An international research team is the first to use artificial intelligence (AI) analysis to identify dual-purpose target candidates for the treatment of cancer and aging, the most promising of which was experimentally validated. The findings were published in the journal Aging Cell.  Researchers from the University of Oslo, University of Chicago Pritzker School of Medicine, and clinical stage AI-driven drug discovery company Insilico Medicine used Insilico’s AI target discovery engine, PandaOmics, to analyze transcriptomic data derived from ...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects neurons in the brain and spinal cord causing loss of muscle control. A study by the University of Barcelona has designed a potential therapeutic strategy to tackle this pathology that has no treatment to date. It is a molecular trap that prevents one of the most common genetic ALS-causing peptide compounds, the Poly-GR dipeptide, from causing its toxic effects in the body. The results show that this strategy reduces the death of neurons in patients and in an animal model (vinegar flies) of the disease.   The first authors of this international research study published in the journal Science Advances are ...

After 40 years of treating metastatic bladder cancer with chemotherapy as a primary treatment, scientists now present a new approach using immunotherapy combinations. The results of not just one, but two studies have been presented at the European Society for Medical Oncology (ESMO) conference in Madrid. The outcomes of these studies are going to revolutionize the landscape of bladder cancer treatment. Traditionally, cisplatin-based chemotherapy has been the standard treatment for bladder cancer patients who are able to tolerate this drug. However, responses have been limited, and durable outcomes rare. Over the past years, two phase-3 clinical trials studied the effects ...

Ithaca, N.Y.—Many songbirds are nesting earlier in spring because of warmer temperatures brought about by climate change. But the shift brings another danger that is especially deadly for nestlings: greater exposure to temperature variability in the form of cold snaps and heat waves. Such extremes result in more nest failures. These findings come from a Cornell Lab of Ornithology study just published in the journal Nature Communications.   "When we talk about temperature changes, the focus is mostly on averages," said co-lead author Conor Taff, a researcher in Cornell University's ...

Extracorporeal membrane oxygenation (ECMO) is a widely used advanced life support procedure that provides cardiac and respiratory support to critically ill patients. ECMO use has been increasing exponentially over the last decade as it has shown success in resuscitating patients in critical situations like the COVID-19 pandemic and is now a lifesaving treatment modality in intensive care units (ICUs). However, prolonged ECMO use may be associated with an increased risk of mortality. Identifying risk factors for in-hospital mortality and developing standardized nursing practice guidelines for ECMO management may improve the survival rates in patients. In this vein, ...

CLEVELAND—A combined $1.35 million from the Dr. Ralph and Marian Falk Medical Research Trust was awarded to two researchers from the Case Western Reserve University School of Medicine to advance their work on finding more effective treatments—and better options—for two debilitating diseases. The Falk Trust awarded Reshmi Parameswaran, an assistant professor in the Department of Medicine, Division of Hematology/Oncology, pathology and pediatrics at the School of Medicine, $1 million over three years for her work in cancer cell therapy. Carlos Subauste, a professor of medicine and pathology at the School of Medicine, received a two-year, ...

WASHINGTON – Children whose mothers are highly stressed, anxious or depressed during pregnancy may be at higher risk for mental health and behavior issues during their childhood and teen years, according to research published by the American Psychological Association. “Our research suggests that psychological distress during the pregnancy period has a small but persistent effect on children’s risk for aggressive, disinhibited and impulsive behaviors,” said study author Irene Tung, PhD, of California State University Dominguez Hills. “These findings add to the evidence that providing widely accessible mental health care and support ...

DALLAS, November 16, 2023 — Disparities in health care persist, with Hispanic and Black adults reporting less satisfaction with their interactions with physicians, leading to poorer quality of care and health outcomes.[1],[2],[3] While 19% of people in the U.S. identify as Hispanic, fewer than 7% of physicians do.[4] This lack of representation in the delivery of health care has been shown to exacerbate health disparities among underrepresented groups and is a significant barrier to the Hispanic Latino community achieving optimal health.[5] In response to this challenge, the American Heart Association, a global force for ...

