Acta Pharmaceutica Sinica B Volume 11, Issue 4 Publishes https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/11/issue/4 Special Issue: The Biological Fate of Drug Nanocarriers This special issue includes seven review and nine research articles from some leading scientists in the field that further the discussion on subtopics of in vivo fate of drug nanocarriers. Guest Editors: Wei Wu, Professor, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China; Tonglei Li, Professor, Department of Industrial & Physical Pharmacy, Purdue University, West Lafayette, IN, USA; Ying Zheng, Professor, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China. The Journal ...

How to predict the sound produced by a tonewood block once carved into the shape of a violin plate? What is the best shape for the best sound? Artificial Intelligence offer answers to these questions. These are the conclusions that researchers of the Musical Acoustics Lab of Politecnico di Milano presented in a study that was recently published in Scientific Reports. In the article "A Data-Driven Approach to Violinmaking" the Chilean physicist and luthier Sebastian Gonzalez (post-doc researcher) and the professional mandolin player Davide Salvi (PhD student) show how a simple and effective neural network is able to predict the vibrational be-havior of violin plates. This prediction is obtained from a limited set of geometric and mechanical ...

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) has helped Gaia achieve millimagnitude (mmag) precision in photometry, according to a study led by researchers from National Astronomical Observatories of Chinese Academy of Sciences (NAOC) and Beijing Normal University (BNU). Their study was published in The Astrophysical Journal. If you look at the sky on a clear, starry night, you may notice that Aldebran is relatively red and Rigel is blue. Why? The answer stems from their intrinsic physical properties. Precisely measuring magnitudes ...

The polar vortex is a large area of upper-atmosphere cyclonic air circulation surrounding both poles. It is bounded by the polar jet stream and its associated cold air is usually confined to the polar regions. Within the Antarctic circle, and southern polar vortex, ozone quantities are the lowest, globally. A research published in Advances in Atmospheric Sciences, led by Dr. LUO Yuhan, corresponding author and Associate Professor at the Hefei Institutes of Physical Science (HFIPS), suggests that the polar vortex plays a key role in Antarctic stratospheric ozone depletion. "The atmosphere over Antarctica is controlled by a strong ...

May 1, 2021 - Rheumatologists in Hong Kong joined hands to develop a set of consensus statements on COVID-19 vaccination for local adult patients with autoimmune rheumatic diseases. These timely statements would serve to be a guide for rheumatologists, other specialists, family physicians, specialty nurses, and the public regarding COVID-19 vaccination for patients with rheumatic diseases. Vaccination against SAR-CoV-2 is a new campaign and a high immunization rate is believed to be the key to end the pandemic. Currently, there are two COVID-19 vaccines available in Hong Kong--the inactivated virus vaccine CoronaVac® ...

Parks played an important role for people seeking respite from the toll of social isolation during the pandemic, and according to new research from Drexel University, they did so without increasing the spread of COVID-19. The study looked at how people used 22 parks in Philadelphia and New York during the height of the pandemic and it found no strong correlation between park use and the number of confirmed cases in surrounding neighborhoods. Published in the Journal of Extreme Events, Drexel's study "Urban Park Usage During the COVID-19 Pandemic" surveyed park visitors over a three-month period from May to July 2020 at small and mid-size parks in New York and Philadelphia. And it compared park usage numbers ...

An essential preliminary to building and construction or resource extraction is studying the geological structure of the site. One of steps of this process is geophysical investigation. This provides a continuous overview of the geological horizons rather than just data on points: boreholes. The standard methods of geophysics help successfully solve this problem in comparatively simple conditions. Yet the classical direct current methods may lead to serious inaccuracy if we have to investigate geologically complex structures with thin layers of sandy and clayey soils. Among the most popular methods ...

Leipzig/Jena/Ilmenau. Mobile apps like Flora Incognita that allow automated identification of wild plants cannot only identify plant species, but also uncover large scale ecological patterns. These patterns are surprisingly similar to the ones derived from long-term inventory data of the German flora, even though they have been acquired over much shorter time periods and are influenced by user behaviour. This opens up new perspectives for rapid detection of biodiversity changes. These are the key results of a study led by a team of researchers from Central Germany, which has recently been published in Ecography. With the help of Artificial Intelligence, plant species ...

The gopher tortoise (Gopherus polyphemus) is declining because of habitat loss and fragmentation, human interaction including collisions with vehicles, predation by domestic animals, and disease. These long-lived reptiles are found throughout Florida and are affected by various diseases including upper respiratory tract disease. A number of pathogens such as Mycoplasma spp., Herpesvirus, and Ranavirus are known to cause upper respiratory tract disease in gopher tortoises. Chronic disease resulting from these pathogens can lead to reduced reproduction, abnormal growth and development, increased susceptibility to secondary ...

