(Singapore – 10:05 a.m. SGT--September 11, 2023) – Osimertinib plus chemotherapy demonstrated a statistically significant and clinically meaningful progression-free survival benefit compared to osimertinib alone, according to research presented today at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer in Singapore. The FLAURA2 study was led by Dr. Pasi A. Jänne from the Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute in Boston, Mass. Osimertinib, a potent third-generation EGFR-TKI with central nervous system activity, has garnered attention for its targeted ...

(Singapore, September 11, 2023, 10:05 a.m. SGT) – Extended pleurectomy decortication combined with chemotherapy is associated with worse survival outcomes, a higher incidence of serious adverse events, and a diminished quality of life compared to platinum and pemetrexed chemotherapy alone, according to research presented today the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer in Singapore. The UK Multicentre Randomised Trial, known as MARS 2, conducted by a team led by Professor  Eric ...

(Singapore – 10:05 a.m. SGT--September 11, 2023) – A modified adenocarcinoma classification approach significantly enhances reproducibility and may be an improvement on the existing World Health Organization classification system, according to research unveiled at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer in Singapore. The study, led by Dr. Erik Thunnissen, Department of Pathology, Amsterdam UMC, VU Medical Center, Amsterdam, The Netherlands, ...

First-ever National Screening Program to Consider Family History (Singapore – 10:05 a.m. SGT--September 11, 2023) – The Taiwan National Lung Cancer Early Detection Program detected 85 percent of lung cancer cases at either a phase 0 or phase 1 level, demonstrating that lung cancer screening can detect lung cancer at an early enough phase to allow doctors to intervene more effectively. The results of the program were presented by Pan-Chyr Yang, MD, PhD from the National Taiwan University Hospital, at the International Association for the Study of Lung Cancer 2023 World Conference ...

[Singapore, 10:05 a.m. SGT--September 11, 2023] – Adding perioperative durvalumab to neoadjuvant chemotherapy did not adversely impact surgery in patients with resectable NSCLC and was associated with a tolerable surgical safety profile, according to research presented today from the phase 3 AEGEAN trial at the International Association for the Study of Lung Cancer 2023 World Conference on Lung Cancer in Singapore. "The AEGEAN trial demonstrated a clinically meaningful improvement in EFS ...

Milan, Italy: People suffering with obstructive sleep apnoea (OSA) can reduce their risk of dying from cardiovascular disease if they use a continuous positive airway pressure (CPAP) machine at night, according to research presented at the European Respiratory Society International Congress in Milan, Italy [1].   CPAP may also work better than a weight loss drug in reducing the build-up of plaque in the arteries around the heart, according to a pilot study also presented at the European Respiratory Society International Congress [2].   People with OSA often snore loudly, their breathing starts and stops during the night, and they may ...

Milan, Italy: Young children growing up in towns and cities suffer from more respiratory infections than those who grow up in the countryside, according to research presented at the European Respiratory Society International Congress in Milan, Italy [1].   A second study, presented at the Congress and published in Pediatric Pulmonology today (Monday) [2], shows that factors such as attending day care, living in a damp home or near dense traffic increase the risk of chest infections in young children, while breastfeeding reduces the risk.   Researchers say that some children, who are otherwise healthy, can suffer with repeated infections, so it is important to understand why ...

Milan, Italy: Babies and young children with more mature communities of bacteria present in their gut are less likely to develop allergy-related wheezing or asthma, according to research presented at the European Respiratory Society International Congress in Milan, Italy [1].   These communities of bacteria, known as microbiota, develop in the human body during the early years of life and are involved in processes that are helpful to the body, such as synthesising vitamins and boosting the immune system, or occasionally unhelpful, such as the role they play ...

About The Study: Among individuals with uncontrolled hypertension in this randomized clinical trial that included 200 participants, use of lorundrostat was effective at lowering blood pressure compared with placebo, which will require further confirmatory studies. Authors: Steven E. Nissen, M.D., of the Cleveland Clinic Foundation, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2023.16029) Editor’s Note: Please see the article for additional ...

