Researchers have mapped out the changes in metabolism that occur after a heart attack, publishing their findings today in the open-access eLife journal. Their study in mice reveals certain genes and metabolic processes that could aid or hinder recovery, and might be good targets for treatments to prevent damage after a heart attack. "Although some studies have looked at how changes in individual body tissues underlie mechanisms of disease, the crosstalk between different tissues and their dysregulation has not been examined in heart attacks or other cardiovascular-related complications," explains first author Muhammad Arif, a PhD student at KTH Royal ...

Controlling, and mitigating the effects of ice growth is crucial to protect infrastructure, help preserve frozen cells and to enhance texture of frozen foods. An international collaboration of Warwick Scientists working with researchers from Switzerland have used a phage display platform to discover new, small, peptides which function like larger antifreeze proteins. This presents a route to new, easier to synthesise, cryoprotectants.Caption: Using viruses (phage display) to identify the one molecule in a billion (peptide8) that controls the formation of ice. Credit: University of Warwick Ice binding proteins, which includes antifreeze proteins, are produced by a large range of species from fish, ...

An investigational gene therapy can safely restore the immune systems of infants and children who have a rare, life-threatening inherited immunodeficiency disorder, according to research supported in part by the National Institutes of Health. The researchers found that 48 of 50 children who received the gene therapy retained their replenished immune system function two to three years later and did not require additional treatments for their condition, known as severe combined immunodeficiency due to adenosine deaminase deficiency, or ADA-SCID. The findings were published today in the New England Journal of Medicine. ADA-SCID, ...

Low doses of a four-drug combination helps prevent the spread of cancer in mice without triggering drug resistance or recurrence, shows a study published today in eLife. The findings suggest a new approach to preventing cancer metastasis in patients by simultaneously targeting multiple pathways within a metastasis-promoting network. They may also help identify people who would most likely benefit from such treatment. Metastasis, the spread of cancerous cells through the body, is a common cause of cancer-related deaths. Current approaches to treating metastatic cancer have focused on high doses of individual drugs or drug combinations to hinder pathways that promote the spread of cancer cells. But these approaches can be toxic to the patient, and may inadvertently activate other pathways ...

A new study from the University of Chicago has found that the photosynthetic bacterium Synechococcus elongatus uses a circadian clock to precisely time DNA replication, and that interrupting this circadian rhythm prevents replication from completing and leaves chromosomes unfinished overnight. The results, published online on May 10 in Proceedings of the National Academy of the Sciences, have implications for understanding how interrupted circadian rhythms can impact human health. Circadian rhythms are the internal 24-hour clock possessed by most organisms on earth, regulating ...

Argonne scientists across several disciplines have combined forces to create a new process for testing and predicting the effects of high temperatures on refractory oxides. Cast iron melts at around 1,200 degrees Celsius. Stainless steel melts at around 1,520 degrees Celsius. If you want to shape these materials into everyday objects, like the skillet in your kitchen or the surgical tools used by doctors, it stands to reason that you would need to create furnaces and molds out of something that can withstand even these extreme temperatures. That's where refractory oxides come in. These ceramic materials can stand up to blistering heat and retain their shape, which makes them useful for all kinds of things, from kilns ...

May 11, 2021 - Like other medical specialties at the start of the COVID-19 pandemic, orthopaedic surgery rapidly pivoted from in-person visits to remote appointments via telemedicine. Analysis of that initial experience finds that some groups of patients faced persistent or worsening disparities as the shift to telemedicine occurred, reports Clinical Orthopaedics and Related Research® (CORR®), a publication of The Association of Bone and Joint Surgeons®. The journal is published in the Lippincott portfolio by Wolters Kluwer. "We found concerning disparities in access ...

TAMPA, Fla. - A hallmark of cancer is its ability to evade the immune system. It is why researchers are focused on finding new strategies and targets to jumpstart the immune system so it can mount a response against tumors. One such target is the inhibitory receptor T-cell immunoglobulin and mucin domain 3 (TIM-3), a protein that is overexpressed in many different types of cancer and is associated with poor patient outcomes. It is known to block the activity of immune cells, such as dendritic cells, but how remains unclear. In a new article published in the journal Immunity, Moffitt Cancer Center researchers show that TIM-3 inhibits the STING signaling pathway in dendritic cells, thereby blocking their ability to elicit an immune response. Dysregulation ...

