A research has developed a new nanoparticle treatment that significantly improves outcomes for severe burn-induced intestinal barrier disruption. The study introduces Luminol-conjugated cyclodextrin (LCD) nanoparticles, offering a promising therapeutic intervention for one of the most critical complications following severe burn injuries. Severe burns can cause critical issues, including deep tissue damage and increased risk of fatal conditions like sepsis and organ failure. A major concern is the disruption of the intestinal barrier, leading to inflammation and systemic ...

The gut microbiota, a complex ecosystem within the human intestinal tract, is increasingly recognized for its vital role in human health and disease. Notably, its relationship with intestinal damage due to burns has been underexplored. New study has unveiled the pivotal role of gut microbiota in the synthesis and degradation of intestinal mucus following burn injuries in mice. Utilizing advanced 16S rRNA and metagenomic sequencing techniques, researchers have identified significant changes in gut microbiota composition and its impact on the intestinal mucus barrier. On a study ...

HOUSTON-(Mar. 14, 2024) – Houston Methodist researchers identified a troublesome subset of T-cells in transplant recipients that may be a more effective therapeutic target for preventing transplant rejection in patients.   Each day, 17 people die waiting for organ transplants, but getting a new organ doesn’t guarantee survival. Despite immunosuppressive medications, rejection of transplanted organs happens in up to 50% of patients, depending on the type of organ transplanted and the duration since the transplantation.   Wenhao Chen, Ph.D., associate professor of transplant immunology with the Houston Methodist Research ...

Researchers unveiled a novel therapy for diabetic wound healing. This research highlights the use of exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells (BMSCs) to significantly enhance wound healing by promoting keratinocyte autophagy. Diabetic wounds, often challenging to treat and prone to complications, can severely impact patients' quality of life. Traditional treatments have struggled with issues like low survival rates of transplanted cells and potential for immune rejection. This research introduces a groundbreaking approach using stem cells' regenerative capabilities. On ...

Medical image analysis using AI has developed rapidly in recent years. Now, one of the largest studies to date has been carried out using AI-assisted image analysis of lymphoma, cancer of the lymphatic system. Researchers at Chalmers University of Technology in Sweden, have developed a computer model that can successfully find signs of lymph node cancer in 90 percent of cases. New computer-aided methods for interpreting medical images are being developed for various medical conditions. They can reduce the workload for radiologists, by giving a second opinion or ranking which patients need treatment the fastest. "An AI-based computer system for interpreting medical images ...

WASHINGTON—Bariatric surgery may result in significant cardiometabolic improvements, particularly among younger, female, or white people and those without comorbidities, according to new research published in the Journal of the Endocrine Society. The United States has the highest obesity rates globally. In 2017-2018, about 40% of U.S. adults had obesity and 9% had severe obesity. The prevalence is particularly high among Black adults. Bariatric surgery is one method to help people with severe obesity lose a lot of weight and improve their health. “Our study highlights how bariatric surgery not only leads to significant weight loss but also substantially improves ...

WASHINGTON, DC (March 14, 2024)—Over the last 16 years, U.S. government funding for research and development (R&D) targeting global health challenges supported dozens of breakthrough innovations while generating billions of dollars in economic benefits, both global and domestic, and spurring a surge of industry investments, according to a new analysis from the Global Health Technologies Coalition (GHTC) and Policy Cures Research (PCR).    “Public funding for global health R&D is small, relative to the incredible returns it provides for fighting neglected ...

Key Takeaways  There was a 15-20% decrease in newly diagnosed breast cancer cases reported to American College of Surgeons Commission on Cancer sites in 2020 compared to 2019.  These study results have implications for how physicians and policymakers can address issues that may arise due to the diagnostic delays that occurred during the COVID-19 pandemic, the authors said.  CHICAGO: Several studies have described the distinct ways the COVID-19 pandemic adversely impacted cancer care, but less is known about the specific ways the pandemic disrupted breast cancer, the ...

