“[...] we present an improved method for G4 landscape determination and by applying it we show that sequence property-specific constraints of the nuclear environment mitigate G4 formation.” BUFFALO, NY- March 18, 2024 – A new research paper was published in Oncotarget's Volume 15 on March 14, 2024, entitled, “G-quadruplex landscape and its regulation revealed by a new antibody capture method.” In this new study, researchers Subhamoy Datta, Manthan Patel, Chakkarai Sathyaseelan, Chandrama Ghosh, Akanksha Mudgal, Divyesh Patel, Thenmalarchelvi Rathinavelan, ...

Prof. ZHOU Meng’s research team from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS), collaborating with Prof. WANG Quanming’s team from Tsinghua University (THU) achieved near-unity room-temperature photoluminescence quantum yield (PLQY) (>99%) in the near-infrared (NIR) emission of metal nanoclusters in solution. Their work was published in Science. Gold nanoclusters (Au NCs) as NIR-emissive materials hold potential in biomedical applications. However, the PLQY of Au NCs in NIR region is typically low, often ...

KANSAS CITY, MO—March 18, 2024—Fatty liver, which can lead to liver damage and disease, can occur from both overeating and starvation. Now, new research shows how naturally starvation-resistant cavefish, unlike other animals, are able to protect their liver and remain healthy. The findings have implications for understanding and potentially addressing liver conditions in humans. Researchers from the Stowers Institute for Medical Research in collaboration with Université Libre de Bruxelles in Belgium and Iowa State University ...

A research team led by Prof. WU Wenbing and Prof. WANG Linfei from the University of Science and Technology of China (USTC), in collaboration with Prof. SI Liang’ s team from Northwest University, developed a new water-soluble sacrificial layer, “super-tectragonal” Sr4Al2O7 (SAOT), with broad tunability in lattice constants, which can be used to prepare high-quality freestanding oxide membrane. Their work was published in Science. Freestanding oxide membrane is a type of low-dimensional quantum material that maintains single-crystal properties even ...

A research team led by Prof. NI Yong and Prof. HE Linghui from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) has developed a new composite glass combining the nacre-inspired structure and shear stiffening gel (SSG) material, maintaining transparency while exhibiting excellent thermal insulation and impact resistance. Their work was published in Advanced Materials. Bulk glass serves as an indispensable structural material in people’s daily lives. However, glass has poor thermal ...

For many people, leaving a job can be like leaving a family — and because of the personal and professional bonds they’ve forged, many naturally stay in touch with their former coworkers and keep apprised of what’s happening in the organization. But what happens when companies make a concerted effort to bolster those bonds, help former employees in their careers and keep them in the loop? According to new research from the UBC Sauder School of Business, it can have big benefits for both employees and employers. For the paper, researchers studied ...

A new analysis led by researchers at the Johns Hopkins Bloomberg School of Public Health estimates that 68 percent of Chicago children under age six live in households with tap water containing detectable levels of lead.  For their analysis, the researchers used machine learning, an artificial intelligence technique, to gauge likely levels of lead in tap water in households across Chicago, based on an existing dataset that includes results from 38,385 tap water tests taken from 2016 to 2023. The tests were from households that had registered for a free self-administered testing service for lead exposure.  The threshold the researchers ...

When a star goes supernova, a massive burst of neutrinos is the first signal that can escape the density of the collapsing star. Detecting and analyzing this phenomenon in real time would allow us insight into stellar dynamics and, potentially, black hole formation. Detection of these types of signals from modern physics detectors is notoriously hard and presents computational challenges that push the bounds of modern and next-generation computing. Transmitting and analyzing the data from the massive particle physics detectors to the next generation of extreme-scale ...

Dr. James McCully of Harvard Medical School and Boston Children's Hospital, USA, invited by Dr. Marvin Edeas, from Institut Cochin, Université Paris Cité, France, will host an instructive discussion on Mitochondrial Transplantation. This collaboration with the World Mitochondria Society (WMS) promises an insightful presentation by Dr. McCully on the topic of "Mitochondrial Transplantation: Rescue of Cellular Viability and Function and Modulation of the Ischemic Phenotype in the Myocardium." Dr. McCully will present ...