The use of lithium metal as the anode for batteries is one of the smarter options with better energy density than other materials. However, the interface between the electrode and electrolyte has quite a few issues that can be addressed for a safer and more functional outcome in the future.   The researchers are keen on replacing the graphite anode with lithium metal anode to construct a battery system with higher energy density. However, the Li metal anode is unstable and readily reacting with electrolyte to form a solid-electrolyte interphase (SEI). Unfortunately, the natural SEI is brittle and fragile, resulting in poor ...

Philadelphia, November 16, 2023 – Immunotherapies that target the CD20 antigen have revolutionized how patients with a variety of blood cancers and hematologic disorders have been treated. However, many patients develop resistance to these treatments due to a loss of the antigen that’s being targeted. Now, a new study from researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania (Penn) has found that gene splicing occurring within these cells can cause significant changes in CD20 protein levels that render the therapies ineffective. The findings, published today by ...

November 16, 2023, Republic of Korea  — The International Vaccine Institute (IVI), an international organization with a mission to discover, develop, and deliver safe, effective, and affordable vaccines for global health, signed an MOU yesterday with University of Cambridge (UCAM), University of Hong Kong (HKU), and the Hong Kong Jockey Club (HKJC) to promote vaccine research and global health initiatives, including the establishment of the Hong Kong Jockey Club Global Health Institute (HKJCGHI).   HKJC will support the HKJCGHI through one of their largest donations in history, ...

About The Study: In this study of 34,000 patients with colorectal cancer (CRC) who underwent surgery from 2004 to 2019, the risk of recurrence decreased over time, and higher disease stage was associated with shorter times from surgery to recurrence. Screening-detected CRC was associated with a lower risk of recurrence. Because the risk of recurrence was so low in selected patient groups, future research is warranted to explore risk-stratified surveillance protocols in patients with CRC.  Authors: Claus Lindbjerg Andersen, Ph.D., of Aarhus University Hospital in Aarhus, Denmark, ...

DALLAS, November 16, 2023 — Cardiovascular mortality is on the rise in rural areas of the United States, where more than 60 million Americans live, according to an American Heart Association presidential advisory. Understanding and addressing the unique health needs of people in rural America is critical to the Association’s pursuit of a world of longer, healthier lives. Today — on National Rural Health Day — the Association, the world’s leading nonprofit organization focused on heart and brain health for all, announces two new collaborative efforts to help close the gap between ...

DALLAS, Nov. 16, 2023 — For people living with a health condition like heart disease or stroke, traveling away from home can pose some special challenges. The American Heart Association, the leading voluntary health organization devoted to a world of longer, healthier lives for all, says with a little pre-travel prep, you can turn travel woes from “oh no” to “let’s go!” “As we look forward to the holidays, many people will be traveling to spend treasured time with family and friends, or maybe just to enjoy some ...

PARIS (16 November, 2023)—Two landmark clinical trials reported today at the Union meeting showed that an oral antibiotic taken for six months once-daily substantially reduced the risk of developing drug-resistant TB. The antibiotic levofloxacin safely reduced the risk of multidrug-resistant (MDR) tuberculosis (TB) disease in children by 56%, researchers from the Desmond Tutu TB Centre at Stellenbosch University announced at the Union Conference in Paris today. The Unitaid-funded trial also showed that levofloxacin given once ...

Investigators from the UCLA Health Jonsson Comprehensive Cancer Center have developed an artificial intelligence (AI) model based on epigenetic factors that is able to predict patient outcomes successfully across multiple cancer types. The researchers found that by examining the gene expression patterns of epigenetic factors — factors that influence how genes are turned on or off — in tumors, they could categorize them into distinct groups to predict patient outcomes across various cancer types better than traditional measures like cancer grade and stage. These findings, described in Communications Biology, also lay the groundwork ...

