The authors of new research say supporting children and young people's mental health is as important as supporting their academic progress, and that particular attention should be paid to the fact that some young people have struggled more than others. Findings from their study, published in the Journal of Affective Disorders, focused on the connections between loneliness, social contact, parental relationships, and the mental health of adolescents aged 11-16 during the first full UK lockdown from March to May 2020. Their analysis drew on self-reported data from 894 young people who each completed a survey throughout to gauge their experiences of lockdown and its effects on their emotions, relationships, and feelings. The team from the universities of Bath, Bristol, ...

Hypoxia, or the inadequate oxygenation of a tissue, is a condition occurring frequently in all solid tumours such as melanoma skin cancer. Melanoma cells are not only able to survive oxygen deprivation, but also to use it to their own advantage by hijacking the anti-tumour immune response and developing resistance mechanisms to conventional anti-cancer therapies. A key gene responsible for cancer cell adaptation to hypoxia is HIF-1α (Hypoxia Inducible Factor-1 alpha). Led by Dr Bassam Janji, head of the Tumor Immunotherapy and Microenvironment (TIME) research group at the Luxembourg Institute ...

A research group led by Professor Sachie Hiratsuka, Institute for Biomedical Research, Shinshu University, has found that a specific sequence of messenger RNA (mRNA), which exists outside cells, binds to receptors on the surface of natural killer (NK) cells and is taken up into the nucleus. The group found that NK cells with mRNA uptake are able to enhance their migration activity and interferon gamma production. Furthermore, NK cells incorporating the mRNA showed an inhibitory effect on cancer metastasis in animal experiments. In recent years, the results of cancer treatment have been improving with the increase of medical ...

Helsinki University research group used live tissue imaging for the first time to visualise the emergence of the mammary gland. Despite long-standing interest, the cellular mechanisms driving the initiation of mammary gland development have remained elusive for decades, mostly due to technical limitations in studying dynamic cell behaviors in live tissues. Recent advances in microscopic methods and availability of various mouse models allowed the research group of Marja Mikkola from HiLIFE Institute of Biotechnology, University of Helsinki to address this question. This is the first time when live tissue imaging has been used to visualise the emergence of the mammary gland. Mammary gland is the class-defining organ of mammals, yet we know surprisingly little how its ...

Acrylamide is a toxic chemical compound that affects the nervous system. Not only is it widely used in industries such as paper production, plastics, and wastewater management, but it is also a byproduct of commonly used food processing methods, which makes human exposure to acrylamide inevitable. Therefore, many studies have focused on understanding the toxic effects of acrylamide and our body's response to them. Generally, in response to toxicity, the body's cells release protective factors and antioxidants to remedy the damage. This response is activated by various cellular machinery. One such activator is a protein called "nuclear factor erythroid 2-related factor 2" (Nrf2), ...

Special diets, exercise programs, supplements and vitamins, there is everywhere something supposed to help us live longer. Whether it actually works has not always been shown, but the average life expectancy of people has increased over the last 150 years. A study by an international team of researchers, including Claudia Fichtel and Peter Kappeler, scientists in the Behavioral Ecology and Sociobiology Unit at the German Primate Center (DPZ) - Leibniz Institute for Primate Research in Göttingen, indicates that we probably cannot slow down aging. The comparative studies with humans and non-human primates, indicates that it is not the rate at which humans age that slows ...

Washington, DC, June 21, 2021 - Depression in youth, between the ages of 10 and 24 years, is both a leading cause of stress and a possible risk factor for future diseases and impairment. Now, a study in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP), published by Elsevier, confirms that depression in childhood or adolescence is associated with higher levels of adult anxiety and substance use disorders, worse health and social functioning, less financial and educational achievement, and increased criminality. The findings are based on the Great Smoky Mountains Study, an ongoing longitudinal ...

TEL AVIV, Israel and RALEIGH, NC, June 21, 2021, RedHill Biopharma Ltd. (Nasdaq: RDHL) ("RedHill" or the "Company"), a specialty biopharmaceutical company, today announced presentation of the positive Phase 2 safety and efficacy data for oral opaganib (Yeliva®, ABC294640) in hospitalized patients with COVID-19 pneumonia at the World Microbe Forum (WMF) 2021 (poster #: 5574). Results and post hoc analyses of data from the 40-patient U.S. Phase 2 study were presented in a poster entitled, "Opaganib, an Oral Sphingosine Kinase-2 (SK2) Inhibitor in COVID-19 Pneumonia: A Randomized, Double-blind, Placebo-controlled Phase 2A Study, in ...

