The presentation summarised the preliminary findings from patients with known or suspected endometriosis who were imaged with a SPECT-CT camera and subsequently underwent planned laparoscopic surgery, a key-hole surgical procedure to establish the presence, absence and location of endometriotic lesions. The imaging findings were compared to the surgical and histology reports and indicate that 99mTc-maraciclatide holds potential as a non-invasive test for early-stage endometriosis. Specifically these preliminary findings demonstrate that 99mTc-maraciclatide has the potential to: Visualise superficial peritoneal endometriosis which is found ...

(Boston)—The MYCN oncoprotein (proteins related to the growth of cancer cells) plays a key role in starting, advancing and making it difficult to treat various human cancers. When MYCN is overactive, especially in high-risk neuroblastoma (childhood cancer often found in the adrenal glands), the tumors become less responsive to immunotherapy—a treatment that uses the body's immune system to fight cancer. Still, recognition of this problem has not led to any effective strategies to tackle this problem.   In a new study from Boston University Chobanian & Avedisian School of Medicine, researchers found that MYCN selectively increases ...

Philadelphia, March 15, 2024 – Researchers from Children’s Hospital of Philadelphia (CHOP) identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells. The findings also indicate that a better understanding of this metabolite and its role in immune response could improve the design of immunotherapies and create longer-lived responses against different types of cancer as well as enhance vaccine strategies. The findings were published ...

Weill Cornell Medicine investigators discovered that unique bacteria colonize the gut shortly after birth and make the neurotransmitter serotonin to educate gut immune cells. This prevents allergic reactions to food and the bacteria themselves during early development. The preclinical study, published in Science Immunology on Mar. 15, showed that bacteria abundant in the guts of newborns produce serotonin, which promotes the development of immune cells called T-regulatory cells or Tregs. These cells suppress inappropriate immune ...

People who identify as lesbian, gay and bisexual – particularly women – respond more positively to tobacco marketing, are more inclined to smoke cigarettes daily and may have a more difficult time quitting, according to two studies by a Rutgers Health researcher.   The studies, published in the Annals of LGBTQ Public and Population Health and Preventive Medicine Reports, investigated how some among the LGBTQ population respond to tobacco marketing, how they use tobacco and their history of quitting using two large national datasets, including the Population Assessment of Tobacco and ...

Researchers from Rensselaer Polytechnic Institute (RPI) will use hemp to develop a commercially viable, durable, and low-embodied-carbon insulated siding product to address what the U.S. Green Building Council says is a “crucial need for building retrofits to improve energy efficiency and reduce carbon emissions.”  The three-year, $1.5 million award given as part of the Buildings Energy Efficiency Frontiers and Innovation Technologies (BENEFIT) funding opportunity from the United States Department of Energy (DOE) will support RPI faculty and industry partners in creating Hemp Retrofit Structural Insulated Panel (HeRS), a hemp-based insulated siding system that ...

Pears are big business in the Pacific Northwest US. But did you know that traditional pear breeding has remained largely unchanged for centuries? This slow process is difficult and costly, requiring the long-term commitment of labor, materials, and land-space resources. However, traditional pear breeding might get some help from genomics, thanks to a unique collaboration between students, scientists, and the pear industry fostered through an initiative called the American Campus Tree Genomes (ACTG).  ACTG was born from two professors’ ...

BIRMINGHAM, Ala. – Hunger can drive a motivational state that leads an animal to a successful pursuit of a goal — foraging for and finding food. In a highly novel study published in Current Biology, researchers at the University of Alabama at Birmingham and the National Institute of Mental Health, or NIMH, describe how two major neuronal subpopulations in a part of the brain’s thalamus called the paraventricular nucleus participate in the dynamic regulation of goal pursuits. This research provides insight into the mechanisms by which the brain tracks motivational ...

“Our approach identified genes that were previously implicated in aging, as well as new ones that may warrant further investigation.” BUFFALO, NY- March 15, 2024 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 5, entitled, “Genome-wide transcriptome profiling and development of age prediction models in the human brain.” Aging-related transcriptome changes in various regions of the healthy human brain have been explored in previous works, however, a study to develop prediction models for age based on the expression levels of specific ...

People with voice disorders, including those with pathological vocal cord conditions or who are recovering from laryngeal cancer surgeries, can often find it difficult or impossible to speak. That may soon change. A team of UCLA engineers has invented a soft, thin, stretchy device measuring just over 1 square inch that can be attached to the skin outside the throat to help people with dysfunctional vocal cords regain their voice function. Their advance is detailed this week in the journal Nature Communications. The new bioelectric system, developed ...

by Jade Boyd Special to Rice News HOUSTON – (March 15, 2024) – Rice University synthetic biologists have found a way to piggyback on the glucose monitoring technology used in automated insulin dosing systems and make it universally applicable for the monitoring and dosing of virtually any drug. In a recently published study in Nature Communications, researchers in the lab of Caroline Ajo-Franklin demonstrated the technique by modifying a blood-glucose sensor to detect the anticancer drug afimoxifene ...

Seven undergraduate students from The University of Texas at Arlington headed to Washington, D.C., for a hands-on program to live, learn and intern in the nation’s capital. Founded in 2001, The Archer Center is the Washington, D.C., campus of the University of Texas System. Students accepted to its Archer Fellowship Program move to the Capitol Hill area of Washington to live with other Archer Fellows and take courses taught by UT faculty and policy experts. The scholars also participate in a ...

