Tumors are not just isolated clumps of abnormal cells but are associated with more complex system known as the “tumor microenvironment” (TME). Over the past few years, research has revealed that the TME consists of a complex combination of blood vessels, connective tissue, and a matrix of extracellular proteins and molecules. Most importantly, the composition of the TME is different from that of nearby healthy tissues. In particular, the lipid and collagen contents of tumors differ from those of normal tissues, making them important potential biomarkers for diagnosing various types of ...

A special focus issue of the peer-reviewed Journal of Integrative and Complementary Medicine (JICM) on Global Public Health is a response to the Declaration of Astana, developed by the World Health Organization and UNICEF. With contributions from traditional, complementary, and integrative medicine (TCIM) scholars and thought leaders around the world, the issue showcases research and scholarship examining the opportunities and challenges that TCIM approaches offer global health to governments and health service providers seeking to fulfill ...

With a group of core partners, Arizona State University is creating a new $25 million collaboration to preserve and restore vitality to Hawaiʻi’s coral reefs and the health of its coastlines. The community-based effort looks to fuse state-of-the-art science programs with the leadership and cultural knowledge of Hawaiʻi’s community partners to enable coastal and reef sustainability for generations to come. Named ʻĀkoʻakoʻa (pronounced ah kō-a kō-a), the effort shares a dual meaning ʻto assemble’ and ‘coral.’ “For ...

Women and men who experience migraine headaches also carry an elevated risk of having an ischemic stroke, but women alone may carry an additional risk of heart attack and hemorrhagic stroke, according to a new study led by Cecilia Hvitfeldt Fuglsang of Aarhus University, Denmark publishing June 13th in the open access journal PLOS Medicine. People diagnosed with migraine are believed to have a higher risk of experiencing a heart attack or stroke before the age of 60. Previous studies have suggested ...

Researchers led by Christi Gendron at the University of Michigan, US, have found the link between death perception and reduced aging in flies. Their new study, published June 13th in the open access journal PLOS Biology shows that a specific group of brain cells in the fly, called R2 and R4 neurons, are activated when flies encounter other dead flies, and that this increased activity leads to more rapid aging. Aging is a complex process that can be affected by both genetics and the environment. While we know that perceptual experiences can affect ...

Study develops primer scheme for human monkeypox virus that can be plugged into currently existing amplicon-based sequencing and bioinformatics infrastructure; this approach has enabled public health laboratories to quickly adapt their genomic workflows in response to a newly emerging pathogen. ##### In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002151 Article Title: Development of an amplicon-based sequencing approach in response ...

Entry of the SARS-CoV-2 virus into human tissues depends on the activity of a host gene that regulates production of a key viral receptor, according to a study publishing June 13th in the open access journal PLOS Biology by Madison Strine and Craig Wilen of Yale University, US, and colleagues. The finding provides important new information on how the virus responsible for COVID-19 causes infection and may lead to new antiviral treatments. In previous work, the authors identified the gene DYRK1A as critical for SARS-CoV-2 pathogenesis. The gene encodes a kinase, a type of enzyme, and had been previously implicated in regulating cell proliferation ...

CHICAGO—June 13,  2023—Illinois Institute of Technology (Illinois Tech) has been named as a Dassault Systèmes Global 3DEXPERIENCE (3DX) Education Centers of Excellence, a prominent distinction achieved by only three universities in the United States. On May 11, Illinois Tech recognized this esteemed recognition with the unveiling of a plaque in the newly-launched 3DEXPERIENCE demonstration space. This prestigious honor places Illinois Tech at the forefront of educational institutions leveraging the most advanced digital technology tools and amplifies Illinois Tech's role in equipping ...

In today's dynamic environment where electricity demand is skyrocketing, power converters are the unsung heroes quietly transforming the way we harness and utilize electrical energy and seamlessly fueling our daily lives – from the ubiquitous wall chargers powering up everything from laptops to cell phones to integral parts of electrical systems that keep offshore wind turbines spinning. By 2030, over 80% of electricity is expected to flow through power converters, creating a pressing need to extend their operational lifetime. “Without power conversion, you cannot really get energy from or efficiently from solar panels and wind turbines, you cannot charge electric ...

