Scientists at Klick Labs have developed a new way to catch the earliest signs the human body is failing to control blood glucose levels, before it reaches prediabetic levels in patients.   In findings published today in Mayo Clinic Proceedings: Digital Health, researchers outlined a new method of analysis that flags a precursor to prediabetes called impaired glucose homeostasis (IGH). When they applied their patented mathematical method to data obtained from continuous glucose monitors (CGMs), scientists found about one in five study participants, considered healthy by medical standards, actually had glucose metabolism similar to those with prediabetes.   “For people ...

Irvine, CA – May 24, 2023 – A University of California, Irvine-led team of researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer’s patients, however, they also have less brain pathology of other neurodegenerative diseases that cause memory and thinking problems. The study, “Superior Global Cognition in Oldest-Old is Associated with Resistance to Neurodegenerative Pathologies: Results from the 90+ Study,” was published in the Journal of Alzheimer’s Disease. “People ...

“Recent findings suggest that neurodegenerative and cardiovascular diseases may have overlapping etiologies [...]” BUFFALO, NY- May 24, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, “Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus.” In this new study, researchers Yury Loika, Elena Loiko, Fan Feng, Eric Stallard, Anatoliy I. Yashin, Konstantin Arbeev, Allison L. Kuipers, Mary F. Feitosa, Michael A. Province, and Alexander ...

SEATTLE – MAY 24, 2023 – Researchers from Fred Hutchinson Cancer Center in Seattle, Scripps Research in La Jolla, California, IAVI and other collaborating institutions have characterized robust T-cell responses in volunteers participating in the IAVI G001 Phase 1 clinical trial to test the safety and immune response of a self-assembling nanoparticle HIV vaccine. Their work, published in Science Translational Medicine, signals a major step toward development of a vaccine approach to end the HIV/AIDS ...

AMHERST, Mass. – While an overwhelming majority of cancer patients experience taste disruption from their disease or treatment, they have consistently reported a lack of support from their doctors about this troubling side effect, according to research. A new study by the University of Massachusetts Amherst, focusing for the first time on the issue from the cancer clinicians’ point of view, reveals not a lack of concern about their patients’ taste loss but a lack of access to educational materials, ...

(Memphis, Tenn.—May 24, 2023) Like thread tightly wrapped around a spool, DNA is wrapped around histones and packaged into structures called nucleosomes. Scientists at St. Jude Children’s Research Hospital are exploring how a type of transcription factor called a pioneer transcription factor accesses DNA even when it is tightly wound. Their work revealed how the epigenetic landscape influences transcription factor binding. Problems with transcription have been implicated in numerous cancers, so this more detailed understanding of the process may aid in developing future therapeutics. The study ...

A widely used compostable plastic persists unchanged in marine environments for at least 14 months, according to a new study in the open-access journal PLOS ONE by Sarah-Jeanne Royer and colleagues from Scripps Institution of Oceanography at the University of California, San Diego. The study highlights the distinction between textile materials that can be composted in a controlled, industrial setting (PLA), and the ones that can undergo biodegradation in natural environments (cellulose-based textiles). The accumulation and persistence of oil-based plastic waste ...

A new analysis of data from more than 10,000 adults shows that people who were physically active had higher pain tolerance than those who were sedentary, and that those with a higher level of activity had a higher level of pain tolerance. Anders Årnes of the University Hospital of North Norway, Tromsø, and colleagues present these findings in the open-access journal PLOS ONE on May 24, 2023. Prior research has suggested the possibility that a habit of engaging in a higher level of physical activity might help ease or prevent chronic pain by boosting pain tolerance. However, most studies on this topic have been small or focused on narrow groups of people. To help clarify the ...

Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0285446 Article Title: Psychosocial correlates in patterns of adolescent emotional eating and dietary consumption Author Countries: USA Funding: The authors received no specific funding for this work. END ...

Coccolithophores, a globally ubiquitous type of phytoplankton, play an essential role in the cycling of carbon between the ocean and atmosphere. New research from Bigelow Laboratory for Ocean Sciences shows that these vital microbes can survive in low-light conditions by taking up dissolved organic forms of carbon, forcing researchers to reconsider the processes that drive carbon cycling in the ocean. The findings were published this week in Science Advances. The ability to extract carbon from the direct absorption of dissolved organic carbon is known as osmotrophy. ...

Plastic pollution is seemingly omnipresent in society, and while plastic bags, cups, and bottles may first come to mind, plastics are also increasingly used to make clothing, rugs, and other textiles.  A new study from UC San Diego’s Scripps Institution of Oceanography, published May 24 in the journal PLOS One, for the first time tracked the ability of natural, synthetic, and blended fabrics to biodegrade directly in the ocean.  Lead author Sarah-Jeanne Royer conducted an experiment off the Ellen Browning Scripps Memorial Pier and found that natural and wood-based cellulose fabrics degraded within a month. Synthetic textiles, including so-called compostable ...

Rising temperatures due to climate change are likely influencing human migration patterns, according to a new study by Rita Issa of University College London and colleagues, published May 24 in the open-access journal PLOS Climate. In the last decade, heatwaves were frequent, and surface temperatures were the warmest on record. As the planet warms, many people are expected to leave their homes to escape extreme temperatures. However, the exact role of heat in human migration is not yet understood. To illuminate this relationship, Issa’s team conducted a review of research documents, ...

The epidemic of firearm injury and death in the USA is preventable, and the field of public health can offer practical solutions, argue Dr. Megan L. Ranney and colleagues in an opinion article in PLOS Global Public Health. Through harm reduction and community engagement programs, public health professionals, healthcare providers and community members can reduce the impact on individuals, families and communities. Despite the attention school and public mass shootings in the US gain, they make up a minority of US firearm injuries and deaths. Most firearm deaths are from homicide and suicide: ...