NEW YORK, NY (March 15, 2024)--Compared to adults, newborns are highly susceptible to infections and these infections can cause serious health complications and even death. One factor known to affect a newborn’s response to infection is a condition called neonatal neutropenia, in which the infant fails to make enough neutrophils, the immune system’s first responders. What underlies this immune deficiency, which greatly increases a newborn’s susceptibility to infection, is largely unknown, leaving clinicians with little understanding of how to prevent or treat it. A new study of mice by Columbia University ...

Perfectly adapted microorganisms live in extreme environments from deep-sea trenches to mountaintops. Learning more about how these extremophiles survive in hostile conditions could inform scientists about life on Earth and potential life on other planets. In ACS’ Journal of Proteome Research, researchers detail a method for more accurate extremophile identification based on protein fragments instead of genetic material. The study identified two new hardy bacteria from high-altitude lakes in Chile — an ...

Most people know about solids, liquids, and gases as the main three states of matter, but a fourth state of matter exists as well. Plasma—also known as ionized gas—is the most abundant, observable form of matter in our universe, found in the sun and other celestial bodies. Creating the hot mix of freely moving electrons and ions that compose a plasma often requires extreme pressures or temperatures. In these extreme conditions, researchers continue to uncover the unexpected ways that plasma can move and evolve. By better understanding the motion of plasma, scientists gain valuable insights into solar physics, astrophysics, ...

Specialized nursing facility clinicians, or SNFists, may decrease the likelihood of nursing home residents experiencing stressful hospitalizations and improve the quality of life in their last days, according to researchers from Weill Cornell Medicine. The paper, published in JAMA Network Open on Mar. 15, examined how SNFists uniquely impacted the care of nursing home residents in their last 90 days, compared with those cared for by other clinicians. This large-scale study is the first of its kind. “The literature has described ...

COLUMBUS, Ohio – Eating fatty food in the days leading up to surgery may prompt a heightened inflammatory response in the brain that interferes for weeks with memory-related cognitive function in older adults – and, new research in animals suggests, even in young adults. The study, building upon previous research from the same lab at The Ohio State University, also showed that taking a DHA omega-3 fatty acid supplement for a month before the unhealthy eating and surgical procedure prevented the effects on memory linked to both the high-fat diet and the surgery in aged ...

Adhesion GPCRs belong to the large family of G protein-coupled receptors (GPCRs). There are about 700 variants in humans, which are responsible for sensory impressions, hormonal cycles, controlling the cardiovascular system and more. GPCRs translate stimuli that hit a cell from outside into an intracellular biochemical signal. The use of the fruit fly as a model animal allows researchers in this field to gain a deep understanding of human diseases, because the animals are genetically very similar to humans. Scientists estimate that around 75 per cent of the genes involved in human diseases ...

The current theoretical model for the composition of the universe is that it’s made of ‘normal matter,’ ‘dark energy’ and ‘dark matter.’ A new uOttawa study challenges this. A University of Ottawa study published today challenges the current model of the universe by showing that, in fact, it has no room for dark matter. In cosmology, the term “dark matter” describes all that appears not to interact with light or the electromagnetic field, or that can only be explained through gravitational force. We can’t see it, nor do we know what ...

A study introduces a novel method for calibrating the spring constant of FluidFM micropipette cantilevers, crucial for the accurate measurement of forces in microfluidic environments. This method addresses the limitations of current calibration techniques, offering a significant advancement in the field of force microscopy. Fluidic force microscopy (FluidFM) combines the sensitivity of atomic force microscopy with microfluidics' capabilities, necessitating precise calibration of its cantilevers for reliable data. Traditional methods, however, struggle with the unique internal structure of FluidFM cantilevers, leading to ...

A recent study published in the Journal of Geographical Sciences in December 2023 reveals a novel method for reconstructing historical warm season temperatures in North China. Utilizing the blue intensity (BI) of tree rings of Picea meyeri, researchers have developed a 281-year chronology, offering unprecedented insights into the region’s climatic past. The escalating public concern over climate warming, due to its significant impacts on society, ecosystems, and the environment, underscores the importance of understanding long-term climatic conditions across different regions. As the limited observational records constrain our comprehensive grasp of climate change, tree-ring data prove ...

Funding will prepare three scientists to improve sustainable development in their country The University has won British Council International Science Partnerships funding of £180,000  The University already has close ties with the sustainability sector in the Philippines. Aston University is to help tackle sustainability problems in the Philippines by offering training to three of the country’s early career researchers. The University has won British Council International Science Partnerships funding of £180,000 to host three scientists ...

A new study reveals a significant increase in aboveground carbon (AGC) in Southwest China from 2013 to 2021, defying the adverse effects of extreme droughts. This achievement underscores the region's pivotal role as a carbon sink, attributed to extensive ecological projects and innovative remote sensing techniques. Over the past four decades, Southwest China has been a major carbon sink, significantly mitigating anthropogenic CO2 emissions. However, recent severe droughts, especially from 2009-2013 and in 2022, have drastically reduced its carbon ...

About The Study: This study quantified the potential savings from eliminating or reducing physical activity disparities, which can help policymakers, health care systems, schools, funders, sports organizations, and other businesses better prioritize investments toward addressing these disparities.  Authors: Bruce Y. Lee, M.D., M.B.A., of Public Health Informatics, Computational, and Operations Research (PHICOR), CUNY Graduate School of Public Health and Health Policy in New York, is the corresponding author. To ...

About The Study: Greater exposure to early-life pain was associated with altered maturation of neonatal structural connectivity, particularly in female infants in this study of 150 very preterm infants. Alterations in structural connectivity were associated with neurodevelopmental outcomes, with potential regional specificities.  Authors: Steven P. Miller, M.D.C.M., M.A.S., of the BC Children’s Hospital Research Institute and University of British Columbia in Vancouver, is the corresponding author.  To ...