By Karina Ninni | Agência FAPESP – A study of 92 adolescents conducted in Brazil suggests girls are more likely than boys to develop metabolic alterations associated with obesity, such as high blood pressure and excessive blood levels of cholesterol and triglycerides (dyslipidemia). The study was conducted with FAPESP’s support by scientists affiliated with the University of São Paulo’s Biomedical Sciences Institute (ICB-USP) and the Medical School of Santa Casa de Misericórdia de São Paulo (FCM-SCMSP). The findings are reported in an article in the journal Frontiers in Nutrition. According to the authors, the obese girls displayed a pattern of lipid profile alterations not seen in girls without obesity and a higher propensity to ...

Asian students and faculty have long been a cornerstone of science in the U.S., drawn by the promise of collaboration and cutting-edge research. However, the Asian community is facing increased racist attacks and scrutiny from the government. A cover story in Chemical & Engineering News, the weekly newsmagazine of the American Chemical Society, explores how Asian scientists are reassessing their futures in the U.S. In the wake of the COVID-19 pandemic, racist attacks against the Asian community in the U.S. have increased notably, with nearly 4,000 incidents reported between March 2020 and February 2021. Some attribute this to former President Donald Trump's rhetoric about the pandemic originating in China, writes Senior Editor Andrea Widener. ...

TAMPA, Fla. -- Melanocytic nevi, or moles, are nonmalignant growths that arise from pigment producing cells of the skin. They are mostly found in sun-exposed areas; however, they also can be found in sun-protected areas, such as the palms, soles of feet and nail beds, where they are known as acral nevi. While the mutation profile of nevi in sun-exposed areas is well understood, less is known about the genes that are commonly mutated in acral nevi. And while a subset of melanoma of sun-exposed skin arises in nevi, the link between nevi and melanoma in acral skin is poorly understood. In ...

NEW YORK, NY--While there was extensive use of drug repurposing throughout the first 10 months of the COVID-19 pandemic, there was substantial heterogeneity over the types of drugs used for treatment purposes globally. Some drugs, including hydroxychloroquine, saw sharp declines in use, while adjunctive therapies grew into a more relied upon method for patient management. In a number of cases, scientific discovery overturned misconceptions proclaimed via press conferences and social media. The OHDSI network study "Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study," published May 11 by The BMJ, provides a global view ...

URBANA, Ill. - Gut health is having a moment, with sales of fermented foods such as kefir, kombucha, and kimchi steadily on the rise. The benefits of "good bacteria" in fermented foods and supplements go well beyond the gut, moderating immune responses, heart health, weight, and even mood. But do products hold up to the claims on their labels? A new study from the University of Illinois and The Ohio State University examined bacterial content of five brands of kefir, a fermented dairy beverage often likened to drinkable yogurt. The research showed the majority of products overstated bacterial density and contained species not included on the label. "Our ...

The ability to connect and feel a sense of belonging are basic human needs but new Swansea University research has examined how these are determined by more than just our personal relationships. Research led by psychologist Professor Andrew Kemp, of the College of Human and Health Sciences, highlights the importance of taking a wider approach to wellbeing and how it can be influenced by issues such as inequality and anthropogenic climate change. Professor Kemp worked with PhD student Jess Mead and consultant clinical psychologist Dr Zoe Fisher, of the University's Health and Wellbeing Academy, on the study which presents a transdisciplinary ...

CHAMPAIGN, Ill. -- Young people with diverse gender identities may be bullied and victimized up to three times more often than peers who identify as male or female, a new study of more than 4,464 adolescents in Illinois found. The students were part of a statewide survey of eighth- through 12th-grade youths in Illinois schools. "Transgender youths reported the highest rates of all forms of peer victimization, which were double to nearly triple those of males and up to 2.6 times higher than those of females," said social work professor Rachel Garthe of the University of Illinois Urbana-Champaign, who led the research. "Slightly ...

Can a protein found in a mosquito lead to a better understanding of the workings of our own brains? Prof. Ofer Yizhar and his team in the Weizmann Institute of Science's Neurobiology Department took a light-sensitive protein derived from mosquitos and used it to devise an improved method for investigating the messages that are passed from neuron to neuron in the brains of mice. This method, reported today in Neuron, could potentially help scientists solve age-old cerebral mysteries that could pave the way for new and improved therapies to treat neurological and psychiatric conditions. Yizhar and his lab team develop so-called optogenetic methods - research techniques that allow them to "reverse engineer" the activity of specific brain circuits ...