In 2013, François ENGLERT and Peter HIGGS won the Nobel Prize in Physics for the theoretical discovery of a mechanism that contributes to our understanding of the origin of mass of subatomic particles, which was confirmed through the discovery of the predicted fundamental particle by the A Toroidal LHC Apparatus (ATLAS) and the Compact Muon Solenoid (CMS) experiments at The European Organization for Nuclear Research (CERN)'s Large Hadron Collider in 2012. The Higgs mode or the Anderson-Higgs mechanism (named after another Nobel Laureate Philip W ANDERSON), has widespread influence ...

A Curtin University-led study of ancient bones on South Australia's Kangaroo Island has provided new information about the Island's past fauna and an insight into how species may live there in the future. Published in Quaternary Science Reviews, the researchers analysed around 2,000 bone fragments with the aim of eventually being able to establish a more complete picture of past biodiversity on the Island. Lead researcher Dr Frederik Seersholm from Curtin's School of Molecular and Life Sciences said DNA studies on such a large scale have never been done on the Island before. "We identified 33 species, 10 of which are extinct on the island today. We also found DNA traces from both the ...

A research team led by Professor Hongzhe SUN, Norman & Cecilia Yip Professor in Bioinorganic Chemistry and Chair Professor from Research Divison for Chemistry and Department of Chemistry, Faculty of Science, in collaboration with Dr Richard Yi-Ysun KAO, Associate Professor from the Department of Microbiology, Li Ka Shing Faculty of Medicine, and Dr Aixin YAN, Associate Professor from School of Biological Sciences, the University of Hong Kong (HKU), discovers that silver (Ag)-based antimicrobials can effectively combat antibiotic resistant Staphylococcus aureus by targeting multiple biological pathways via functional disruption of key proteins and can be further exploited to enhance the efficacy of conventional antibiotics ...

Microalgae are "simple" organisms of single cells, yet they pack a mighty potential punch when it comes to helping humanity achieve carbon neutrality, according to researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS). Their metabolic activities play fundamental roles in global carbon cycling and convert carbon dioxide into a wide variety of high-value macromolecules. Now, the QIBEBT researchers have developed a way to rapidly determine exactly which microalgae -- out of the millions of variations -- can most readily convert carbon dioxide into valuable compounds that can be used for fuels, food and drugs. They published ...

Fragrances are functional molecules with a pleasant scent that are widely used in aqueous products (cosmetics and detergents) and on surfaces such as textiles, leather and wallpaper. However, maintaining gentle and continuous scent on these items is an ongoing challenge in the field of flavours and fragrances. Profragrances are delivery systems used to control the release of the volatile compounds in fragrances. They have fragile chemical bonds that can be stimulated by ambient conditions such as light, temperature, pH value and even oxygen. Drawing on these molecular profragrances, ...

Carbon dioxide (CO2) emissions from human activities have risen drastically over the last century and a half and are seen as the primary cause of global warming and abnormal weather patterns. So, there has been considerable research focus, in a number of fields, on lowering our CO2 emissions and its atmospheric levels. One promising strategy is to chemically break down, or 'reduce,' CO2 using photocatalysts--compounds that absorb light energy and provide it to reactions, speeding them up. With this strategy, the solar powered reduction of CO2, where no other artificial source of energy is used, becomes ...

Scientists have used a compound made from a starch derivative and baking soda to help convert mechanical to electrical energy. The approach, developed by scientists at Daegu Gyeongbuk Institute of Technology (DGIST), with colleagues in Korea and India, is cost-effective and biocompatible, and can help charge low-energy electronics like calculators and watches. The details were published in the journal Advanced Functional Materials. "Triboelectric nanogenerators harvest mechanical energy and convert it into an electric current," explains DGIST robotics engineer Hoe Joon Kim. "But many of the materials used in these devices are considered a biohazard and are not suitable for wearable ...

Meningiomas, which originate in the meninges surrounding the brain, are the most common type of benign brain tumours. The primary treatment for meningiomas is neurosurgery. Since the risks associated with surgical treatment increase as people get older and develop other diseases, over 80-year-old patients with brain tumours are not operated on almost anywhere in the world. In Finland, the life expectancy and functional capacity of the elderly population have improved in recent decades, while the number of elderly brain tumour patients who are in good condition is continuously growing. This is why surgeries have increased in prevalence at the Neurosurgery Clinic of the Helsinki University Hospital in the treatment of elderly patients who have lost their ...

Tropical cyclones (TCs) can bring strong wind, heavy rain, and storm surge. Meteorologists are concerned that the effects of global warming may change how these storms impact humans. Scientists use global climate models (GCMs) in climate change studies to simulate future changes in temperature, precipitation, etc. However, due to their coarse resolutions, many models cannot properly simulate small-scale weather and climate systems like TCs, which means that they cannot capture all the dynamic processes within a TC. A study led by Prof. Gao Xuejie from the Institute ...