Lysophospholipids are phospholipids that have just one fatty acid chain, and in recent years, the role of lysophospholipids in physiology and pathophysiology has attracted attention. Lysophosphatidylethanolamine (LPE) is a type of lysophospholipid that are reportedly present in the brain that consist of many species with different fatty acid chain lengths and degrees of unsaturation. The latest studies in animal models have reported elevated levels of LPE in the brain after traumatic brain injury and cerebral ischemia. Fluctuations in LPE concentration have also been reported in the plasma of patients with major depression and Alzheimer's disease. Although these reports suggest the involvement of LPE in brain function, the role of LPE in the brain has remained unclear. Therefore, ...

Smaller, faster, more energy-efficient: future requirements to computing and data storage are hard to fulfill and alternative concepts are continuously explored. Small magnetic textures, so-called skyrmions, may become an ingredient in novel memory and logic devices. In order to be considered for technological application, however, fast and energy-efficient control of these nanometer-sized skyrmions is required. Magnetic skyrmions are particle-like magnetization patches that form as very small swirls in an otherwise uniformly magnetized material. In particular ferromagnetic thin films, skyrmions are stable at room temperature, with diameters down to the ten-nanometer range. It is known that skyrmions can be created and moved by short pulses of electric current. Only recently it was discovered ...

Researchers have recently extracted the proton mass radius from the experimental data. A research group at the Institute of Modern Physics (IMP) of the Chinese Academy of Sciences (CAS) presented an analysis of the proton mass radius in Physical Review D on May 11. The proton mass radius is determined to be 0.67 ± 0.03 femtometers, which is obviously smaller than the charge radius of the proton. In the Standard Model, the proton is a composite particle made of quarks and gluons and it has a non-zero size. The radius of the proton is a global and fundamental property of the proton. It is related to the color confinement radius -- a property governed by quantum chromodynamics (QCD). The radius of the proton is approximately 100,000 times smaller ...

Atoms are the basic building blocks for all materials. To tailor functional properties, it is essential to accurately determine their atomic structures. KAIST researchers observed the 3D atomic structure of a nanoparticle at the atom level via neural network-assisted atomic electron tomography. Using a platinum nanoparticle as a model system, a research team led by Professor Yongsoo Yang demonstrated that an atomicity-based deep learning approach can reliably identify the 3D surface atomic structure with a precision of 15 picometers (only about 1/3 of a hydrogen atom's radius). The atomic displacement, strain, and facet analysis revealed that the surface atomic structure and strain are ...

The study conducted by the University of Turku and the Finnish Institute for Health and Welfare together with an international research team is so far the largest population-level study in the world examining the connection between human gut microbiota and health and mortality in the following decades. The composition of the research subjects' gut microbiota was analysed from stool samples collected in 2002. The researchers had access to follow-up data on the subjects' mortality until 2017, i.e., close to the present day. "Many bacterial strains that are known ...

Acetone, a volatile solvent used for everything from removing nail polish and cleaning textiles to manufacturing plastics, could get a sustainability boost from a new strain of bacteria engineered by a research team based in Japan. They published the details of the heat-loving, acetone-producing bacteria called Moorella thermoacetica on April 23 in AMB Express. Acetone is typically produced through the widely used cumene method, which is cost-effective but not sustainable. The process, developed in 1942, involves converting two non-renewable resources into acetone and phenol, another chemical ...

The human brain is a vast network of billions of biological cells called Neurons which fires electrical signals that process information, resulting in our sense and thoughts. The ion channels of atomic scale in each neuron cell membrane plays a key role in such firings that opens and closes the ion flow in an individual cell by the electrical voltage applied across the cell membrane, acting as a "biological transistor" similar to electronic transistors in computers. For decades, scientists have learned that biological ion channels are life's transistors capable to gate extremely fast and precisely selective permeation of ions through the atomic-scale selectivity filters to maintain vital living functions. However, ...

Researchers from the £12 million Developing Human Connectome Project have used the dramatic advances in medical imaging the project has provided to visualise and study white matter pathways, the wiring that connects developing brain networks, in the human brain as it develops in the womb. Published today in Proceedings of the National Academy of Sciences of The United States of America, the study used magnetic resonance images (MRI) with unprecedented resolution from more than 120 healthy fetuses across the second and third trimesters of pregnancy to define how the structural connections in their ...

