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Mucus and mucins may become the medicine of the future

2021-07-07
Many people instinctively associate mucus with something disgusting, but in fact, it has incredibly many valuable functions for our health. It keeps track of our important intestinal flora and feeds the bacteria. It covers all internal surfaces of our body, and, as a barrier to the outside world, it helps us protect ourselves from infectious diseases. This is because mucus acts as a filter that keeps the bacteria in or out, and the bacteria feed on the sugars in the mucus between meals. So, if we can produce the mucus that is already present in the body with the right sugars, it might be used in brand new medical treatments. Now, researchers from the DNRF Centre ...

Igniting plasmas in liquids

Igniting plasmas in liquids
2021-07-07
Physicists of Ruhr-Universität Bochum (RUB) have taken spectacular pictures that allow the ignition process of plasma under water to be viewed and tracked in real time. Dr. Katharina Grosse has provided the first data sets with ultra-high temporal resolution, supporting a new hypothesis on the ignition of these plasmas: In the nanosecond range, there is not enough time to form a gas environment. Electrons generated by field effects lead to the propagation of the plasma. The nanosecond plasma ignites directly in the liquid, regardless of the polarity of the voltage. The report from the Collaborative Research Centre 1316 "Transient Atmospheric Pressure Plasmas: from Plasma to Liquids to Solids" has been published in the Journal of Applied Physics and Rubin, the ...

For female vampire bats, an equal chance to rule the roost

2021-07-07
COLUMBUS, Ohio - Female vampire bats establish an egalitarian community within a roost rather than a society based on a clear hierarchy of dominance that is often seen in animal groups, a new study suggests. Researchers observed more than 1,000 competitions for food among a colony of 33 adult female bats and juveniles living in captivity, assigning a rank to each bat based on a calculation of wins and losses in those contests. The team found that, unlike in many mammal societies, the higher-ranking animal didn't necessarily win every bout over food, and there was a randomness to the ranking order - no specific quality they measured gave a bat a better chance at dominance, so any adult female had an equal opportunity to rank very high or very low on a scale of ...

Greater investment and innovation in educating children about environmental issues needed to help future generations respond to the climate emergency, experts urge

2021-07-07
Environmental education provision needs greater investment and innovation if future generations are to be able to respond fully to the climate emergency, experts have said. The deepening environmental crisis will continue to worsen if there is not significant support and investment in environmental and science education, researchers have warned. Reforms would help young people to address the complex, interlinked and dynamic issues of our contemporary situation. The experts argue Governments and other organisations must direct more funding to education innovation in response to consistent warnings from scientists about trends in the deteriorating state of ecosystems, biodiversity and climate, amongst other environmental issues. Writing in Environmental Education ...

The reproductive advantages of large male fish

The reproductive advantages of large male fish
2021-07-07
In mosquitofish, of the genus Gambusia, male fish are smaller than females - sometimes only half the size. Biologists had previously assumed that smaller male mosquitofish had at least some reproductive advantages. Researchers from the transregional collaborative research centre NC³ at Bielefeld University have shown in a systematic review and meta-analysis that larger mosquitofish are actually more successful at reproduction: they can, for instance, better challenge their rivals; they produce more sperm; and they are preferred by female fish. The re-searchers are presenting their findings today (07.07.2021) in the Journal of Animal Ecology. Mosquitofish are small fish with nondescript coloring of the genus Gambusia, which contains some 45 species. ...

Like a molten pancake

2021-07-07
There are some large shield volcanoes in the world's oceans where the lava is usually not ejected from the crater in violent explosions, but flows slowly out of the ground from long fissures. In the recent eruption of the Sierra Negra volcano in the Galapagos Islands, which lie just under a thousand kilometres off South America in the Pacific Ocean, one of these fissures was fed through a curved pathway in June 2018. This 15 kilometre-long pathway, including the kink, was created by the interaction of three different forces in the subsurface, Timothy Davis and Eleonora Rivalta from the GFZ German ...

