ABSTRACTS: CT016, CT018 ORLANDO, Fla. ― Researchers from The University of Texas MD Anderson Cancer Center presented promising findings from multiple clinical trials today at the American Association for Cancer Research (AACR) Annual Meeting 2023. The studies, which describe results from a novel FGFR inhibitor and from new PARP/ATR inhibitor combinations, were featured in a plenary session highlighting novel biomarker-driven molecularly targeted therapy trials. Information on all MD Anderson AACR Annual Meeting content can be found at MDAnderson.org/AACR. Basket trial results suggest wider population may benefit from FGFR inhibitor pemigatinib ...

BINGHAMTON, N.Y. -- A tiny biobattery that could still work after 100 years has been developed by researchers at Binghamton University, State University of New York. Last fall, Binghamton University Professor Seokheun “Sean” Choi and his Bioelectronics and Microsystems Laboratory published their research into an ingestible biobattery activated by the Ph factor of the human intestine.  Now, he and PhD student Maryam Rezaie have taken what they learned and incorporated it into new ideas for use outside the body. A new study in the journal Small, which covers nanotechnology, shares the results from using spore-forming bacteria similar ...

ITHACA, N.Y. – Youth in the U.S. are targets of cross-platform digital abuse from peers, strangers, offline acquaintances and even relatives, with threats ranging from harassment and sexual violence to financial fraud, according to a new study from Cornell University and Google researchers. Aided by firsthand accounts, researchers identified the need for more resources to educate youth and parents on digital abuse. They call for better communication and coordination among adult stakeholders in implementing sound protective practices. “We really need to take a closer look at the types of things that young people are experiencing online, because these experiences ...

    U.S. middle and high schools with the most students taking prescription stimulants to treat ADHD also had, overall, the highest percentage of students who misused prescription stimulants within the past year.   The University of Michigan-led study highlights a significant association between ADHD stimulant therapy in schools and prescription stimulant misuse, said Sean Esteban McCabe, U-M professor of nursing and principal investigator on the study.    At some schools, 25% or more of kids reported misusing prescription stimulants in the past year—meaning they used ...

Bottom Line: The U.S. Preventive Services Task Force (USPSTF) concludes that the current evidence is insufficient to assess the balance of benefits and harms of visual skin examination by a clinician to screen for skin cancer in adolescents and adults. Skin cancer is the most commonly diagnosed cancer in the U.S. There are different types of skin cancer varying in disease incidence and severity. Basal and squamous cell carcinomas are the most common types of skin cancer but infrequently lead to death or substantial morbidity. Melanomas represent about 1% of skin cancer and cause the most skin cancer deaths. The USPSTF routinely ...

About The Study: In this study of more than 600,000 individuals, SARS-CoV-2 infection was associated with a higher risk of diabetes and may have contributed to a 3% to 5% excess burden of diabetes at a population level. Authors: Naveed Z. Janjua M.B.B.S, Dr.P.H., of the British Columbia Centre for Disease Control in Vancouver, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi: 10.1001/jamanetworkopen.2023.8866) Editor’s Note: Please see the article for additional information, including other authors, author contributions ...

About The Study: In this survey study of 19,000 patients attending 49 abortion clinics in 29 states, considering self-managed abortion was common before accessing in-clinic care, particularly among those on the margins of access or with a preference for at-home care. These findings suggest a need for expanded access to telemedicine and other decentralized abortion care models. Authors: Abigail R. A. Aiken, Ph.D., of the University of Texas at Austin, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi: ...

Researchers have identified a strong association between prevalence of prescription stimulant therapy for attention-deficit/hyperactivity disorder (ADHD) and rates of prescription stimulant misuse (taken in a way other than as directed by a clinician) by students in middle and high schools. The study, which appeared today in JAMA Network Open, highlights the need for assessments and education in schools and communities to prevent medication-sharing among teens. This is especially important considering non-medical use of prescription stimulants among teens remains more prevalent than misuse ...

