Strokes cause numerous changes in gene activity in affected small blood vessels in the brain, and these changes are potentially targetable with existing or future drugs to mitigate brain injury or improve stroke recovery, according to a study led by Weill Cornell Medicine scientists. In the study, which appears Apr. 14 in the Proceedings of the National Academy of Sciences, the researchers performed a comprehensive survey, in a preclinical model, of gene activity changes in small blood vessels in the brain following stroke. Comparing these changes to those that have been recorded in stroke patients, they catalogued hundreds ...

Along their eight arms, octopuses have highly sensitive suckers that allow methodical explorations of the seafloor as they search for nourishment in a “taste by touch” approach. Squids, on the other hand, use a much different tactic to find their next meal: patiently hiding until they ambush their prey in swift bursts. In a unique analysis that provides a glimpse into the origin stories of new animal traits, a pair of research studies led by University of California San Diego and Harvard University scientists has traced the evolutionary adaptations of octopus and squid sensing capabilities. The studies, featured on ...

 In tropical regions of the planet, savannas and forests often coexist in the same area and are exposed to the same climate. An example is the Cerrado, a Brazilian biome that includes several types of vegetation, from broad-leaved and sclerophyllous in dense woodland or shrubland (cerrado sensu stricto) to semi-evergreen in closed-canopy forest (cerradão), as well as grassland with scattered shrubs (campo sujo) and even semi-deciduous seasonal forest.  Areas of cerradão develop in the absence of fire, in both poor and moderately fertile soil (dystrophic to mesotrophic). This coexistence intrigues botanists and ecologists ...

DETROIT – A researcher from Wayne State University’s Department of Biological Sciences has received a five-year, $1.95 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to identify mechanisms that regulate inositol synthesis in mammalian cells and determine the cellular consequences of inositol depletion. Inositol is a type of sugar that is essential for the viability of eukaryotic cells. Myo-inositol is the precursor of all inositol compounds, which play pivotal roles in cell signaling and metabolism. Consistent with its importance, a disturbance of inositol homeostasis ...

University of Cincinnati Cancer Center researchers will present more than a dozen abstracts at the American Association for Cancer Research Annual Meeting 2023, held in Orlando, Florida, April 14-19, including findings that could advance treatments for head and neck and breast cancers. Enzyme shows promise as target to treat HPV negative head and neck cancer  Vinita Takiar’s lab in UC’s Department of Radiation Oncology studies how to improve radiation therapy for head and neck cancer patients.   Julianna Korns, a doctoral student working in Takiar’s lab, and her colleagues study an enzyme called Plk1 that allows healthy cells to divide ...

Wind speed and direction provide clues for forecasting weather patterns. In fact, wind influences cloud formation by bringing water vapor together. Atmospheric scientists have now found a novel way of measuring wind – by developing an algorithm that uses data from water vapor movements. This could help predict extreme events like hurricanes and storms. A study published by University of Arizona researchers in the journal Geophysical Research Letters provides, for the first time, data on the vertical distribution of horizontal winds ...

Long obscured in the shadows of history, the world’s first nomadic empire - the Xiongnu - is at last coming into view thanks to painstaking archaeological excavations and new ancient DNA evidence. Arising on the Mongolian steppe 1,500 years before the Mongols, the Xiongnu empire grew to be one of Iron Age Asia’s most powerful political forces - ultimately stretching its reach and influence from Egypt to Rome to Imperial China. Economically grounded in animal husbandry and dairying, the Xiongnu were famously nomadic, building their empire on the backs of horses. ...

The 2022 eruption of a submarine volcano in Tonga was more powerful than the largest U.S. nuclear explosion, according to a new study led by scientists at the University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science and the Khaled bin Sultan Living Oceans Foundation.   The 15-megaton volcanic explosion from Hunga Tonga-Hunga Ha'apai, one of the largest natural explosions in more than a century, generated a mega-tsunami with waves up to 45-meters high (148 feet) along the coast of Tonga’s Tofua Island and waves up to 17 meters (56 feet) on Tongatapu, ...