Slow music in tunnels can keep drivers focused and safe

2021-07-07
Driving through a tunnel is a challenging and risky task. Drivers need to lower their speed and adapt to poor light, while the enclosed space may make them anxious. Preventing accidents is a public health challenge that uses insights from engineering, psychology, physiology, and neuroscience. Here, in a virtual reality (VR) study in Frontiers in Psychology, scientists from China, Canada, and the USA show that playback of slow music inside tunnels can reduce tension and fatigue in drivers, making them less prone to speeding and overtaking. These results imply that well-chosen background music can help improve road safety. "When drivers go through a tunnel, they need to process a large amount ...

Wild birds learn to avoid distasteful prey by watching others

2021-07-07
How do predators know to avoid brightly-coloured toxic prey? A collaboration of researchers has put social information theory to the test in a reliable real-world system to find the answer - by copying what others do, or do not, eat. An international team of researchers from Finland, New Zealand, Colombia and the U.K. have provided the first evidence that wild birds can learn to avoid distasteful prey by observing what others eat. "We've known for a long time that predators, like birds, associate brightly coloured warning signals with the danger of eating certain prey types. However, ...

New clues to why there's so little antimatter in the universe

2021-07-07
Imagine a dust particle in a storm cloud, and you can get an idea of a neutron's insignificance compared to the magnitude of the molecule it inhabits. But just as a dust mote might affect a cloud's track, a neutron can influence the energy of its molecule despite being less than one-millionth its size. And now physicists at MIT and elsewhere have successfully measured a neutron's tiny effect in a radioactive molecule. The team has developed a new technique to produce and study short-lived radioactive molecules with neutron numbers they can precisely control. They hand-picked several isotopes of the same molecule, each with one more neutron than the next. When they measured each molecule's energy, they were able to detect small, nearly imperceptible changes of the nuclear ...

Cancer screenings rebounded in 2020 after COVID but racial disparities remain

2021-07-07
BOSTON - The numbers of cancer screening tests rebounded sharply in the last quarter of 2020, following a dramatic decline in the first months of the COVID-19 pandemic, at one large hospital system in the Northeastern United States. These findings were released in a study published in Cancer Cell. The research also found an increase in racial and socioeconomic disparities among users of some screening tests during the pandemic. Study co-senior author Toni K. Choueiri, MD, director of the Lank Center for Genitourinary Oncology at Dana-Farber Cancer Institute, said following a dramatic decline during the first pandemic peak, there was a "substantial increase in screening procedures during the more recent periods ...

Researchers detail the most ancient bat fossil ever discovered in Asia

Researchers detail the most ancient bat fossil ever discovered in Asia
2021-07-07
LAWRENCE -- A new paper appearing in Biology Letters describes the oldest-known fragmentary bat fossils from Asia, pushing back the evolutionary record for bats on that continent to the dawn of the Eocene and boosting the possibility that the bat family's "mysterious" origins someday might be traced to Asia. A team based at the University of Kansas and China performed the fieldwork in the Junggar Basin -- a very remote sedimentary basin in northwest China -- to discover two fossil teeth belonging to two separate specimens of the bat, dubbed Altaynycteris aurora. The new fossil specimens help scientists better understand ...

Next generation cytogenetics is on its way

2021-07-07
Dutch-French research shows that Optical Genome Mapping (OGM) detects abnormalities in chromosomes and DNA very quickly, effectively and accurately. Sometimes even better than all existing techniques together, as they describe in two proof-of-concept studies published in the American Journal of Human Genetics. This new technique could radically change the existing workflow within cytogenetic laboratories. Human hereditary material is stored in 46 chromosomes (23 pairs). Although those chromosomes are quite stable, changes in number or structure can still occur. A well-known example is Down syndrome, which is caused by an extra ...