Point: Novel chiral diacid monomers were synthesized. Chirally interactive BioNylons were prepared. BioNylon showed thermal/mechanical performances than conventional Nylons. BioNylons disintegrated and degraded with pepsin. Summary: Marine plastic waste problems have been more serious year by year. One of the worst issues is that creatures in ocean are going extinct by mistakenly swallowing them.. Conventional biodegradable plastics are degradable in digestive enzymes, but their performances are too low to use in society. In this study, researchers from JAIST have used bio-derived resources such as itaconic acid and amino acid for the syntheses of high-performance BioNylons having the pepsin degradation function. Ishikawa, ...

Quantum mechanics can be used to create more stable and more easily produced organic solar cells. These are the findings of new research from the University of Gothenburg. Organic solar cells have many advantages compared with traditional silicon-based solar cells. They can be manufactured cheaply at a large scale using printing presses, and they are light, malleable and flexible. The problem is that today's organic solar cells are not as stable and effective as silicon-based solar cells. In a new study, a research group has taken on this problem and found a way that can lead to more cost-effective solar cell technology. "There are excellent opportunities for utilising quantum efficiencies to change different chemical ...

The Sturtian Snowball Earth glaciation (717~660 million years ago) represents the most severe icehouse climate in Earth's history. Geological evidence indicates that, during this glaciation, ice sheets extended to low latitudes, and model simulations suggest global frozen ocean as well as a prolonged shut-down of the hydrological cycles. The Snowball Earth hypothesis poses that the Sturtian global glaciation is directly triggered by intense continental weathering that scavenges atmospheric CO2, while the global frozen condition is terminated by ...

One of the most basic structural aspects of relativistic spacetime is the description of how time and distances are altered by motion. The theory of special relativity describes a spacetime framework for linear constant motion in which time dilates and lengths contract in response to motion. This framework is described by the Lorentz transformation, which encompasses mathematical formulas that describe how time and distance are altered between moving reference frames. The Lorentz transformation also describes how a stationary observer views time in the moving frame to be offset with distance. ...

One of the most prominent evils of rapid industrialization has been the emission of toxic pollutants into the surrounding biosphere, with often disastrous consequences for human beings. Several industrial processes, such as chemical manufacturing and printing, along with facilities such as power plants emit volatile organic compounds (VOCs) that are known to be cancer-causing and raise an important environmental issue in need of a solution. Traditionally, VOCs are controlled via a process called "catalytic oxidation," in which they are converted into benign materials in the presence of noble metal (e.g. gold, silver, and platinum) ...

A new study from the University of Surrey has revealed 'real world' factors that influence people's interest in adopting a dietary pattern called time-restricted feeding. According to NHS England, 67 per cent of men and 60 per cent of women in the UK are overweight or obese - with more than 11,000 yearly hospital admissions directly attributable to obesity. Time-restricted feeding, which is a type of intermittent fasting, is the practice of restricting the time between the first and last food intake each day - therefore prolonging the daily fasting period. In a study published by the ...

A new study from the University of Portsmouth calls for further government oversight to curb potential illegal activity through these zones. This study demonstrates the attractive trading advantages offered by freeports to enable enterprise and innovation. Eight new freeports in England are due to enter operation in late 2021, which are hoped to drive investment, economic opportunities and growth to those regions. However, researchers also advise that stronger regulation is needed to prevent Freeports being abused for money-laundering and tax-evasion purposes. The study, ...

Young children in deprived areas see nature and outdoor spaces as being associated with "happy places", according to a new study published in the journal Child Indicators Research. Researchers Dr Nicola Walshe and Dr Zoe Moula from Anglia Ruskin University (ARU) asked 91 children aged seven and eight from two primary schools in areas of relatively high deprivation in the East of England to draw their happy place, before engaging them in group discussions about how they perceive their own wellbeing. More than half of the children created drawings that included aspects of nature and outdoor spaces, such as trees, grass, parks, gardens, lakes, rivers, outdoor playgrounds, rainbows or sunlight. Trees, ...

