About The Study: In this randomized clinical trial of 345 patients with mild-to-moderate COVID-19, viral load rebound and symptom rebound were both common after a standard 5-day course of antiviral treatment with either VV116 or nirmatrelvir-ritonavir. Prolongation of treatment duration might be investigated to reduce COVID-19 rebound.  Authors: Yufang Bi, M.D., and Yiping Xu, M.Sc., of the Shanghai Jiao Tong University School of Medicine in Shanghai, China, are the corresponding authors.  To access the embargoed study: Visit our For ...

About The Study: The findings of this study of 4,515 adolescents suggest that in-person schooling and several coping behaviors (caring for one’s body, exercising, and engaging in healthy behaviors) were associated with significantly higher positive affect and lower perceived stress during the COVID-19 pandemic among adolescents with high adverse childhood experiences (ACEs). Adolescents with high ACEs demonstrated especially greater mental health scores when they reported in-person schooling. Future studies should build on these findings to identify clinical and school-based mental health protective ...

Chlorophyll a fluorescence (ChlF) has been a pivotal tool in understanding plant photochemistry, offering insights into the energy transfer processes within chloroplasts and the efficiency of Photosystem II (PSII). Researchers have relied on quantifying ChlF through specific measures such as F0, Fm, and Fv under various lighting conditions to assess photosynthetic activities. Nonetheless, the technique encounters obstacles owing to the intrinsic uncertainties in gauging the absolute magnitude of ChlF and the fluctuation in baseline levels affected by environmental conditions. This complicates the interpretation of ...

Allergic transfusion reactions (ATRs), a potentially life-threatening side effect of blood transfusions with unclear mechanisms, may be linked to food allergies in pediatric patients as per a recent study by scientists from Japan. They found that ATRs may be triggered by the presence of allergens in the donor’s blood, influenced by their pre-donation diet. These findings could pave the way for safer blood transfusions through the development of preventive measures and countermeasures for ATRs. Blood transfusions are often life-saving procedures in various medical settings. They are required not only after severe blood loss ...

Melissa A. Kelly, MS, CGC is the recipient of the 2024 ACMG Foundation Carolyn Mills Lovell Genetic Counselor Award. Ms. Kelly received the Lovell award for her platform presentation at the 2024 ACMG Annual Clinical Genetics Meeting, “Integrating genomic medicine into healthcare: Experience disclosing >5,000 clinically relevant results within the Geisinger MyCode Community Health Initiative.” Ms. Kelly said, “Thank you to the ACMG Foundation. I am humbled and honored to receive the Carolyn Mills Lovell Genetic Counselor Award. Throughout my career, I have seen many ways in which patients and their families interact with and are impacted ...

Rory James Tinker, MD is the recipient of the 2024 Richard King Trainee Award. This award was instituted by the ACMG Foundation for Genetic and Genomic Medicine to encourage American Board of Medical Genetics and Genomics (ABMGG), international equivalents, or genetic counseling trainees in their careers and to foster the publication of the highest quality research in Genetics in Medicine (GIM), an official journal of the ACMG.   Each year the editorial board reviews all articles published in GIM by ...

Meena Sethuraman, BS is the 2024 recipient of the ACMG Foundation/Revvity Travel Award. Ms. Sethuraman was selected to receive the award for her platform presentation, "Characterizing pathogenicity of ACADVL variants in very long-chain acyl-CoA dehydrogenase deficiency.” Meena Sethuraman is a third-year medical student in the Physician Scientist Training Program at the University of Pittsburgh School of Medicine. Her research,  being conducted with Dr. Jerry Vockley, FACMG, involves studying genetic variants in fatty acid oxidation disorders. Meena previously received her BS in Neurobiology at the University of Washington. Her undergraduate and post-baccalaureate ...

Each year, the ACMG Foundation for Genetic and Genomic Medicine grants its Next Generation fellowship awards to promising early career professionals in a range of medical genetics and genomics specialties including Clinical Biochemical Genetics Laboratory, Laboratory Genetics and Genomics, Medical Biochemical and Ophthalmic Genetics. Support for this year’s class of Fellows was generously provided by Pfizer, Sanofi, Spark Therapeutics, Bionano and Horizon Therapeutics. The ACMG Foundation depends on corporate ...

