We still do not understand exactly how antibiotics kill bacteria. However, this understanding is necessary if we want to develop new antibiotics. And that is precisely what is urgently needed, because bacteria are currently showing more and more resistance to existing antibiotics. Therefore, researchers from the University Hospital Bonn (UKB) and the University of Bonn used high-performance microscopes to observe the effect of different antibiotics on the cell division of Staphylococcus aureus. They found that the biosynthesis of peptidoglycan, core component of the bacterial cell wall, is the driving force during the entire process of cell division. In ...

Alliance for Cancer Gene Therapy (ACGT) will award the Edward Netter Leadership Award to Crystal Mackall, MD, of Stanford University, at the ACGT Awards Luncheon on March 30 at Riverpark restaurant at the Alexandria Center for Life Science, located at 450 E. 29th St., New York City. Named for ACGT co-founder, Edward Netter, the award recognizes a researcher who has made unparalleled and groundbreaking contributions to the field of cell and gene therapy for cancer. Dr. Mackall is a leader in advancing cell and gene therapies for the treatment of solid tumors, with a major focus on children’s cancers. In addition to being an ACGT Research ...

Issues around the loss of coastal heritage due to climate change and how these can be effectively addressed in policy will be discussed during a major conference taking place at the University of East Anglia (UEA) next week. The conference will discuss a range of pressing issues including how behavioural science can inform choices about what should be saved and how archaeological landscapes are valued, to the human cost of heritage loss and the role art and exhibitions play in addressing ecological crisis. Heritage takes many forms, and includes physical artifacts, buildings and ecosystems, but also the rich cultural and social aspects ...

For decades, health care practitioners have used body mass index (BMI) as an indicator of a person’s health. But this equation only considers height and weight, and may not capture an accurate picture of a person’s risk for obesity-related diseases, like heart disease, diabetes, and certain cancers. Jacob Earp, assistant professor of kinesiology in the College of Agriculture, Health and Natural Resources, recently published papers in the International Journal of Environmental Research and Public Health and Nutrition, Metabolism and Cardiovascular Diseases that include a series of equations that add simple circumference measurements to better predict how a person’s ...

Amsterdam, March 23, 2023 – When Marina Noordegraaf was diagnosed with Parkinson's disease at age 49, she noticed when it came to treatment decisions, she sometimes felt powerless. She observed that she herself played an active role in communicating her hopes and wishes to her healthcare professionals, which were not automatically taken into account. She took back control by taking her own hope seriously, prescribing her own recipe of “hopamine,” a self-invented word representing ...

Physical exercise practiced by patients submitted to bariatric surgery acts on brain regions involved in food intake, reducing hunger or accelerating satiety, for example. This was the result observed in a clinical trial conducted at Hospital das Clínicas (HC), the hospital complex run by the University of São Paulo’s Medical School (FM-USP) in Brazil. An article on the study, pointing to positive effects of exercise on obesity-related conditions in post-bariatric patients, is published in the International Journal of Obesity. The study showed that an exercise ...

The ever-increasing generation of plastic solid waste has resulted in global plastic pollution both on land and in the oceans. Projections show that plastic waste will double in the next 20 years, causing further environmental problems. Large amounts of plastic waste are, at present, incinerated or deposited in landfills. This not only degrades the environment but also depletes valuable resources. In this light, recycling plastics such as polymers is a promising sustainable alternative for waste management. But this involves the breaking of chemical bonds between ...

Astrophysicists at the Institute for Advanced Study, the Flatiron Institute and their colleagues have leveraged artificial intelligence to uncover a better way to estimate the mass of colossal clusters of galaxies. The AI discovered that by just adding a simple term to an existing equation, scientists can produce far better mass estimates than they previously had. The improved estimates will enable scientists to calculate the fundamental properties of the universe more accurately, the astrophysicists reported March 17, 2023, in the Proceedings of the National Academy of ...

