Flu: Interferon-gamma from T follicular helper cells is required to create lung-resident memory B cells
BIRMINGHAM, Ala. – During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into antibody producing cells. Another path is the B cells that differentiate into lung-resident memory B cells, or lung-BRMs, that are critical for pulmonary immunity.
Unlike antibody-producing B cells that help fight the current infection, the long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes. ...