[Singapore -- 10:35 a.m. SGT--September 10, 2023] - The combination of benmelstobart, anlotinib, and chemotherapy demonstrated significant benefits compared to placebo and chemotherapy in terms of median progression-free survival and overall survival for patients with extensive-stage small-cell lung cancer. The research was presented today at the International Association for the Study of Lung Cancer 2023 World Conference on Lung Cancer in Singapore. Extensive-stage small-cell lung cancer is a challenging malignancy to treat, ...

[Singapore -- 10:35 a.m. SGT--September 10, 2023] -- Identifying and analyzing volatile organic compounds in exhaled breath of patients with malignant pleural mesothelioma showed promise as a screening method for MPM, according to research presented today at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer in Singapore. Malignant pleural mesothelioma (MPM) is a challenging disease with limited treatment options and a poor prognosis. To improve ...

[Singapore -- 10:35 a.m. SGT--September 10, 2023) -- The International Association for the Study of Lung Cancer (IASLC) World Conference on Lung Cancer 2023 in Singapore is set to witness a monumental breakthrough in the field of metastatic non-small cell lung cancer (NSCLC) treatment. Research findings from the CheckMate 227 trial will be presented, shedding light on the extraordinary six-year survival and quality of life benefits associated with first-line nivolumab + ipilimumab therapy. CheckMate 227 Part 1 showed that a combination ...

[Singapore -- 10:35 a.m. SGT--September 10, 2023] — The oral, selective KRAS G12C inhibitor  The oral, selective KRAS G12C inhibitor  KRAS-G12C inhibitor adagrasib demonstrated durable clinical activity, with a median overall survival of 14.1 months and approximately one in three patients alive at two years, according to research presented today at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer in Singapore.   KRAS-G12C mutations occur in approximately 14% of patients with NSCLC. The KRYSTAL-1 study, a multi-cohort Phase 1/2 trial, evaluated adagrasib as a monotherapy or in combination for patients with KRAS-G12C-mutated ...

[Singapore -- 10:35 a.m. SGT--September 10, 2023) –The stigma that patients face when diagnosed with lung cancer is associated with poorer psychosocial outcomes, including distress and isolation, delayed help-seeking, and concerns about the quality of care, according to research presented today at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer in Singapore. The study, conducted by a team of researchers led by Nathan Harrison, a behavioral scientist and PhD student ...

Milan, Italy: The colour of the phlegm from patients with the lung disease bronchiectasis can indicate the degree of inflammation in their lungs and predict their future outcomes, according to new research presented at the European Respiratory Society International Congress in Milan, Italy [1].   The study of nearly 20,000 patients from 31 countries is the first time that the colour of phlegm (also known as sputum) has been shown to provide clinically relevant information that reflects prognoses and, therefore, can aid decisions about ...

Tokyo, Japan – Researchers from Tokyo Metropolitan University have shown that the protein Musashi-2 (Msi2) plays a key role in the regulation of mass and metabolic processes in skeletal muscle. They studied mice with the Msi2 gene knocked out and found reduced muscle mass due to fewer type 2a muscle fibers. Myoglobin and mitochondria were also reduced. Type 2a fibers respond sensitively to training and illnesses; insights into their regulation will prove valuable in new therapies.   Skeletal muscle fibers are truly fascinating in how responsive they are. With training, we can significantly improve muscle mass, strength and endurance. On the other hand, with age or extended ...

One radiologist supported by AI detected more cases of breast cancer in screening mammography than two radiologists working together, reports the ScreenTrustCAD study from Karolinska Institutet in The Lancet Digital Health. The researchers say that AI is now ready to be implemented in breast cancer screening. For over 30 years, screening mammography has been an important key in reducing breast cancer mortality rates. However, challenges include a lack of radiologists and that not all cancers are detected. Several retrospective studies have shown that artificial ...