Solar-induced chlorophyll fluorescence (SIF) and the photochemical reflectance index (PRI) have emerged as significant tools in assessing the photosynthetic and carbon sequestration capacities of terrestrial vegetation, particularly for estimating gross primary productivity (GPP). However, the relationship between SIF, PRI, and GPP encounters challenges due to large temporal and spatial variabilities as well as the influence of various observational factors such as canopy structure and physiological state. Despite the potential of multi-angle observations and the Bidirectional Reflectance Distribution Function (BRDF) model to mitigate these ...

Corvallis, OR — The Alliance of World Scientists (AWS) is pleased to announce the six recipients of the 2024 Planet Earth Award: Dr. S Faizi, Dr. James Hansen, Dr. Denise Margaret S. Matias, Dr. Kimberly Nicholas, Dr. Jamie Pittock, and Dr. Fernando Valladares. Planet Earth Award The AWS Planet Earth Award acknowledges individuals who champion life on Earth. These individuals demonstrate exceptional creativity or contributions in their work in science-based advocacy with the public, ...

Computers work in digits — 0s and 1s to be exact. Their calculations are digital; their processes are digital; even their memories are digital. All of which requires extraordinary power resources. As we look to the next evolution of computing and developing neuromorphic or “brain like” computing, those power requirements are unfeasible. To advance neuromorphic computing, some researchers are looking at analog improvements. In other words, not just advancing software, but advancing hardware too. Research from the University of California San Diego and UC Riverside shows a promising new way to store and transmit information ...

DALLAS (SMU) – What exactly happens at the tiny scale at which individual atoms exist and interact? SMU chemist Elfi Kraka and her colleagues have been working on developing a computational tool aimed at providing answers to that mystery. Mathematical functions used to calculate the potential energy of a system of atoms are called interatomic potentials. Machine learning interatomic potentials (MLIP)s have become an efficient and less expensive alternative to traditional quantum chemical simulations, which even on today’s high-performance computing often become out of reach for larger ...

Although women have breastfed since the beginning of time, there is very little scientific research on how exercise affects breast milk. Online forums for pregnant women and new mothers are full of questions about this exact issue: Can exercise cause breast milk to go sour? What happens to breast milk if you do high-intensity interval training? Will strenuous exercise affect your milk supply? “There are so many myths about exercise and breast milk. We simply need more knowledge,” says researcher Trine Moholdt at the Norwegian University of Science and Technology (NTNU). She heads several international research projects ...

The ACMG Foundation for Genetic and Genomic Medicine is proud to present the ACMG Foundation/David L. Rimoin Inspiring Excellence Award to Christiana Wang, BS for her featured platform presentation at the 2024 ACMG Annual Clinical Genetics Meeting, “Antisense oligonucleotide targeting a linked-SNP provides allele-specific and effective knockdown to a dominant negative SPTAN1 pathogenic variant.” Christiana Wang, BS, is a second-year PhD candidate in the Department of Molecular ...

ATLANTA – New data provided by studying the beluga whales at Georgia Aquarium helps close a key information gap about how much food these whales need to thrive. The information will inform important management decisions for their counterparts in Alaska’s Cook Inlet, which are protected under the U.S. Endangered Species Act (ESA). A new study released in the Journal of Experimental Biology, led by Terrie M. Williams, Director of the Integrative Carnivore EcoPhysiology Lab, with her graduate student Jason John at the University of California-Santa Cruz in partnership ...

Americans already living in housing supported by federal housing assistance programs have significantly lower blood lead levels than counterparts who would later join these programs, according to new research led by environmental health scientists at Columbia University Mailman School of Public Health and Tufts Medical Center. The findings appear in the peer-reviewed journal Environmental Health Perspectives. “Living in federally-supported housing—especially public housing—limited opportunities for residents’ exposure to lead,” says first author MyDzung Chu, Ph.D., assistant professor in the Institute for ...