Change in respiratory care strategies for preterm infants improves health outcomes

Change in respiratory care strategies for preterm infants improves health outcomes
2021-07-07
A decade's worth of data shows that neonatologists are shifting the type of respiratory support they utilize for preterm infants, a move that could lead to improved health outcomes. Using two large national datasets that included more than 1 million preterm infants, researchers in a new Vanderbilt-led study found that from 2008 to 2018 there was a greater than 10% decrease in the use of mechanical ventilation for this patient population. Concurrently, there was a similar increase in the use of non-invasive respiratory support, such as continuous positive airway pressure (CPAP), for these infants. The ...

New computational technique, software identifies cell types within a tumor and its microenvironment

2021-07-07
(Boston)--The discovery of novel groups or categories within diseases, organisms and biological processes and their organization into hierarchical relationships are important and recurrent pursuits in biology and medicine, which may help elucidate group-specific vulnerabilities and ultimately novel therapeutic interventions. Now a new study introduces a novel computational methodology and an associated software tool called K2Taxonomer, which support the automated discovery and annotation of molecular classifications at multiple levels of resolution from high-throughput bulk and single cell 'omics' data. The study includes a case ...

The Obesity Society issues new position statement:

2021-07-07
SILVER SPRING, Md.--Vaccines such as Pfizer, Moderna, Johnson & Johnson and AstraZeneca are designed to prevent severe Coronavirus-19 Disease (COVID-19) due to acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and are highly efficacious. The efficacy is not different in people with and without obesity except for AstraZeneca which is not known, according to a new position statement from The Obesity Society (TOS), the leading scientific membership organization advancing the science-based understanding of the causes, consequences, prevention and treatment of obesity. Trials have demonstrated high efficacy in individuals ...

Gene therapy in early stages of Huntington's disease may slow down symptom progression

Gene therapy in early stages of Huntington's disease may slow down symptom progression
2021-07-07
In a new study on mice, Johns Hopkins Medicine researchers report that using MRI scans to measure blood volume in the brain can serve as a noninvasive way to potentially track the progress of gene editing therapies for early-stage Huntington's disease, a neurodegenerative disorder that attacks brain cells. The researchers say that by identifying and treating the mutation known to cause Huntington's disease with this type of gene therapy, before a patient starts showing symptoms, it may slow progression of the disease. The findings of the study were published May 27 in the journal Brain. "What's exciting about this study is the opportunity to identify a reliable biomarker that can ...

McMaster researchers identify how VITT happens

McMaster researchers identify how VITT happens
2021-07-07
Hamilton, ON (July 7, 2021) - A McMaster University team of researchers recently discovered how, exactly, the COVID-19 vaccines that use adenovirus vectors trigger a rare but sometimes fatal blood clotting reaction called vaccine-induced immune thrombotic thrombocytopenia or VITT. The findings will put scientists on the path of finding a way to better diagnose and treat VITT, possibly prevent it and potentially make vaccines safer. The researchers' article was fast-tracked for publication today by the prestigious journal Nature in its accelerated article preview because of the importance of the research. "Our work also answers important ...

New generation anti-cancer drug shows promise for children with brain tumours

New generation anti-cancer drug shows promise for children with brain tumours
2021-07-07
A genetic map of an aggressive childhood brain tumour called medulloblastoma has helped researchers identify a new generation anti-cancer drug that can be repurposed as an effective treatment for the disease. This international collaboration, led by researchers from The University of Queensland's (UQ) Diamantina Institute and WEHI in Melbourne, could give parents hope in the fight against the most common and fatal brain cancer in children. UQ lead researcher Dr Laura Genovesi said the team had mapped the genetics of these aggressive brain tumours for five ...

Not only humans got talent, dogs got it too!

Not only humans got talent, dogs got it too!
2021-07-07
Some exceptionally gifted people have marked human history and culture. Leonardo, Mozart, and Einstein are some famous examples of this phenomenon. Is talent in a given field a uniquely human phenomenon? We do not know whether gifted bees or elephants exist, just to name a few species, but now there is evidence that talent in a specific field exists, in at least one non-human species: the dog. A new study, just published in Scientific Reports, found that, while the vast majority of dogs struggle to learn object labels (such as the names of their toys), when tested in strictly controlled conditions, a handful of gifted word learner ...