ATLANTA, April 18, 2023 – A new study by researchers at the American Cancer Society (ACS) shows almost three-quarters of a million more adults in the United States, ages 18-29 years, used e-cigarettes between 2019-2021 during the period that spanned the EVALI outbreak (E-cigarette or vaping product use–associated lung injury) and COVID-19 pandemic. Scientists report the year-on-year increase was primarily among adults who never smoked cigarettes. The study was published today in the American Journal of Preventive Medicine (AJPM). “Unfortunately, these numbers show we’re moving in the wrong direction concerning e-cigarette use in this vulnerable ...

Brand-name drugs cost two to three times more in the U.S. than in other countries, but many of the top-selling brand name drugs may provide little added therapeutic benefit. A new study led by researchers at Brigham and Women’s Hospital, a founding member of Mass General Brigham, used public Medicare data to identify the 50 highest-selling brand-name drugs in 2020. The researchers evaluated their therapeutic benefit compared to existing standards of care, based on ratings from the national health technology assessment (HTA) organizations of Canada, France, and Germany. The team found that 27 of the 50 drugs received ...

Stars that contain comparatively large amounts of heavy elements provide less favourable conditions for the emergence of complex life than metal-poor stars, as scientists from the Max Planck Institutes for Solar System Research and for Chemistry as well as from the University of Göttingen have now found. The team showed how the metallicity of a star is connected to the ability of its planets to surround themselves with a protective ozone layer. Crucial to this is the intensity of the ultraviolet light that the star emits into space, in different wavelength ranges. The study provides scientists searching ...

Supersolids are a relatively new and exciting area of research. They exhibit both solid and superfluid properties simultaneously. In 2019, three research groups were able to demonstrate this state for the first time beyond doubt in ultracold quantum gases, among them the research group led by Francesca Ferlaino from the Department of Experimental Physics at the University of Innsbruck and the ÖAW Institute for Quantum Optics and Quantum Information (IQOQI) in Innsbruck. In 2021, Francesca Ferlaino's team studied in detail the life cycle of supersolid states ...

University of School of Medicine researchers have identified a gene that plays a crucial role in determining our risk for heart attacks, deadly aneurysms, coronary artery disease and other dangerous vascular conditions. The discovery advances our understanding of the underlying causes of a wide range of serious health conditions, including atherosclerosis (hardening of the arteries), and moves us closer to new treatments and preventive measures that could help people live longer, healthier lives. “The first step towards translating the knowledge of population risk for vascular disease is disentangling the fundamental cellular ...

(WASHINGTON, DC, April 18, 2023) – Children with acute lymphoblastic leukemia (ALL) who live in extreme poverty and were undergoing maintenance therapy faced an almost two-fold greater risk of relapse compared with kids who weren’t as poor, according to a study published in today’s issue of Blood. Moreover, a higher proportion of these children had difficulty adhering to treatment, though researchers said this only partially explains the link between poverty and the risk of relapse. “ALL is a curable disease, so while we observed relatively few relapses in total, children living in extreme poverty – those whose families were really stretched thin and not able ...

Vitamin D deficiency could be the reason African American men experience more aggressive prostate cancer at a younger age compared with European American men, new research from Cedars-Sinai Cancer suggests. The multi-institutional study, published today in Cancer Research Communications, a journal of the American Association for Cancer Research (AACR), could pave the way for revised nutritional guidelines. While previous research has investigated vitamin D in the context of health disparities, this is the first study to look at its functions in a genome-wide manner in African American versus European American ...

New York, New York — The American Federation for Aging Research (AFAR) and Hevolution Foundation are pleased to announce the inaugural Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research recipients. Eighteen three-year awards of US $375,000 each have been granted to support research projects in basic biology of aging or geroscience — a research paradigm based on addressing the biology of ...

NEWPORT NEWS, VA – In a unique analysis of experimental data, nuclear physicists have made the first-ever observations of how lambda particles, so-called “strange matter,” are produced by a specific process called semi-inclusive deep inelastic scattering (SIDIS). What’s more, these data hint that the building blocks of protons, quarks and gluons, are capable of marching through the atomic nucleus in pairs called diquarks, at least part of the time. These results come from an experiment conducted at the U.S. Department of Energy’s Thomas Jefferson National Accelerator Facility. It’s a result that has been ...

