QUT PhD researcher Zachariah Schuurs said the research team had identified a new binding site on the SARS-CoV-2 spike protein. "Binding of the CoV-2 spike protein to heparan sulphate (HS) on cell surfaces is generally the first step in a cascade of interactions the virus needs to initiate an infection and enter the cell. "Most research has focused on understanding how HS interacts on the receptor-binding domain (RBD) and furin cleavage site of the SARS-CoV-2 virus's spike protein, as these typically bind different types of drugs, vaccines and antibodies. "We have identified a novel binding site on the N-terminal domain (NTD), a different area of the virus's spike that facilitates the binding of HS. This helps to better understand how the virus ...

A new study of lithium production in a classical nova found a production rate of only a couple of percent that seen in other examples. This shows that there is a large diversity within classical novae and implies that nova explosions alone cannot explain the amount of lithium seen in the current Universe. This is an important result for understanding both the explosion mechanism of classical novae and the overall chemical evolution of the Universe. In the modern world, lithium is used in the rechargeable batteries powering smartphones and other devices. ...

Cheap to produce and long to degrade, plastic was once a manufacturing miracle. Now, plastic is an environmental plague, clogging landfills and choking waterways. A Japan-based research team has turned back to nature to develop an approach to degrading the stubborn substance. Similar to how a protein binds to cellulose in plants or to chitin in crustaceans to initiate decomposition, an engineered protein is on its way to binding to plastic particles in an effort to more efficiently break them down. They published their results on June 29 in ACS Catalysis, a journal of the American Chemical Society. "Polyethylene ...

In two recent articles published in Schizophrenia Bulletin, Sharon Hunter, PhD, an associate professor in the University of Colorado School of Medicine Department of Psychiatry, and M. Camille Hoffman, MD, MSc, an associate professor in the University of Colorado School of Medicine Department of Obstetrics and Gynecology, along with their research group, have uncovered a potential link between choline deficiency in Black pregnant women in the United States and increased risk of developmental and behavioral issues that can evolve into mental illness later in their children's lives. The first article, published in November 2020, is a study, titled, "Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness." The ...

Scientists at KAIST have fabricated a laser system that generates highly interactive quantum particles at room temperature. Their findings, published in the journal Nature Photonics, could lead to a single microcavity laser system that requires lower threshold energy as its energy loss increases. The system, developed by KAIST physicist Yong-Hoon Cho and colleagues, involves shining light through a single hexagonal-shaped microcavity treated with a loss-modulated silicon nitride substrate. The system design leads to the generation of a polariton laser at room temperature, which is exciting because this usually requires cryogenic temperatures. The researchers found another unique and counter-intuitive feature of this design. Normally, energy is lost during laser operation. ...

Australian scientists researching how our immune system responds to COVID-19 have revealed that those infected by early variants in 2020 produced sustained antibodies, however, these antibodies are not as effective against contemporary variants of the virus. The research is one of the world's most comprehensive studies of the immune response against COVID-19 infection. It suggests vaccination is more effective than the body's natural immune response following infection and shows the need to invest in new vaccine designs to keep pace with emerging COVID variants. Published today in PLOS ...

Polymer composite materials that combine magnetic and electrical properties are the subjects of particular attention for modern-day researchers. Their basic property is the ability to convert electric polarization into a magnetic field and vice versa. Although some materials exhibit a much better magnetoelectric effect, polymer-based composites are easier not only to produce but also to modify. Such composites have great potential in a variety of different fields. For example, using them as a basis, scientists can develop surfaces that help cultivate various cells. In this case, polymer composites serve as a substrate through which it is possible to affect the culture using a non-contact and controlled electric charge and morphological properties ...

DANVILLE, Pa. - Having multiple chronic health conditions and living in a rural area were the top two factors affecting increased healthcare system contact among older patients with bladder cancer, a research team has found. The Geisinger-led team evaluated 73,395 Medicare beneficiaries age 66 and older who had been diagnosed with non-muscle-invasive bladder cancer to assess their treatment burden, defined as the number of days the patients had contact with a health system in the year following diagnosis. Nearly two-thirds of the patients had multiple co-existing chronic conditions at the time of bladder cancer diagnosis, as well as other aging-related conditions, including a history of falls, ...