Residential heating by coal has for decades been the major contributor to the high levels of air pollution in Krakow, Poland. New research finds a nearly 40 percent decline in the annual average concentration of respirable particulate matter (PM2.5) in Kraków, Poland, between 2010 and 2019 following the implementation of policies targeting emissions from the burning of coal and other solid fuels. Researchers show the improvement in air quality translated to substantial benefits for children’s outcomes, including fewer cases of asthma and better birth outcomes. The ...

Nagoya University researchers and their colleagues in Japan have found that middle-age obesity is caused by age-related changes in the shape of neurons in the hypothalamus, a region of the brain that controls metabolism and appetite. A protein called melanocortin-4 receptor (MC4R) detects overnutrition and regulates metabolism and appetite to prevent obesity. According to their study in rats, MC4Rs were concentrated in primary cilia (antenna-like structures) that extend from a couple of groups of hypothalamic neurons. The study also showed that the primary cilia became shorter with age, which decreased MC4Rs accordingly, ...

Recently, Nano Research announced awardees of the 2023 Nano Research Young Innovators (NR45) Awards in Bio-inspired Nanomaterials. Thirty-three outstanding young investigators under the age of 45 were selected for their extraordinary contributions in developing bio-inspired nanomaterials with applications spanning clean energy, human healthcare, monitoring, and disease treatments. They were selected through a competitive process by an award committee from Nano Research’s editorial board. Congratulations to all the 33 awardees in 2023!   The NR45 Awards ...

A medical waste treatment system, which is capable of 99.9999 percent sterilization by using high-temperature and high-pressure steam, has been developed for the first time in the country. The Korea Institute of Machinery and Materials (President Seog-Hyeon Ryu, hereinafter referred to as KIMM), an institute under the jurisdiction of the Ministry of Science and ICT, has succeeded in developing an on-site-disposal type medical waste sterilization system that can help to resolve the problem caused by medical waste, which has become a national and social issue as the volume of medical waste continues ...

A research team, affiliated with UNIST, has unveiled for the first time a new principle of motion in the microworld, where objects can move in a directed manner simply by changing their sizes periodically within a substance known as liquid crystal. Led by Professor Jonwoo Jeong and his research team in the Department of Physics at UNIST, this discovery is poised to have far-reaching implications across various research fields, including the potential development of miniature robots in the future. In their research, the team observed that air bubbles within ...

A four-year study by Dartmouth researchers captures the most in-depth data yet on how college students' self-esteem and mental health fluctuates during their four years in academia, identifying key populations and stressors that the researchers say administrators could target to improve student well-being. The study also provides among the first real-time accounts of how the coronavirus pandemic affected students' behavior and mental health. The stress and uncertainty of COVID-19 resulted in long-lasting behavioral changes that persisted as a "new normal" even as the pandemic diminished, including feeling more stressed, less socially engaged, and sleeping more. The ...

Participation in recreational activities — including golfing, gardening or yard work, woodworking and hunting — may be associated with an increase in a person’s risk for developing amyotrophic lateral sclerosis, or ALS, a Michigan Medicine study finds.  While many activities were associated with increased ALS risk, several were sex specific. The results are published in the Journal of the Neurological Sciences.  “We know that occupational risk factors, like working in manufacturing and trade industries, are linked to an increased risk for ALS, and this adds to a growing literature that recreational activities may also represent ...

Is there a way to stick hard and soft materials together without any tape, glue or epoxy? A new study published in ACS Central Science shows that applying a small voltage to certain objects forms chemical bonds that securely link the objects together. Reversing the direction of electron flow easily separates the two materials. This electroadhesion effect could help create biohybrid robots, improve biomedical implants and enable new battery technologies. When an adhesive is used to attach two things, it binds the surfaces either through mechanical or electrostatic forces. But sometimes those attractions or bonds are difficult, if not ...

A new study reveals that many people living in extreme poverty in low- and middle-income countries (LMICs) have conditions that lead to heart disease, the world’s #1 cause of death — overturning ‘conventional wisdom’. In the largest analysis of its kind exploring the relationship between poverty and cardiovascular disease (CVD) risk factors, experts discovered a high prevalence of hypertension, diabetes, smoking, obesity, and dyslipidemia in LMICs regardless of income —yet most adults living in extreme poverty were not treated for these CVD-related conditions.   An international group of researchers note that their findings, ...