Most common bone and joint (orthopaedic) procedures, such hip replacements and shoulder repair surgery, are not backed up by high quality evidence, mainly because of a lack of definitive trials, suggests an analysis of data published by The BMJ today. Yet despite the lack of strong supporting evidence, some of these procedures are still recommended by national guidelines in certain situations, the findings show. Musculoskeletal conditions affect around 1 in 4 UK adults and account for over 25% of all NHS surgical interventions at a cost of £4.76 billion each year. National ...

Muscle relaxant drugs are largely ineffective for low back pain, despite being widely prescribed for this condition, suggests an analysis of the latest evidence published by The BMJ today. The findings show that muscle relaxants might reduce pain in the short term, but the effect is too small to be considered clinically meaningful, and there is an increased risk of side effects. But the researchers stress that the certainty of evidence is low and say large trials are urgently needed to resolve uncertainties around the use of these drugs for back pain. Low back pain is a global public health problem and muscle relaxants (a broad class of drugs that include ...

Mandatory covid-19 vaccination for care home workers is unnecessary, disproportionate and misguided, warn experts And is based on unreliable data In The BMJ today, experts argue that mandatory vaccination is "unnecessary, disproportionate, and misguided." The government decision to remove the right of care home staff in England to choose whether or not to be vaccinated against covid-19 is a profound departure from public health norms. The intended next step is a rapid and massive expansion of compulsory vaccination to legally require covid-19 and flu vaccination of all frontline health and social care workers, subject to consultation. But Lydia Hayes, Professor of Law at Kent ...

An estimated 8.4 billion people could be at risk from malaria and dengue by the end of the century if emissions keep rising at current levels, according to a new study published in The Lancet Planetary Health. The research team estimates that this worst-case scenario would mean the population at risk of the diseases might increase by up to 4.7 additional billion people (relative to the period 1970-1999), particularly in lowlands and urban areas, if temperatures rise by about 3.7°C 1 by 2100 compared to pre-industrial levels. The study was led by the London School of Hygiene & Tropical Medicine (LSHTM) with partners from Umeå University, Sweden; Abdus Salam ...

LOS ANGELES - A new prognostic tool developed by researchers from the UCLA Jonsson Comprehensive Cancer Center and five other institutions helps predict which men with advanced metastatic prostate cancer will respond favorably to a novel targeted therapy. The tool, described in a study published today in Lancet Oncology, analyzes a wide spectrum of imaging and clinical data and is intended to assist physicians considering treating patients with Lutetium-177 prostate-specific membrane antigen, or LuPSMA. LuPSMA, which binds to PSMA proteins and delivers targeted radiation to prostate cancer tissue, offers a new option to men with PSMA-positive metastatic cancer that is castration-resistant, meaning it has stopped ...

The protein actin is ubiquitous and essential for life. In mammals, every cell expresses two of its forms, beta-actin and gamma-nonmuscle-actin. Despite having distinct roles, the two forms are nearly identical, sharing 99% of their amino acid sequence. Research by Anna Kashina of Penn's School of Veterinary Medicine and colleagues has shown that, contrary to scientific dogma, it's not the slight differences in amino acid sequence that govern these proteins' discrete functions in the cell. Rather, their nucleotide sequences--the "letters" that make up their DNA coding sequence, which differ by roughly 13% between the two forms--are responsible for their individual roles in organisms' ...

Researchers have produced vaccine-like immune responses to a dangerous bacterium by colonizing 26 healthy volunteers with a related, but harmless, commensal bacterial species. The first-in-human, controlled infection study showed the strategy was safe, as no side effects were reported and the volunteers didn't transmit the commensal bacteria to bedroom-sharers over the 90-day study. Neisseria lactamica is a member of the microbiome that usually resides in the upper airways of children but can also safely colonize the airways of adults. Some researchers theorize that these bacteria ...

By 2050, faster adoption of electric vehicles (EVs) and faster generation of renewable energy will result in 99% less fossil fuel consumed and 93% less CO2 emissions from passenger and freight vehicles on O?ahu. That's under the most ambitious scenario in an article published in World Electric Vehicle Journal, by University of Hawai?i at Mānoa School of Ocean and Earth Science and Technology (SOEST) faculty member Katherine McKenzie. McKenzie, based at the Hawai?i Natural Energy Institute in SOEST, created mathematical models of four scenarios based on projections for the switch to electric passenger and freight ...