Opioid prescribing preferences and practices among surgical residents and faculty differ, according to a new study published in the journal Surgery. The study, titled "Evaluation of opioid prescribing preferences among surgical residents and faculty," was based on a survey of 56 residents and 57 faculty within the University of Colorado School of Medicine Department of Surgery. In the survey, participants were asked how many oxycodone tablets they would prescribe for 14 common surgical procedures. Answers were compared between residents and faculty, as well as against the Opioid Prescribing Engagement Network (OPEN) guidelines and actual opioids ...

A new screening method that can test the effectiveness of therapeutic molecules designed to 'glue' proteins together in the body has been developed by researchers at the University of Birmingham and the University of Leicester. The research paves the way for drug developers to screen large numbers of potential new drug compounds to discover new treatments for diseases such as breast cancer and Parkinson's disease. The ways in which proteins interact with each other are fundamental to all cell functions. These interactions underpin every function of a healthy body, with any slight change in these interactions resulting in disease. A handful ...

Scientists at the University of Cambridge have identified rare genetic variants - carried by one in 3,000 people - that have a larger impact on the risk of developing type 2 diabetes than any previously identified genetic effect. Type 2 diabetes is thought to be driven in part by inherited genetic factors, but many of these genes are yet unknown. Previous large-scale studies have depended on efficient 'array genotyping' methods to measure genetic variations across the whole genome. This approach typically does a good job at capturing the common genetic differences between people, though individually these each confer only small increases in diabetes ...

DALLAS, July 7, 2021 -- Myocarditis in children is a rare yet challenging condition to treat. Diagnosis and treatment includes multiple options, and many cases of myocarditis resolve on their own, according to a new scientific statement from the American Heart Association, "Diagnosis and Management of Myocarditis in Children," published today in Circulation, the Association's flagship journal. The scientific statement writing group reviewed the latest research to develop guidance in diagnosis and treatment for myocarditis in children. Myocarditis is inflammation of the middle layer of the wall of the heart muscle, the myocardium, and it ...

The newly developed method lets researchers rapidly and accurately measure stress hormones in snow leopards without the need for bulky equipment or specialised knowledge. It uses widely available equipment that can be carried into the field, allowing hormone extraction from faecal samples and analysis to be done on site. This differs from existing approaches to hormone monitoring in wild animals, where faecal samples must be taken to laboratories for hormone extraction and analysis. These approaches are particularly limiting in remote locations, such as the Himalayas. "Because conventional hormone monitoring methods require frozen and refrigerated chemical reagents, and laboratory equipment, it is almost impossible to use them on-site." explained ...

CLEVELAND, Ohio (July 7, 2021)--Estrogen has been thought to play a role in a woman's risk of developing Alzheimer disease (AD). A new study has taken a different approach to identifying risk factors for AD by examining the association between a woman's reproductive life span as an indicator of endogenous estrogen exposure and levels of cerebrospinal fluid biomarkers. Study results are published online in Menopause, the journal of The North American Menopause Society (NAMS). Alzheimer disease represents 60% to 70% of all dementia diagnoses, making it the most common form of dementia. Approximately ...

A new study in the Journal of the European Economic Association, published by Oxford University Press, finds that electoral districts with a larger gender pay gaps show favoritism toward male political candidates in Parliamentary elections, with fewer female candidates on the ballot. The researchers here gathered data for seven parliamentary elections in France between 1988 and 2017. Researchers studied candidates from the Left and Right political coalitions, which account for 80% of elected members of Parliament. The researchers consulted administrative and web data on candidates and electoral outcomes, survey data on ...

Oncotarget published "Association between miRNA signatures in serum samples from epidermal growth factor inhibitor treated patients and skin toxicity" which reported that on average 70% of patients treated with EGFRIs suffer from skin toxicity. Studies showed a correlation between overall survival and the appearance of a skin rash, which is used as a biomarker for therapy efficacy. In this study, the authors searched for associations of miRNA expression profiles in serum, with the severity of skin rash, in order to identify tentative therapy predictive biomarkers. In this cohort of patients treated with EGFR inhibiting monoclonal antibodies, miR-21 and miR-520e serum concentrations were negatively correlated with severity of skin rash whereas for miR-31, a positive correlation was ...