By Shawn Ballard Nanomaterials already play a vital role in enhancing the performance of everyday products from electronics to cosmetics to food packaging. But, beyond their usefulness in making images sharper and products more stable, researchers in the McKelvey School of Engineering at Washington University in St. Louis have shown nanoparticles may also be an essential tool in advancing our understanding of the brain and opening new avenues for treating neurological disorders such as Parkinson's disease and epilepsy. Srikanth Singamaneni, the Lilyan & ...

Viral infections trigger more cases of intussusception, the common cause of bowel blockages in young children, than previously thought, according to a new study.  The research, led by Murdoch Children’s Research Institute (MCRI) and published in Clinical Infectious Diseases, found during the COVID-19 lockdowns hospital admissions for intussusception, a medical emergency involving obstruction of the intestine, among young children significantly decreased. For the study, 12 years of data was analysed across Victoria, NSW and Queensland. ...

Material scientists from the University of British Columbia Stewart Blusson Quantum Matter Institute (Blusson QMI) will lead the development of a multi-million world-class crystal growth facility thanks to $5.8 million in investments by the Canada Foundation for Innovation (CFI) and the B.C. Knowledge Development Fund (BCKDF) announced today. Blusson QMI Scientific Director Andrea Damascelli said the investment will strengthen Canada’s position as a leader in quantum research and technology. “The investment enables the establishment of state-of-the-art research infrastructure that is unique in Canada and will deliver exceptional impact for quantum material design, technology ...

‘Access to education’ is recognized as a fundamental human right and is listed as one of the United Nations’ sustainable development goals to achieve by 2030. Quality education unlocks opportunities and gives individuals the freedom to make livelihood choices and shape their own destinies. However, an increasing number of refugee children are deprived of this fundamental right. According to the UNHCR, between 2010 and 2022, the number of child refugees doubled from 20.6 million to about 43.3 million.   An overwhelming majority of these refugees are displaced to neighboring countries that are short on resources and lack adequate educational infrastructure ...

There is a growing emphasis for corporations to consider their impact on the environment, society, and its stakeholders. Broadly falling under environmental, social and governance or ESG, this involves practices such as using sustainably sourced materials, reducing carbon emissions, improving labor practices, fostering positive community relations, and promoting ethical corporate behavior, including efforts against anti-competitive practices and corruption.   The first mention of ESG appears in a 2004 UN report ...

With global goals set on transitioning away from fossil fuels, fuel cells stand out as a promising carbon-free energy source. Comprising an anode and a cathode separated by an electrolyte, fuel cells convert the chemical energy of fuel directly into electricity. The anode receives the fuel, while an oxidant, typically oxygen from the air, is introduced at the cathode. In a hydrogen fuel cell, hydrogen undergoes oxidation at the anode, producing hydrogen ions and electrons. The ions move through the electrolyte to the cathode, and electrons flow through an external circuit, generating electricity. At the cathode, oxygen combines with the hydrogen ions ...

DURHAM, NC – Living in a poorer neighborhood is linked to accelerated brain aging and increased dementia risk early in life, regardless of income level or education, a Duke University-led study finds. The study, which appears March 14 in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, suggests that targeting disadvantaged neighborhoods for dementia prevention programs and encouraging clinicians to consider a patient’s address could help lower dementia risk. “If you want to prevent dementia, and you’re not asking someone ...

UC Riverside scientists confirm, for the first time, that a potentially fatal dog parasite is present in a portion of the Colorado River that runs through California.  The parasite, Heterobilharzia americana, is a flatworm commonly referred to as liver fluke. Previously found almost exclusively in Texas and other Gulf Coast states, it has never been reported this far west. The worm can cause canine schistosomiasis, an illness that impacts the liver and intestines of dogs.  “Dogs can die from this infection, so we are hoping ...