Five years ago, researchers at Northwestern University made international headlines when they discovered that human eggs, when fertilized by sperm, release billions of zinc ions, dubbed "zinc sparks." Now, Northwestern has teamed up with the U.S. Department of Energy's (DOE) Argonne National Laboratory and Michigan State University (MSU) to reveal that these same sparks fly from highly specialized metal-loaded compartments at the egg surface when frog eggs are fertilized. This means that the early chemistry of conception has evolutionary roots going back at least 300 million years, to the last common ancestor between frogs and people. "This work may help inform our understanding of the interplay of dietary zinc status and human fertility." -- Thomas O'Halloran, professor, Michigan State ...

The measures taken during the COVID-19 pandemic limited the access of citizens to natural objects. It is still unexplored, what consequences this had for the residents and what conclusions should be drawn for more effective urban planning. RUDN University scientists with colleagues from Australia and Germany studied how the restrictions associated with COVID-19 affected the use of blue and green infrastructure by citizens in Moscow (Russia) and Perth (Australia), and what consequences this had for their health. In the article "Human Dimensions of Urban Blue and Green Infrastructure during a Pandemic. The Case Study of Moscow (Russia) ...

Bahamian mosquitofish in habitats fragmented by human activity are more willing to explore their environment, more stressed by change and have smaller brain regions associated with fear response than mosquitofish from unaffected habitats. The new study from North Carolina State University shows that these fish have adapted quickly in specific ways to human-driven change, and cautions that environmental restoration projects should understand these changes so as not to damage adapted populations. The Bahamas mosquitofish is a small, coastal fish species that frequently inhabits tidal creeks - shallow, tidally influenced marine ecosystems. ...

In 2019, Anaïs Llorens and Athina Tzovara -- one a current, the other a former University of California, Berkeley, postdoctoral scholar at the Helen Wills Neuroscience Institute (HWNI) -- were attending a scientific meeting and pleased that one session, on gender bias in academia, attracted nearly a full house. The problem: The audience of some 300 was almost all women. Where were the men, they wondered? More than 75% of all tenured faculty in Ph.D. programs around the world are men, making their participation key to solving the problem of gender bias, which negatively impacts the careers, work-life balance and mental health of all women in science, and even more ...

FOR IMMEDIATE RELEASE In what turned out to be one of the most important accidents of all time, Scottish bacteriologist Alexander Fleming returned to his laboratory after a vacation in 1928 to find a clear zone surrounding a piece of mold that had infiltrated a petri dish full of Staphylococcus aureus (S. aureus), a common skin bacterium he was growing. That region of no bacterial growth was the unplanned birth of a medical miracle, penicillin, and would lead to the era of antibiotics. Now, END ...

When gravitational waves were first detected in 2015 by the advanced Laser Interferometer Gravitational-Wave Observatory (LIGO), they sent a ripple through the scientific community, as they confirmed another of Einstein's theories and marked the birth of gravitational wave astronomy. Five years later, numerous gravitational wave sources have been detected, including the first observation of two colliding neutron stars in gravitational and electromagnetic waves. As LIGO and its international partners continue to upgrade their detectors' sensitivity to gravitational waves, they will be able to probe a larger volume of the universe, thereby making the detection ...

As the COVID-19 pandemic wanes in the U.S., a new study from the University of Maryland School of Medicine (UMSOM) and University of Maryland Medical Center (UMMC) finds that hospitals nationwide may not be adequately prepared for the next pandemic. A 10-year analysis of hospitals' preparedness for pandemics and other mass casualty events found only marginal improvements in a measurement to assess preparedness during the years leading up to the COVID-19 pandemic. The study was published last month in the Journal of Healthcare Management. "Our work links objective healthcare data to a hospital score that ...

If a virtual world has ever left you feeling nauseous or disorientated, you're familiar with cybersickness, and you're hardly alone. The intensity of virtual reality (VR)--whether that's standing on the edge of a waterfall in Yosemite or engaging in tank combat with your friends--creates a stomach-churning challenge for 30-80% of users. In a first-of-its kind study, researchers at the University of Maryland recorded VR users' brain activity using electroencephalography (EEG) to better understand and work toward solutions to prevent cybersickness. The research was conducted by Eric Krokos, who received his Ph.D. in computer science in 2018, and Amitabh Varshney, a professor of computer science ...

