The primary cilium, an antenna-like subcellular structure ('organelle') protruding from the outside of many types of vertebrate cells, has an important but previously overlooked role in guiding the growth of lymphatic vessels, shows a new study. The authors show for the first time that mouse and human lymphatic endothelial cells (LECs) - which make up the inner and outer lining of lymphatic vessels - use primary cilia. They find that LEC primary cilia may direct the growth of a functional lymphatic network, not only during prenatal development, but also throughout life during inflammation and wound healing and in response to cancer. They show that mice in which the formation of primary cilia in LECs is prevented develop lymphatic ...

Bethesda, MD (May 14, 2021) -- Daily probiotic use was associated with fewer upper respiratory symptoms in overweight and older people, according to a study that suggests a potential role for probiotics in preventing respiratory infections. The study was selected for presentation at Digestive Disease Week® (DDW) 2021. "This is not necessarily the most intuitive idea, that putting bacteria into your gut might reduce your risk of respiratory infection," said Benjamin Mullish, MD, a lead researcher on the study and clinical lecturer in the Division of Digestive Diseases, Imperial College London, England, "but it's further ...

Bethesda, MD (May 14, 2021) -- Despite the fact that certain racial and ethnic minorities get pancreatic cancer more often, are diagnosed at a younger age and die sooner, clinical trials fail to include representative proportions of non-White patients at every phase of study, according to research that was selected for presentation at Digestive Disease Week® (DDW) 2021. "We see disparities in representation across all kinds of clinical trials, so we were not surprised to see that it also occurs in pancreatic cancer trials. But hopefully we can make a change in that arena in the future," said Kelly Herremans, MD, lead researcher on the study and surgical research fellow at the University ...

Bethesda, MD (May 14, 2021) -- Combining minimally invasive endoscopic sleeve gastroplasty (ESG) with the diabetes drug semaglutide can provide additional significant weight loss for patients who are not candidates for invasive weight-loss surgery, according to research that was selected for presentation at Digestive Disease Week® (DDW) 2021. "As the worldwide obesity rate continues to climb, so do the number of people seeking bariatric surgery to treat their condition," said Anna Carolina Hoff, MD, lead researcher on the study and founder and clinical director of Angioskope Brazil, São José dos Campos. "Surgical procedures are some of the most successful ways to help patients lose weight, but they ...

Bethesda, MD (May 14, 2021) -- Inpatient consults for alcohol-related gastrointestinal (GI) and liver diseases have surged since the beginning of the COVID-19 pandemic and remained elevated, according to research selected for presentation at Digestive Disease Week® (DDW) 2021. The proportion of patients that required inpatient endoscopic interventions for their alcohol-related GI and liver diseases has also increased, highlighting an apparent worsening trend in the severity of disease. "When we went into lockdown, many people experienced significant negative ...

Monash University researchers have validated a way to successfully detect a diverse range of bacteria (pathogens) that cause diarrhoeal disease in informal settlements. Better protection from disease for people living in communities facing water, sanitation and hygiene challenges is essential, as microbes that cause gastrointestinal disease (enteropathogens) are responsible for 1.4 million deaths per year, predominantly in children under five, and cause impaired nutrition and development. However, it is highly challenging to effectively monitor their spread due to the sheer number of pathogens and sources involved. Numerous enteropathogens cause diarrhoea and other gastrointestinal diseases, spanning viruses, bacteria, amoeba, and worms, each with distinct characteristics. Moreover, ...

Researchers from Monash University, Queensland University of Technology, and Capital University of Economics and Business published a new paper in the Journal of Marketing that examines the effects of imaginative product displays in retail stores on customers' purchase behavior. The study, forthcoming in the Journal of Marketing, is titled "Gimmicky or Effective? The Effects of Imaginative Displays on Customers' Purchase Behavior" and is authored by Hean Tat Keh, Di Wang, and Li Yan. Imaginative displays are constructed using multiple units of the same product in a novel, yet aesthetically appealing, form. Results from six ...

People with healthier heart structure and function appear to have better cognitive abilities, including increased capacity to solve logic problems and faster reaction times, according to research led by Queen Mary University of London and the Radcliffe Department of Medicine at University of Oxford. Dr Zahra Raisi-Estabragh, BHF Clinical Research Training Fellow at Queen Mary University of London said: "Heart disease and dementia are important and growing public health problems, particularly in ageing populations. "We already knew that patients with heart disease were more likely to have dementia, and vice versa, but we've now shown that these links between heart and brain health are also present in healthy people. We demonstrated for the ...