Political parties regularly claim to have their finger on the pulse and be able to read the public mood. Yet a new study challenges the idea that being political makes you good at understanding others: it shows gender, not politics, is a far more important factor in determining people’s social skills. Analysis of a sample of 4,000 people from across the UK, compiled by a team of psychologists at the University of Bath, highlights that being female and educated are the biggest determinants of whether you can understand or read others’ ...

The prevalence of sleep disorders, like sleep apnea, is on the rise in the U.S., but current protocols to conduct clinically accepted assessments are expensive and inconvenient. Georgia Tech researchers have created a wearable device to accurately measure obstructive sleep apnea — when the body repeatedly stops and restarts breathing for a period — as well as the quality of sleep people get when they are at rest. Under conventional methods, people who are suspected of having some sleep issue or disorder ...

To know when it’s time for a meal – and when to stop eating again – is important to survive and to stay healthy, for humans and animals alike. Researchers at the Max Planck Institute for Biological Intelligence investigated how the brain regulates feeding behavior in mice. The team found that the hormone ghrelin activates specialized nerve cells in a brain region known as the amygdala. Here, the interaction between ghrelin and the specialized neurons promotes food consumption and conveys ...

A team of researchers at the University of Houston College of Pharmacy is reporting that by manipulating TAK1, a signaling protein that plays an important role in development of the immune system, they can slow down disease progression and improve muscle function in Duchenne muscular dystrophy (DMD).  DMD, caused by mutations in dystrophin gene, is an inheritable neuromuscular disorder that occurs in one out of 3,600 male births. DMD patients undergo severe muscle wasting, inability to walk and eventually death in their early thirties due to respiratory failure. The ...

Research question Can these contributions to standing postural control be quantified from CoP trajectories in neurotypical adults? Methods Instantaneous contributions can be negative or larger than one, and integrated contributions sum to equal one. Proof-of-concept demonstrations validated these calculated contributions by restricting CoP motion under one or both feet. We evaluated these contributions in 30 neurotypical young adults who completed two (eyes opened; eyes closed) 30-s trials of bipedal standing. We evaluated the relationships between limb contributions, self-reported limb dominance, and between-limb ...

A University of Texas at Arlington civil engineering researcher will use a NASA grant to help forecasters better predict extreme weather events using a variety of existing NASA data sources. Yu Zhang, associate professor in the Department of Civil Engineering, said the $638,000 grant will use ocean circulation data, atmospheric conditions and current weather information to make longer-range forecasting more reliable. Having a more accurate forecast could help officials make better decisions about the state’s water resources—for example, knowing when to release water from reservoirs. “Using ...

A University of Texas at Arlington engineering researcher who studies traumatic brain injuries  has received funding to use computer motion simulation that replicates the movements of a person performing activities that could lead to injury. The project, funded by a nearly $1 million grant from the Office of Naval Research Defense University Research Instrumentation Program (DURIP), will use real-time data of phantom head and phantom body reactions to ascertain what physical injuries could come from those motions. Ashfaq Adnan, a UT Arlington professor in the Department of Mechanical and Aerospace Engineering, is leading the project, called “System for Remote ...

To prevent our body’s cells from overflowing with garbage and to keep them healthy, the waste inside them is constantly being disposed of. This cleaning process is called autophagy. Scientists have now, for the first time, rebuilt the complex nanomachine in the laboratory that starts this process – and it works quite differently from other cellular machines. The researchers’ new insights could help open up new approaches for the treatment of cancer, immune disorders, and neurodegenerative diseases in ...

Today, large commercial jets fly around 580 mph. The Lockheed SR-71 Blackbird introduced in 1966 is the fastest supersonic jet vehicle in the world, reaching speeds of more than 2,200 mph, nearly four times faster than a commercial jet. The fastest rocket-powered hypersonic vehicle developed in the late 1960s carrying a human has been the North American X-15, reaching a top speed of 4,520 mph, twice that of the SR-71. Recently, the U.S. Air Force has awarded a contract to engineer Project Mayhem with the goal to reach 4,603 mph. Now, imagine a vehicle that could fly much faster, maybe even above 6,905 mph, which is beyond nine times the speed of sound. The University of Texas at Arlington’s ...

PHILADELPHIA – The federal health system for reporting “adverse events” after vaccination, known as VAERS, is designed to assist in the early detection of complications and responsive action. But when the pandemic and advent of new vaccines for Covid-19 turned a spotlight on this formerly little-known system, the flood of web and social media references to it was accompanied by confusion about what the system is and what the reports in it signify. A new report from the Annenberg Public Policy Center examines misconceptions about the government’s Vaccine Adverse ...

CAMBRIDGE, MA — In computer graphics and computer-aided design (CAD), 3D objects are often represented by the contours of their outer surfaces. Computers store these shapes as “thin shells,” which model the contours of the skin of an animated character but not the flesh underneath. This modeling decision makes it efficient to store and manipulate 3D shapes, but it can lead to unexpected artifacts. An animated character’s hand, for example, might crumple when bending its fingers — a motion that resembles how an empty rubber glove deforms rather than the motion of a hand filled with bones, tendons, ...

Atlanta (May 24, 2023) - Chemical Insights Research Institute (CIRI) of UL Research Institutes and the Campus Safety, Health, and Environmental Management Association (CSHEMA), announce the publication of, “UL 200B: Guidance Document for Safe Use of 3D Printing for Institutions of Higher Education.” The availability of 3D printing has fostered creative and innovative learning experiences for many within the large population of students in higher education. There are roughly 17.3 million undergraduates in the U.S. alone. Because 3D printers are affordable compact, and user friendly, they can ...