The American College of Medical Genetics and Genomics (ACMG) has released its highly anticipated 2023 update to the recommended minimum gene list for the reporting of secondary findings (SF): “ACMG SF v3.2 List for Reporting of Secondary Findings in Clinical Exome and Genome Sequencing: A Policy Statement of the American College of Medical Genetics and Genomics (ACMG).” In 2021, the ACMG Board of Directors and Secondary Findings Working Group (SFWG) stated that the College would update the list annually. Today’s update (SF v3.2) is being published in ACMG’s flagship journal, Genetics ...

NEW YORK, NY – June 22, 2023 – The Lupus Research Alliance awarded its 2023 Lupus Insight Prize to Carola Vinuesa, MD, PhD, of The Francis Crick Institute, for her seminal discovery that a mutation in a specific human gene causes systemic lupus erythematosus (SLE), uncovering an important target for the development of novel treatment. The Lupus Insight Prize is awarded each year to an outstanding investigator who has made a significant discovery that will advance our understanding of the pathogenesis, diagnosis, or treatment of lupus. Dr. Vinuesa ...

In the United States, sickle cell disease affects about 100,000 people and about 2 million Americans carry this genetic mutation. The most common and serious problems caused by sickle cell disease are anemia, pain and organ failure – stroke affects about 10 out of 100 children who have this disease. The national median life expectancy for people who have sickle cell disease can reach up to age 50.  This inherited, lifelong blood disorder is characterized by rigid and sickle-shaped red blood cells due to a dramatic change in their morphology. They stick to blood vessels, blocking ...

Washington, D.C. – Investigators in Israel and Italy have developed a model of the blood-brain barrier, studies of which may lead to prevention of meningitis in newborns. The research is published in Microbiology Spectrum, a journal of the American Society for Microbiology.  The investigators further developed a platform called organs-on-a-chip—invented during the 2000s—to construct the model. These devices, which are modeled after microchips, contain tiny channels lined with living human ...

Leishmaniasis is a tropical disease caused by parasites known as Leishmania, which are transmitted to humans and animals through the bites of more than 90 species of sand flies. Considered a neglected tropical disease, leishmaniasis is found in approximately 88 countries primarily located in South and Central America, the Middle East and western Asia. As many as 1 million new cases are diagnosed each year and more than 350 million people are at risk of infection. Some forms of the disease ...

The UK is to launch a clinical trial of a ‘poo transplant’ that researchers believe could treat advanced liver disease and fight antimicrobial resistance. The trial’s investigators also provide evidence for the first time that a faecal transplant can dramatically improve gut health. The PROMISE trial is led by King’s College London and funded by a National Institute for Health and Care Research (NIHR) and Medical Research Council (MRC) partnership. It will recruit patients with cirrhosis from across the UK to test whether oral Faecal Microbiota Transplant (FMT) capsules from freeze-dried stool from healthy volunteers reduces the likelihood of getting an ...

Alexandria, VA, USA – A study that introduces a new strategy to promote customized, oral health self-care by using an online platform to connect dental professionals and patients will be presented at the 101st General Session of the IADR, which will be held in conjunction with the 9th Meeting of the Latin American Region and the 12th World Congress on Preventive Dentistry on June 21-24, 2023, in Bogotá, Colombia. The Interactive Talk presentation, “An Online Platform to Promote Customized Self Oral Healthcare,” will take place on Thursday, ...

Alexandria, VA, USA – A study examining the effect of COVID-19 lockdowns on Bolivian dental school graduates will be presented at the 101st General Session of the IADR, which will be held in conjunction with the 9th Meeting of the Latin American Region and the 12th World Congress on Preventive Dentistry on June 21-24, 2023, in Bogotá, Colombia. The Interactive Talk presentation, “Covid–19 Pandemic Effects on Graduates’ Self Confidence to Execute Dental Clinical Procedures,” will take place on Thursday, June 22, 2023, at 2 p.m. Colombia Time (UTC-05:00) during the “Attitude ...