UNIVERSITY PARK, Pa. — New research provides insight into how an enzyme that helps regulate aging and other metabolic processes accesses our genetic material to modulate gene expression within the cell. A team led by Penn State researchers have produced images of a sirtuin enzyme bound to a nucleosome—a tightly packed complex of DNA and proteins called histones—showing how the enzyme navigates the nucleosome complex to access both DNA and histone proteins and clarifying how it functions in humans and other animals.  A paper describing the results appears April 14 in the journal ...

Has potential to help geneticists investigate vital issues such as antibacterial resistance Will untangle the genetic components shared due to common ancestry from the ones shared due to evolution The work is result of a four-year international collaboration.     Aston University has worked with international partners to develop a software package to help scientists answer key questions about genetic factors associated with shared characteristics among different species. Called CALANGO (comparative analysis with annotation-based genomic ...

A new analysis of the carbon footprint of products used in the five most common surgical operations carried out in the NHS in England shows that 68% of carbon contributions come from single-use items, such as single-use gowns, patient drapes and instrument table drapes. Published by the Journal of the Royal Society of Medicine, the analysis highlights significant carbon contributors were the production of single use items and their waste disposal, together with processes for decontaminating reusable products. Researchers ...

ROCKVILLE, Md.—New research shows that several anti-obesity medications could be manufactured and profitability sold worldwide at far lower estimated lower prices compared to their high costs, according to a new study in Obesity, The Obesity Society’s (TOS) flagship journal. “Access to medicine is a fundamental element of the human right to health. While the obesity pandemic grows, especially amongst low-income communities, effective medical treatments remain inaccessible for millions in need. Our study highlights the inequality in pricing that exists for effective anti-obesity medications, ...

BOSTON – New research from Boston Medical Center concluded that offering medications to treat opioid addiction in jails and prisons leads to a decrease in overdose deaths. Published in JAMA Network Open, the study also found that treating opioid addiction during incarceration is cost-effective in terms of healthcare costs, incarceration costs, and deaths avoided. Overdoses kill more than 100,000 people per year in America and this number continues to increase every year. People with addiction are more likely to be incarcerated than treated, with those from communities of color who use drugs more likely to be incarcerated than ...

The objective of the Activity Group on Financial Mathematics and Engineering is to advance fundamental research and implementation of practices in financial engineering, computation, and operations. The group aims at fostering collaborations among applied mathematicians, applied probabilists, statisticians, computer and data scientists, economists, as well as industry practitioners. The conference will expose state-of-art mathematical and computational tools in quantitative finance, including its uses in the public and private sector. The activity group promotes and supports the development of financial mathematics and engineering as an academic discipline. END ...

Certain ambrosia beetles species engage in active agriculture. As social communities, they breed and care for food fungi in the wood of trees and ensure that so-called weed fungi spread less. Researchers led by Prof. Dr. Peter Biedermann, professor of Forest Entomology and Forest Protection at the University of Freiburg, now demonstrate for the first time that ambrosia beetles can distinguish between different species of fungi by their scents. "The results can contribute to a better understanding of why beetles selectively colonise trees with conspecifics and how ...

Study: "Following the Letter of the Law: 2020–2021 Retention Outcomes Under Michigan’s Read by Grade Three Law" Authors: Andrew Niel Utter (Michigan State University), John Westall (Michigan State University), Katharine O. Strunk (Michigan State University) Embargoed until: 12:01 a.m. CT Friday, April 14 This study will be presented at the place-based component of the 2023 Annual Meeting of the American Educational Research Association.  Session: Minding the Gap in Accountability Policy Implementation Date/Time: Friday, April 14, 2:50 p.m. – 4:20 p.m. CT Main Findings: Under Michigan’s “Read by Grade ...