Sophia Antipolis, 14 May 2021: Nearly one in four patients with heart failure is depressed or anxious, according to a study published during this week's Heart Failure Awareness Days. Patients with heart failure were 20% more likely to develop these mental health issues during the five years after diagnosis compared to those with cancer. The findings are published in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).1 "The treatment of mental illnesses in cancer patients - psycho-oncology - is long-established but similar services ...

Higher levels of ozone from air pollution are linked to an increased risk of developing fibroids among Black American women according to a large study published today (Friday) in Human Reproduction [1], one of the world's leading reproductive medicine journals. Fibroids are non-cancerous growths that develop in and around the womb. They are diagnosed in 25-30% of pre-menopausal women, but the true incidence is thought to be between 70-80%. Many fibroids do not cause symptoms but when they do, they are one of the main reasons women are admitted to hospital for inpatient care. Symptoms can include heavy or painful periods, stomach and back pain, constipation, frequent need to urinate, and pain or discomfort during sex. In some ...

The need to evacuate an intensive care unit (ICU) or operating theatre complex during a fire or other emergency is a rare event but one potentially fraught with difficulty: not only is there a risk that patients may come to significant harm but also that staff may be injured and unable to work. Therefore, the Association of Anaesthetists and the Intensive Care Society are today publishing new 2021 guidelines regarding fire safety and emergency evacuation of ICUs and operating theatres in Anaesthesia (a journal of the Association of Anaesthetists). These guidelines ...

LA JOLLA, CA--A family of proteins that sense mechanical force--and enable our sense of touch and many other important bodily functions--also are essential for proper root growth in some plants, according to a study led by scientists at Scripps Research and Howard Hughes Medical Institute (HHMI). The discovery, published in the END ...

According to data from a cohort of adult and pediatric patients with antibody deficiencies, patients that often fail to make protective immune responses to infections and vaccinations showed robust T-cell activity and humoral immunity against SARS-CoV-2 structural proteins. The new study, led by researchers at Children's National Hospital, is the first to demonstrate a robust T-cell response against SARS-CoV-2 in immunocompromised patients. "If T-cell responses to SARS-CoV-2 are indeed protective, then it could suggest that adoptive T-cell immunotherapy might benefit more profoundly immunocompromised patients," said Michael Keller, M.D., director of the Translational Research Laboratory in the ...

Scientists at the Skolkovo Institute of Science and Technology (Skoltech) and their colleagues from the University of Graz & the Kanzelhöhe Observatory (Austria) and the ESA European Space Operations Centre developed a method and software called RESONANCE to predict the solar radio flux activity for 1-24 months ahead. RESONANCE will serve to improve the specification of satellite orbits, re-entry services, modeling of space debris evolution, and collision avoidance maneuvers. The research results were published in the high-profile Astrophysical Journal Supplement Series. Since the launch of Sputnik, the Earth's first artificial satellite, in ...

The work was sponsored by Russian Science Foundation; the project, headed by Professor Anatolii Mokshin, is titled "Theoretical, simulating and experimental research of physico-mechanical traits of amorphous-producing systems with heterogeneous local visco-elastic properties". "We performed calculations for porous nitinol," shares first co-author, Associate Professor Bulat Galimzyanov. "It's widely used in various industries thanks to its unique physico-mechanical properties, such as low volume weight, high corrosion resistance, high biocompatibility and shape memory. Obtaining nitinol as amorphous foam is very labor-intensive, it requires high temperatures and extremely high melt cooling rate (over 1,000,000 K per second). Obviously, traditional experiments ...

A large-scale randomised trial of annual screening for ovarian cancer, led by UCL researchers, did not succeed in reducing deaths from the disease, despite one of the screening methods tested detecting cancers earlier. Results from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) have been published in a report in the medical journal The Lancet. In the UK, 4,000 women die from ovarian cancer each year. It is not usually diagnosed until it is at a late stage and hard to treat. UKCTOCS was designed to test the hypothesis that a reliable screening ...

BOSTON - B cells are the immune cells responsible for creating antibodies, and most B cells, known as B2 cells, produce antibodies in response to a pathogen or a vaccine, providing defense and immunity against infections. But a small subset of long-lived B cells, known as B1 cells, are quite different from their short-lived cousins, the B2 cells. Instead of producing antibodies in response to invaders, they spontaneously make antibodies that perform vital housekeeping functions, such as removing waste like oxidized LDL cholesterol from the blood. Like all the cells in the body, B1 and B2 cells have the same DNA, and therefore the same starting set of instructions. It is through epigenetic modifications, which ...