Patients with a rare genetic bone marrow disorder which puts them at increased risk of blood cancers could benefit from a discovery that may lead to new treatments to slow or reverse the disease.   In a new study published in Cell Reports, scientists from the University of Birmingham and University of Warwick have found that affected blood stem cells that are produced in bone marrow produce much fewer immune cells used to fight infection. The mutation in the GATA2 gene in these blood stem cells results in impaired ability to repair ongoing damage to their DNA and puts patients at risk of developing blood cancers.  The median age for patients developing Acute Myeloid Leukaemia who ...

PULLMAN, Wash. – Taking a cue from the structural complexity of trees and bones, Washington State University engineers have created a way to 3D-print two types of steel in the same circular layer using two welding machines. The resulting bimetallic material proved 33% to 42% stronger than either metal alone, thanks in part to pressure caused between the metals as they cool together. The new method uses commonplace, relatively inexpensive tools, so manufacturers and repair shops could use it in the ...

Butterflies are being hit hardest by urban growth. Shrinking habitats and food availability are causing their populations to decline. The same applies to many wild bees that fly early in spring. According to a new study by the Martin Luther University Halle-Wittenberg (MLU) and the Chinese Academy of Sciences in "Ecology Letters", pollination has not yet been impacted by this because honeybees, for example, can compensate for the reduction of urban pollinators. The study is the first comprehensive analysis of the subject and includes data from 133 studies. The results underline the importance ...

About The Study: This systematic review and meta-analysis including 52 studies found children, adolescent, and young adult patients with cancer experience an increased risk of depression, anxiety, and psychotic disorders after cancer remission compared with siblings and noncancer-matched controls. Timely identification, preventive efforts, and psycho-oncological intervention for psychological comorbidity are recommended.  Authors: Ainsley Ryan Yan Bin Lee, M.B.B.S. (Hons.), and Cyrus Su Hui Ho, Ph.D., of the National University of Singapore, are the corresponding authors. To access the embargoed study: Visit our For The Media ...

Evidence is mounting that astronauts are more susceptible to infections while in space. For example, astronauts on board the International Space Station (ISS) commonly suffer from skin rashes, as well as respiratory and non-respiratory diseases. Astronauts are also known to shed more live virus particles, for example Epstein-Barr virus, varicella-zoster responsible for shingles, herpes-simplex-1 responsible for sores, and cytomegalovirus. These observations suggest that our immune system might be weakened by space travel. But what could cause such an immune deficit? “Here we show that the expression of many ...

As North America recovers from some of the worst air quality in decades due to wildfires, one of the largest and most comprehensive studies into the long-term health impact of smoke exposure raises significant concerns about the long-term health impact of the Canadian wildfires. The study found that a 10 μg/m3 increase of wildfire-related PM2.5 exposure was associated with a 0.4% higher risk of all-cause and nonaccidental mortality, and a 0.5% increase in risk of dying from neoplasms.  On June 8, at the peak of the wildfire pollution, ...

The lack of registration of medicines in Kenya, Tanzania and Uganda is limiting access to safe, effective, and affordable essential medicines, according to a new analysis from Newcastle University in the UK and Makerere University in Uganda, published by the Journal of the Royal Society of Medicine. Before a medicine can be made available in a country, manufacturers must apply to the medicine regulatory agency of the country for a licence to sell it and demonstrate the medicine is safe and effective. This is known as market registration. The researchers compared the ...

Researchers have shed light on how a highly infectious virus, that has recently transferred from animals to people, is able to enter human cells. The University of Queensland’s Dr Ariel Isaacs and Dr Yu Shang Low have uncovered the structure of the fusion protein of Langya virus, which was discovered in people in eastern China in August 2022. Dr Isaacs said the virus caused fever and severe respiratory symptoms and was from the same class of viruses as the deadly Nipah and Hendra viruses. “We’re ...

Alexandria, VA – The International Association for Dental Research (IADR) announced nine recipients of the 2023 IADR Centennial Travel Awards for New Investigators. The recipients were recognized during the Opening Ceremonies of the 101st General Session of the IADR, which was held in conjunction with the 9th Meeting of the Latin American Region and the 12th World Congress on Preventive Dentistry, that took place on June 21, 2023, in Bogotá, Colombia. The recipients are: Sebastián ...