Dissatisfaction with married life raises the risk of dying from a cerebrovascular accident: A new Tel Aviv University study reveals that perceiving marriage as unsuccessful is a significant predictor of death from a CVA and premature death among men, no less that well-known risk factors such as smoking and lack of physical activity. The study was based on extensive health data from more than 30 years of research that tracked the deaths of 10,000 Israeli men. The study was led by researchers from the School of Public Health at the Sackler Faculty of Medicine, Tel Aviv University: Prof. Uri Goldbort from the Department of Epidemiology and Preventive Medicine, who initiated and managed the long-term study; Dr. Shahar Lev-Ari, the head ...

Research has found that training stroke survivors to walk at a faster speed during recovery can help improve the brain function that enables people to walk and perform another task simultaneously, known as dual-task walking. The research, led by academics at Oxford Brookes University, was funded by the Stroke Association. People who've had a stroke often struggle to walk and do tasks that involve thinking at the same time, for example, activities such as walking and holding a conversation, or planning what to do next. To effectively walk in the community, cognitive effort is needed to navigate safely and deal with distractions. Many people fail to regain this ability after a stroke. Dual-task ...

Vitamin B12 is essential for proper functioning of the nervous system and blood cells and also plays an important role in DNA synthesis in all our cells. Vitamin B12 deficiency causes fatigue, muscle weakness, headaches, and sometimes even serious neurological symptoms. Usually, the necessary amounts of B12 are absorbed from food in our digestive tract; however, in 0.1-2% of individuals, the epithelial lining of the stomach fails to produce a glycoprotein intrinsic factor that is needed for proper absorption of B12. This leads to vitamin B12 deficiency and a certain type of anemia called pernicious anemia. Pernicious ...

The research team used data from world renowned health study Children of the 90s, to answer three research questions: Is school enjoyment patterned by biological sex at birth, socioeconomic background of cognition? How does school enjoyment relate to GCSE achievement? Does school enjoyment relate to social or sex differences in GCSE achievement? The team found that pupil's school enjoyment measured at six years old is patterned by their sex and cognitive ability but not their family's socioeconomic background. For example, girls were twice as likely to report enjoying school than boys. School enjoyment strongly related to GCSE achievement at age 16 even after consideration of their socioeconomic background ...

UNIVERSITY PARK, Pa. -- Workers in the service industry are often pressured by their employers to give friendly "service with a smile." New research suggests that when those employees also rely on tips to earn a living, it creates a power dynamic between the employee and customer that may increase the likelihood of sexual harassment on the job. Alicia Grandey, liberal arts professor of psychology at Penn State, said the findings could give insight into how companies can help reduce sexual harassment from customers, including raising employees' hourly wages. "It may not be necessary to completely eliminate customer tips, but rather reduce the dependence on tips by offering a livable wage," Grandey said. "Based on our results, if employees were ...

WASHINGTON (June 21, 2021)--Previous research has suggested that the stress of discrimination may play a role in the development of health problems that disproportionately affect lesbian, gay and bisexual individuals. A study published today finds that when lesbian, gay and bisexual adults are exposed to even mild anti-gay prejudice, it triggers bodily changes such as increases in blood pressure that can contribute to heart disease. "This study provides strong evidence that when LGB people experience anti-gay prejudice, their bodies respond with increases in heart rate and blood pressure, and in the stress hormone cortisol," David M. Huebner, a professor of prevention and community health at the George Washington University and lead author of the study, said. "When the body responds ...

Lesbian, gay and bisexual people who encounter homophobic attitudes experience increases in heart rate, blood pressure and stress hormones, potentially putting them at risk for multiple health problems, according to research published by the American Psychological Association. "This study shows the potentially toxic impact discriminatory attitudes can have on lesbian, gay and bisexual people's health," said lead author David M. Huebner, PhD, associate professor of prevention and community health at The George Washington University. "This is just one more, among many, corrosive effects of homophobia." In the study, published in the journal Health Psychology, researchers looked at 134 lesbian, gay and bisexual ...

Relationships are often undermined by everyday frustrations like work stress or financial anxiety, but how do couples handle a challenge as unprecedented as the COVID-19 pandemic? People who blamed their stress on the pandemic more than on their partner were happier in their relationship, a new study in Social Psychological and Personality Science reports. Previous research has shown that romantic partners tend to be more critical toward each other when experiencing common stress, but major events like natural disasters are not always associated with poor relationship functioning. Because these significant stressors ...