With the goal of fostering awareness and identifying strategies to reduce bias within the medical genetics field and to improve health equity, members of the ACMG’s Social, Ethical and Legal Issues (SELI) and Diversity, Equity and Inclusion (DEI) Committees collaborated to address factors in which bias can occur in clinical genetic testing in a just-published statement, “Clinical, technical, and environmental biases influencing equitable access to clinical genetics/genomics testing: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG)”. This is the first joint statement of the ACMG’s ...

As researchers continue to make advances in new cancer prevention and treatment methods, it will not have much impact if the community is unaware and not engaged. For this reason, community outreach and engagement (COE) efforts are an important pillar of the University of Cincinnati Cancer Center’s mission. Cancer Center researchers will present research abstracts on several COE initiatives at the American Association for Cancer Research Annual Meeting 2023, held in Orlando, Florida, April 14-19. Encouraging ...

Young babies and newborn mice can naturally heal damage to the bones that form the top of the skull, but this ability is lost in adults. In a new study published in Proceedings of the National Academy of Sciences, University of Pittsburgh researchers developed a novel approach that promoted bone regeneration in mice without implantation of bone tissue or biomaterials. The technique uses a device similar to an orthodontic wire used to realign teeth to carefully stretch the skull along its sutures, activating ...

When it comes to height, our fate is sealed along with our growth plates—cartilage near the ends of bones that hardens as a child develops. Research publishing April 14 in the journal Cell Genomics shows that cells in these plates determine the length and shape of our bones and can hint at our stature. The study identified potential "height genes" and found that genetic changes affecting cartilage cell maturation may strongly influence adult height. "The study is really understanding ...

Associate Professor Jonathan Boreyko leads a team at Virginia Tech that has built a strong portfolio of work with ice and water, exploring the possibilities for de-icing planes, building novel water harvesting devices, and creating snow globes out of bubbles. This familiarity with water has given the team a strong sense of its behavior in different states, leading to a new project that shows how ice quenches heat in comparison to water. The findings were published in Chem on April 14. Mojtaba Edalatpour and master’s student Camryn ...

Chronic conditions such as type 2 diabetes, asthma, HIV infection, and mental illness may be greatly undertreated in the U.S. jail and prison population, suggests a new study from researchers at the Johns Hopkins Bloomberg School of Public Health. For their analysis, the researchers used national health survey data covering 2018 to 2020 to estimate rates of chronic conditions among recently incarcerated people, and a commercial prescription database to estimate the distribution of medication treatments to the jail and prison population. Their analysis suggests ...

About The Study: In a study of matched pairs of counties that reopened with in-person versus virtual instruction at the secondary school level in the 2020 to 2021 academic year, counties with in-person school instructional models early in the COVID-19 pandemic experienced increases in county-level COVID-19 incidence at six and eight weeks after in-person reopening, compared with counties with virtual instructional models.  Authors: Meredith Matone, Dr.P.H., of Children’s Hospital of Philadelphia, is the corresponding author.  To access the embargoed study: Visit our For The ...

About The Study: The findings of this study of survival outcomes for 1,618 U.S. counties suggest that greater representation of Black primary care physicians (PCPs) in the PCP workforce is associated with improved survival-related outcomes for Black individuals, although there was a dearth of U.S. counties with at least one Black PCP during each study time point. Investments to build a more representative PCP workforce nationally may be important for improving population health.  Authors: John E. Snyder, M.D., M.S., M.P.H., and Rachel D. Upton, Ph.D., of the U.S. Department of Health and Human Services in Rockville, Maryland, are the corresponding ...

About The Study: In this study of 81,755 Medical College Admission Test examinees, American Indian or Alaska Native, Black, and Hispanic students reported lower parental educational levels, greater educational and financial barriers, and greater discouragement from pre-health advisers than white students. These barriers may deter groups underrepresented in medicine from applying to and matriculating at medical school.  Authors: Jessica Faiz, M.D., M.S.H.P.M., of the Veterans Affairs Greater Los Angeles Healthcare System and UCLA in Los Angeles, is the corresponding ...