Booster vaccinations against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being promoted worldwide to counter the coronavirus disease 2019 (COVID-19) pandemic. Recent studies on the effectiveness of the third dose of the vaccine found improved efficacy against SARS-CoV-2 infection and a reduction in hospitalization. However, most studies on the effect of the third vaccination have been limited to a relatively short period of time after the third dose, and few longitudinal analyses of the effects of the third vaccination with an anti−SARS-CoV-2 vaccine have been reported.   Researchers from Tokyo Metropolitan Institute of Medical ...

Humans perceive five basic taste sensations: sweet, umami, bitter, salty, and sour. Specific foods trigger taste recognition of these sensations through the activation of different receptors in our taste buds. In the case for table salt, the concentration is also an important factor in determining taste. For instance, the preferable concentration of table salt is 100 mM, at which humans perceive a salty taste. However, higher concentrations of salt, over 500 mM, may be perceived as bitter and/or sour, while very low concentrations, below 10 mM, are perceived as sweet by humans. Scientific ...

The research published in the Journal of Infection investigated the use of metagenomic next-generation sequencing (mNGS) in diagnosing bloodstream infections (BSIs) for immunocompromised hematology patients. Hematology patients are highly susceptible to BSIs, which can have severe consequences such as septic shock, multiple-organ failure, disseminated intravascular coagulation, and even death. An accurate and quick microbiological diagnosis of BSI is therefore essential for the control of the infection. In the study, conducted ...

March 23, 2023 – Despite the broad diversity of the U.S. population, dietary recommendations often overlook the positive contributions of cultural foods to build healthy dietary patterns. This is especially true when it comes to carbohydrate food guidance, where prevailing approaches have historically focused on only three components— carbohydrates, sugar, and dietary fiber—ignoring other important nutrient and cultural considerations. However, a new paper published in Nutrients highlights a more holistic approach, called the Carbohydrate Food Quality ...

Honeybees are famously finicky when it comes to being studied. Research instruments and conditions and even unfamiliar smells can disrupt a colony’s behavior. Now, a joint research team from the Mobile Robotic Systems Group in EPFL’s School of Engineering and School of Computer and Communication Sciences and the Hiveopolis project at Austria’s University of Graz have developed a robotic system that can be unobtrusively built into the frame of a standard honeybee hive. Composed of an array of thermal sensors and actuators, the system measures and modulates honeybee behavior through ...

PARAMUS, N.J. (March 23, 2023) – Octapharma USA has provided a grant for an educational program on pediatric acute-onset neuropsychiatric syndrome (PANS) and PANDAS, a subset of PANS associated with strep, to be held during the National Home Infusion Association (NHIA) Annual Conference scheduled for March 25 – 27 in Washington, D.C. Octapharma is enrolling more patients and sites for its phase 3 multicenter superiority study comparing the effectiveness of panzyga® (immune globulin intravenous, human - ifas) 10% liquid preparation versus placebo ...

Continued warming of the climate would see a rise in the number and spread of potentially fatal infections caused by bacteria found along parts of the coast of the United States. Vibrio vulnificus bacteria grow in warm shallow coastal waters and can infect a cut or insect bite during contact with seawater. A new study led by the UK’s University of East Anglia (UEA) shows that the number of V. vulnificus infections along the East Coast of the US, a global hotspot for such infections, has gone ...

(SAN ANTONIO) MARCH 23, 2023 -  Guenevere Chen, an associate professor in the UTSA Department of Electrical and Computer Engineering, recently published a paper on USENIX Security 2023 that demonstrates a novel inaudible voice trojan attack to exploit vulnerabilities of smart device microphones and voice assistants — like Siri, Google Assistant, Alexa or Amazon’s Echo and Microsoft Cortana — and provide defense mechanisms for users. The researchers developed Near-Ultrasound Inaudible Trojan, or NUIT (French for “nighttime”) to study how hackers exploit speakers and ...