Strawberry production is one of the driving forces in the Spanish agriculture sector, as strawberries are highly valued for their organoleptic characteristics and health benefits. These two factors, their economic relevance, and the value that consumers assign them, make this fruit an object of scientific research from multiple perspectives, including that of food safety. A research project headed by Liliana Pérez-Lavalle, Elena Carrasco, Pedro Vallesquino-Laguna, Manuel Cejudo, Guiomar Denisse Posada and Antonio Valero has aimed to evaluate whether the Salmonella Thompson bacteria, one of the pathogens that can contaminate the fruit through sewage and/or the soil, could penetrate through the roots ...

Gold leaf -- gold metal hammered into thin sheets -- is used by artists and crafters to gild picture frames, artwork and clothing. Despite its luxurious appearance, the material is affordable and available at most craft stores. Now, researchers reporting in ACS Central Science have developed gold leaf electrodes that, in combination with a CRISPR-based assay, could sensitively detect human papillomavirus (HPV) DNA in human samples. The method also could be modified to diagnose other viral infections. Previous research indicates that about 80% of new cases of sexually transmitted infections, such as HPV and human immunodeficiency virus (known ...

Earthworms improve the soil by aerating it, breaking down organic matter and mineralizing nutrients. Now, researchers reporting in ACS' Environmental Science & Technology have dug up another possible role: reducing the number and relative abundance of antibiotic-resistance genes (ARGs) in soils from diverse ecosystems. These results imply that earthworms could be a natural, sustainable solution to addressing the global issue of antibiotic resistance, the researchers say. The overuse of antibiotics in humans and animals has caused ARGs to accumulate in soils, which could contribute to the rise in antibiotic-resistant infections. Earthworms consume tons of soil per year worldwide, and their guts have a unique combination of low-oxygen conditions, neutral pH and native microbial ...

Coal combustion by power plants and industry pollutes the air, causing many governments to implement mitigation actions and encourage cleaner forms of energy. Now, a new study in ACS' Environmental Science & Technology indicates that in China, indoor air pollution from residential coal burning causes a disproportionate number of premature deaths from exposure to tiny, inhalable pollutants known as PM2.5. In China, coal is still the largest source of energy, although recent mitigation actions have replaced some coal-fired power plants with petroleum- or natural gas-powered plants. Also, many coal-fired power plants and industrial boilers have installed equipment that reduces ...

COLUMBUS, Ohio - Kindergartners from low-income families spent more than six hours a day in front of screens during two early months of the COVID-19 pandemic, a small Ohio study suggests. That is nearly double the screen time found before the pandemic in similar children, according to other research. Caregivers from low-income households may have faced more difficulties than those from more advantaged families in managing the time their children spent watching TV and using computers, phones and tablets when child care was shut down, according to the researchers. Still, the results are concerning, said Rebecca Dore, lead author of the study and senior research ...

Everyone has at some point been charmed by the sound of a person's voice: but can we believe our ears? What can a voice really reveal about our character? Now an international research team led by the University of Göttingen has shown that people seem to express at least some aspects of their personality with their voice. The researchers discovered that a lower pitched voice is associated with individuals who are more dominant, extrovert and higher in sociosexuality (more interested in casual sex). The findings were true for women as well as for men. The results were published in the Journal of Research in Personality. The researchers analysed data from over 2,000 participants and included ...

In Amyotrophic Lateral Sclerosis (ALS), the progressive death of neurons that control body movement leads to paralysis of muscles in the limbs and gradually of the whole body, which ultimately makes it impossible to breathe. ALS is currently untreatable, and its cause is unknown. It is known, however, that in 10% of affected individuals there is a strong genetic component, which causes the disease to occur in several members of a single family. In about half of these cases of familial ALS, the origin lies in a gene called C9ORF72. But why do mutations in this gene kill motor neurons? The answer may have been found by the Genomic Instability Group headed by Óscar Fernández-Capetillo at the Spanish National Cancer Research Centre (CNIO), who discovered ...

The property that makes fluorescent lights buzz could power a new generation of more efficient computing devices that store data with magnetic fields, rather than electricity. A team led by University of Michigan researchers has developed a material that's at least twice as "magnetostrictive" and far less costly than other materials in its class. In addition to computing, it could also lead to better magnetic sensors for medical and security devices. Magnetostriction, which causes the buzz of fluorescent lights and electrical transformers, occurs when a material's shape and magnetic field are linked--that is, a change in shape causes a change in magnetic field. The property could be key to a new generation of computing devices called ...