Mice with a defected human gene responsible for a rare genetic disease, called congenital adrenal hyperplasia, have been developed for the first time. The achievement, presented at the 25th European Congress of Endocrinology, may help to develop new therapies for people with the most common type of congenital adrenal hyperplasia. Congenital adrenal hyperplasia (CAH) is a group of inherited conditions, which affects about 1 in 15,000 births. In the most common form, called 21-hydroxylase deficiency, mutations in the CYP21A2 gene cause the adrenal glands ...

Carbon dioxide (CO2) is a major greenhouse gas emitted through various types of human activities. In an effort to decrease humanity’s carbon footprint, scientists and policymakers across the globe are continuously trying to explore new methods for reducing atmospheric CO2 emissions and converting them into useful forms. In this regard, the electrochemical method of reducing CO­2 to other carbonaceous forms like carbon monoxide, alcohols and hydrocarbon has gained considerable attention. Against this ...

Hot flashes, night sweats and sleep disturbances are common symptoms of menopause that can affect health, quality of life and work productivity. A new review published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.221438 recommends menopausal hormone therapy, historically known as hormone replacement therapy (HRT), as first-line treatment in people without risk factors. Menopausal symptoms may occur up to 10 years before the last menstrual period and can last more than 10 years, with negative effects for many people. "Menopause and perimenopause can be associated with distressing ...

Engineers at the University of Waterloo have discovered a new way to program robots to help people with dementia locate medicine, glasses, phones and other objects they need but have lost.  And while the initial focus is on assisting a specific group of people, the technology could someday be used by anyone who has searched high and low for something they’ve misplaced. “The long-term impact of this is really exciting,” said Dr. Ali Ayub, a post-doctoral fellow in electrical and computer engineering. “A user can be involved not just with a companion robot but a personalized ...

**Note: the release below is a special early release from the European Congress on Obesity (ECO, Dublin, 17-20 May). Please credit the conference if you use this story** New research to be presented at this coming week’s European Congress on Obesity in Dublin, Ireland (17-20 May) and published in the Journal of the National Cancer Institute shows that both the metabolically healthy and unhealthy ‘forms’ of obesity are associated with an increased risk of various obesity-related cancers, with the relationship stronger in metabolically unhealthy obesity. The study is by Dr Ming Sun, Lund University, Malmö, ...

The hormone oxytocin is important for social interaction and to control emotions. A deficiency of this hormone has previously been assumed in various diseases such as autism, but has never been proven. Now, for the first time, researchers from the University of Basel and the University Hospital of Basel have succeeded in demonstrating a deficiency of oxytocin in patients with a deficiency of vasopressin caused by a disease of the pituitary gland. This finding could be key to developing new therapeutic approaches. The hormones oxytocin and vasopressin are produced in the same area of the brain ...

Nearly 2 percent of the U.S. population reported cocaine use in 2020, and the highly addictive substance was involved in nearly one in five overdose deaths, according to the Centers for Disease Control.  In Virginia, the number of cocaine-related overdoses has been increasing since 2013, with 968 fatal overdoses in 2022, according to preliminary data from the Virginia Department of Health, a 20 percent increase over 2021. Of those, four in five included fentanyl — prescription, illicit or analog — a driving force behind the fatalities. Researchers at the ...

In a recently published commentary, UK HealthCare physicians call for standard-of-care treatment for opioid use disorder (OUD) among patients who are incarcerated. The viewpoint article by Anna-Maria South, M.D., Laura Fanucchi, M.D., and Michelle Lofwall, M.D., published in JAMA April 24 highlights the barriers to initiating medication for opioid use disorder (MOUD) among people who are incarcerated. For patients with opioid use disorder, medications such as buprenorphine and methadone are considered by the medical community as standard of care treatments, as they alleviate withdrawal symptoms, reduce cravings and pain, ...