With animal-free dairy products and convincing vegetarian meat substitutes already on the market, it’s easy to see how biotechnology can change the food industry. Advances in genetic engineering are allowing us to harness microorganisms to produce cruelty-free products that are healthy for consumers and healthier for the environment. One of the most promising sources of innovative foods is fungi – a diverse kingdom of organisms that naturally produce a huge range of tasty and nutritious ...

In a worldwide first-of-its-kind study published in the prestigious journal Nature Communications this week, a team of scientists from Children’s Medical Research Institute (CMRI) tested novel gene therapies in a whole human liver, with the goal of developing more effective treatments for life-threatening inherited diseases. Gene therapy is a revolutionary approach to treating serious genetic diseases that most commonly involves replacing or repairing a faulty gene. The most efficient delivery systems today are those based on a harmless virus named adeno-associated ...

Researchers at the Francis Crick Institute have shed light on how cancer cells survive in the first few hours after being cut off from a supply of oxygen. Published today in The EMBO Journal, this finding could one day help to prevent cancer from becoming resistant to therapy. A major use of oxygen by cells is for energy production. When oxygen supplies are low, most cells can survive because they adapt, by changing which proteins they make, to produce energy through different processes than in normal oxygen levels. This is coordinated by a protein called HIF1α, which turns on the activity of genes. Although HIF1α ...

Research Highlights: In a review of data for more than 90,000 veterans hospitalized with stroke, African American veterans who had been previously diagnosed with post-traumatic stress disorder (PTSD) were significantly more likely to be re-hospitalized than African American veterans without PTSD. In contrast, white veterans with PTSD were not significantly more likely to be re-hospitalized after stroke than white veterans without PTSD. Illicit drug use and Type 2 diabetes also raised the hospital readmission risk in African American veterans ...

A new method of timber analysis developed by researchers from the University of Gothenburg can confidently identify the location in which the tree was harvested. The method has been developed with the aim of combating illegal timber imports from Russia and Belarus. Illegal logging and the associated trade in wood products is a global problem that threatens some of the world's most important ecosystems. Researchers are trying to combat this practise with a new scientific method that can reveal ...

Arlington, Va. — March 14, 2024 — A new proof-of-concept study published today in the American Journal of Infection Control (AJIC) reports that artificial intelligence (AI) technologies can accurately identify cases of healthcare-associated infections (HAI) even in complex clinical scenarios. The study, which highlights the need for clear and consistent language when using AI tools for this purpose, illustrates the potential for incorporating AI technology as a cost-effective component of routine infection surveillance programs. According to the most recent HAI Hospital ...

Governments must act now to address the effects of climate change and air pollution on fertility rates and reproductive health, says a document published by the European Society of Human Reproduction and Embryology (ESHRE) today (Thursday). The factsheets* provide comprehensive information on global warming, evidence of its impact on fertility, and calls on policymakers to promote swift prevention measures. Priorities should be to reach net zero CO2 emissions within the next 20 years, and to keep global warming within a 1.5% increase, says the expert ...

In preparation for the 2024 Olympic surfing competition, a new judging tower is being constructed in the reef lagoon at Teahupo’o, Tahiti. Researchers from the University of Hawai‘i (UH) at Mānoa, UH Hilo, and Arizona State University and community partners in Tahiti recently published a study in Remote Sensing that assessed the potential impacts of the tower and emphasized the importance of protecting the valuable reef—both as an integral part of the ecosystem and a resource for the local community.  “We ...

DURHAM, N.H. — Carbon dioxide (CO2) emissions are not typically associated with water ways, like streams and rivers, but emerging research shows that water bodies play an important role in storing and releasing carbon dioxide. As many states look for cost-effective ways to mitigate climate change, scientists at the New Hampshire Agricultural Experiment Station at the University of New Hampshire looked at a way to optimize CO2 sensors to better measure carbon dioxide emissions in lotic, or moving, bodies of water offering a new tool that can help provide valuable information for everything from land use to climate action plans. “These sensors, adapted for highly ...