization of neural circuits in behavior and developing new genetic tools to advance the field of neuroscience. The Gruber Neuroscience Prize, established in 2004, honors scientists for major discoveries that have advanced the understanding of the nervous system. The prize is part of the Gruber International Prize Program, hosted by the Gruber Foundation, which honors individuals in the fields of ...

Pore pressure diffusion generated by carbon dioxide injected underground at a carbon storage site in the Illinois Basin is the likely cause of hundreds of microearthquakes that took place at the site between 2011 and 2012, according to a new analysis. The modeling study published in the Bulletin of the Seismological Society of America indicates that pressure diffusion along existing faults into the basement rock could have destabilized the faults where the microseismicity—ranging from Mw -2 to 1—occurred, said Ruben Juanes of MIT and colleagues. There are some similarities between CO2 injection and wastewater injection from oil and gas operations, although globally the ...

ITHACA, N.Y. – Conversational agents (CAs) such as Alexa and Siri are designed to answer questions, offer suggestions – and even display empathy. However, new research finds they do poorly compared to humans when interpreting and exploring a user’s experience. CAs are powered by large language models (LLMs) that ingest massive amounts of human-produced data, and thus can be prone to the same biases as the humans from which the information comes. Researchers from Cornell University, Olin College and Stanford University tested this theory ...

Researchers using NASA’s James Webb Space Telescope may have detected atmospheric gases surrounding 55 Cancri e, a hot rocky exoplanet 41 light-years from Earth. This is the best evidence to date for the existence of any rocky planet atmosphere outside our solar system.  Renyu Hu from NASA’s Jet Propulsion Laboratory (JPL) in Pasadena, California, is lead author on a paper published today in Nature. “Webb is pushing the frontiers of exoplanet characterization to rocky planets,” Hu said. “It is truly ...

New research from a multi-disciplinary team at Trinity College Dublin suggests a “tailored vaccine” might hold the key to treating bacteria-driven flares of eczema in children.  The team has taken several leaps forward in understanding how the immune response works in cases of eczema driven by the common, troublesome Staphylococcus aureus bacterium, and in doing so they have identified new cellular targets for a vaccine. Eczema, also known as atopic dermatitis, affects up to one in four children in Ireland. Common symptoms include itchy, dry skin, and – when bacteria are involved – weeping wounds that can ...

HOUSTON ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson offer insights into expanding the use of FGFR inhibitors, maintaining radiation therapy as standard of care for locally recurrent endometrial cancer, an antibody-drug ...

In daily life, when two objects are “indistinguishable,” it’s due to an imperfect state of knowledge. As a street magician scrambles the cups and balls, you could, in principle, keep track of which ball is which as they are passed between the cups. However, at the smallest scales in nature, even the magician cannot tell one ball from another. True indistinguishability of this type can fundamentally alter how the balls behave. For example, in a classic experiment by Hong, Ou and Mandel, two identical photons (balls) striking opposite sides of a half-reflective mirror are always ...

Researchers in the emerging field of spatial computing have developed a prototype augmented reality headset that uses holographic imaging to overlay full-color, 3D moving images on the lenses of what would appear to be an ordinary pair of glasses. Unlike the bulky headsets of present-day augmented reality systems, the new approach delivers a visually satisfying 3D viewing experience in a compact, comfortable, and attractive form factor suitable for all-day wear. “Our headset appears to the outside world just like an everyday pair of glasses, but what the wearer sees through the lenses is an enriched world overlaid with vibrant, full-color 3D computed imagery,” said Gordon ...

About The Study: More than 320,000 children in the U.S. lost a parent to drug overdose between 2011-2021, with significant disparities evident across racial and ethnic groups. Given the potential short- and long-term negative impact of parental loss, program and policy planning should ensure that responses to the overdose crisis account for the full burden of drug overdose on families and children, including addressing the economic, social, educational, and health care needs of children who have lost parents to overdose.  Corresponding Author: To contact the ...

About The Study: The findings of this study suggest that there is a high prevalence of harassment in OB-GYN despite being a predominantly female field for the last decade.  Corresponding Author: To contact the corresponding author, Ankita Gupta, M.D., M.P.H., email ankita.gupta@louisville.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2024.10706) Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, ...