Brigham researchers found an association between alterations in circadian rest-activity rhythms and risk of frailty incidence in older adults Wearable devices can be used to measure a variety of signs and signals related to our health. A new study by researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, suggests that such devices may also be able to help predict older adults at risk of health complications related to frailty. The team found an association between disturbances in daily patterns of rest and activity, or circadian ...

Threats posed by the climate crisis disproportionally affect certain communities and social groups that are more exposed. People living in low- and middle-income (LMIC) countries are at heightened risk. Within these countries, women typically face higher climate risk than men. To show where women working in agri-food systems – systems that encompass production, but also post-harvest handling and distribution – are most threated by climate change, an international team of researchers has developed a hotspot map that identifies and ranks localities by threat level. “We show that significant ...

Minimizing energy consumption is a fundamental element in our journey towards sustainable societies, and advanced materials play a key role in this regard. Carbon-fiber-reinforced plastics (CFRPs) and carbon-fiber-reinforced thermoplastics (CFRTPs) are two prominent examples of composite materials that can significantly improve energy efficiency in various fields of application. These composites are made of carbon fibers embedded in a polymer matrix, such as epoxy resin. Thanks to their low weight and remarkable mechanical strength, CFRPs and CFRTPs can greatly ...

A research team led by Dr. Jae-woong Ko from the Department of Engineering Ceramics at the Korea Institute of Materials Science(KIMS) has succeeded in localizing silicon nitride bearing ball manufacturing technology for electric vehicle drive modules. KIMS is a government-funded research institute under the Ministry of Science and ICT. This achievement is significant because it overcomes the limitations of foreign dependence and opens up the possibility of domestic supply and demand. Silicon nitride bearing ...

Infants prenatally exposed to cannabis are more likely to be born preterm, have a low birth weight, and require neonatal intensive care unit (NICU) care than infants without prenatal cannabis exposure, according to a study published today in the scientific journal Addiction. However, cannabis-exposed infants are not at greater risk of birth defects or death within one year, including sudden unexpected infant death. First author Ms. Maryam Sorkhou comments, “The global increase in cannabis use among women of reproductive age also extends to pregnant women.  ...

Research that could lead to the first early detection blood test for pancreatic cancer has received critical funding from PanKind, The Australian Pancreatic Cancer Foundation. Pancreatic cancer is one of Australia’s biggest killers, with poor survival rates marred by a lack of distinct symptoms and screening tools needed to detect the disease in its initial stages.  It’s hoped the test will, for the first time, accurately identify patients with early stages of pancreatic cancer – a crucial step towards improving survival ...

A recent study published in Progress in Neurobiology and led by researchers at the University of Arizona College of Medicine – Tucson has developed an improved method to study Parkinson’s disease in the lab. Along the way, researchers also uncovered clues that may help scientists figure out how to detect Parkinson’s earlier and point the way toward better treatments. Around a million Americans are living with Parkinson’s disease, a neurological disorder that causes difficulty in movement, balance and cognition. Symptoms worsen until tasks like ...

Warming has played a crucial role in various industrial and agricultural processes throughout history. Night-time warming, however, presents a distinct challenge due to the absence of solar radiation. During the night, direct radiative heat loss to outer space through the atmospheric transparent window (8-14 μm) can cause temperature to drop below freezing, posing significant threats to agriculture (crops), transportation (outdoor cables), and more.   Traditionally, achieving night-time warming ...

With the benefits of reducing time-cost and human efforts, automated testing has been widely used for quality assurance of mobile applications (apps). However, in complex interactive activities, manual testing can achieve higher coverage. However, the effectiveness of manual testing is highly dependent on the vital User Operation Process (UOP) of experienced testers. To solve the problems, a research team led by Zhenyu CHEN and Chunrong FANG published their new research on 15 Oct 2023 in Frontiers of Computer Science co-published ...