EAST LANSING, Mich. - As climate change threatens global food security, researchers at Michigan State University are building better beans crucial to human nutrition by tapping into the genetics of the more heat-resistant tepary bean. The tepary bean (Phaseolus acutifolius A. Gray) is a sister of the common bean which includes kidney, pinto and navy beans. "The common bean is the number one source of protein and nutrients for many people living in Central America and Africa," said Robin Buell, a professor of plant biology in MSU's College of Natural Science and former director of the Plant Resilience Institute. Her research on bean genetics was published May 11 in Nature Communications. "Mother nature has already made plants that are adapted to different climates," ...

Molecules are the building blocks for our modern world, from phones to cars to Doritos. But coming up with new ones is still an incredibly costly and time-consuming process. A group of University of Chicago chemists wants to find a better way. "If you look at a diagram of a molecule, it seems like you should be able to just snap them together like Tinkertoys, but you can't," said Asst. Prof. Mark Levin. "We'd like to change that." Their new discovery, published May 12 in Nature, represents a first step towards that transformation: a way to easily cut nitrogen atoms from molecules. Despite decades of experiments, chemistry remains an art in many ways because molecules are built in a long, iterative process: attaching ...

In plants, disease resistance proteins serve as major immune receptors that sense pathogens and pests and trigger robust defense responses. Scientists previously found that one such disease resistance protein, ZAR1, is transformed into a highly ordered protein complex called a resistosome upon detection of invading pathogens, providing the first clue as to how plant disease resistance proteins work. Precisely how a resistosome activates plant defenses, however, has been unclear. A joint team led by Profs. ZHOU Jianmin, CHEN Yuhang and HE Kangmin at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and Prof. CHAI Jijie at Tsinghua University recently employed state-of-the-art electrophysiology and single-molecule imaging to investigate the molecular ...

Scientists are exploring a number of ways for people with disabilities to communicate with their thoughts. The newest and fastest turns back to a vintage means for expressing oneself: handwriting. For the first time, researchers have deciphered the brain activity associated with trying to write letters by hand. Working with a participant with paralysis who has sensors implanted in his brain, the team used an algorithm to identify letters as he attempted to write them. Then, the system displayed the text on a screen - in real time. The innovation could, with further development, let people with paralysis rapidly ...

PROVIDENCE, R.I. [Brown University] -- Researchers with the BrainGate collaboration have, for the first time, used an implanted sensor to record the brain signals associated with handwriting, and used those signals to create text on a computer in real time. In a study published in the journal Nature, a clinical trial participant with cervical spinal cord injury used the system to "type" words on a computer at a rate of 90 characters per minute, more than double the previous record for typing with a brain-computer interface. This was done by the participant merely thinking about the hand motions involved in creating written letters. The research team is hopeful that such a system could one day help to restore ...

Scientists have for the first time revealed the structure surrounding important receptors in the brain's hippocampus, the seat of memory and learning. The study, carried out at Oregon Health & Science University, published today in the journal Nature. The new study focuses on the organization and function of glutamate receptors, a type of neurotransmitter receptor involved in sensing signals between nerve cells in the hippocampus region of the brain. The study reveals the molecular structure of three major complexes of glutamate receptors in the hippocampus. The findings may be immediately useful in drug development for conditions such as epilepsy, said senior author Eric Gouaux, Ph.D., senior scientist in the OHSU Vollum Institute, ...

Stanford scientists' software turns 'mental handwriting' into on-screen words, sentences Call it "mindwriting." The combination of mental effort and state-of-the-art technology have allowed a man with immobilized limbs to communicate by text at speeds rivaling those achieved by his able-bodied peers texting on a smartphone. Stanford University investigators have coupled artificial-intelligence software with a device, called a brain-computer interface, implanted in the brain of a man with full-body paralysis. The software was able to decode information from the BCI to quickly convert the man's thoughts about handwriting into text on a computer screen. The man was able to write ...