PROVIDENCE, R.I. [Brown University] -- Since the 1950s, political scientists have theorized that political polarization -- increased numbers of "political partisans" who view the world with an ideological bias -- is associated with an inability to tolerate uncertainty and a need to hold predictable beliefs about the world. But little is known about the biological mechanisms through which such biased perceptions arise. To investigate that question, scientists at Brown University measured and compared the brain activity of committed partisans (both liberals and conservatives) as ...

If you're a fan of spy movies, you've probably come across scenes where the intelligence agents try to identify or detect a perpetrator using some sophisticated image enhancement technology on surveillance camera images. While the idea behind surveillance cameras and object detection is the same in real life, unlike in movies, there is often a trade-off between the camera's field-of-view and its resolution. Surveillance cameras are typically required to have a wide field-of-view to make the detection of a threat more likely. Due to this, omnidirectional ...

The first frost of autumn may be grim for gardeners but the latest evidence reveals it is a profound event in the life of plants. The discovery may affect how we grow crops in a fluctuating climate and help us better understand molecular mechanisms in animals and humans. Much of our understanding of how plants register temperature at a molecular level has been gained from the study of vernalization - the exposure to an extended period of cold as a preparation for flowering in spring. Experiments using the model plant Arabidopsis have shown how this prolonged period of cold lifts the brake on flowering, a gene called FLC. This biochemical brake also involves another molecule COOLAIR which is antisense to FLC. This means it lies on the ...

Researchers at Hospital for Special Surgery (HSS) have identified gaps in patient knowledge about pain management and opioid use before total hip replacement, including misconceptions about how much pain relief to expect from opioids after surgery, how to use multiple modes of pain relief (multimodal analgesia) safely and effectively, and proper opioid storage and disposal. These findings were presented at the 2021 Spring American Society of Regional Anesthesia and Pain Medicine (ASRA) Annual Meeting.1 "Patients who are not taught about opioids and pain management may have difficulty with pain control and worse functional outcomes after total ...

Researchers at Hospital for Special Surgery (HSS) have identified risk factors for persistent opioid use after surgery in pediatric patients.1 Study findings were presented at the 2021 Spring American Society of Regional Anesthesia and Pain Medicine (ASRA) Annual Meeting. Previous research indicates that prescription patterns for opioids after surgery in children and adolescents may be associated with long-term use and abuse.2 "Pediatric patients have developing brains that are uniquely vulnerable to addiction, and we need to learn to treat their pain safely without putting them at additional ...

In a study carried out in mice at the University of Chicago, researchers found that lasofoxifene outperformed fulvestrant, the current gold-standard drug, in reducing or preventing primary tumor growth. It also was more effective at preventing metastasis in the lung, liver, bone and brain, the four most common areas for this cancer to spread. Additionally, while fulvestrant and similar drugs often cause unwanted, menopausal-like side effects, lasofoxifene prevents some of these symptoms. The research was published on May 13 in END ...

How people consume news and take actions based on what they read, hear or see, is different than how human brains process other types of information on a daily basis, according to researchers at the University of Missouri School of Journalism. While the current state of the newspaper industry is in flux, these journalism experts discovered people still love reading newspapers, and they believe a newspaper's physical layout and structure could help curators of digital news platforms enhance their users' experiences. "Many people still love print newspapers, and to an extent, we also see that they like the digital replicas of print newspapers as much as they do the physical version," said Damon Kiesow, a professor of journalism professions and co-author on the study. "But we believe there ...

In a paper published in the May 13th, 2021 issue of PLOS Genetics, a Z-RNA nanoswitch that regulates interferon immune responses is described. The switch, less than 5 nanometer in length, is based on sequences, called flipons, that change outcomes by altering their three dimensional conformation. The Z-RNA nanoswitch flips from the shorter right-handed A-RNA helix ("on") to the longer left-handed Z-RNA helix ("off"). The flip ends immune responses against self RNAs, but not against viruses. Surprisingly, the Z-RNA nanoswitch sequence is encoded by "junk DNA". The Z-RNA nanoswitch is used by some cancers to silence anti-tumor immune responses. In other cases, a malfunction of the Z-RNA nanoswitch causes inflammatory disease. In the ...