Researchers present novel principle for nitric oxide-mediated signalling in blood vessels
Although a simple molecule, nitric oxide is an important signal substance that helps to reduce blood pressure by relaxing the blood vessels. But how it goes about doing this has long been unclear. Researchers at Karolinska Institutet in Sweden now present an entirely novel principle that challenges the Nobel Prize-winning hypothesis that the substance signals in its gaseous form. Their findings are presented in the journal Nature Chemical Biology.
That the simple molecule nitric oxide or nitrogen monoxide (NO) serves as a signal substance in many important physiological processes has been known for some time. For example, the discovery of the compound’s ...