What The Study Did: Researchers describe overdose deaths in San Francisco before and after the initial COVID-19 shelter-in-place order to try to make clear whether characteristics of fatal overdoses changed during this time in an effort to guide future prevention efforts. Authors: Luke N. Rodda, Ph.D., of the Office of the Chief Medical Examiner for the city and county of San Francisco, is the corresponding author. To access the embargoed study:  Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.10452) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, ...

What The Study Did: Rates of preterm birth and stillbirth in Ontario, Canada, during the first six months of the COVID-19 pandemic are evaluated in this study. Authors: Andrea N. Simpson, M.D., M.Sc., of St Michael's Hospital, Unity Health Toronto, in Toronto, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.10104) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full study is linked to this news release. Embed this ...

What The Study Did: This survey study estimated the number of children and adolescents in the United States who have received medical care as a result of assault, abuse or exposure to violence. Authors: David Finkelhor, Ph.D., of the University of New Hampshire in Durham, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.9250) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and ...

What The Study Did: Researchers used registry data to examine the number, characteristics and outcomes of patients with sunburns severe enough to warrant admission to specialist burn services in Australia and New Zealand. Authors: Lincoln M. Tracy, Ph.D., of Monash University in Melbourne, Australia, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamadermatol.2021.1110) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, ...

What The Study Did: Delayed localized injection-site reactions to the Moderna COVID-19 vaccine for 16 patients are described in this report. Authors: Alicia J. Little, M.D., Ph.D., of the Yale University School of Medicine in New Haven, Connecticut, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamadermatol.2021.1214) Editor's Note: The article includes conflicts of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict ...

HOUSTON - The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) plays an important and previously unknown role in blocking a form of cell death called ferroptosis, according to a new study published today in Nature by researchers at The University of Texas MD Anderson Cancer Center. Preclinical findings suggest that targeting DHODH can restore ferroptosis-driven cell death, pointing to new therapeutic strategies that may be used to induce ferroptosis and inhibit tumor growth. "By understanding ferroptosis and how cells defend against it, we can develop therapeutic strategies to block those defense mechanisms and trigger cell death," said senior author Boyi Gan, Ph.D., associate professor of Experimental ...

LA JOLLA, CALIF. - May 12, 2021 - Scientists at Sanford Burnham Prebys Medical Discovery Institute have taken a deep dive into a previously overlooked family of proteins and discovered that they are essential to maintaining the energy that cells need to grow and survive. The proteins, known as lipid kinases, produce messengers that help balance cellular metabolism and promote overall health. The findings, published in Developmental Cell, provide further support to pursue lipid kinases as promising therapeutic targets for diseases that demand excess energy, such as cancer. "Cancer cells are hungry--they grow faster than most cell types and need energy to support their aggressive attempts to metastasize," says Brooke Emerling, Ph.D., assistant professor in the ...

Social anxiety disorder can cause considerable suffering in children and adolescents and, for many with the disorder, access to effective treatment is limited. Researchers at Centre for Psychiatry Research at Karolinska Institutet and Region Stockholm in Sweden have now shown that internet-delivered cognitive behavioural therapy is an efficacious and cost-effective treatment option. The study is published in the journal JAMA Psychiatry. Social anxiety disorder (SAD, previously known as social phobia) has a typical onset during childhood and is characterised by an intense and persistent fear of being scrutinised and negatively evaluated in social or performance situations. The fear typically leads to avoidance of such anxiety triggering situations or are endured under great ...

The acidity of the atmosphere is increasingly determined by carbon dioxide and organic acids such as formic acid. The second of these contribute to the formation of aerosol particles as a precursor of raindrops and therefore impact the growth of clouds and pH of rainwater. In previous atmospheric chemistry models of acid formation, formic acid tended to play a small role. The chemical processes behind its formation were not well understood. An international team of researchers under the aegis of Forschungszentrum Jülich has now succeeded in filling this gap and deciphering the dominant ...

Long-lasting, quick-charging batteries are essential to the expansion of the electric vehicle market, but today's lithium-ion batteries fall short of what's needed -- they're too heavy, too expensive and take too long to charge. For decades, researchers have tried to harness the potential of solid-state, lithium-metal batteries, which hold substantially more energy in the same volume and charge in a fraction of the time compared to traditional lithium-ion batteries. "A lithium-metal battery is considered the holy grail for battery chemistry because of its high capacity and energy density," said Xin Li, Associate Professor ...