Cells are capable of translating mechanical changes into biological responses. This process is known as mechanotransduction and plays a fundamental role in the progression of solid tumors, such as breast cancer. It is well-established that a common mechanical alteration in cancer progression involves tissue hardening. This stiffness is precisely what is detected during self-examinations or breast palpations for potential tumor detection. The stiffness of breast tissue triggers a chain reaction, inducing tension within cells and distorting their nuclei. Ultimately, this nuclear deformation activates genes responsible for controlling cell proliferation, which are closely associated ...

September 14, 2023 — More than 90% of the active members of the National Association of Neonatal Nurses (NANN) believe the organization should pursue racial equity work, and many have specific suggestions for a strategic plan. This feedback comes from the survey results the association released this month in its journal, Advances in Neonatal Care. The journal is published in the Lippincott portfolio by Wolters Kluwer.  "Neonatal care has advanced significantly in recent years, yet ...

The rate at which the universe is expanding, known as the Hubble constant, is one of the fundamental parameters for understanding the evolution and ultimate fate of the cosmos. However, a persistent difference called the “Hubble Tension” is seen between the value of the constant measured with a wide range of independent distance indicators and its value predicted from the big bang afterglow. NASA’s James Webb Space Telescope provides new capabilities to scrutinize and refine some of the strongest observational evidence for this tension. Nobel Laureate Adam Riess from the Johns Hopkins University and ...

PHILADELPHIA – CAR T cell therapy pioneer Carl June, MD, the Richard W. Vague Professor in Immunotherapy in the Perelman School of Medicine at the University of Pennsylvania and director of the Center for Cellular Immunotherapies (CCI) at Penn Medicine’s Abramson Cancer Center, has been named a winner of the 2024 Breakthrough Prize in Life Sciences for the development of chimeric antigen receptor (CAR) T cell immunotherapy, a revolutionary cancer treatment approach in which each patient’s T cells are modified to target and kill their cancer cells. The invention sparked a new path in cancer care, harnessing the power of patients’ own immune systems, a once-elusive ...

One quarter of food consumed in the EU-27 originates from outside the region, highlighting the vulnerability of the EU’s food system.  New research coordinated by Global Footprint Network’s sustainability scientists in collaboration with food system experts published the article “EU-27 Ecological Footprint was primarily driven by food consumption and exceeded regional biocapacity from 2004 to 2014” today in Nature Food. The way food is provided to and consumed by Europeans represents ...

UNIVERSITY PARK, Pa. — Rivers are warming and losing oxygen faster than oceans, according to a Penn State-led study published today (Sept. 14) in the journal Nature Climate Change. The study shows that of nearly 800 rivers, warming occurred in 87% and oxygen loss occurred in 70%. The study also projects that within the next 70 years, river systems, especially in the American South, are likely to experience periods with such low levels of oxygen that the rivers could “induce acute death” for certain species of fish and threaten aquatic diversity at large. “This is a wake-up call,” ...

A model to map energy demand down to street level shows cooling demand in the capital grew by 5% per year between 1980 and 2022 as summers heat up. The Demand.ninja model, created by researchers at Imperial College London and TU Delft, was designed to show how the weather influences hourly energy consumption in buildings. It can also account for changes in demand as the climate changes, including the increase in cooling demand in the summer as heatwaves become more common and more intense. Countries ...

Researchers have discovered a new way to target and kill cancer cells in hard-to-treat brain tumours using electrically charged molecules to trigger self-destruction, that could be developed into a spray treatment used during surgery. A multidisciplinary team of researchers from the University of Nottingham, led by the School of Pharmacy found a new way to harness the extraordinary capabilities of bio-nanoantennae—gold nanoparticles intricately coated with specialised redox active molecules to induce programmed cell death, or apoptosis, in cancer cells on electrical stimulation. The research ...