A research team consisting of Tsutomu Kobayashi, Ichiro Hasuo, Fuyuki Ishikawa, and Shinya Katsumata at the National Institute of Informatics (NII, Japan) and Rick Salay and Krzysztof Czarnecki at University of Waterloo (Canada) developed a method that automatically transforms models of controller software into models that satisfy safety requirements even when there is uncertainty in sensing the state of the environment. In addition to the transformation, the method generates formulas that represent the degree of uncertainty that the controller software can tolerate. The method can be applied to various controller systems that interact with the external environment, ...

In the line-up of wild African fruits, the marula is the best known. For thousands of years, people have depended on the trees for food, medicines, and more. It is also exported globally as the rockstar ingredient of a cream liqueur. The fruit is a success story far beyond the savannas and bushveld where the trees grow. But there is a whole choir of other wild, indigenous fruits in Southern Africa. And some exceed daily nutritional values recommended by the WHO and others. Research from the University of Johannesburg uncovers a variety of building blocks for protein in the fruit of 14 species. Several are analyzed for ...

Coastal communities across the world are increasingly facing up to the huge threats posed by a combination of extreme storms and predicted rises in sea levels as a result of global climate change. However, scientists at the University of Plymouth have developed a simple algorithm-based model which accurately predicts how coastlines could be affected and - as a result - enables communities to identify the actions they might need to take in order to adapt. The Forecasting Coastal Evolution (ForCE) model has the potential to be a game-changing advance in coastal evolution science, allowing adaptations in the shoreline to be predicted over timescales of anything from days to decades and beyond. This broad range of timescales means that the model is capable of predicting ...

Philadelphia, July 7, 2021 - Tourette syndrome, a neurodevelopmental disorder, causes motor and phonic "tics" or uncontrollable repeated behaviors and vocalizations. People affected by Tourette syndrome can often suppress these tics for some time before the urges become overwhelming, and researchers have long wondered at the neural underpinnings of the suppression effort. Now, in a new study using a non-invasive technique to measure brain activity called high-density electroencephalography (hdEEG), researchers at Yale School of Medicine have assessed the impact of tic suppression on functional ...

Frailty is a better predictor than factors such as age when determining how older adults fare one year after receiving critical care. A team led by researchers from the University of Waterloo analyzed data from more than 24,000 community-dwelling older adults receiving home care in Ontario who were subsequently admitted into an intensive-care unit (ICU). They applied three different measures for baseline frailty and found that an individual's level of frailty was linked to survival one year later. The most frail ICU survivors had only a one in five chance of living to one year after discharge. Clinical frailty is age-related and characterized ...

The UK public is likely to take the COVID-19 pandemic less seriously once restrictions are lifted, according to new research led by Cardiff University. Psychologists found lockdown in itself was a primary reason why so many people were willing to abide by the rules from the start - believing the threat must be severe if the government imposes such drastic measures. The team from Cardiff and the universities of Bath and Essex examined the reasons behind headline polling support for COVID-19 measures. They carried out two UK surveys*, six months apart, during 2020. Their findings are published today in the journal Royal Society Open Science. Lead author Dr Colin Foad said: "Surprisingly, we found that people judge the severity ...

An unknown methane-producing process is likely at work in the hidden ocean beneath the icy shell of Saturn's moon Enceladus, suggests a new study published in Nature Astronomy by scientists at the University of Arizona and Paris Sciences & Lettres University. Giant water plumes erupting from Enceladus have long fascinated scientists and the public alike, inspiring research and speculation about the vast ocean that is believed to be sandwiched between the moon's rocky core and its icy shell. Flying through the plumes and sampling their chemical makeup, the Cassini spacecraft detected a relatively high concentration of certain molecules associated with hydrothermal vents on the bottom of Earth's oceans, specifically dihydrogen, ...

Using artificial intelligence, UT Southwestern scientists have identified thousands of genetic mutations likely to affect the immune system in mice. The work is part of one Nobel laureate's quest to find virtually all such variations in mammals. "This study identifies 101 novel gene candidates with greater than 95% chance of being required for immunity," says END ...

Five Simon Fraser University scholars are among international scientists sounding an alarm over the "pervasive social and ecological consequences" of the destruction and suppression of the knowledge systems of Indigenous Peoples and local communities. Their paper, published today in the Journal of Ethnobiology, draws on the knowledge of 30 international Indigenous and non-Indigenous co-authors, and highlights 15 strategic actions to support the efforts of Indigenous Peoples and local communities in sustaining their knowledge systems and ties to lands. Study co-lead, SFU archaeology professor Dana Lepofsky, says, "We ...