ROCHESTER, Minn. — In a randomized trial, published in The Lancet Oncology, Mayo Clinic Comprehensive Cancer Center researchers uncover evidence supporting a shorter treatment time for breast cancer patients. The study compared two separate dosing schedules of pencil-beam scanning proton therapy, the most advanced type of proton therapy known for its precision in targeting cancer cells while preserving healthy tissue to reduce the risk of side effects. Survival rates for breast cancer continue to improve due to advances in diagnosis and treatment, leading to increasing emphasis on reducing the long-term ...

A University of Texas at Arlington hydrologist’s study in the Nature journal Scientific Data provides the first-ever global estimate of human destruction of natural floodplains. The study can help guide future development in a way that can restore and conserve vital floodplain habitats that are critical to wildlife, water quality and reducing flood risk for people. Adnan Rajib, a UT Arlington assistant professor in the Department of Civil Engineering, was the lead author on the published study, “Human Alterations of the Global Floodplains.” His doctoral student, Qianjin Zheng, played a significant ...

Images Researchers at Michigan State University have shown that table salt outperforms other expensive catalysts being explored for the chemical recycling of polyolefin polymers, which account for 60% of plastic waste.   The research, published in the journal Advanced Sustainable Systems, shows that sodium chloride could provide a safe, inexpensive and reusable way to make plastics more recyclable.   The team also showed that table salt and other catalysts could be used in the recycling of metallized plastic films — like ...

FINDINGS In a recent study led by Lei Jiang, Ph.D., an assistant professor of molecular and cellular endocrinology, a team of researchers from City of Hope and the University of Texas Southwestern Medical Center, found a potential new target for treating patients with metastatic cancer. Their findings were published in the August 29 issue of the journal Cell Reports.  The goal of the team’s study was to elucidate the role of reductive carboxylation in redox metabolism, a process believed to be important for metastatic cancer. Reductive carboxylation is best known as a metabolic pathway that provides a molecule called acetyl-CoA so that it can be turned into lipids, which ...

A three-year, $3.4 million grant to investigate how Alzheimer’s disease is connected to multiple chronic diseases has been awarded to UTHealth Houston researchers by the National Institute on Aging, part of the National Institutes of Health. To study this, a team led by Xiaoqian Jiang, PhD, principal investigator and professor and chair in the Department of Health Data Science and Artificial Intelligence with McWilliams School of Biomedical Informatics at UTHealth Houston, will build risk trajectory maps for patients using clinical data and electronic health records. Specifically, they will develop electronic health records ...

September 8, 2023 – SwiftPharma, a Belgium-based manufacturer, and the Population Council, a global nonprofit research organization, have signed a Manufacturing Master Service Agreement for the plant-based manufacture of Griffithsin to further the Council’s development of a Griffithsin fast-dissolving vaginal insert for protection against HIV.     The Population Council has been developing a non-antiretroviral HIV-prevention method containing Griffithsin (GRFT) in a fast-dissolving insert (FDI). This Griffithsin FDI is an on-demand, user-controlled, portable prevention technology in early development ...

Safety-net hospitals have a common mission to provide care for Medicaid beneficiaries and those who are uninsured, but there’s no universal definition for these hospitals—complicating efforts to allocate funding. In a new analysis published in JAMA Network Open and led by researchers at the NYU School of Global Public Health, the research team looked at five established definitions for safety-net hospitals and found that different criteria captured varying hospitals and characteristics. As a result, when the Centers for Medicaid and Medicare Services (CMS) use one definition ...

The world saw another year full of extreme weather events resulting from climate change in 2022, from intense storms to soaring temperatures and rising sea levels. Antarctica was no exception, according to new research published this week.    In the 33rd annual State of the Climate report, an international assessment of the global climate published Sept. 6 in the Bulletin of the American Meteorological Society, CU Boulder researchers report that the planet’s coldest and driest continent experienced both an unprecedented heatwave and extreme precipitation last year.  “My hope is that the public starts to see both the fragility and complexity of these ...