You may have heard it said before that a picture is worth a thousand words, but what about an emoji? Since emoji were first created in the 1990s, their use has evolved and increased significantly in text messaging, social media, email and more. And now, even clinicians are using them when communicating with each other at work. “It's very interesting, the idea that a single emoji has some some kind of meaning, but could mean something different to different people,” said Colin Halverson, PhD, assistant professor of medicine at Indiana University School of Medicine. Halverson, along with Mike ...

ProtectedSeas Navigator—the first global map of the world’s marine life regulations and their boundaries is now available. Navigator is a free, interactive map of over 21,000 marine protected and managed areas across 220 countries and territories and in over 25 languages. Navigator offers a global view of marine life protections to help inform progress towards international conservation goals, including protecting 30 percent of the global ocean by 2030, which was adopted at the UN Biodiversity ...

KANSAS CITY, MO—June 13, 2023—Lacking bones, brains, and even a complete gut, the body plans of simple animals like sea anemones appear to have little in common with humans and their vertebrate kin. Nevertheless, new research from Investigator Matt Gibson, Ph.D., at the Stowers Institute for Medical Research shows that appearances can be deceiving, and that a common genetic toolkit can be deployed in different ways to drive embryological development to produce very different adult body plans.     It is well established that sea anemones, corals, and their jellyfish relatives shared a common ancestor with humans that plied the Earth’s ancient oceans ...

OFFSHORE WIND POWER OFFERS A PROMISING SOLUTION to the challenge of decarbonizing coastal China. China’s coastal provinces, though small in land mass, are home to 76% of the population; they are also responsible for 72% of total national power consumption and 70% of total CO2 emissions. Transitioning the coastal areas away from fossil fuels is one of China’s core challenges for achieving carbon neutrality by 2060, and offshore wind power may hold the key. New research published in Nature Communications develops a bottom-up model to ...

The first side-necked turtle ever to be found in the UK has been discovered by an amateur fossil collector and palaeontologists at the University of Portsmouth. The fossil remains are the earliest of a so-called side-necked pan-pleurodiran turtle, named as such because they fold their neck into their shell sideways when threatened. This does mean they can only see out with one eye. Originally found on a National Trust beach on the Isle of Wight, the turtle fossil is an almost complete shell with cervical, dorsal and caudal vertebrae, scapulae, pelvic girdle and appendicular bones. Sadly, the skull was missing. Lead author, Megan Jacobs, ...

LOS ANGELES -- A new study from Keck Medicine of USC has uncovered significant racial disparities in the diagnosis, treatment and outcomes of peripheral artery disease (PAD) among Black and white patients in the United States.   PAD, which affects approximately eight to 12 million Americans and is associated with nearly half of the 150,000 yearly amputations in the U.S., is a potentially life-threatening condition in which the arteries that carry blood from the heart to the legs narrow or become blocked by the buildup of fatty plaque. This can lead to a heart attack, stroke or amputation of the affected limb.  “We discovered that Black patients are nearly 50% less ...

About The Study: The findings of this study suggest that current dementia risk scores have limited clinical utility for estimation of 10-year dementia risk. Further research is needed to develop more accurate algorithms for estimation of dementia risk. Authors: Mika Kivimäki, Ph.D. of University College London, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi: 10.1001/jamanetworkopen.2023.18132) Editor’s Note: Please see the article for ...

About The Study: This study found that when clinicians use emoji and emoticons in secure clinical texting systems, these symbols function primarily to convey new and interactionally salient information. These results suggest that concerns about the professionalism of emoji and emoticon use may be unwarranted. Authors: Colin M. E. Halverson, Ph.D., of the Indiana University School of Medicine in Indianapolis, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi: 10.1001/jamanetworkopen.2023.18140) Editor’s Note: Please ...