About The Study: The findings of this study of 805,000 patients ages 18 or older suggest that receipt of physical therapy (PT) after presentation for dizziness was associated with a reduction in fall risk during the subsequent 12 months; thus, timely PT referral for dizziness may be beneficial for these patients. Future research, ideally with a clinical trial design, is needed to explore the independent impact of PT on subsequent falls for adults with dizziness.  Authors: Meredith E. Adams, M.D., M.S., of ...

About The Study: The results of this study of 2,176 counties suggest that breast cancer mortality in the U.S. can be affected by where individuals live, and that more comprehensive and geographically targeted interventions may lead to healthier communities.  Authors: Taylor Anderson, Ph.D., of George Mason University in Fairfax, Virginia, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2023.33618) Editor’s Note: Please see the article for additional information, including other authors, author contributions ...

Combination immunotherapy with the anti-PD-L1 monoclonal antibody durvalumab and other novel agents outperforms durvalumab alone in the neoadjuvant (pre-surgical) setting for early-stage non-small-cell lung cancer (NSCLC), according to researchers at The University of Texas MD Anderson Cancer Center.  The findings, published today in Cancer Discovery, were first presented at the American Association for Cancer Research (AACR) Annual Meeting 2022.     The multicenter, randomized Phase II NeoCOAST clinical trial evaluated neoadjuvant durvalumab alone ...

NEW YORK – The era of artificial-intelligence chatbots that seem to understand and use language the way we humans do has begun. Under the hood, these chatbots use large language models, a particular kind of neural network. But a new study shows that large language models remain vulnerable to mistaking nonsense for natural language. To a team of researchers at Columbia University, it’s a flaw that might point toward ways to improve chatbot performance and help reveal how humans process language.    In a paper published online today in Nature Machine Intelligence, ...

 Flexible thin-film electrodes placed directly on brain tissue show promise for the diagnosis and treatment of epilepsy, as demonstrated recently by scientists at Tokyo Tech. Thanks to an innovative yet straightforward design, these durable electrodes accurately match the mechanical properties of brain tissue, leading to better performance during electrocorticography recordings and targeted neural stimulation. Measuring brain activity is a useful technique for diagnosing epilepsy and other neuropsychiatric disorders. Among the several approaches adopted, electroencephalography (EEG) is the least invasive. During EEG recordings, electrodes ...

Although a simple molecule, nitric oxide is an important signal substance that helps to reduce blood pressure by relaxing the blood vessels. But how it goes about doing this has long been unclear. Researchers at Karolinska Institutet in Sweden now present an entirely novel principle that challenges the Nobel Prize-winning hypothesis that the substance signals in its gaseous form. Their findings are presented in the journal Nature Chemical Biology. That the simple molecule nitric oxide or nitrogen monoxide (NO) serves as a signal substance in many important physiological processes has been known for some time. For example, the discovery of the compound’s ...

A team of researchers, led by a University of Hawai‘i (UH) at Mānoa planetary scientist, discovered that high energy electrons in Earth’s plasma sheet are contributing to weathering processes on the Moon's surface and, importantly, the electrons may have aided the formation of water on the lunar surface. The study was published today in Nature Astronomy.  Understanding the concentrations and distributions of water on the Moon is critical to understanding its formation and evolution, and to providing water resources for future human exploration. The new ...

Areas in Vancouver with the greatest need for restorative nature often have the least exposure to it, according to a new UBC study published recently in Ambio. These neighbourhoods include Strathcona, downtown Vancouver, the West End, southern Sunset and Marpole. The researchers developed a new tool, the local restorative nature (LRN) index to assess spaces for the presence of qualities that promote mental well-being. While initially applied in Vancouver, the index can also be used in any urban landscape, according to lead author Dr. Tahia Devisscher, an assistant professor in the faculty of forestry. We sat down with Dr. Devisscher to discuss the study findings and ...

PHILADELPHIA – Many Americans do not know what rights are protected under the First Amendment and a substantial number cannot name all three branches of government, according to the 2023 Annenberg Constitution Day Civics Survey. The Annenberg Public Policy Center’s annual, nationally representative survey finds that when U.S. adults are asked to name the specific rights guaranteed by the First Amendment to the Constitution, only one right is recalled by most of the respondents: Freedom of speech, ...