UC Riverside scientists have significantly advanced the race to control plant responses to temperature on a rapidly warming planet. Key to this breakthrough is miRNA, a molecule nearly 200,000 times smaller than the width of a human hair. With moderate increases in temperature, plants grow taller to avoid hotter ground and get fresher air. A landmark study published in the journal Nature Communications demonstrates that microRNA or miRNA is required for this growth. The study also identifies which miRNA molecules — out of more than 100 possibilities — are the essential ones.  “We found that without miRNA plants will not grow, even ...

Medical sleep treatment may reduce self-harm in young people with anxiety and depression, an observational study from Karolinska Institutet in Sweden suggests. The risk of self-harm increased in the months preceding melatonin prescription and decreased thereafter, especially in girls. The study is published in The Journal of Child Psychology and Psychiatry. Melatonin is a hormone that controls the sleep-wake cycle and is the most commonly prescribed drug for sleep disturbances in children and adolescents in Sweden. Melatonin use has dramatically increased in recent years, and it is available over the counter in Sweden since 2020. “Given the established link between sleep ...

Applying hydrostatic pressure as an external stimulus, Tokyo Tech and Keio University researchers demonstrate a new way to regulate singlet fission (SF), a process in which two electrons are generated from a single photon, in chromophores, opening doors to the design of SF-based materials with enhanced (photo)energy conversion. Their method overrides the strict requirements that limit the molecular design of such materials by realizing an alternative control strategy. Singlet fission (SF) is a process in which ...

Researchers at Chalmers University of Technology, Sweden, have developed a new method that can easily purify contaminated water using a cellulose-based material. This discovery could have implications for countries with poor water treatment technologies and combat the widespread problem of toxic dye discharge from the textile industry. Clean water is a prerequisite for our health and living environment, but far from a given for everyone. According to the World Health Organization, WHO, there are currently over two billion people living with limited or no access to clean water. This global challenge ...

Imagine a home computer operating 1 million times faster than the most expensive hardware on the market. Now, imagine that level of computing power as the industry standard. University of Arizona researchers hope to pave the way for that reality using light-based optical computing, a marked improvement from the semiconductor-based transistors that currently run the world. "Semiconductor-based transistors are in all of the electronics that we use today," said Mohammed Hassan, assistant professor of physics and optical sciences. "They're part of every industry – from kids' toys to ...

Older adults with depression are actually aging faster than their peers, UConn Center on Aging researchers report. “These patients show evidence of accelerated biological aging, and poor physical and brain health,” which are the main drivers of this association, says Breno Diniz, a UConn School of Medicine geriatric psychiatrist and author of the study, which appears in Nature Mental Health on March 22. Diniz and colleagues from several other institutions looked at 426 people with late-in-life ...

Despite nearly 60 years of research, there is still a lack of high certainty evidence on the effectiveness and safety of commonly used painkillers (analgesics) for short bouts of low back pain, finds an analysis of the evidence published by The BMJ. The researchers say that until higher quality trials comparing analgesics with each other are published, “clinicians and patients are advised to take a cautious approach to manage acute non-specific low back pain with analgesic medicines.” Analgesics such as paracetamol, ibuprofen, and codeine ...

Ending performance related payments for NHS GPs in Scotland was associated with a decline in the quality of some aspects of care compared with England where financial incentives have continued, finds a study published by The BMJ today. The researchers say further research is needed to better understand the full impact of withdrawal and the accompanying refocusing of quality improvement resources. The NHS Quality and Outcomes Framework (QOF) pay-for-performance scheme began in 2004. It was designed to remunerate general practices for providing good quality care across a range of key areas such as cancer, diabetes, heart disease, mental health, and obesity. In 2016, Scotland abolished ...

Philadelphia, March 22, 2023 – Researchers from the Neuroscience Center at Children’s Hospital of Philadelphia (CHOP) have developed a prediction model that determines which newborn babies are likely to experience seizures in the Neonatal Intensive Care Unit (NICU). This model could be incorporated into routine care to help the clinical team decide which babies will need electroencephalograms (EEGs) and which babies can be safely managed in the Neonatal Care Unit without monitoring through EEGs. This would allow families and providers to care for babies ...