INDIANAPOLIS – Serving on the front lines in the arduous battle against the coronavirus, emergency department (ED) physicians are among the true heroes of the pandemic, working long, stressful hours at great personal risk, especially in the many months before vaccines became available. A pilot study examining the feasibility, receptivity and preliminary effectiveness of peer-support groups for ED doctors during COVID-19 found this support provided potential benefit in terms of reduction of mental health stresses involved in emergency care during this time. The researchers assessed change in symptoms of distress, depression and burnout before and after participating ...

Public health messages that focus on protecting others are more effective at increasing vaccination rates than messages focused on protecting oneself, according to a study. Vaccine hesitancy is a challenge for public health workers and others concerned with reducing the deleterious effects of infectious diseases. Elizabeth Shanahan and colleagues tested three visual policy narrative messages promoting COVID-19 vaccination that emphasized protecting oneself, one’s circle of friends and family, or one’s community. A non-narrative control message simply urged participants to “get the vaccine” with an accompanying image of a syringe. ...

A research article by scientists at the Nanjing University of Aeronautics and Astronautics developed a neural control algorithm to coordinate the adhesive toes and limbs of the climbing robot. The new research article, published in the journal Cyborg and Bionic Systems, provided a novel hybrid-driven climbing robot and introduced a neural control method based on CPG (Central Pattern Generator) for coordinating between adhesion and motion.    “Currently, the movement speed and stability of climbing robots have not yet reached the level of biological organisms. Animals have flexible climbing abilities on various slopes and roughness, ...

Children with COVID-19 can be treated safely at home, helping to take the burden off the hospital system, according to a new study. The research, led by Murdoch Children’s Research Institute and published in Archives of Disease in Childhood, found COVID-positive children with moderate symptoms or pre-existing high-risk conditions could be treated effectively via a Hospital-in-the-Home (HITH) program. Additionally, many more sick children without COVID-19 were treated at home during the pandemic. Murdoch Children’s Dr Laila Ibrahim said the program took pressure off paediatric emergency departments ...

Weight regains is a common problem for weight loss individuals. A number of studies have shown that weight loss in overweight people results in a reduction in whole-body energy expenditure. This reduction in energy expenditure is disproportionate across tissues, known as energetic mismatch which primarily originates from lean tissue, thus increasing weight regain risk. Although this phenomenon has long been identified and has been suggested that weight loss may alter skeletal muscle mitochondrial respiration, the mechanisms ...

Ocean-based hydrophones in the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO)’s seismic-acoustic monitoring network could provide a better look at how ocean temperatures are changing over time, according to a presentation at the Seismological Society of America (SSA)’s 2023 Annual Meeting. Finding new ways to monitor ocean temperatures is important for determining rates of warming, sea level rise and climate-related ocean circulation patterns as average global temperatures continue to rise, the researchers said. Sound ...

In the wake of the 2020-2021 Southwest Puerto Rico earthquake sequence, researchers asked emergency responders and residents in affected communities about the information they needed to prepare for the next earthquake. Residents surveyed door to door and in focus groups said they wanted to know more about and have easier access to an aftershock forecast, along with information on potential tsunami risk, according to a presentation at the SSA 2023 Annual Meeting. Residents also wanted more information tailored specifically to their local area, said Jenniffer M. Santos-Hernández ...

Barcelona, Spain – 18 April 2023:  Patients with severe COVID-19 requiring mechanical ventilation are 16 times more likely to develop ventricular tachycardia within six months compared to their peers without severe infection, according to research presented at EHRA 2023, a scientific congress of the European Society of Cardiology (ESC).1 Risks of other heart rhythm disorders were also elevated.   “The actual likelihood of developing ventricular tachycardia or other arrhythmias after severe COVID-19 is low for the individual ...