The study across three countries led by the Department of Psychology’s Dr Paul Hanel discovered people who prioritised achievement over enjoyment were less happy on the next day. Whereas those who aimed for freedom said they had a 13% increase in well-being, recording better sleep quality and life satisfaction. And participants who tried to relax and follow their hobbies recorded an average well-being boost of 8% and a 10% drop in stress and anxiety. Dr Hanel worked with colleagues at the University of Bath on the Journal of Personality-published study. For the first ...

Boston, MA – New polling data released late last week shows 77% of surveyed Massachusetts residents support a $600 state Child and Family Tax Credit. This polling confirms the popularity of the more generous Child and Family Tax Credit included in the House tax package, which is under consideration alongside the Senate tax bill by a bicameral conference committee. “The overwhelming support for a $600 tax credit per child matches up with the stories I have heard from families across my district, and the experiences of working Massachusetts families that they need more financial ...

WASHINGTON — Capturing blur-free images of fast movements like falling water droplets or molecular interactions requires expensive ultrafast cameras that acquire millions of images per second. In a new paper, researchers report a camera that could offer a much less expensive way to achieve ultrafast imaging for a wide range of applications such as real-time monitoring of drug delivery or high-speed lidar systems for autonomous driving. “Our camera uses a completely new method to achieve high-speed imaging,” said Jinyang Liang from the Institut national de la recherche scientifique (INRS) ...

INDIANAPOLIS – Research scientists led by Johanne Eliacin, PhD, of the U.S. Department of Veterans’ Affairs (VA) and Regenstrief Institute, have developed PARTNER-MH, an innovative, peer-led patient navigation program to support racially and ethnically minoritized veterans seeking mental healthcare, regardless of the types of mental health services needed or their mental health diagnoses. In two peer-reviewed published papers they report significant improvements in mental health outcomes and high participant satisfaction with the program. PARTNER-MH, developed for VA mental ...

Newborn screening (NBS) is routinely performed across the world using biochemical testing methods. Recent advancements in genetic sequencing are a potential game-changer for newborn screening, swiftly assessing a comprehensive range of monogenic disorders. Yet, the effectiveness of genetic sequencing as an alternative method for NBS has not previously been studied. To evaluate the outcomes of applying gene panel sequencing as a first-tier newborn screening test, a recent study conducted by eight NBS centers and BGI Genomics was ...

When people feel that their resources are scarce – that they don’t have enough money or time to meet their needs – they often make decisions that favor short-term gains over long-term benefits. Because of that, researchers have argued that scarcity pushes people to make myopic, impulsive decisions. But a study published by the American Psychological Association provides support for a different, less widely held view: People experiencing scarcity make reasonable decisions based on their circumstances, and only ...

A team of researchers, jointly led by Professor Hyun-Wook Lee and Professor Dong-Hwa Seo from the School of Energy and Chemical Engineering at the Ulsan National Institute of Science and Technology (UNIST), in collaboration with Professor Seok Woo Lee from Nanyang Technological University in Singapore, has achieved significant breakthroughs in harnessing low-grade heat sources (<100 °C) for efficient energy conversion. Their groundbreaking work focuses on developing a highly efficient Thermally Regenerative Electrochemical Cycle (TREC) system capable of converting small temperature differences into usable energy. Conventional energy-harvesting ...

Building a mathematics-based understanding of biology at all scales of life — from individual cells to interactions between species — is the goal of a new $50 million institute supported by the U.S. National Science Foundation in partnership with the Simons Foundation. The two organizations are each providing $25 million to launch the National Institute for Theory and Mathematics in Biology (NITMB). The institute will bring together experts across the mathematical and biological sciences to explore research challenges related to a broad range of topics and industries, such as the environment, biomedicine and biotechnology. The institute will be led by Northwestern University ...