The COVID-19 pandemic exacerbated fear of childbirth among pregnant people in the U.S., according to a new Dartmouth study. The researchers were particularly interested in understanding, from a U.S. context, which factors predict childbirth fear and how the pandemic has affected this fear and birth outcomes. The findings are published in Evolution, Medicine, and Public Health. "Our results showed really high rates of childbirth fear in our sample," says first author Zaneta Thayer '08, an associate professor of anthropology at Dartmouth. "Since there's no pre-pandemic U.S. data, we cannot compare our data to that context but we know that ...

A team of neuroscientists at the Medical University of South Carolina (MUSC) has identified changes in the activity of brain cells known as pyramidal neurons, which contribute to drug seeking in a preclinical model of opioid use disorder. After access to heroin was stopped, these neurons became more excitable. The activity of these neurons was restored to normal by blocking the enzyme protein kinase A (PKA). Inhibiting this enzyme also reduced opioid-seeking behavior. Jacqueline McGinty, Ph.D., professor of neuroscience, and Saurabh Kokane, Ph.D., a postdoctoral scholar in McGinty’s laboratory, recently published their team’s findings in the Journal of Neuroscience. The risk ...

High levels of the stress hormone cortisol during the third trimester of pregnancy may improve speech and language skills in the first 3 years of a child’s life, according to research presented at the 25th European Congress of Endocrinology in Istanbul. The findings help researchers further understand the role cortisol plays in both fetal and child development. Language development during early childhood can indicate how well a baby’s nervous system was developed in the womb. Prenatal exposure to cortisol – a steroid hormone that helps the body respond to ...

Anabolic steroids not only can cause serious side effects during use, such as heart failure and depression, but can continue being harmful years after stopping, according to two studies presented at the 25th European Congress of Endocrinology in Istanbul. These studies, supported by the Novo Nordisk Foundation, were carried out by researchers from the Copenhagen University Hospital Rigshospitalet who investigated the impact of anabolic steroids in former users. Anabolic steroids – synthetic hormones ...

Long COVID risk has been found to increase with low levels of vitamin D, according to research presented at the 25th European Congress of Endocrinology in Istanbul. The findings suggest that individuals should have their vitamin D levels checked after COVID-19. Also known as post COVID-19 syndrome, long COVID is a new condition in which the effects of COVID-19 last for more than 12 weeks after contracting the initial infection. Studies have shown that it affects 50-70% of patients previously hospitalised for COVID-19, yet very little is known about the condition. One risk factor for worse outcomes for hospitalised COVID-19 patients, such as intubation and mechanical ventilation ...

May 12, 2023 — Accelerated schedules for repetitive transcranial magnetic stimulation (rTMS) can be offered to patients experiencing treatment-resistant major depressive disorder (MDD), a group of clinician–researchers and neuroscientists have concluded. The group cautions that such treatment should be proposed only after detailed discussion with patients about acceleration being an alternate form of rTMS scheduling, with documentation of informed consent. The recommendations are published in a ...

Reston, VA—A newly published meta-analysis indicates that amino acid PET can accurately differentiate recurrent or progressive brain metastases from treatment-related changes. A specificity of 84 percent suggests that it may reduce the number of invasive procedures and overtreatment in patients who in fact experience treatment-related changes. This research was published in the May issue of The Journal of Nuclear Medicine. Brain metastases occur in 20 to 40 percent of all cancer patients and are most likely ...

Key takeaways Researchers studied the way different generations in Romania determined the truth of information following the country’s transition from authoritarianism to democracy. Those who were born and raised after the transition were more likely than older cohorts to compare and evaluate different perspectives before deciding who is right. The factors associated with the youngest generation’s style of thinking were greater exposure to formal education and social media.​​​​​ While people change and learn throughout life, experts recognize ...