Embargoed by Nature Communications until 10 a.m. Central Time on Tuesday, June 13 SAN ANTONIO (June 13, 2023) — Researchers from The University of Texas Health Science Center at San Antonio, working with collaborators in five countries, today revealed that the capacity to resist or recover from infections and other sources of inflammatory stress — called “immune resilience” — differs widely among individuals. The researchers developed a unique set of metrics to quantify the level ...

Following encouraging results from pre-clinical research and a recent clinical trial on stem cell-based treatments for patients with Type 1 diabetes, researchers are now working on maximizing the function and potential of stem cell-based treatments for future application in patients.    More than 8 billion people worldwide live with Type 1 diabetes (T1D) according to recent estimates. In T1D, the so-called beta cells in the pancreas do not make enough of the hormone insulin due to the destruction of beta-cells by the immune system leading to blood sugar levels rising above normal levels. Over time, T1D can lead to severe organ damage. There is no cure ...

Researchers have used heart and lung stem cells infected with the virus that causes COVID-19 to better understand how the disease impacts different organs, paving the way for more targeted treatments. The research, co-led by Murdoch Children’s Research Institute and the Peter Doherty Institute for Infection and Immunity (Doherty Institute), found the responses to SARS-CoV-2 varied significantly depending on the cell type, allowing the team to identify effective anti-viral drugs to treat infection in heart and lung cells. The findings were published in the 10th anniversary edition of Stem Cell Reports.  Murdoch ...

Four state policies introduced during the COVID-19 pandemic to spur expansion of telehealth were associated with expansion of such services by mental health facilities, but growth of telehealth was lower among facilities in counties with the greatest proportion of Black residents, according to a new RAND Corporation study.   Expansion of telehealth also was lower among facilities that accepted Medicaid or the Children’s Health Insurance Program, two government insurance programs that aid primarily lower-income Americans, according to the study.   The findings show that disparities in access to mental health care persisted even as ...

Only 1 in 4 residential addiction treatment facilities caring for U.S. adolescents under 18 years old offer buprenorphine, a medication used to treat opioid use disorder, according to a new study. Only 1 in 8 offer buprenorphine for ongoing treatment. These findings highlight a significant gap in access to evidence-based addiction treatment among young people. Published in JAMA, this study was supported by the National Institute on Drug Abuse (NIDA) and the National Center for Advancing Translational Sciences ...

LA JOLLA (June 13, 2023)—The immune system protects the body from invaders, such as bacteria, viruses, or tumors, with its intricate network of proteins, cells, and organs. Specialized immune cells, called cytotoxic T cells, can develop into short-lived effector cells that kill infected or cancerous cells within our bodies. A small portion of those effector cells remain after an infection and become longer-lived memory cells, which “remember” infections and respond when infections reappear. ...

PHILADELPHIA—The Pew Charitable Trusts today announced the 22 researchers selected to join the Pew Scholars Program in the Biomedical Sciences. These early-career scientists will receive four years of funding to spearhead innovative studies exploring human health and medicine. “From vaccine development to treatments for complex diseases, biomedical research is foundational to solving some of the world’s greatest health challenges,” said Susan K. Urahn, Pew’s president and CEO. “Pew is thrilled to welcome this new class of researchers and support their efforts to advance scientific knowledge and improve human ...

PHILADEPHIA—The Pew Charitable Trusts and the Alexander and Margaret Stewart Trust announced today the 2023 class of the Pew-Stewart Scholars Program for Cancer Research. These early-career scientists will receive four-year grants to explore new horizons in cancer development, diagnosis, and treatment. This class marks the 10th year the Alexander and Margaret Stewart Trust has partnered with Pew to build a legacy of innovative cancer research. “Cancer is one of the most pressing challenges facing biomedical researchers today,” said Susan K. Urahn, Pew’s president and CEO. “Pew ...