Although wastewater disposal has been the primary driving force behind increased earthquake activity in southern Kansas since 2013, a new study concludes that the disposal has not significantly changed the orientation of stress in the Earth's crust in the region. Activities like wastewater disposal can alter pore pressure, shape and size within rock layers, in ways that cause nearby faults to fail during an earthquake. These effects are thought to be behind most recent induced earthquakes in the central and eastern United States. It is possible, however, that human activity could also lead to earthquakes by altering the orientation of stresses that act on faults in the region, said U.S. Geological Survey seismologist ...

As more evidence emerges that opioid overdose deaths have increased dramatically since the onset of COVID-19, the Centre for Addiction and Mental Health (CAMH), in collaboration with subject matter experts and medical regulatory authorities across Canada, have now released updated national clinical guidelines for the treatment of opioid use disorder. END ...

When someone is suspected of criminal activity, one of the most important questions they are asked is if they have a credible alibi. Playing back past events in our minds, however, is not like playing back a video recording. Recollections of locations, dates, and companions can become muddled with the passage of time. If a suspect's memories are out of line with documented events, a once-plausible alibi can crumble and may be seen as evidence of guilt. To put people's memories of past whereabouts to the test, a team of researchers tracked the locations of 51 volunteers for one month and found that their recollections were wrong approximately 36% of the time. "This is the first study to examine memory for where ...

Uppsala University scientists have designed a new mouse model that facilitates study of factors contributing to the progression of human bladder cancer and of immune-system activation when the tumour is growing. Using this model, they have been able to study how proteins change before, while and after a tumour develops in the bladder wall. The study has now been published in the scientific journal PLOS ONE. "The model was designed both to contain specific oncogenes, as they're called -- mutations that can drive tumour growth -- and to show a high incidence of harmful mutations, which we often see in people who get bladder cancer. These harmful mutations arise because of smoking, for instance, which is ...

Sudanese Islamic burial sites are distributed according to large-scale environmental factors and small-scale social factors, creating a galaxy-like distribution pattern, according to a study published July 7, 2021 in the open-access journal PLOS ONE by Stefano Costanzo of the University of Naples "L'Orientale" in Italy and colleagues. The Kassala region of eastern Sudan is home to a vast array of funerary monuments, from the Islamic tombs of modern Beja people to ancient burial mounds thousands of years old. Archaeologists don't expect these monuments are randomly placed; their ...

GPS data from cell phones may provide insight into how city inhabitants are using their urban greenspaces, in a study published July 7, 2021 in the open-access journal PLOS ONE by Meghann Mears and Paul Brindley from the University of Sheffield, UK, and colleagues. Urban greenspaces confer a range of health and well-being benefits on city inhabitants and provide connection to nature. In this study, Mears and colleagues use cellphone GPS data to assess how frequently residents of the city of Sheffield in the UK engage with their local urban greenspaces, and whether this engagement was different across demographic groups. The authors used the "Shmapped" app, developed as part of the Improving Well-being through Urban Nature project, to track how frequently 240 users based in Sheffield ...

New iguanodon-like dinosaur identified from jawbone fossil from Spain was likely a 6-8m long herbivore, closely related to species found in modern-day China and Niger. INFORMATION: Article Title: A new Styracosternan hadrosauroid (Dinosauria: Ornithischia) from the Early Cretaceous of Portell, Spain Funding: The authors received no specific funding for this work. Competing Interests: The authors have declared that no competing interests exist. Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253599 ...

Brain microstructure may help explain the benefits of physical activity on cognition in older adults, according to MRI scans of 318 brains post-mortem. INFORMATION: Article Title: Physical activity, brain tissue microstructure, and cognition in older adults Funding: This work was supported in part by the National Institute on Aging (https://www.nia.nih.gov) grants K25 AG61254 (RJD), K01 AG64044 (VNP), K01 AG50823 (BDJ), R01 AG17917 (DAB), R01 AG47976 (ASB), R01 AG56352 (ASB), R01 AG64233 (JAS, KA), and P30 AG10161 (DAB), the National Institute of Neurological Disorders and Stroke (https://www.ninds.nih.gov) grant UH3 NS100599 ...

HOUSTON - (July 7, 2021) - A thin shell of soft polymer can help keep knotty ceramic structures from shattering, according to materials scientists at Rice University. Ceramics made with 3D printers crack under stress like any plate or bowl. But covered in a soft polymer cured under ultraviolet light, the same materials stand a far better chance of keeping their structural integrity, much like a car windshield's treated glass is less likely to shatter. The research at Rice's Brown School of Engineering, which appears in Science Advances, demonstrates the concept on schwarzites, complex lattices that for decades existed only as theory but can now be made with 3D printers. With added polymers, they come to resemble structures ...