It was commonly assumed that wildlife products are exported from low-income countries to meet the demand of consumers in wealthy economies, and therefore, a widening wealth gap may drive up the volume of global trade and endanger wildlife. Recently, a research team co-led by Research Division for Ecology and Biodiversity (E&B), Faculty of Science, the University of Hong Kong (HKU) and the Science Unit (SU) of Lingnan University (LU) corroborated this premise by analysing global wildlife trade databases. The research team includes Dr Jia Huan LIEW, Research Assistant Professor of SU, ...

YouTube channels run by zoos focus on entertainment over education, according to a new study. The videos also focus disproportionately on mammals, rather than reflecting the diversity of zoos' animals. Conservation was the focus of just 3% of zoo videos in the study - but it found that conservation content in videos is gradually increasing. The study evaluated the most recent and most-viewed videos, so the findings partly reflect the public's preference for certain species and content. Of the animals that appeared in zoos' most-viewed videos, the top nine were mammals - with giant pandas ...

Teamwork is becoming increasingly common in modern science. In this context, the effect of different characteristics of a team on its research performance has been studied extensively. Various factors such as team size, number of countries involved, universities, disciplines, and workload distribution have been found to have a significant contribution on the paper's role in advancing science. The question of how the freshness of the team influences its research performance, however, has not been studied systematically. A research team may consist ...

Most of us have imagined how free it would feel to float around, like an astronaut, in conditions of reduced gravity. But have you ever considered what the effects of reduced gravity might have on muscles? Gravity is a constant force on Earth which all living creatures have evolved to rely on and adapt to. Space exploration has brought about many scientific and technological advances, yet manned spaceflights come at a cost to astronauts, including reduced skeletal muscle mass and strength. Conventional studies investigating the effects of reduced gravity on muscle mass and function have used a ground ...

Duluth, Minnesota - A new paper in the May issue of Nature Communications demonstrates why keeping local lakes and other waterbodies clean produces cost-effective benefits locally and globally. A single season of a lake or water body with a harmful algal bloom that results in public do-not-drink orders, damages to fishing activity, lost recreational opportunities, decreased property values and increased likelihood of low birth weight among infants born to mothers exposed to polluted water bodies are but just a handful of reasons why clean water is important. Most everyone wants their local lake or stream to be clean and useable for drinking, fishing, swimming and recreation. But previous cost-benefit studies showed the costs ...

LUND, Sweden--May 11, 2021--PolarCool AB (publ), a Swedish medical device company focusing on treatment of sports-related traumatic brain injury (TBI) and whiplash, today announced that it has submitted a 510(k) pre-market notification to the U.S. Food and Drug Administration (FDA) for the PolarCap® System. This submission follows publication of statistically significant clinical results in the scientific journal Concussion, showing clear benefit for use of the PolarCap® System in the treatment of concussions among players of 15 elite Swedish Ice-Hockey teams in the Swedish Hockey Leagues (SHL). The incidence of sports-related concussions is a significant national health ...

Pregnant women who are hospitalized with COVID-19 and viral pneumonia are less likely than non-pregnant women to die from these infections, according to a new study by researchers with The University of Texas Health Science Center at Houston (UTHealth) and the University of Maryland School of Medicine (UMSOM). The study was published today in Annals of Internal Medicine. The study examined medical records from nearly 1,100 pregnant patients and more than 9,800 non-pregnant women ages 15 to 45 who were hospitalized with COVID-19 and pneumonia. Less than 1% of the pregnant patients died from COVID-19 compared to 3.5% of non-pregnant patients, according to the study findings. Currently, the Centers ...

Lichen communities may take decades -- and in some cases up to a century -- to fully return to chaparral ecosystems after wildfire, finds a study from the University of California, Davis, and Stanford University. The study, published today in the journal Diversity and Distributions, is the most comprehensive to date of long-term lichen recolonization after fire. Unlike conifer forests, chaparral systems in California are historically adapted to high-intensity fires -- they burn hot, fast and tend to regenerate quickly. However, with more frequent fires predicted under a drier, warming climate ...

In order for metal nanomaterials to deliver on their promise to energy and electronics, they need to shape up -- literally. To deliver reliable mechanical and electric properties, nanomaterials must have consistent, predictable shapes and surfaces, as well as scalable production techniques. UC Riverside engineers are solving this problem by vaporizing metals within a magnetic field to direct the reassembly of metal atoms into predictable shapes. The research is published in The Journal of Physical Chemistry Letters. Nanomaterials, which are made of particles measuring 1-100 nanometers, are typically ...