Winston-Salem, North Carolina – March 18, 2024 – The Regenerative Manufacturing Innovation Consortium (RegMIC), a leading organization focused on advancing the field of regenerative medicine, today announced its annual meeting, scheduled for May 15, 2024, at the DoubleTree by Hilton Charlotte Airport. RegMIC is an initiative from the Regenerative Medicine Development Organization (ReMDO). This year’s meeting will convene industry leaders, researchers, and innovators to explore the latest advancements and opportunities in regenerative ...

U.S. Energy Secretary Jennifer Granholm appointed Joe Powell, the founding executive director of the Energy Transition Institute at the University of Houston, to the U.S. Department of Energy’s Industrial Technology Innovation Advisory Committee (ITIAC). The 18-member committee, a diverse group of stakeholders who report directly to Granholm, will create a comprehensive strategy to accelerate the development of innovative technologies and processes designed to help decarbonize the American industrial sector and reduce emissions. This sector is ...

One of the largest studies on wildlife activity—involving more than 220 researchers, 163 mammal species and 5,000 camera traps worldwide—reveals that wild animals react differently to humans depending on where the animals live and what they eat. Bigger herbivores—plant-eating animals like deer or moose—tend to become more active when humans are around, while meat-eaters like wolves or wolverines tend to be less active, preferring to avoid risky encounters. Urban animals like deer or raccoons may become more active around people, as they get used to human presence and find food like garbage or plants, which they can access at night. But ...

The Organoid group at the Hubrecht Institute have identified a new link between FBXW7 mutations and EGFR signaling activity. The FBXW7 gene is commonly mutated in colorectal cancer and such mutations have been associated with worse treatment outcome. The researchers used colon organoids and the CRISPR/Cas9 gene editing technique to investigate the consequences of multiple common FBXW7 mutations. Further understanding of the link with EGFR signaling could help improve treatment strategies for colorectal cancer. The research was published on March 14th in Proceedings of the national academies of sciences (PNAS). Cancer is caused by the accumulation of mutations in different ...

The use of antipsychotics during pregnancy isn’t linked to childhood neurodevelopmental disorders or learning difficulties, UNSW Sydney-led study shows – giving assurance to those concerned about continuing their medications during pregnancy.  Antipsychotics – a branch of medication designed to treat schizophrenia and bipolar disorder – are important tools for mental health care management. They work by blocking the effect of dopamine, which can help reduce psychotic symptoms such as hallucinations or delusions.  These versatile ...

For younger Black patients living in rural parts of the Southeastern United States, peer coaching is more effective than traditional clinical care in controlling high blood pressure, according to a new study led by investigators at Weill Cornell Medicine and NewYork-Presbyterian. The investigators learned that for people under age 60 who have persistently uncontrolled hypertension, the benefits of working with a peer health coach were equivalent to what would be expected from taking a low dose of blood pressure medication. The findings were published March 18 in JAMA Internal Medicine. The randomized ...

About The Study: The findings of this study indicate that childhood lead exposure from drinking water is widespread in Chicago, and racial inequities are present in both testing rates and exposure levels. Machine learning may assist in preliminary screening for lead exposure, and efforts to remediate the effects of environmental racism should involve improving outreach for and access to lead testing services.  Authors: Benjamin Q. Huynh, Ph.D., of the Johns Hopkins University Bloomberg School of Public Health in Baltimore, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2024.0133) Editor’s ...

Mothers and daughters have a strong bond, yet do you know that connections reminiscent of this close relationship extend all the way to the cellular level? During the process of cell division, new daughter cells inherit a mix of genetic material and other molecules from their mother cells. This inheritance includes both beneficial components, which can help them for a robust start in life, and potentially harmful mutations or damaged molecules, posing significant challenges for the newly born daughter cells. How daughter cells manage and ...