NEW YORK – May 12, 2023 – The Cardiovascular Research Foundation (CRF) announced that TVT: The Structural Heart Summit will feature 15 Late-Breaking Clinical Science studies. An annual meeting featuring cutting-edge research and techniques for structural heart interventions, TVT will take place June 7-10, 2023, at the Phoenix Convention Center – West in Phoenix, Arizona. TVT has become the epicenter of innovation and collaboration in the structural heart arena over its 16-year history. The meeting brings together world-renowned experts and master operators to help translate novel discoveries into practical therapies for patients with valvular heart disease. TVT’s ...

Misael Cabrera has been selected through a nationwide search as the inaugural director of the School of Mining and Mineral Resources. The school was created in 2021 and is jointly housed in the College of Engineering and the College of Science, with strong partnerships to additional colleges and centers. “Our role is to deliver talent and technology through research, but also to change the top-of-mind association with mining. We can create real solutions that both industry and our planet need,” said Cabrera. Cabrera, who began the position in April, most ...

The spread of drug-resistant microbes has become a global health concern that threatens our ability to treat infections. The widespread use of antimicrobials in livestock, such as swine farms, exacerbates this problem. Therefore, we need surveillance systems to monitor these microbes to support the public health authorities. To this end, researchers have tracked the antimicrobial resistance of Escherichia coli isolated from swine. Antimicrobials are essential for preventing and treating infections in humans and animals. According to the US Food and Drug Administration, 70% of all antibiotic ...

In the context of increasing energy demands and environmental concerns, renewable energy solutions are crucial for achieving net-zero emissions by 2050. Microbial electrochemical technologies, such as SMFCs, are cost-effective and environmentally friendly, making them an attractive option for green energy systems. SMFCs utilize endogenous microorganisms present in soil to convert organic matter into electricity, offering a sustainable energy source and a self-powered in situ bioremediation strategy for contaminated soils. Cathode materials play a significant role in the performance of microbial fuel cells. In this study, researchers compared the performance ...

Ruminants like cows have developed an unusual way of digesting their food: they ingest plants, give them a rough chewing and then swallow the half-chewed mash before regurgitating it repeatedly and continuing to chew. This has clear advantages, as a research team including the University of Göttingen has shown: the regurgitated mushy food contains much less hard grit, sand and dust than the food that they first ingested. This protects the teeth from being ground down during the chewing process. This ...

“We recently unveiled a new interesting role for SASP: its ability to induce neuroendocrine transdifferentiation (NED) in breast cancer epithelial cells [3].” BUFFALO, NY- May 12, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, “The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation.” In this editorial, researchers Anda Huna, Nadine Martin and David Bernard from the Université de Lyon discuss the senescence-associated secretory phenotype (SASP). SASP, ...

Larry Steckel, row crop weed specialist and professor in the Department of Plant Sciences at the University of Tennessee Institute of Agriculture, has been named a Fellow of the Southern Weed Science Society (SWSS).  The award was given to honor Steckel’s years of research and contributions to weed prevention in row crop agriculture. Steckel was among only a small group of esteemed researchers to receive the honor, presented to him during the annual meeting of the SWSS. Steckel says he is proud to be named a Fellow, and that he knows the research and extension work conducted by weed specialists across the ...

Manufacturing and metrology considerations are key when designing with freeform optics Close communication between optics designers and manufacturers can help prevent problems Québec City, Canada -- Although optical components such as lenses are traditionally spherical in shape, freeform optical components, which have little to no symmetry around the optical axis, are becoming more common. Freeform optical components are attractive because they can be designed to behave in ways traditional optics cannot, offering optical design flexibility ...

A team of scientists from the Department of Energy’s Ames National Laboratory have developed a way to collect terahertz imaging data on materials under extreme magnetic and cryogenic conditions. They accomplished their work with a new scanning probe microscope. This microscope was recently developed at Ames Lab. The team used the ultralow temperature terahertz microscope to take measurements on superconductors and topological semimetals. These materials were were exposed to high magnetic fields and temperatures below liquid helium (below 4.2 ...