Cutting through noise for better solar cells

Cutting through noise for better solar cells
2021-07-07
As society moves towards a renewable energy future, it's crucial that solar panels convert light into electricity as efficiently as possible. Some state-of-the-art solar cells are close to the theoretical maximum of efficiency--and physicists from the University of Utah and Helmholtz-Zentrum Berlin have figured out a way to make them even better. In a new study, physicists used a technique known as cross-correlation noise spectroscopy to measure miniscule fluctuations in electrical current flowing between materials inside silicon solar cells. The researchers identified crucial electrical ...

Harnessing AI to discover new drugs

2021-07-07
Nature has a vast store of medicinal substances. "Over 50 percent of all drugs today are inspired by nature," says Gisbert Schneider, Professor of Computer-Assisted Drug Design at ETH Zurich. Nevertheless, he is convinced that we have tapped only a fraction of the potential of natural products. Together with his team, he has successfully demonstrated how artificial intelligence (AI) methods can be used in a targeted manner to find new pharmaceutical applications for natural products. Furthermore, AI methods are capable of helping to find alternatives to these compounds that have the same effect but are much easier and therefore cheaper to ...

Researchers identify ultrastable single atom magnet

Researchers identify ultrastable single atom magnet
2021-07-07
Researchers at the IBS Center for Quantum Nanoscience at Ewha Womans University (QNS) have shown that dysprosium atoms resting on a thin insulating layer of magnesium oxide have magnetic stability over days. In a study published in Nature Communications they have proven that these tiny magnets have extreme robustness against fluctuations in magnetic field and temperature and will flip only when they are bombarded with high energy electrons through the STM-tip. Using these ultra-stable and yet switchable single-atom magnets, the team has shown atomic-scale control of the magnetic field within ...

Anti-androgen therapy can fuel spread of bone tumours in advanced prostate cancer

2021-07-07
Dr Bock, under the mentorship of Distinguished Professor Dietmar Hutmacher, from QUT Centre for Biomedical Technologies, has focused her research on bone metastases from breast and prostate cancers. She developed 3D miniature bone-like tissue models in which 3D printed biomimetic scaffolds are seeded with patient-derived bone cells and tumour cells to be used as clinical and preclinical drug testing tools. The research team investigated their hypothesis that traditional anti-androgen therapy had limited effect in the microenvironment of prostate cancer bone tumours. The team's findings are published in Science Advances. "We wanted to see if the therapy could be a contributor of cancer cells' adaptive responses that fuelled bone ...

The shape of nanoparticles in body fluids may help identify the type of cancer

The shape of nanoparticles in body fluids may help identify the type of cancer
2021-07-07
A recent study by scientists from Japanese universities has shown that the shape of cell-derived nanoparticles, known as "extracellular vesicles" (EVs), in body fluids could be a biomarker for identifying types of cancer. In the study, the scientists successfully measured the shape distributions of EVs derived from liver, breast, and colorectal cancer cells, showing that the shape distributions differ from one another. The findings were recently published in the journal Analytical Chemistry. Early detection of cancerous tumors in the body is essential for ...

Mount Sinai research reveals how Ebola virus manages to evade the body's immune defenses

2021-07-07
New York, NY (July 6, 2021) - Mount Sinai researchers have uncovered the complex cellular mechanisms of Ebola virus, which could help explain its severe toll on humans and identify potential pathways to treatment and prevention. In a study published in mBio, the team reported how a protein of the Ebola virus, VP24, interacts with the double-layered membrane of the cell nucleus (known as the nuclear envelope), leading to significant damage to cells along with virus replication and the propagation of disease. "The Ebola virus is extremely skilled at dodging the body's immune defenses, and in our study we characterize an important way in which that evasion occurs through disruption of the nuclear envelope, mediated by the VP24 protein," says co-senior ...
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