Embargoed press materials are now available for Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology. Top scientists and educators in the field will gather at the meeting, March 23–26 in San Antonio.   Reporters are invited to attend an exciting lineup of in-person scientific sessions in San Antonio or access press materials electronically. Register now or find more information in the #DiscoverBMB newsroom. Please note that only a limited number of complementary on-site press passes will be issued, so advance registration is recommended.   Explore the schedule at a ...

Researchers at the Weizmann Institute of Science in Israel have identified a yeast that could be used to prevent invasive candidiasis, a major cause of death in hospitalized and immunocompromised patients. The study, to be published March 18 in the Journal of Experimental Medicine (JEM), shows that the novel yeast lives harmlessly in the intestines of mice and humans and can displace the yeast responsible for candidiasis, Candida albicans. Millions of microbial species live within or on the human body, many of them being harmless or even beneficial to human health. The microscopic yeast C. albicans is commonly found in the intestines ...

EMBARGOED FOR RELEASE Monday, March, 18,2024 10 a.m. EDT Contact: NIH Office of Communications and Public Liaison NIH News Media Branch 301-496-5787 NIH studies find severe symptoms of “Havana Syndrome,” but no evidence of MRI-detectable brain injury or biological abnormalities Compared to healthy volunteers, affected U.S. government personnel did not exhibit differences that would explain symptoms   Using advanced imaging techniques and in-depth clinical assessments, a research team at the National Institutes of Health (NIH) found no significant evidence of MRI-detectable brain injury, nor differences in most clinical measures compared to ...

About The Study: In this exploratory study, there were no significant differences between individuals reporting anomalous health incidents and matched control participants with respect to most clinical, research, and biomarker measures, except for objective and self-reported measures of imbalance and symptoms of fatigue, posttraumatic stress, and depression. This study did not replicate the findings of previous studies, although differences in the populations included and the timing of assessments limit direct comparisons. ...

About The Study: In this exploratory neuroimaging study, there were no significant differences in imaging measures of brain structure or function between individuals reporting anomalous health incidents and matched control participants after adjustment for multiple comparisons. U.S. government personnel stationed internationally have reported anomalous health incidents, with some individuals experiencing persistent debilitating symptoms.  Authors: Carlo Pierpaoli, M.D., Ph.D., of the National Institute of Biomedical Imaging and Bioengineering in ...

Global coffee consumption generates millions of tons of spent coffee grounds each year, which can be damaging to wildlife and the environment. However, new research published in the Journal of Chemical Technology and Biotechnology reveals that spent coffee grounds could be repurposed to act as a powerful adsorbent of bentazone, a herbicide commonly used in agriculture that is highly neurotoxic. In the study, investigators found that when they used zinc chloride to activate the carbon from spent coffee grounds, the activated carbon showed a 70% efficiency in bentazone removal. ...

Astronomers have charted the largest-ever volume of the universe with a new map of active supermassive black holes living at the centers of galaxies. Called quasars, the gas-gobbling black holes are, ironically, some of the universe’s brightest objects. The new map logs the location of about 1.3 million quasars in space and time, the furthest of which shone bright when the universe was only 1.5 billion years old. (For comparison, the universe is now 13.7 billion years old.) “This quasar catalog is different from all previous catalogs in that it gives us a three-dimensional map of the largest-ever volume of the universe,” says map co-creator David Hogg, a ...

Life can be hard for a raptor. If you’re a teenager from the city, it’s even harder. That’s according to a new study published in the Journal of Raptor Research titled “Causes of Death of Female Cooper’s Hawks (Accipiter cooperii) from an Urban Setting in New Mexico, USA,” conducted by Brian A. Millsap and his colleagues at the US Fish and Wildlife Service. Over the course of 11 years, his research team affixed GPS transmitters to 158 female Cooper’s hawks in the Albuquerque area. Of those, 88 died and were found, allowing the researchers to investigate cause of death. The ...