Alexandria, VA – The International Association for Dental Research (IADR) announced six recipients of the 2023 IADR Colgate Research Travel Awards. The recipients were recognized during the Opening Ceremonies of the 101st General Session of the IADR, which was held in conjunction with the 9th Meeting of the Latin American Region and the 12th World Congress on Preventive Dentistry, that took place on June 21, 2023, in Bogotá, Colombia. The recipients are: Alaa Al Atta, University of Sharjah, United Arab Emirates Leonardo Libardi Pagotto, ...

Alexandria, VA – The International Association for Dental Research (IADR) announced five recipients of the 2023 IADR Kulzer Travel Awards. The recipients were recognized during the Opening Ceremonies of the 101st General Session of the IADR, which was held in conjunction with the 9th Meeting of the Latin American Region and the 12th World Congress on Preventive Dentistry, that took place on June 21, 2023, in Bogotá, Colombia. The recipients are: Alaa Al Atta, University of Sharjah, United Arab Emirates Apurva Mishra, National University of Singapore Clarice Sabino, São Paulo State University, Brazil Po-Chun Tseng, Ludwig Maximilian ...

Alexandria, VA – The International Association for Dental Research (IADR) has announced that Marina Miteva is the 2023 recipient of the IADR Newell W. Johnson Travel Award. Miteva, from Medical University of Sofia, Bulgaria, was recognized during the Opening Ceremonies of the 101st General Session of the IADR, which was held in conjunction with the 9th Meeting of the Latin American Region and the 12th World Congress on Preventive Dentistry, that took place on June 21, 2023, in Bogotá, Colombia. Miteva’s ...

Alexandria, VA, USA – The International Association for Dental Research (IADR) announced that Domenick Zero is this year’s recipient of the IADR Distinguished Scientist William H. Bowen Research in Dental Caries Award. Zero, from Indiana University, Indianapolis, USA, was recognized during the Opening Ceremonies of the 101st General Session of the IADR, which was held in conjunction with the 9th Meeting of the Latin American Region and the 12th World Congress on Preventive Dentistry, that took place on June 21, 2023, in Bogotá, Colombia. Zero is Professor, Department of Cariology, Operative Dentistry and Dental Public Health, Indiana University. A central theme ...

Alexandria, VA – The International Association for Dental Research (IADR) has announced the 2023 recipients of the IADR LION Dental Research Award. The recipients were recognized during the Opening Ceremonies of the 101st General Session of the IADR, which was held in conjunction with the 9th Meeting of the Latin American Region and the 12th World Congress on Preventive Dentistry, that took place on June 21, 2023, in Bogotá, Colombia. The 2023 Recipients are: Mateus Xavier Queiroz, University ...

Alexandria, VA – The International Association for Dental Research (IADR) has announced that María Paula Contreras Becerra is the 2023 recipient of the IADR David B. Scott Fellowship. Contreras Becerra, from the Universidad Nacional de Colombia (UNAL), Bogotá, was recognized during the Opening Ceremonies of the 101st General Session of the IADR, which was held in conjunction with the 9th Meeting of the Latin American Region and the 12th World Congress on Preventive Dentistry, that took place on June 21, 2023, in Bogotá, Colombia. Contreras Becerra’s ...

Alexandria, VA – The International Association for Dental Research (IADR) has announced that Salma Kabbashi is the recipient of the 2023 IADR John Gray Fellowship. Kabbashi, from the University of the Western Cape, Cape Town, South Africa, was recognized during the Opening Ceremonies of the 101st General Session of the IADR, which was held in conjunction with the 9th Meeting of the Latin American Region and the 12th World Congress on Preventive Dentistry, that took place on June 21, 2023, in Bogotá, Colombia. Kabbashi’s research work seeks to support ...

Alexandria, VA – The International Association for Dental Research (IADR) and American Association for Dental, Oral, and Craniofacial Research (AADOCR) have announced the winner of the 2023 IADR/AADOCR William J. Gies Award in the category of Biological Research. The winning paper in the biologic research category was recognized during the Opening Ceremonies of the 101st General Session of the IADR, which was held in conjunction with the 9th Meeting of the Latin American Region and the 12th World Congress on Preventive Dentistry, that took place on June 21, 2023, in Bogotá, Colombia. The winning paper in the biologic research ...